LOCUS       NM_144903               2018 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus aldolase B, fructose-bisphosphate (Aldob), mRNA.
ACCESSION   NM_144903
VERSION     NM_144903.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Buziau,A.M., Oosterveer,M.H., Wouters,K., Bos,T., Tolan,D.R.,
            Agius,L., Ford,B.E., Cassiman,D., Stehouwer,C.D.A., Schalkwijk,C.G.
            and Brouwers,M.C.G.J.
  TITLE     Hepatic glucokinase regulatory protein and carbohydrate response
            element binding protein attenuation reduce de novo lipogenesis but
            do not mitigate intrahepatic triglyceride accumulation in Aldob
            deficiency
  JOURNAL   Mol Metab 87, 101984 (2024)
   PUBMED   38972375
  REMARK    GeneRIF: Hepatic glucokinase regulatory protein and carbohydrate
            response element binding protein attenuation reduce de novo
            lipogenesis but do not mitigate intrahepatic triglyceride
            accumulation in Aldob deficiency.
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Andres-Hernando,A., Orlicky,D.J., Kuwabara,M., Fini,M.A.,
            Tolan,D.R., Johnson,R.J. and Lanaspa,M.A.
  TITLE     Activation of AMPD2 drives metabolic dysregulation and liver
            disease in mice with hereditary fructose intolerance
  JOURNAL   Commun Biol 7 (1), 849 (2024)
   PUBMED   38992061
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Li,M., He,X., Guo,W., Yu,H., Zhang,S., Wang,N., Liu,G., Sa,R.,
            Shen,X., Jiang,Y., Tang,Y., Zhuo,Y., Yin,C., Tu,Q., Li,N., Nie,X.,
            Li,Y., Hu,Z., Zhu,H., Ding,J., Li,Z., Liu,T., Zhang,F., Zhou,H.,
            Li,S., Yue,J., Yan,Z., Cheng,S., Tao,Y. and Yin,H.
  TITLE     Aldolase B suppresses hepatocellular carcinogenesis by inhibiting
            G6PD and pentose phosphate pathways
  JOURNAL   Nat Cancer 1 (7), 735-747 (2020)
   PUBMED   35122041
REFERENCE   6  (bases 1 to 2018)
  AUTHORS   Maine,A.B., Stauffer,J.K., Tolan,D.R. and Ciejek-Baez,E.
  TITLE     Unique use of alternative polyadenylation signals in the mouse
            aldolase B gene
  JOURNAL   Biochim Biophys Acta 1129 (2), 243-245 (1992)
   PUBMED   1730064
REFERENCE   7  (bases 1 to 2018)
  AUTHORS   Henry,I., Gallano,P., Besmond,C., Weil,D., Mattei,M.G., Turleau,C.,
            Boue,J., Kahn,A. and Junien,C.
  TITLE     The structural gene for aldolase B (ALDB) maps to 9q13----32
  JOURNAL   Ann Hum Genet 49 (3), 173-180 (1985)
   PUBMED   3000275
REFERENCE   8  (bases 1 to 2018)
  AUTHORS   Sala-Trepat,J.M., Poiret,M., Sellem,C.H., Bessada,R., Erdos,T. and
            Gluecksohn-Waelsch,S.
  TITLE     A lethal deletion on mouse chromosome 7 affects regulation of
            liver-cell-specific functions: posttranscriptional control of serum
            protein and transcriptional control of aldolase B synthesis
  JOURNAL   Proc Natl Acad Sci U S A 82 (8), 2442-2446 (1985)
   PUBMED   3857594
REFERENCE   9  (bases 1 to 2018)
  AUTHORS   Stoltzner,G.
  TITLE     Effects of life-long dietary protein restriction on mortality,
            growth, organ weights, blood counts, liver aldolase and kidney
            catalase in Balb/C mice
  JOURNAL   Growth 41 (4), 337-348 (1977)
   PUBMED   604178
REFERENCE   10 (bases 1 to 2018)
  AUTHORS   Hue,L. and Hers,H.G.
  TITLE     The conversion of (4- 3 H)fructose and of (4- 3 H)glucose to liver
            glycogen in the mouse. An investigation of the glyceraldehyde
            crossroads
  JOURNAL   Eur J Biochem 29 (2), 268-275 (1972)
   PUBMED   4343087
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK168997.1, AK167566.1 and
            AL772310.27.
            
            On Aug 21, 2015 this sequence version replaced NM_144903.2.
            
            Summary: This gene encodes a subunit of the homotetrameric enzyme
            aldolase B, an isozyme of the class I fructose 1,6-bisphosphate
            aldolase enzyme. This enzyme catalyzes the conversion of fructose
            1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde
            3-phosphate. Homozygous knockout mice for this gene exhibit liver
            damage and death following fructose ingestion. A pseudogene of this
            gene has been identified in the genome. [provided by RefSeq, Aug
            2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168997.1, BC024056.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1586              AK168997.1         2-1587
            1587-2010           AK167566.1         1538-1961
            2011-2018           AL772310.27        123985-123992       c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.57 cM"
     gene            1..2018
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /note="aldolase B, fructose-bisphosphate"
                     /db_xref="GeneID:230163"
                     /db_xref="MGI:MGI:87995"
     exon            1..113
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     exon            114..235
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..1218
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /EC_number="4.1.2.13"
                     /note="liver-type aldolase"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase B"
                     /protein_id="NP_659152.1"
                     /db_xref="CCDS:CCDS18176.1"
                     /db_xref="GeneID:230163"
                     /db_xref="MGI:MGI:87995"
                     /translation="MAHRFPALTPEQKKELSEIAQRIVANGKGILAADESVGTMGNRL
                     QRIKVENTEENRRQFRELLFSVDNSISQSIGGVILFHETLYQKDSQGNLFRNVLKEKG
                     IVVGIKLDQGGAPLAGTNKETTIQGLDGLSERCAQYKKDGVDFGKWRAVLRIADQCPS
                     SLAIQENANALARYASICQQNGLVPIVEPEVLPDGDHDLEHCQYVSEKVLAAVYKALN
                     DHHVYLEGTLLKPNMVTAGHACTKKYTPEQVAMATVTALHRTVPAAVPGICFLSGGMS
                     EEDATLNLNAINRCPLPRPWKLSFSYGRALQASALAAWGGKAANKKATQEAFMKRAMA
                     NCQAAQGQYVHTGSSGAAATQSLFTASYTY"
     exon            236..447
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     exon            448..502
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     exon            503..663
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     exon            664..747
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     exon            748..922
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1122
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..2018
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1561..1566
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /note="hexamer: AAGAAA"
     polyA_site      1562
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /note="major polyA site"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /note="hexamer: AATAAA"
     polyA_site      1586
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
     regulatory      1996..2001
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
                     /note="hexamer: AATAAA"
     polyA_site      2015
                     /gene="Aldob"
                     /gene_synonym="Aldo-2; Aldo2"
ORIGIN      
        1 agaccttgat aagagggcta taaaaaccgt gctctctgag cagatccatc gtatttggcg
       61 gctgccacct cacacagctt ctgatacctt ggaggactct tcccctttgc tgtacctgtc
      121 atcatggctc accgatttcc agccctcacc ccagagcaga agaaggagct ctctgaaatt
      181 gcccagcgca ttgttgccaa tgggaagggc atcctggctg cagatgaatc tgtgggtacc
      241 atgggaaacc gcctgcaaag gataaaggtg gagaacaccg aagagaaccg aaggcagttc
      301 cgagaactcc tctttagtgt ggacaattcc attagccaga gcatcggcgg agtgatcctt
      361 ttccacgaga ccctctacca gaaggacagc cagggaaatc tgttcagaaa cgttctcaag
      421 gagaagggaa ttgtggtggg catcaagttg gaccaaggag gtgccccgct tgcaggaaca
      481 aacaaggaaa ccaccattca agggcttgat ggcctctctg aacgctgtgc tcagtacaag
      541 aaagatggag ttgactttgg gaagtggcgt gctgtgttga ggattgctga ccagtgtcct
      601 tccagccttg ctatccaaga aaatgccaat gctctggctc gctatgccag catctgtcag
      661 cagaatgggc tggtccctat tgttgagcca gaggtgcttc ctgacggaga ccatgacctg
      721 gagcactgcc agtatgtttc tgagaaggtc ctggctgctg tctacaaggc tctcaatgat
      781 catcatgttt acctagaagg caccttgcta aagccaaaca tggtgactgc tggacatgcc
      841 tgcacgaaga agtatacacc agagcaggtg gctatggcca ctgtcacagc tctccacaga
      901 actgttcctg cagctgttcc tggtatctgc tttttgtctg gaggtatgag tgaggaggat
      961 gctacactta acctcaatgc tatcaaccgt tgccctctac caaggccctg gaaactaagc
     1021 ttttcatatg gaagagccct ccaggccagt gcattggctg cctggggtgg caaggctgca
     1081 aacaagaagg caacccagga agctttcatg aagcgggcta tggctaactg ccaggcggcc
     1141 caaggacagt acgttcacac aggctcttca ggtgctgctg ccacccagtc gctcttcaca
     1201 gcctcctaca cctattagat actgtcacca ccagccaggc tccagttctc ctaaatattt
     1261 tggagacctg aatggctcag tcaaccctgg aaattagata acatttgatt gaacttctga
     1321 aaacacaaca catgtgaatc ataaacacaa gagaaaagcc aaatcagctt tgaaacccaa
     1381 gaatgagcat gtcacccaat agtctctcaa cacttccagt tccctatgtt ccagaacatt
     1441 catccaagaa aagaacaggc cacgactgag aaaagcaact cagaagcaga ggatggagaa
     1501 gggcatttta ataaacatag ttaccagggg ttggttatag aagaggcaca gcaacagaaa
     1561 aagaaataaa acgtgtatga accttccgtt ggtacagttt cactttcctg ctcttgttga
     1621 gggatcctgc atttcattgt ctttgcctat accagataca accccaatag tcaggatcct
     1681 cagccccaga tgctcactac agtcaagtgg ctgatggctc cctttagctg aattacacta
     1741 gaaactctac cagattaaat aagagttctt ttggggcttc ctatatgcag tcatacttga
     1801 gaacagtcag tctagacttc tagcttgaga atatttgaga atactaagct gcaacagaga
     1861 ctcatctctt ccaagctatg gagtgtagag aatgagttga taaacctgac ttggcatact
     1921 cctctccagg aatccaggtt ttgtgacaca gaactacatt ttcctctcaa agtcaagctg
     1981 gtcccccagc tgtgcaataa acaatcgttg aataattt
//
