LOCUS       NM_001177307            1595 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus aldolase A, fructose-bisphosphate (Aldoa), transcript
            variant 1, mRNA.
ACCESSION   NM_001177307
VERSION     NM_001177307.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1595)
  AUTHORS   Lagani,G.D., Sha,M., Lin,W., Natarajan,S., Kankkunen,M.,
            Kistler,S.A., Lampl,N., Waxman,H., Harper,E.R., Emili,A.,
            Beffert,U. and Ho,A.
  TITLE     Beyond Glycolysis: Aldolase A Is a Novel Effector in
            Reelin-Mediated Dendritic Development
  JOURNAL   J Neurosci 44 (42), e0072242024 (2024)
   PUBMED   39227156
  REMARK    GeneRIF: Beyond Glycolysis: Aldolase A Is a Novel Effector in
            Reelin-Mediated Dendritic Development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1595)
  AUTHORS   Buth,J.E., Dyevich,C.E., Rubin,A., Wang,C., Gao,L., Marks,T.,
            Harrison,M.R., Kong,J.H., Ross,M.E., Novitch,B.G. and Pearson,C.A.
  TITLE     Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha
            signaling to promote neural progenitor cell maintenance
  JOURNAL   EMBO Rep 25 (5), 2202-2219 (2024)
   PUBMED   38600346
REFERENCE   3  (bases 1 to 1595)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1595)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1595)
  AUTHORS   Sakai,D., Murakami,Y., Shigeta,D., Tomosugi,M., Sakata-Haga,H.,
            Hatta,T. and Shoji,H.
  TITLE     Glycolytic activity is required for the onset of neural plate
            folding during neural tube closure in mouse embryos
  JOURNAL   Front Cell Dev Biol 11, 1212375 (2023)
   PUBMED   37465012
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1595)
  AUTHORS   Vemuganti,S.A., Bell,T.A., Scarlett,C.O., Parker,C.E., de
            Villena,F.P. and O'Brien,D.A.
  TITLE     Three male germline-specific aldolase A isozymes are generated by
            alternative splicing and retrotransposition
  JOURNAL   Dev Biol 309 (1), 18-31 (2007)
   PUBMED   17659271
REFERENCE   7  (bases 1 to 1595)
  AUTHORS   Lupo,A., Costanzo,P., Medugno,L., Romeo,I., Salvatore,F. and
            Izzo,P.
  TITLE     Negative regulation of the mouse aldolase A gene. A cell
            cycle-dependent DNA binding activity functions as a silencer of
            gene transcription
  JOURNAL   J Biol Chem 272 (50), 31641-31647 (1997)
   PUBMED   9395505
REFERENCE   8  (bases 1 to 1595)
  AUTHORS   Stauffer,J.K., Colbert,M.C. and Ciejek-Baez,E.
  TITLE     Nonconservative utilization of aldolase A alternative promoters
  JOURNAL   J Biol Chem 265 (20), 11773-11782 (1990)
   PUBMED   2365699
REFERENCE   9  (bases 1 to 1595)
  AUTHORS   Mestek,A., Stauffer,J., Tolan,D.R. and Ciejek-Baez,E.
  TITLE     Sequence of a mouse brain aldolase A cDNA
  JOURNAL   Nucleic Acids Res 15 (24), 10595 (1987)
   PUBMED   3697100
REFERENCE   10 (bases 1 to 1595)
  AUTHORS   Paolella,G., Buono,P., Mancini,F.P., Izzo,P. and Salvatore,F.
  TITLE     Structure and expression of mouse aldolase genes. Brain-specific
            aldolase C amino acid sequence is closely related to aldolase A
  JOURNAL   Eur J Biochem 156 (2), 229-235 (1986)
   PUBMED   3009179
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124505.4.
            
            On Sep 9, 2022 this sequence version replaced NM_001177307.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13422603.364027.1,
                                           SRR13948564.1791148.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849388
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-141               AC124505.4         139813-139953       c
            142-294             AC124505.4         138742-138894       c
            295-427             AC124505.4         138412-138544       c
            428-639             AC124505.4         138105-138316       c
            640-694             AC124505.4         137622-137676       c
            695-855             AC124505.4         137363-137523       c
            856-939             AC124505.4         136985-137068       c
            940-1114            AC124505.4         136718-136892       c
            1115-1314           AC124505.4         136381-136580       c
            1315-1595           AC124505.4         136002-136282       c
FEATURES             Location/Qualifiers
     source          1..1595
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1595
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /note="aldolase A, fructose-bisphosphate"
                     /db_xref="GeneID:11674"
                     /db_xref="MGI:MGI:87994"
     exon            1..141
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..294
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1410
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /EC_number="4.1.2.13"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; fructose-bisphosphate aldolase A; muscle-type
                     aldolase"
                     /codon_start=1
                     /product="fructose-bisphosphate aldolase A isoform 1
                     precursor"
                     /protein_id="NP_001170778.1"
                     /db_xref="CCDS:CCDS52399.1"
                     /db_xref="GeneID:11674"
                     /db_xref="MGI:MGI:87994"
                     /translation="MATRRPDGSSFNMTRLSLALAFSFPPVASEQPHSELGNTQQQTE
                     LGKESTATGTMPHPYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIG
                     TENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVG
                     IKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAI
                     MENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHV
                     YLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEA
                     SINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYIKRALANSLA
                     CQGKYTPSGQSGAAASESLFISNHAY"
     exon            295..427
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            428..639
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            640..694
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..855
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            856..939
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1114
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1314
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1595
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1573..1578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /note="hexamer: AATAAA"
     polyA_site      1595
                     /gene="Aldoa"
                     /gene_synonym="Aldo-1; Aldo1"
                     /note="major polyA site"
ORIGIN      
        1 cccccccaac ccagctgaat aggctgcgtt ctcttggaac gcgcagcaga acgaggttct
       61 ggtgacccta gccgcgttcg ctccttagtc ctttcgccta cccaccggcg taccaggcag
      121 acccaccccg tcctgtgcca ggcaaggtga cccatggcaa cgcgcaggcc agatgggtcc
      181 agcttcaaca tgacccgcct gtccctggct ctggcttttt cctttccccc agttgccagt
      241 gagcaacccc actctgagct gggcaacacc cagcaacaga cagagttagg aaaggaaagc
      301 actgccaccg gcaccatgcc ccacccatac ccagcactga ccccggagca gaagaaggag
      361 ctgtctgaca tcgctcaccg cattgtggct ccgggcaagg gcatcctggc tgcagatgag
      421 tccaccggaa gcattgccaa gcgcctgcag tccattggca ccgagaacac cgaggagaac
      481 aggcgcttct accgccagct gctgctgact gcagacgacc gtgtgaatcc ctgcattggg
      541 ggggtgatcc tcttccacga gacactgtac cagaaggcag atgatggacg tcccttcccc
      601 caagttatca agtccaaggg tggtgttgtg ggcattaagg tagataaggg tgtggtgccc
      661 ctggcaggaa ccaatggcga gacaactacc caggggctgg atgggctgtc tgaacgctgt
      721 gcccagtata agaaggatgg agccgacttt gccaagtggc gctgtgtgct aaagattggg
      781 gaacatactc cctcggccct ggccatcatg gaaaatgcca atgttctggc ccgttatgcc
      841 agcatctgcc agcagaatgg cattgtaccc attgtggagc ctgaaattct ccctgatggg
      901 gaccatgact tgaagcgctg ccagtatgtt actgagaagg tcctggcggc tgtctacaag
      961 gctctgagcg accaccatgt ctatctggaa ggcacattgc tgaagcccaa catggtcacc
     1021 cctggccatg cttgcaccca gaaattttcc aatgaggaga ttgccatggc aacggtcaca
     1081 gcacttcgtc gcacagtgcc ccctgctgtc actggggtca ctttcctgtc tggagggcag
     1141 agtgaggaag aggcatccat caacctcaat gctatcaaca agtgccccct gctgaagcca
     1201 tgggccttga ctttctccta tggtcgagcc ctgcaggcct ctgctctaaa ggcctggggt
     1261 gggaagaagg agaacctgaa ggcagcccag gaggagtaca tcaagcgcgc cctggccaac
     1321 agcctcgctt gtcaaggaaa gtatacccca agtggccagt ctggagccgc agccagtgaa
     1381 tctctcttca tctctaacca tgcctactaa ccagagctga actaaggctg ctccatcaac
     1441 actccaggcc cctgcctacc cacttgctat tgaagagggg tcttcaggct ctttcccatc
     1501 actcttgctg ctgccctcgt gtgcggtgtt gtctgtgaat gctaaatctg ccatcccttc
     1561 cagcccactg ccaataaaca actatttaag gggga
//
