LOCUS       NM_019993               2833 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus aldehyde dehydrogenase 9, subfamily A1 (Aldh9a1),
            transcript variant 1, mRNA.
ACCESSION   NM_019993 XM_991914
VERSION     NM_019993.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2833)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2833)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2833)
  AUTHORS   Xu,Y. and Xie,J.
  TITLE     Etomoxir regulates the differentiation of male germ cells by
            specifically reducing H3K27ac level
  JOURNAL   BMC Dev Biol 21 (1), 5 (2021)
   PUBMED   33517883
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2833)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   5  (bases 1 to 2833)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 2833)
  AUTHORS   Levi,B.P., Yilmaz,O.H., Duester,G. and Morrison,S.J.
  TITLE     Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in
            the mouse hematopoietic and nervous systems
  JOURNAL   Blood 113 (8), 1670-1680 (2009)
   PUBMED   18971422
REFERENCE   7  (bases 1 to 2833)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   8  (bases 1 to 2833)
  AUTHORS   Hitzemann,R., Reed,C., Malmanger,B., Lawler,M., Hitzemann,B.,
            Cunningham,B., McWeeney,S., Belknap,J., Harrington,C., Buck,K.,
            Phillips,T. and Crabbe,J.
  TITLE     On the integration of alcohol-related quantitative trait loci and
            gene expression analyses
  JOURNAL   Alcohol Clin Exp Res 28 (10), 1437-1448 (2004)
   PUBMED   15597075
  REMARK    Erratum:[Alcohol Clin Exp Res. 2004 Dec;28(12):1930]
REFERENCE   9  (bases 1 to 2833)
  AUTHORS   Vaz,F.M., Fouchier,S.W., Ofman,R., Sommer,M. and Wanders,R.J.
  TITLE     Molecular and biochemical characterization of rat
            gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for
            the involvement of human aldehyde dehydrogenase 9 in carnitine
            biosynthesis
  JOURNAL   J Biol Chem 275 (10), 7390-7394 (2000)
   PUBMED   10702312
REFERENCE   10 (bases 1 to 2833)
  AUTHORS   Eddleston,J., Murdoch,J.N., Copp,A.J. and Stanier,P.
  TITLE     Physical and transcriptional map of a 3-Mb region of mouse
            chromosome 1 containing the gene for the neural tube defect mutant
            loop-tail (Lp)
  JOURNAL   Genomics 56 (2), 149-159 (1999)
   PUBMED   10051400
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC113970.8.
            
            On Aug 14, 2018 this sequence version replaced NM_019993.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132336.1, AK165730.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               AC113970.8         110413-110838
            427-572             AC113970.8         112942-113087
            573-702             AC113970.8         114849-114978
            703-837             AC113970.8         116094-116228
            838-1034            AC113970.8         116952-117148
            1035-1175           AC113970.8         117732-117872
            1176-1364           AC113970.8         121825-122013
            1365-1452           AC113970.8         122226-122313
            1453-1594           AC113970.8         124930-125071
            1595-1707           AC113970.8         126197-126309
            1708-2833           AC113970.8         127827-128952
FEATURES             Location/Qualifiers
     source          1..2833
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 74.74 cM"
     gene            1..2833
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /note="aldehyde dehydrogenase 9, subfamily A1"
                     /db_xref="GeneID:56752"
                     /db_xref="MGI:MGI:1861622"
     exon            1..426
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1802
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.19"
                     /EC_number="1.2.1.47"
                     /EC_number="1.2.1.46"
                     /note="isoform 1 is encoded by transcript variant 1;
                     4-trimethylaminobutyraldehyde dehydrogenase;
                     gamma-aminobutyraldehyde dehydrogenase; aldehyde
                     dehydrogenase family 9 member A1; formaldehyde
                     dehydrogenase"
                     /codon_start=1
                     /product="4-trimethylaminobutyraldehyde dehydrogenase
                     isoform 1"
                     /protein_id="NP_064377.2"
                     /db_xref="CCDS:CCDS35765.1"
                     /db_xref="GeneID:56752"
                     /db_xref="MGI:MGI:1861622"
                     /translation="MILGAVGSVLTSLLRIHRAAAVAAMSTGTFVVSQPLNYRGGARV
                     EPVDASGTEKAFEPATGRVIATFACSGEKEVNLAVENAKAAFKLWSKKSGLERCQVLL
                     EAARIIKERKDEIATVETINNGKSIFEARLDVDTCWQCLEYYAGLAASMAGEHIQLPG
                     GSFGYTRREPLGVCVGIGAWNYPFQIACWKSAPALACGNAMIFKPSPFTPVSALLLAE
                     IYTKAGAPPGLFNVVQGGAATGQFLCHHREVAKISFTGSVPTGVKIMEMSAKGVKPIT
                     LELGGKSPLIIFSDCNMENAVKGALMANFLTQGQVCCNGTRVFVQKEIADKFINEVVK
                     QTQKIKLGDPLLEDTRMGPLINAPHLERVLGFVKLAKEQGATVLCGGEVYVPEDPKLK
                     HGYYMTPCILTNCRDDMTCVKEEIFGPVMSILTFGTEAEVLERANDTTFGLAAGVFTR
                     DIQRAHRVAAELQAGTCYINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVC
                     VEMGDVESAF"
     exon            427..572
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            573..702
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            703..837
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            838..1034
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1175
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1364
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1452
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1594
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1707
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..2833
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2572..2577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /note="hexamer: AATAAA"
     polyA_site      2589
                     /gene="Aldh9a1"
                     /gene_synonym="Abaldh; ESTM40; TMABA-DH; Tmabadh"
                     /note="major polyA site"
ORIGIN      
        1 actgtccctt cctcccagtg ggctctactg ggctctcctt gagggccccg ggtcttcaca
       61 ctcacggtcc acacctcccc gaggtcctgt tccctagtgg tccacccctg cccagccagg
      121 gtcgcctctt tccatgggcc acgccccaga gattccgccc ctcgccactc cctcctcgtt
      181 accgcgctat ctccccctcc agtagtaatc tgctggggct tccggacgct ttgcacgcgt
      241 agcagatgat cctcggtgca gtcggttctg tgctgacctc gctcctccgc attcaccggg
      301 ctgcagcagt cgccgccatg agtactggca ccttcgtcgt gtcgcagccg ctcaactacc
      361 gcggcggggc ccgtgtggag ccggtggatg cttccggcac ggagaaagcg ttcgagccag
      421 ccaccggccg agtgattgcc actttcgcgt gttcaggaga aaaggaagta aacttggccg
      481 ttgagaatgc aaaggctgcc tttaaactct ggagtaagaa aagtggcctg gagcgctgcc
      541 aagtcctcct agaggctgcc cggatcatca aggagcggaa ggatgaaatt gccaccgtgg
      601 agaccatcaa caacgggaag tccatatttg aggcccgcct ggatgttgac acttgctggc
      661 agtgcctgga atactatgca gggctggctg catccatggc aggcgagcac attcagctcc
      721 caggagggtc cttcggctac acccgaagag agccgcttgg ggtgtgtgtg gggataggag
      781 catggaacta tcccttccag atcgcctgtt ggaagtctgc tccggctctg gcttgtggta
      841 atgccatgat ctttaagcct tctcccttca cgcctgtgtc tgctctgctc ctggctgaga
      901 tctacaccaa agcgggtgcg cctccggggc tcttcaacgt ggtgcaaggt ggggctgcca
      961 caggccagtt tctgtgtcat catcgcgagg tggccaaaat ctccttcacc ggaagtgtgc
     1021 ccactggcgt gaagatcatg gagatgtccg ctaagggagt caagcccatt actttggaac
     1081 ttgggggcaa atctcctctc atcatcttct cagactgtaa tatggagaat gctgtgaagg
     1141 gggccctgat ggccaacttc ctcacacaag gacaggtctg ctgcaatggg actagagtct
     1201 ttgtgcaaaa ggaaattgct gataaattca taaatgaggt tgtgaagcag actcagaaga
     1261 taaaacttgg agaccccctt ctggaagata cgaggatggg cccactcatc aacgccccac
     1321 atctggaacg agtcctcggg tttgtcaagt tggcaaagga gcagggtgct actgtgctgt
     1381 gtggtggaga ggtgtatgta ccagaggacc ccaaattaaa acatggatat tacatgacac
     1441 cttgcatttt aactaattgc agagacgaca tgacttgtgt aaaagaagag atctttggac
     1501 cagtcatgtc cattttaaca tttggaactg aagccgaggt tctagagcga gctaatgaca
     1561 ccacttttgg actagcagct ggggtcttca ccagggacat ccagagggca caccgggtgg
     1621 cggctgagct gcaggctgga acgtgctaca ttaacaacta taatgtcagc ccagtggagc
     1681 tgccctttgg tggctacaag aagtcaggat ttggcagaga gaatggccgt gtgacgattg
     1741 agtactactc tcagctgaag acggtgtgtg tggagatggg cgacgtggag tcagcctttt
     1801 gaaacccagg gaagcctgct ggcgtagcca agctgtggaa tgagttgact gccttgacag
     1861 gcagcataac tgaatagctt cttacatcca ggctttgggt cattagtgtg ataacgggtc
     1921 agtgttgtcc tctgtcttac agtcaccttc ccagtttgaa aatgtgcaca agtgcctttc
     1981 agatggtagc caggtaacct gttgtcccag cccctgagaa atatgtagac cccagaagcg
     2041 cactcttcag acataggcag gccacagctc tgctcctaca catttgtccc accaacaatg
     2101 gcagctttct agtttgcttt aaagcaggcc ttccttcctg ggttcctggt gaatcagtac
     2161 atatacattc tttgttcatt gacaactaaa aaacaaattc ttaaagcttt tatttggagc
     2221 tgggcagtac tggtatgtgc ctttaatccc ggcacttggg aggcagagac aggtggatgt
     2281 ctgagtttag agccagcctg gtctacagag tgaattccag tctaggaagg tctacataga
     2341 gaaatcctgt ctcaaacaaa acaaaacaaa aaaaaaccca taaataaata aaaaaatgta
     2401 aaaagctgtt attcttagta tttgtgggct atgtgactca ttggcattta aacagctgtg
     2461 ttctaactaa ctagcaagac agctcagtgg gtaaggtctt atcacttaaa cccagtgact
     2521 tcaggtttat ctctagaacc caccccttcc ccatatcata cactgcacaa taataaaatc
     2581 tttctcaaac gctgtgtttt tctgtccttt ctttgagaaa ccggaccacc tggctagaga
     2641 gacaggtagt tggtggagtc ggattttacg cagataactg acttgcctca gtaaacactc
     2701 atcctgtctt ccacagcact ttatctctga ttcttgcagt acagcctatg gccatagaac
     2761 cgaagagaac ctttagaatg tgtgagttat ttgtacgcta ccattacagt gaattaaaaa
     2821 cctattacac tgc
//
