LOCUS       NM_178713               2243 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 8 family, member A1 (Aldh8a1),
            mRNA.
ACCESSION   NM_178713 XM_989328
VERSION     NM_178713.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2243)
  AUTHORS   Teletin,M., Vernet,N., Yu,J., Klopfenstein,M., Jones,J.W.,
            Feret,B., Kane,M.A., Ghyselinck,N.B. and Mark,M.
  TITLE     Two functionally redundant sources of retinoic acid secure
            spermatogonia differentiation in the seminiferous epithelium
  JOURNAL   Development 146 (1) (2019)
   PUBMED   30487180
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2243)
  AUTHORS   Ioannou,M., Serafimidis,I., Arnes,L., Sussel,L., Singh,S.,
            Vasiliou,V. and Gavalas,A.
  TITLE     ALDH1B1 is a potential stem/progenitor marker for multiple pancreas
            progenitor pools
  JOURNAL   Dev Biol 374 (1), 153-163 (2013)
   PUBMED   23142317
REFERENCE   3  (bases 1 to 2243)
  AUTHORS   Sima,A., Parisotto,M., Mader,S. and Bhat,P.V.
  TITLE     Kinetic characterization of recombinant mouse retinal dehydrogenase
            types 3 and 4 for retinal substrates
  JOURNAL   Biochim Biophys Acta 1790 (12), 1660-1664 (2009)
   PUBMED   19766701
  REMARK    GeneRIF: Kinetic characterization of RALDH3 and 4, providing their
            specificities for retinal isomer substrates.
REFERENCE   4  (bases 1 to 2243)
  AUTHORS   Levi,B.P., Yilmaz,O.H., Duester,G. and Morrison,S.J.
  TITLE     Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in
            the mouse hematopoietic and nervous systems
  JOURNAL   Blood 113 (8), 1670-1680 (2009)
   PUBMED   18971422
REFERENCE   5  (bases 1 to 2243)
  AUTHORS   Hu,P., Zhang,M. and Napoli,J.L.
  TITLE     Ontogeny of rdh9 (Crad3) expression: ablation causes changes in
            retinoid and steroid metabolizing enzymes, but RXR and androgen
            signaling seem normal
  JOURNAL   Biochim Biophys Acta 1770 (4), 694-705 (2007)
   PUBMED   17270348
REFERENCE   6  (bases 1 to 2243)
  AUTHORS   Romand,R., Kondo,T., Fraulob,V., Petkovich,M., Dolle,P. and
            Hashino,E.
  TITLE     Dynamic expression of retinoic acid-synthesizing and -metabolizing
            enzymes in the developing mouse inner ear
  JOURNAL   J Comp Neurol 496 (5), 643-654 (2006)
   PUBMED   16615129
REFERENCE   7  (bases 1 to 2243)
  AUTHORS   Makita,T., Duncan,S.A. and Sucov,H.M.
  TITLE     Retinoic acid, hypoxia, and GATA factors cooperatively control the
            onset of fetal liver erythropoietin expression and erythropoietic
            differentiation
  JOURNAL   Dev Biol 280 (1), 59-72 (2005)
   PUBMED   15766748
REFERENCE   8  (bases 1 to 2243)
  AUTHORS   Fan,X., Molotkov,A., Manabe,S., Donmoyer,C.M., Deltour,L.,
            Foglio,M.H., Cuenca,A.E., Blaner,W.S., Lipton,S.A. and Duester,G.
  TITLE     Targeted disruption of Aldh1a1 (Raldh1) provides evidence for a
            complex mechanism of retinoic acid synthesis in the developing
            retina
  JOURNAL   Mol Cell Biol 23 (13), 4637-4648 (2003)
   PUBMED   12808103
REFERENCE   9  (bases 1 to 2243)
  AUTHORS   Lin,M., Zhang,M., Abraham,M., Smith,S.M. and Napoli,J.L.
  TITLE     Mouse retinal dehydrogenase 4 (RALDH4), molecular cloning, cellular
            expression, and activity in 9-cis-retinoic acid biosynthesis in
            intact cells
  JOURNAL   J Biol Chem 278 (11), 9856-9861 (2003)
   PUBMED   12519776
  REMARK    GeneRIF: RALDH4 molecular cloning, cellular expression, and
            activity in 9-cis-retinoic acid biosynthesis in intact cells
REFERENCE   10 (bases 1 to 2243)
  AUTHORS   Zhuang,R., Lin,M. and Napoli,J.L.
  TITLE     cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a
            short-chain dehydrogenase active in a reconstituted path of
            9-cis-retinoic acid biosynthesis in intact cells
  JOURNAL   Biochemistry 41 (10), 3477-3483 (2002)
   PUBMED   11876656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK050298.1 and AC153557.8.
            
            On Dec 19, 2006 this sequence version replaced NM_178713.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF510322.1, AK143752.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1658              AK050298.1         2-1659
            1659-2243           AC153557.8         185937-186521
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 9.75 cM"
     gene            1..2243
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /note="aldehyde dehydrogenase 8 family, member A1"
                     /db_xref="GeneID:237320"
                     /db_xref="MGI:MGI:2653900"
     exon            1..179
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..1505
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /EC_number="1.2.1.32"
                     /note="retinal dehydrogenase type 4; aldehyde
                     dehydrogenase family 8 member A1; retinal dehydrogenase 4"
                     /codon_start=1
                     /product="2-aminomuconic semialdehyde dehydrogenase"
                     /protein_id="NP_848828.1"
                     /db_xref="CCDS:CCDS23723.1"
                     /db_xref="GeneID:237320"
                     /db_xref="MGI:MGI:2653900"
                     /translation="MAGKRELLMLENFIGGKFLPCNSYIDSYDPSTGEVYCKVPNSGK
                     EEIEAAVEAAREAFPAWSSRSPQERSLVLNRLADVLEQSLEELAQAESKDQGKTLTLA
                     RTMDIPRSVLNFRFFASSNLHHVSECTQMSHLGCMHYTVRTPVGIAGLISPWNLPLYL
                     LTWKIAPAIAAGNTVIAKPSEMTSVTAWMFCKLLDKAGVPPGVINIVFGTGPRVGEAL
                     VSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLEECIPATV
                     RSSFANQGEICLCTSRIFVQRSIYSEFLKRFVEATRKWKVGVPSDPSANMGALISKAH
                     LEKVRSYVLKAQTEGARILCGEGVDQLSLPLRNQAGYFMLPTVITDIKDESRCMTEEI
                     FGPVTCVVPFDSEEEVITRANSVRYGLAATVWSKDVGRIHRVAKKLQSGLVWTNCWLI
                     RELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITIKY"
     exon            180..327
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /inference="alignment:Splign:2.1.0"
     exon            328..483
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /inference="alignment:Splign:2.1.0"
     exon            484..633
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /inference="alignment:Splign:2.1.0"
     exon            634..890
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1052
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..2243
                     /gene="Aldh8a1"
                     /gene_synonym="Raldh4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtcacagag ggctgctgta cacagagggc actttcctaa catggctgga aaaagggaac
       61 ttttgatgtt ggagaacttt ataggtggga agtttttacc ctgtaactca tatatagatt
      121 cttacgatcc atcaacaggg gaagtttatt gcaaagttcc aaacagtggg aaagaagaga
      181 ttgaagctgc cgtggaggct gccagagagg ccttccctgc ctggtcatcc cggagtcccc
      241 aggaacgttc tctcgtcctg aacaggctgg ctgatgtact ggagcagtct ctggaggagt
      301 tagctcaggc agaatctaaa gaccaaggga aaaccctcac gctggcaagg accatggaca
      361 ttcctcggtc tgttctgaac ttccggttct tcgcttcctc caacctgcac cacgtatcgg
      421 agtgcacaca gatgagccac ctgggctgta tgcattacac cgttcgcacc ccggtgggaa
      481 ttgctggttt gatcagccct tggaatttac cactctacct gctgacctgg aagatagctc
      541 cggccatcgc tgctgggaat accgtgatag ccaagcccag tgagatgact tctgtgactg
      601 cctggatgtt ttgtaaactc ttggataaag caggtgtccc accaggtgtg atcaacattg
      661 tgtttggaac agggccgagg gttggtgaag cccttgtgtc tcaccccgag gtacccttga
      721 tctcgttcac tgggagccag cccacagctg aacggattac ccagctcagt gccccccact
      781 gcaagaagct ttccctggag ctgggaggca agaatcctgc tatcatcttt gaggatgcca
      841 acctggagga gtgtatcccg gcaaccgtta ggtccagctt tgctaaccag ggggagattt
      901 gcctttgtac cagtagaatc tttgtccaga gaagcatcta cagtgaattt ctgaagaggt
      961 ttgtggaagc taccagaaag tggaaagttg gtgttccttc tgacccatca gccaacatgg
     1021 gtgctctgat aagcaaagca catttggaga aagtcagaag ttatgtcttg aaagctcaga
     1081 ctgagggtgc ccggattctc tgtggtgagg gtgtggacca gctgagcctt ccactcagga
     1141 accaggcagg ctacttcatg cttcccacgg tgataacaga cattaaggat gagtcccgct
     1201 gcatgacgga agagatcttt ggtccagtga cgtgtgttgt tccgtttgat agtgaagagg
     1261 aagtgattac gagagctaac agtgttagat acgggctggc agccacagtg tggtccaagg
     1321 atgtggggcg catccacagg gtagctaaga agcttcagtc ggggctggtc tggaccaact
     1381 gctggctcat cagggagctg aacctgccct ttggagggat gaagagctct ggaataggaa
     1441 gagaaggagc caaggactca tatgacttct ttactgaaat aaaaaccatt accattaaat
     1501 actgatcatc ctacagctgc tgtggttgac gcctgccagc agagaatcgc ttgtcagtgc
     1561 agtcaacaga gatcctagga catgttcagt catgccgctg cttgccagga gactggctct
     1621 caatgaccac tgatggtatt tttaccagct tgtgaaggaa aaaaaaaagg cagtttttat
     1681 gaatttttga aaatctgccc aaatcaggtg tttttatttg caaatacaca gcaaaaacaa
     1741 aacaaaggcc tgggagatga ctcagtgggt agcgtgcttg ctgtatgagc acaagaccct
     1801 gagctcagat cccagcatca gtgcaaaaga ctgacctggt ggtatataac acaacacaca
     1861 cacacacacc accaccacca ccaccagcag cgacaacaac aacaacaaca acaacaacaa
     1921 caacaagcct gaagagaaac aacgcaccat caatttctcc cttgacaaag ctttgaagat
     1981 gagcctctca gccccatagc cactacccaa ctttgactgc taattgcctg agcccttcat
     2041 atcgggaagt gatggttgtc cgaagagctt gtgagcgtca cacacgatag atcttactaa
     2101 atatgtctga tacaagtaag ggaaaacaag gtagttatta ttttttagag gttaactcag
     2161 aacacaaaac atagtctggt ccattttcat tgtcaagtct agtcaactct gattcttcaa
     2221 agaagcaata aattgttcag cag
//
