LOCUS       NM_138600               2911 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus aldehyde dehydrogenase family 7, member A1 (Aldh7a1),
            transcript variant 1, mRNA.
ACCESSION   NM_138600
VERSION     NM_138600.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2911)
  AUTHORS   Yan,J., Wu,J., Xu,M., Wang,M. and Guo,W.
  TITLE     Disrupted de novo pyrimidine biosynthesis impairs adult hippocampal
            neurogenesis and cognition in pyridoxine-dependent epilepsy
  JOURNAL   Sci Adv 10 (14), eadl2764 (2024)
   PUBMED   38579001
REFERENCE   2  (bases 1 to 2911)
  AUTHORS   Imbard,A., Schwendimann,L., Lebon,S., Gressens,P., Blom,H.J. and
            Benoist,J.F.
  TITLE     Liver and brain differential expression of one-carbon metabolism
            genes during ontogenesis
  JOURNAL   Sci Rep 11 (1), 21132 (2021)
   PUBMED   34702858
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2911)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2911)
  AUTHORS   Lee,J.S., Lee,H., Woo,S.M., Jang,H., Jeon,Y., Kim,H.Y., Song,J.,
            Lee,W.J., Hong,E.K., Park,S.J., Han,S.S. and Kim,S.Y.
  TITLE     Overall survival of pancreatic ductal adenocarcinoma is doubled by
            Aldh7a1 deletion in the KPC mouse
  JOURNAL   Theranostics 11 (7), 3472-3488 (2021)
   PUBMED   33537098
  REMARK    GeneRIF: Overall survival of pancreatic ductal adenocarcinoma is
            doubled by Aldh7a1 deletion in the KPC mouse.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2911)
  AUTHORS   Al-Shekaili,H.H., Petkau,T.L., Pena,I., Lengyell,T.C.,
            Verhoeven-Duif,N.M., Ciapaite,J., Bosma,M., van Faassen,M.,
            Kema,I.P., Horvath,G., Ross,C., Simpson,E.M., Friedman,J.M., van
            Karnebeek,C. and Leavitt,B.R.
  TITLE     A novel mouse model for pyridoxine-dependent epilepsy due to
            antiquitin deficiency
  JOURNAL   Hum Mol Genet 29 (19), 3266-3284 (2020)
   PUBMED   32969477
  REMARK    GeneRIF: A novel mouse model for pyridoxine-dependent epilepsy due
            to antiquitin deficiency.
REFERENCE   6  (bases 1 to 2911)
  AUTHORS   Ko,M.S., Threat,T.A., Wang,X., Horton,J.H., Cui,Y., Wang,X.,
            Pryor,E., Paris,J., Wells-Smith,J., Kitchen,J.R., Rowe,L.B.,
            Eppig,J., Satoh,T., Brant,L., Fujiwara,H., Yotsumoto,S. and
            Nakashima,H.
  TITLE     Genome-wide mapping of unselected transcripts from extraembryonic
            tissue of 7.5-day mouse embryos reveals enrichment in the t-complex
            and under-representation on the X chromosome
  JOURNAL   Hum Mol Genet 7 (12), 1967-1978 (1998)
   PUBMED   9811942
REFERENCE   7  (bases 1 to 2911)
  AUTHORS   Skvorak,A.B., Robertson,N.G., Yin,Y., Weremowicz,S., Her,H.,
            Bieber,F.R., Beisel,K.W., Lynch,E.D., Beier,D.R. and Morton,C.C.
  TITLE     An ancient conserved gene expressed in the human inner ear:
            identification, expression analysis, and chromosomal mapping of
            human and mouse antiquitin (ATQ1)
  JOURNAL   Genomics 46 (2), 191-199 (1997)
   PUBMED   9417906
REFERENCE   8  (bases 1 to 2911)
  AUTHORS   Paznekas,W.A., Zhang,N., Gridley,T. and Jabs,E.W.
  TITLE     Mouse TCOF1 is expressed widely, has motifs conserved in nucleolar
            phosphoproteins, and maps to chromosome 18
  JOURNAL   Biochem Biophys Res Commun 238 (1), 1-6 (1997)
   PUBMED   9299440
REFERENCE   9  (bases 1 to 2911)
  AUTHORS   Dixon,J., Hovanes,K., Shiang,R. and Dixon,M.J.
  TITLE     Sequence analysis, identification of evolutionary conserved motifs
            and expression analysis of murine tcof1 provide further evidence
            for a potential function for the gene and its human homologue,
            TCOF1
  JOURNAL   Hum Mol Genet 6 (5), 727-737 (1997)
   PUBMED   9158147
REFERENCE   10 (bases 1 to 2911)
  AUTHORS   Gill,R.K. and Christakos,S.
  TITLE     Identification of sequence elements in mouse calbindin-D28k gene
            that confer 1,25-dihydroxyvitamin D3- and butyrate-inducible
            responses
  JOURNAL   Proc Natl Acad Sci U S A 90 (7), 2984-2988 (1993)
   PUBMED   8464915
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY017676.1, AK169195.1 and AK004991.1.
            
            On May 15, 2008 this sequence version replaced NM_138600.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012407.1, AK145873.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                BY017676.1         1-58
            59-1899             AK169195.1         2-1842
            1900-2911           AK004991.1         2028-3039
FEATURES             Location/Qualifiers
     source          1..2911
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 30.55 cM"
     gene            1..2911
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /note="aldehyde dehydrogenase family 7, member A1"
                     /db_xref="GeneID:110695"
                     /db_xref="MGI:MGI:108186"
     exon            1..266
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            267..320
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            321..386
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            387..467
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            468..591
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            592..724
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            725..769
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            770..847
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            848..945
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            946..987
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1082
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1167
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1274
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1391
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1489
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1563
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1639
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..2911
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /note="hexamer: ATTAAA"
     polyA_site      1903
                     /gene="Aldh7a1"
                     /gene_synonym="Atq1; D18Wsu181e"
                     /note="major polyA site"
ORIGIN      
        1 tctccggggc ggggggcgga gctgtatttc cggggctgcc ctggcggagg ggcttcttgc
       61 gtgctgagct cagtatgtgg cgtgtgcccc gcaggctctg tgtgcagtct gtgaagacca
      121 gcaagctttc cggaccttgg agcaggcccg ccgcccacat gtctactctg ctgatccatc
      181 atccccagta tgcctggctg caagacctgg ggctccgcga ggataacgag ggcgtgtata
      241 atggaagctg gggcggccgg ggagaggtaa ttacgaccta ttgtcctgct aacaatgagc
      301 caatagcaag agtccgacag gccagcctga aggactatga agaaaccatc gggaaagcca
      361 agaaagcctg gaacatctgg gcagatattc ctgccccaaa acgcggagaa atagtcagaa
      421 agattggcga tgccttccgg gagaagatcc aactactggg aagactggtg tctttggaga
      481 tggggaaaat cctggtggaa ggaataggcg aggttcagga gtacgtggac gtctgcgatt
      541 atgctgctgg cttgtcgagg atgatcgggg gacccacctt gccttctgaa agacccggcc
      601 atgctctcat cgaaatgtgg aatcccttag gcttggtggg aatcatcact gccttcaatt
      661 tccccgtggc tgtgtttggc tggaacaatg ccatagctct gatcacaggg aatgtctgcc
      721 tttggaaagg agcaccgact acgtccctcg ttagtgtggc tgtcacaaag atcatagccc
      781 aggttttgga ggacaacctg ctgcccggtg ccatttgttc cctggtttgt ggtggagcag
      841 atatcggcac aacgatggcc agagatgagc gtgtgaacct gctgtccttc actgggagca
      901 ctcaggtggg gaaggaggtg gccctcatgg tgcaggagag gtttgggaaa agcttgttgg
      961 agcttggagg aaacaatgcc attattgctt tcgaggacgc ggacctcagc ttggttgttc
     1021 cgtcagttct gtttgccgcc gtgggaacag ctgggcaaag gtgtaccact gtgaggagac
     1081 tgtttttgca cgaaagcatc cataatgaag ttgtggacag actgagaagt gcctactcac
     1141 agatccgtgt tgggaacccc tgggacccca atatcctcta tggaccgctc cataccaaac
     1201 aggcagtgag catgtttgtg agagccgtgg aagaagccaa gaaacaaggg ggcacagtgg
     1261 tctatggggg caaggtcatg gaccaccctg gcaattacgt ggaacccacc attgtgaccg
     1321 gtcttgccca tgatgcgccc attgttcacc aggagacttt tgccccaatc ctctatgtct
     1381 tcaaattcca ggatgaagaa gaggtctttg aatggaacaa tgaagtaaaa cagggacttt
     1441 caagtagtat ctttaccaaa gatttgggca gaatcttccg ctggcttgga cctaaaggtt
     1501 ccgactgtgg catcgtgaac gtcaatattc ctaccagcgg ggctgagatt ggtggtgcgt
     1561 ttggcggaga gaagcacact ggcggtggcc gggagtctgg cagcgacgcc tggaagcagt
     1621 acatgaggag atccacatgt accatcaact acagcacgtc cctccctctg gctcagggaa
     1681 tcaagtttca gtgatactgc gtgggcttgg cgtcccttag ccattcctgt ggctgctcgg
     1741 aagaagcctg aaaggaccct gacttgcccc ggataaatga tggctttgag tacggacagc
     1801 agtgtctaat ctccagtgat tcccagaccc ctgtctaaat caagatactc atttatcaaa
     1861 agttcaaaat taaatattca caacctagct gcatttagca aaagataggt ttggtgagtt
     1921 tttatgttac taattacttt ttttattaca gctaatcatt tcttagtgaa gtacatgcca
     1981 tcataggagg ttggggccat ggaaaatgca ataggaagga agaagtcttt gcagtggaga
     2041 aatgtcttct aagcagtgct gaatcctcat ggtcccgtcc tggcaggggt tgaaggggag
     2101 aggtaccccc acatgctggg gacctcagca cagtttcatg tgcatgattt gcagtgctcc
     2161 aaatgacaat gggccatttt tgggtgaggt gaggaactta acactgttgt gaatggttgc
     2221 tgggatgtgt caacccctgg gttcaaatct cagtaccacc acaacaaaga taatgctcta
     2281 aaaataatgc tcacccagtt aagactgctc ctgactgtgt cagccagaaa gaaatgtgca
     2341 ggggtagaca gaccttcgtt cttgttccaa accttgctgg gaacttaggg actgaagttg
     2401 ctcgtgaaag cacatctgga tgcccgagtc acctcaggct tctgcagctg ctcatgggtt
     2461 tctcctctgg gaaggtcact gctgagaggc taaggtctca ctgggaagct gtgctgggcc
     2521 cagcggtccc tgctctcctg tggtgccgtt gctctgtact tctgtgtagc agtcaccact
     2581 gggcctgctc ctgccacatc gggctcctgg agaaaccctt agggaatagg acattgtagg
     2641 cctcatgagt cgtcatggtg tggaaagatt tggacaatag taagaaatct gggggactga
     2701 cagtgtgggg aagaagcagg ggggacacta atactaacat attaaataat atggtgatat
     2761 acctttatat aattaaattt gtagtagatt tgactataaa aattaaaggg gctgtgaata
     2821 tagcttggtt aggtaggctg cttgccactc aatgcctggg attccatctc cagcactgca
     2881 ctaaattcat ataaatacat gcatttaagt c
//
