LOCUS       NM_175438               3355 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 4 family, member A1 (Aldh4a1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_175438
VERSION     NM_175438.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3355)
  AUTHORS   Li,J., Chen,R., Zhou,J., Wang,Y., Zhao,X., Liu,C., Zhou,P.,
            Chen,Y., Song,L., Li,N., Yan,H. and Zhao,H.
  TITLE     Atherosclerotic Autoantigen ALDH4A1 as a Novel Immunological
            Indicator for Plaque Erosion in Patients with ST Segment Elevated
            Myocardial Infarction
  JOURNAL   Thromb Haemost 124 (6), 584-594 (2024)
   PUBMED   38109905
  REMARK    GeneRIF: Atherosclerotic Autoantigen ALDH4A1 as a Novel
            Immunological Indicator for Plaque Erosion in Patients with ST
            Segment Elevated Myocardial Infarction.
REFERENCE   2  (bases 1 to 3355)
  AUTHORS   Shi,Y., Huang,D., Song,C., Cao,R., Wang,Z., Wang,D., Zhao,L.,
            Xu,X., Lu,C., Xiong,F., Zhao,H., Li,S., Zhou,Q., Luo,S., Hu,D.,
            Zhang,Y., Wang,C., Shen,Y., Su,W., Wu,Y., Schmitz,K., Wei,S. and
            Song,W.
  TITLE     Diphthamide deficiency promotes association of eEF2 with p53 to
            induce p21 expression and neural crest defects
  JOURNAL   Nat Commun 15 (1), 3301 (2024)
   PUBMED   38671004
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3355)
  AUTHORS   Bogner,A.N., Stiers,K.M., McKay,C.M., Becker,D.F. and Tanner,J.J.
  TITLE     Structural basis for the stereospecific inhibition of the dual
            proline/hydroxyproline catabolic enzyme ALDH4A1 by
            trans-4-hydroxy-L-proline
  JOURNAL   Protein Sci 30 (8), 1714-1722 (2021)
   PUBMED   34048122
  REMARK    GeneRIF: Structural basis for the stereospecific inhibition of the
            dual proline/hydroxyproline catabolic enzyme ALDH4A1 by
            trans-4-hydroxy-L-proline.
REFERENCE   4  (bases 1 to 3355)
  AUTHORS   Lorenzo,C., Delgado,P., Busse,C.E., Sanz-Bravo,A.,
            Martos-Folgado,I., Bonzon-Kulichenko,E., Ferrarini,A.,
            Gonzalez-Valdes,I.B., Mur,S.M., Roldan-Montero,R.,
            Martinez-Lopez,D., Martin-Ventura,J.L., Vazquez,J., Wardemann,H.
            and Ramiro,A.R.
  TITLE     ALDH4A1 is an atherosclerosis auto-antigen targeted by protective
            antibodies
  JOURNAL   Nature 589 (7841), 287-292 (2021)
   PUBMED   33268892
  REMARK    GeneRIF: ALDH4A1 is an atherosclerosis auto-antigen targeted by
            protective antibodies.
REFERENCE   5  (bases 1 to 3355)
  AUTHORS   Klimovich,B., Stiewe,T. and Timofeev,O.
  TITLE     Inactivation of Mdm2 restores apoptosis proficiency of
            cooperativity mutant p53 in vivo
  JOURNAL   Cell Cycle 19 (1), 109-123 (2020)
   PUBMED   31749402
REFERENCE   6  (bases 1 to 3355)
  AUTHORS   Lock,L.F., Pines,J., Hunter,T., Gilbert,D.J., Gopalan,G.,
            Jenkins,N.A., Copeland,N.G. and Donovan,P.J.
  TITLE     A single cyclin A gene and multiple cyclin B1-related sequences are
            dispersed in the mouse genome
  JOURNAL   Genomics 13 (2), 415-424 (1992)
   PUBMED   1535334
REFERENCE   7  (bases 1 to 3355)
  AUTHORS   Rohdewohld,H. and Gruss,P.
  TITLE     The gene for the POU domain transcription factor Oct-6 maps to the
            distal end of mouse chromosome 4
  JOURNAL   Mamm Genome 3 (2), 119-121 (1992)
   PUBMED   1352157
REFERENCE   8  (bases 1 to 3355)
  AUTHORS   Neumann,P.E., Mueller,G.G. and Sidman,R.L.
  TITLE     Identification and mapping of a mouse gene influencing cerebellar
            folial pattern
  JOURNAL   Brain Res 524 (1), 85-89 (1990)
   PUBMED   2400934
REFERENCE   9  (bases 1 to 3355)
  AUTHORS   Huppi,K., Mock,B.A., Schricker,P., D'Hoostelaere,L.A. and Potter,M.
  TITLE     Organization of the distal end of mouse chromosome 4
  JOURNAL   Curr Top Microbiol Immunol 137, 276-288 (1988)
   PUBMED   3166417
REFERENCE   10 (bases 1 to 3355)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of aldehyde dehydrogenase isozymes in the
            mouse: localization of Ahd-1 encoding the mitochondrial isozyme on
            chromosome 4
  JOURNAL   Biochem Genet 16 (11-12), 1207-1218 (1978)
   PUBMED   751648
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA494657.1, CF536864.1, CK332989.1, CD354968.1 and AL831790.3.
            
            On Mar 21, 2009 this sequence version replaced NM_175438.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039281.1, AK044712.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-672               CA494657.1         38-709
            673-1116            CF536864.1         35-478
            1117-1475           CK332989.1         227-585
            1476-2057           CD354968.1         108-689
            2058-3355           AL831790.3         31684-32981
FEATURES             Location/Qualifiers
     source          1..3355
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.79 cM"
     gene            1..3355
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /note="aldehyde dehydrogenase 4 family, member A1"
                     /db_xref="GeneID:212647"
                     /db_xref="MGI:MGI:2443883"
     exon            1..304
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             246..1934
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /EC_number="1.2.1.88"
                     /note="delta-1-pyrroline-5-carboxylate dehydrogenase,
                     mitochondrial; P5C dehydrogenase; aldehyde dehydrogenase
                     family 4 member A1; L-glutamate gamma-semialdehyde
                     dehydrogenase"
                     /codon_start=1
                     /product="delta-1-pyrroline-5-carboxylate dehydrogenase,
                     mitochondrial precursor"
                     /protein_id="NP_780647.3"
                     /db_xref="CCDS:CCDS18848.1"
                     /db_xref="GeneID:212647"
                     /db_xref="MGI:MGI:2443883"
                     /translation="MLPLPSLRRSLLSHAWRGAGLRWKHTSSLKVTNEPILAFSQGSP
                     ERDALQKALKDLKGQMEAIPCVVGDEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLN
                     RAIDAALAARKEWDLKPMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEID
                     AAAELIDFFRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNL
                     AGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTFGDTVTSSE
                     HLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKNFHFVHSSADVDSVVSG
                     TLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLLEEHSRIKVGDPAEDFGTFFSAVID
                     AKAFARIKKWLEHARSSPSLSILAGGQCNESVGYYVEPCIIESKDPQEPIMKEEIFGP
                     VLTVYVYPDDKYRETLQLVDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDK
                     STGSVVGQQPFGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ"
     exon            305..398
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..491
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..539
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            540..695
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..845
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..920
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1108
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1182
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1379
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1427
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1580
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1702
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1821
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..3355
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3331..3336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /note="hexamer: AGTAAA"
     polyA_site      3351
                     /gene="Aldh4a1"
                     /gene_synonym="A930035F14Rik; Ahd-1; Ahd1; Aldh4; Aldh5a1;
                     E330022C09; P5cd; P5cdh; P5cdhl; P5cdhs; Ssdh1"
                     /note="major polyA site"
ORIGIN      
        1 atcatttcag ggcttttctg ctgcattctc ttgacccgca gtccacagta gcaattttga
       61 tgttaaatac agctgatgtt tattgacaga gggggaaggg tacccgagga ggggccccga
      121 aggaggtgga ccgggcgatg ctgcgcctcc cgcagaggta gtgcgctccg ggcttgtcta
      181 gtccagcccg gtggggctga ctctgagctt cccacagctg cgcaagactg ttaagagtct
      241 ccgcgatgct gccgctgccg tcgctccgcc gatccctgct gtcccatgcc tggaggggcg
      301 ctgggctacg atggaagcac acctcctctc tgaaggtgac caatgagccc atcttagcat
      361 tctctcaggg aagccccgag cgggatgcac tgcagaaggc tctgaaggac ctgaagggcc
      421 agatggaagc catcccctgc gttgtcgggg acgaggaggt gtggacctcc gatatacagt
      481 accagttgtc gccctttaac catgcacaca aggtggccaa gttctgctat gctgataagg
      541 ccttgctcaa cagagccatc gatgctgcct tggctgccag gaaagagtgg gacctgaagc
      601 ccatggcaga ccgggcccag gtcttcctga aggcggcaga tatgctgagt gggccccgaa
      661 gggcggaagt ccttgccaag accatggtgg gacagggcaa gaccgtgatc caagcagaga
      721 tcgatgctgc agccgaactc atcgacttct tcaggttcaa cgcaaagttc gccgtggaac
      781 tggaggggga acagcccatc agtgtgccac ccagcaccaa ccacacggtg taccggggac
      841 tggagggctt cgtggcggcc atctctccct tcaacttcac cgcgattgga ggcaacctgg
      901 caggcgctcc ggccttaatg ggcaacgtgg ttctgtggaa gcccagtgac actgccatgc
      961 tggctagcta cgccgtctac cgcatcctcc gggaggccgg cttgcccccc aacataatcc
     1021 agtttgtgcc agccgacggg ccaaccttcg gggacacagt caccagctca gagcaccttt
     1081 gtggcatcaa ttttacaggc agtgtcccca ccttcaaaca cctgtggagg caggtggccc
     1141 agaacctgga ccggttccgt accttcccac gcttggctgg agagtgtggc gggaagaatt
     1201 tccattttgt gcacagctcg gccgacgtgg acagcgtggt gagcgggacg ctgcgctcgg
     1261 cattcgagta cggcggccag aagtgctcag cctgctcgcg cctctacgtg ccgaagtcgc
     1321 tgtggccgca gatcaaaggg cgactgctgg aggaacacag caggatcaaa gtgggggatc
     1381 ctgcagagga ctttgggacc ttcttctccg cagtgattga tgccaaggcc tttgctcgca
     1441 ttaagaagtg gttggagcat gcacgttcct cgcccagcct cagcatcctg gcagggggcc
     1501 agtgtaacga gtcagtgggt tactacgtgg aaccatgtat cattgagagc aaggacccac
     1561 aggaacccat catgaaggag gagatcttcg gtcctgtgtt gacagtatat gtgtacccag
     1621 atgataaata cagagagacg ctgcagctgg ttgacagcac taccagctat ggcctcacgg
     1681 gggcagtgtt cgcccaggat aaagcgattg tccaggaggc tacgaggatg ctgaggaacg
     1741 ctgctggcaa cttctacatc aacgataagt ctactgggtc tgtggtgggc cagcagccct
     1801 tcgggggcgc ccgggcctca ggaaccaatg acaagccagg aggtccccac tacatcttac
     1861 gctggacatc accccaggtc atcaaggaga ctcataagcc cctgggggac tggcgatact
     1921 cctacatgca gtgagcccag gccagcacct ctgttgtcaa gcagatgtcc atccagatga
     1981 ctgacatctc tgcactgacc ccctgctccc caccagcttc ttctggactc tctacagctg
     2041 agctggaccc tgtcctggcc actgggtgcc tgtcctcgga gtcaggtgcc caggcttcgg
     2101 gtcatattgg ggaggatcag cccagtccac ccagaattct cattcgctgc ggaacgccct
     2161 ggtacctggc aggttccccg cctgtctgct tttctctcct catcctgggc ctggtgactc
     2221 agagggcctc agaacctaaa gggatattct caggaccctg tcagggaagg agacagctct
     2281 ggtgtctcac ctcaccactc agagactcct gaccttggcc ttgtccccta cacatgtcca
     2341 gtgagatagg acctcagcca gatgactgca ggggcatcag ctggctttgt cccttggtct
     2401 gtgctagctc cttctgcagg gacttgtatc tagccatatg cctttagtcc catgtgcctt
     2461 cctccagggt gcttgtgcat ccctgagcct tcatccctcc tggacacctg ctgggagtga
     2521 ccagtggtgg tcatcccata caggctgagt ctgggaaacc tcgaggcggg cctccattcc
     2581 atactcttgt gggatggatg cagccagccc agtggtagcc agggagagct cctgcttggg
     2641 tcctggataa tcaaatgttt ctagtggctt gaaagcacac atgacttttt aaggacattt
     2701 gcctggggtc cacatggaac tggtatagct gtcaccaagg gctacgctga agggtggggt
     2761 accagtacca gggccagctc tgccttctgc ttcctttcag ggtccatgtt gcttcccagg
     2821 gagcaggact cggctacaaa tgtcccagtt gtgcagttgt acactgtgag ggggtggggc
     2881 tactgccacc cgagaaaaaa aatgccagat atctactcaa agtggccatg gagggagggg
     2941 aggggcagac tggcttctca ttcctaatct aatgaactgc cagagtcttg tcacgtggtt
     3001 ctgtgtggtg tcgtgggagg gaggagtaac tccggagccc aatggctagg tttagaaatg
     3061 gctttctgtc ccacccccac ccccccaaat ggtcaaaaaa atcatgtaat ttctccaacc
     3121 ttccatgtct aaaatggtga cgattccgtc atatgcacgg aggatcaatg agctaattcc
     3181 tgtggatttc agacaaatga tcagaaatgt cacccgttcg tttgttctcc taccagtatg
     3241 tgctgtggtg gctgatctta tgtgtcacct ttgcctggcc atggttccca gagacctggt
     3301 cagccactgt ggaagttttt atgatggtgc agtaaatatg tgggcaaaat actta
//
