LOCUS       NM_001177438            2161 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 3 family, member B2 (Aldh3b2),
            mRNA.
ACCESSION   NM_001177438 XM_129134
VERSION     NM_001177438.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2161)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2161)
  AUTHORS   Nojiri,K., Fudetani,S., Arai,A., Kitamura,T., Sassa,T. and
            Kihara,A.
  TITLE     Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide
            Levels in a Mouse Model of Sjogren-Larsson Syndrome
  JOURNAL   Mol Cell Biol 41 (10), e0035221 (2021)
   PUBMED   34370553
  REMARK    GeneRIF: Impaired Skin Barrier Function Due to Reduced
            omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson
            Syndrome.
REFERENCE   3  (bases 1 to 2161)
  AUTHORS   Kitamura,T., Takagi,S., Naganuma,T. and Kihara,A.
  TITLE     Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets
            via two C-terminal tryptophan residues and lipid modification
  JOURNAL   Biochem J 465 (1), 79-87 (2015)
   PUBMED   25286108
  REMARK    GeneRIF: ALDH3B2 acts to remove lipid-derived aldehydes in lipid
            droplets generated via oxidative stress as a quality control
            mechanism.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC133523.3.
            
            On Apr 9, 2010 this sequence version replaced XM_129134.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136505.1, SRR13422591.182949.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-286               AC133523.3         209209-209494
            287-449             AC133523.3         214380-214542
            450-560             AC133523.3         214942-215052
            561-681             AC133523.3         215295-215415
            682-767             AC133523.3         215534-215619
            768-849             AC133523.3         215732-215813
            850-1236            AC133523.3         216111-216497
            1237-1403           AC133523.3         216887-217053
            1404-1503           AC133523.3         217573-217672
            1504-2161           AC133523.3         217889-218546
FEATURES             Location/Qualifiers
     source          1..2161
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.69 cM"
     gene            1..2161
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /note="aldehyde dehydrogenase 3 family, member B2"
                     /db_xref="GeneID:621603"
                     /db_xref="MGI:MGI:2147613"
     exon            1..286
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1688
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.48"
                     /note="aldehyde dehydrogenase 8; long-chain fatty aldehyde
                     dehydrogenase"
                     /codon_start=1
                     /product="aldehyde dehydrogenase family 3 member B2"
                     /protein_id="NP_001170909.1"
                     /db_xref="CCDS:CCDS50347.1"
                     /db_xref="GeneID:621603"
                     /db_xref="MGI:MGI:2147613"
                     /translation="MSAAETGSEPSQGAGPSEATLHSLREAFNAGRTRPTEFRTAQLR
                     SLGRFLQENKELLQDALAKDVGKSGFESDMSEIILCENEVDLALKNLQTWMKDEPVST
                     NLLTKLSSAFIRKEPFGLVLIIAPWNYPVNLMIIPLVGAIAAGNCVVLKPSEISKNTE
                     KVLAELLPQYLDQSCFAVMLGGPEETRQLLEHKFDYIFFTGSPRVGKIVMTAAAKHLT
                     PITLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYILCSQEMQERLVPA
                     LQNSITRFYGDNPQTSPNLGRIINQKHFKRLQGLLGCGRVAIGGQSDEGERYIAPTVL
                     VDVQETEPVMQEEIFGPILPLVTVRSLDEAIEFINRREKPLALYAFSNNNQVVNQMLE
                     RTSSGGFGGNDGFLYLTLPALPLGGVGNSGMGRYHGKFSFDTFSHHRACLLRSPGMEK
                     LNDLRYPPYGPWNQQLISWAIGSRSCTLL"
     exon            287..449
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            450..560
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            561..681
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            682..767
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            768..849
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1236
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1403
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1404..1503
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..2161
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2076
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /note="major polyA site"
     regulatory      2123..2128
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2146
                     /gene="Aldh3b2"
                     /gene_synonym="C130048D07Rik"
ORIGIN      
        1 agaacattca gacgcacaga gaagcccgta cagcctgcca ttccggttcc ctagagctgt
       61 gcccaggagg caatgaggga gggaaggcgt ggagtttagg agacagctgc cccacccacc
      121 acctgttaga gcttcaagac caggcgctgc actgccagat agggcaaggc agtgtgaccc
      181 cacctagaag gatcggcaga ggcaattgag agcctggcta caagagttgc tgcacatctg
      241 gagccagaat gtctgctgca gagacaggct cggagccctc tcagggggca ggcccctctg
      301 aggccacact gcacagcctg cgggaggcct tcaatgcagg gcggactcgg cctactgagt
      361 ttcggactgc acagctgcgg agcctgggtc gcttcttgca ggaaaacaaa gagctgctgc
      421 aagatgcact ggctaaggac gtgggcaagt caggcttcga gtcagacatg agtgagatca
      481 tcctgtgcga gaatgaggtg gacctggccc tcaagaacct gcagacctgg atgaaggacg
      541 agcctgtgtc caccaacttg ctcaccaagc tgagctcagc cttcatccgg aaagagccct
      601 ttggcctggt gcttatcatt gcaccctgga attatcctgt gaacttgatg atcatacctt
      661 tagtgggggc cattgctgca ggaaactgtg tggtgctgaa gccatcagaa attagcaaga
      721 acacagagaa ggtgctggca gagctgctgc cccagtatct ggaccagagc tgctttgctg
      781 tgatgttggg aggacccgag gagaccaggc agctgctgga acacaaattt gactatatct
      841 tcttcacagg aagtcctcgg gtaggcaaga tcgtcatgac tgctgctgcc aaacacctga
      901 cacccatcac cctggagctg gggggtaaga acccctgcta tgtggatgac aactgcgacc
      961 cccagacagt ggccaaccgt gtggcctggt tccgctattt caatgccggc cagacctgtg
     1021 tggcccccga ttatatcctg tgtagccagg agatgcagga gcggttggtg cctgccctgc
     1081 agaattccat cacgcgtttc tatggagata acccacagac ctcccccaac ctgggcagaa
     1141 tcatcaacca gaagcatttc aagaggctcc agggattgct gggctgtggc cgtgtggcca
     1201 tcggtggcca gagtgatgag ggagagcgct acattgcccc cacagtgctg gtagacgtgc
     1261 aggagacaga gcccgtgatg caggaggaga tctttgggcc catcctgccc ctggtgactg
     1321 tgagaagcct ggatgaagcc attgagttca tcaaccggcg ggagaagcct ctggcgctgt
     1381 atgccttctc caacaacaac caggtggtga atcagatgtt ggaacgcacc agcagcggtg
     1441 gctttggagg caacgatggc ttcctctacc tgaccctacc agctctgcct ttggggggag
     1501 ttggcaacag cgggatgggc aggtaccatg gcaagttctc ctttgacacc ttctcccacc
     1561 atcgtgcctg cctgctgcgc agccctggga tggaaaagct taatgacctc cgttacccgc
     1621 cttatggtcc ctggaaccaa caactgataa gctgggccat aggctcccgg agctgcaccc
     1681 tcctgtgaat gccaccttga ctcctctctc ctgcttccct gccccaacct acctgagctt
     1741 tcagcggctt ccaagtcccc agtggttttt gaaaggcagg tgtctggccc agcctgtgaa
     1801 taccccactt ctggaatgtt ttctgaatgt acccgcagcc aggcagatgt ataccccttt
     1861 ccatagcaca gcatcctcag cagcctcctg ctcttctgct tagacagaga agccccctca
     1921 ccaagtttgg gcagatctgg tgactaaggc agacttaatt tgtcagatcg taacaggatc
     1981 ccaaaagaca gagcagctgc tcacaacttc atccatacct agagggtggc tttgtcccac
     2041 ctgaagtgac atgatcatga cctcaaatca gaattactgg tggaatctca gtgtgttcat
     2101 ttgttacttt cctgtagctt ctattaaatg acctcacatg ggcaaattca gggagaaaag
     2161 a
//
