LOCUS       NM_026316               1912 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 3 family, member B1 (Aldh3b1),
            mRNA.
ACCESSION   NM_026316
VERSION     NM_026316.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1912)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1912)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1912)
  AUTHORS   Kitamura,T., Takagi,S., Naganuma,T. and Kihara,A.
  TITLE     Mouse aldehyde dehydrogenase ALDH3B2 is localized to lipid droplets
            via two C-terminal tryptophan residues and lipid modification
  JOURNAL   Biochem J 465 (1), 79-87 (2015)
   PUBMED   25286108
REFERENCE   4  (bases 1 to 1912)
  AUTHORS   Marchitti,S.A., Brocker,C., Orlicky,D.J. and Vasiliou,V.
  TITLE     Molecular characterization, expression analysis, and role of
            ALDH3B1 in the cellular protection against oxidative stress
  JOURNAL   Free Radic Biol Med 49 (9), 1432-1443 (2010)
   PUBMED   20699116
REFERENCE   5  (bases 1 to 1912)
  AUTHORS   Levi,B.P., Yilmaz,O.H., Duester,G. and Morrison,S.J.
  TITLE     Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in
            the mouse hematopoietic and nervous systems
  JOURNAL   Blood 113 (8), 1670-1680 (2009)
   PUBMED   18971422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY194399.1 and BC046597.1.
            
            On Jul 24, 2018 this sequence version replaced NM_026316.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046597.1, AK154500.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                BY194399.1         6-67
            63-1912             BC046597.1         1-1850
FEATURES             Location/Qualifiers
     source          1..1912
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.63 cM"
     gene            1..1912
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /note="aldehyde dehydrogenase 3 family, member B1"
                     /db_xref="GeneID:67689"
                     /db_xref="MGI:MGI:1914939"
     exon            1..83
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            84..246
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     CDS             85..1491
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /EC_number="1.2.1.5"
                     /EC_number="1.2.1.28"
                     /EC_number="1.2.1.7"
                     /EC_number="1.2.1.48"
                     /note="aldehyde dehydrogenase 7; long-chain fatty aldehyde
                     dehydrogenase; medium-chain fatty aldehyde dehydrogenase"
                     /codon_start=1
                     /product="aldehyde dehydrogenase family 3 member B1"
                     /protein_id="NP_080592.2"
                     /db_xref="CCDS:CCDS29403.1"
                     /db_xref="GeneID:67689"
                     /db_xref="MGI:MGI:1914939"
                     /translation="MDSFEDKLQQLREAFKEGRTRSAEFRAAQLQGLSHFLRDNKQQL
                     QEALAQDLHKSAFEAEVSEIAISQAEVDLALRNLRSWMKDEKVSKNLATQLDSAFIRK
                     EPFGLVLIIVPWNYPINLTLVPLVGAIAAGNCVVLKPSEISKATEKILAEVLPRYLDQ
                     SCFTVVLGGRQETGQLLEHKFDYIFFTGNAYVGKIVMAAAAKHLTPITLELGGKNPCY
                     VDDNCDPQIVANRVAWFRYFNAGQTCVAPDYILCSQEMQERLVPALQNAITRFYGDNP
                     QTSPNLGRIINQKHFKRLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQETEPVMQEE
                     IFGPILPLVTVRSLDEAIEFMNRREKPLALYAFSKRSQVIKQVLARTSSGGFCGNDGF
                     MHMTLSSLPFGGVGTSGMGRYHGKFSFDTFSNQRACLLRSPGMEKINDLRYPPYSSRN
                     LRVLLVAMEERCCSCTLL"
     exon            247..357
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            358..478
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            479..564
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            565..646
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            647..1033
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1200
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1300
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1894
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1829..1834
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /note="hexamer: AATAAA"
     polyA_site      1849
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /note="major polyA site"
     regulatory      1870..1875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /note="hexamer: ATTAAA"
     polyA_site      1894
                     /gene="Aldh3b1"
                     /gene_synonym="1700001N19Rik; ALDH4; ALDH7"
                     /note="major polyA site"
ORIGIN      
        1 aggcactgtt ggaccttgca taagggcagg gtgccaggca gagccggaca gccaggaagc
       61 agtgcagctt ggcgaagccg caggatggac tcgtttgaag acaagcttca gcagctgcgg
      121 gaggccttca aggaggggcg gacgaggtca gctgagttcc gagcggcaca gctgcaaggc
      181 ctgagccact tcctccgaga caacaaacaa cagctgcagg aggcgttggc ccaagacctg
      241 cacaagtcag ccttcgaggc cgaggtgtct gagattgcca tcagtcaggc cgaggtggac
      301 ctggccctca ggaacctgcg gtcttggatg aaggatgaga aagtgtccaa gaatctggct
      361 acacagctgg actcagcctt catccggaag gagcccttcg gtctggtgct tatcatcgtg
      421 ccctggaatt atcccattaa cctgacactc gtgccgctgg tgggggccat agctgcaggg
      481 aattgtgtgg tgctcaagcc ctcagagatc agcaaggcca ctgaaaagat actggctgag
      541 gtcctgcccc gctatctgga ccagagctgc tttactgtgg tactgggtgg gcgtcaggag
      601 accgggcagc tgctggaaca caagttcgac tacatcttct tcacagggaa tgcttatgta
      661 ggcaagatcg tcatggctgc tgctgccaaa cacctgacac ccatcaccct ggagctgggg
      721 ggtaagaacc cctgctatgt ggatgacaac tgcgaccccc agatagtggc caaccgtgtg
      781 gcctggttcc gctactttaa tgccggccag acctgtgtgg cccccgatta tatcctgtgt
      841 agccaggaga tgcaggagcg gttggtgcct gccctacaga atgccatcac acgtttctat
      901 ggagacaacc cacagacctc ccccaacctg ggcagaatca tcaaccagaa gcatttcaag
      961 cgactccagg gattgctggg ctgtggccgt gtggccatcg gtggccagag tgatgaggga
     1021 gagcgctaca ttgcccccac agtgttagtg gacgtgcagg agacagagcc tgtgatgcag
     1081 gaggagatct ttgggcccat cctgcccctg gtgactgtga gaagcctgga tgaagccatc
     1141 gagttcatga accggcggga gaagccactg gcgctgtatg ccttctccaa gagaagccag
     1201 gttatcaaac aggtgttggc ccggaccagc agcgggggat tctgtgggaa tgatggcttc
     1261 atgcacatga ccctgtccag ccttcctttt ggaggagtgg gaaccagcgg gatgggcagg
     1321 taccacggca agttctcctt tgacaccttc tccaaccagc gtgcctgtct gctgcgcagc
     1381 ccgggaatgg agaaaatcaa tgacttgcgc tacccaccct actccagtcg caacctcagg
     1441 gtgttgttgg tggccatgga ggagaggtgc tgcagctgca ccctgctgta agcaggggtt
     1501 ttggggtaca ggagcctgcc tggggcacag cttcagagaa gtggcctgcc agggccaagg
     1561 ccacagagca gtctgctcag cccttcttgg tggagccctc tgcctcctgg ggctcccctt
     1621 tttggacctt tgaataagat aggctgaggg taggaaggca ggaagggatg cagtgaccat
     1681 agaatcttcg agaaaacaga gcacttctga actacccacc ctctcgtgga tagtgttgca
     1741 agggagcagt gataatcggc acaggtcata ctctgtgacc aggcctgtct gggtcttctc
     1801 actctcagtt ttctatctgc acaatggaaa taaaacagcc ttaacaaaac agcctatcgt
     1861 cgtggaagta ttaaactagg agggctgact ccaaaaaaaa aaaaaaaaaa aa
//
