LOCUS       NM_001331114            3246 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus aldehyde dehydrogenase family 3, subfamily A2
            (Aldh3a2), transcript variant 1, mRNA.
ACCESSION   NM_001331114 XM_006532029
VERSION     NM_001331114.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3246)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3246)
  AUTHORS   Nojiri,K., Fudetani,S., Arai,A., Kitamura,T., Sassa,T. and
            Kihara,A.
  TITLE     Impaired Skin Barrier Function Due to Reduced omega-O-Acylceramide
            Levels in a Mouse Model of Sjogren-Larsson Syndrome
  JOURNAL   Mol Cell Biol 41 (10), e0035221 (2021)
   PUBMED   34370553
  REMARK    GeneRIF: Impaired Skin Barrier Function Due to Reduced
            omega-O-Acylceramide Levels in a Mouse Model of Sjogren-Larsson
            Syndrome.
REFERENCE   3  (bases 1 to 3246)
  AUTHORS   Yusuf,R.Z., Saez,B., Sharda,A., van Gastel,N., Yu,V.W.C.,
            Baryawno,N., Scadden,E.W., Acharya,S., Chattophadhyay,S., Huang,C.,
            Viswanathan,V., S'aulis,D., Cobert,J., Sykes,D.B., Keibler,M.A.,
            Das,S., Hutchinson,J.N., Churchill,M., Mukherjee,S., Lee,D.,
            Mercier,F., Doench,J., Bullinger,L., Logan,D.J., Schreiber,S.,
            Stephanopoulos,G., Rizzo,W.B. and Scadden,D.T.
  TITLE     Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death
            and the synthetic lethality of ferroptosis inducers
  JOURNAL   Blood 136 (11), 1303-1316 (2020)
   PUBMED   32458004
  REMARK    GeneRIF: Aldehyde dehydrogenase 3a2 protects AML cells from
            oxidative death and the synthetic lethality of ferroptosis
            inducers.
REFERENCE   4  (bases 1 to 3246)
  AUTHORS   Kanetake,T., Sassa,T., Nojiri,K., Sawai,M., Hattori,S.,
            Miyakawa,T., Kitamura,T. and Kihara,A.
  TITLE     Neural symptoms in a gene knockout mouse model of Sjogren-Larsson
            syndrome are associated with a decrease in
            2-hydroxygalactosylceramide
  JOURNAL   FASEB J 33 (1), 928-941 (2019)
   PUBMED   30085884
REFERENCE   5  (bases 1 to 3246)
  AUTHORS   Bulusu,V., Prior,N., Snaebjornsson,M.T., Kuehne,A., Sonnen,K.F.,
            Kress,J., Stein,F., Schultz,C., Sauer,U. and Aulehla,A.
  TITLE     Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to
            Mouse Embryo Mesoderm Development
  JOURNAL   Dev Cell 40 (4), 331-341 (2017)
   PUBMED   28245920
REFERENCE   6  (bases 1 to 3246)
  AUTHORS   Vasiliou,V., Puga,A. and Nebert,D.W.
  TITLE     Negative regulation of the murine cytosolic aldehyde
            dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2
            proteins
  JOURNAL   Biochem Biophys Res Commun 187 (1), 413-419 (1992)
   PUBMED   1520328
REFERENCE   7  (bases 1 to 3246)
  AUTHORS   McCaffery,P., Tempst,P., Lara,G. and Drager,U.C.
  TITLE     Aldehyde dehydrogenase is a positional marker in the retina
  JOURNAL   Development 112 (3), 693-702 (1991)
   PUBMED   1935685
REFERENCE   8  (bases 1 to 3246)
  AUTHORS   Engler,P., Haasch,D., Pinkert,C.A., Doglio,L., Glymour,M.,
            Brinster,R. and Storb,U.
  TITLE     A strain-specific modifier on mouse chromosome 4 controls the
            methylation of independent transgene loci
  JOURNAL   Cell 65 (6), 939-947 (1991)
   PUBMED   2044153
REFERENCE   9  (bases 1 to 3246)
  AUTHORS   Timms,G.P. and Holmes,R.S.
  TITLE     Genetics and ontogeny of aldehyde dehydrogenase isozymes in th
            mouse: evidence for a locus controlling the inducibility of the
            liver microsomal isozyme
  JOURNAL   Biochem Genet 19 (11-12), 1223-1236 (1981)
   PUBMED   7337695
REFERENCE   10 (bases 1 to 3246)
  AUTHORS   Timms,G.P. and Holmes,R.S.
  TITLE     Genetics of aldehyde dehydrogenase isozymes in the mouse: evidence
            for multiple loci and localization of Ahd-2 on chromosome 19
  JOURNAL   Genetics 97 (2), 327-336 (1981)
   PUBMED   7274657
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672172.7.
            
            On Mar 2, 2023 this sequence version replaced NM_001331114.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.22582.1,
                                           SRR7652917.161232.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               AL672172.7         39972-40245         c
            275-506             AL672172.7         38182-38413         c
            507-592             AL672172.7         37364-37449         c
            593-801             AL672172.7         35337-35545         c
            802-919             AL672172.7         31859-31976         c
            920-1061            AL672172.7         29857-29998         c
            1062-1228           AL672172.7         26742-26908         c
            1229-1328           AL672172.7         24061-24160         c
            1329-1564           AL672172.7         21980-22215         c
            1565-1677           AL672172.7         21047-21159         c
            1678-3246           AL672172.7         17871-19439         c
FEATURES             Location/Qualifiers
     source          1..3246
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..3246
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /note="aldehyde dehydrogenase family 3, subfamily A2"
                     /db_xref="GeneID:11671"
                     /db_xref="MGI:MGI:1353452"
     exon            1..274
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1645
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.94"
                     /note="isoform 1 is encoded by transcript variant 1;
                     alcohol dehydrogenase family 3, subfamily A2; aldehyde
                     dehydrogenase 3; aldehyde dehydrogenase family 3 member
                     A2; aldehyde dehydrogenase 4, liver microsomal (class 3)
                     regulator; fatty aldehyde dehydrogenase variant form"
                     /codon_start=1
                     /product="aldehyde dehydrogenase family 3 member A2
                     isoform 1"
                     /protein_id="NP_001318043.1"
                     /db_xref="GeneID:11671"
                     /db_xref="MGI:MGI:1353452"
                     /translation="MERQVLRLRQAFRSGRSRPLRFRLQQLEALRRMVQEREKEILAA
                     IAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPL
                     GVVLIIGAWNYPFVLTMQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLY
                     AIVNGGIPETTELLKQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDR
                     DCDLDVACRRIAWGKYMNCGQTCIAPDYILCEASLQNQIVQKIKETVKDFYGENIKAS
                     PDYERIINLRHFKRLQSLLKGQKIAFGGEMDEATRYLAPTILTDVDPNSKVMQEEIFG
                     PILPIVSVKNVDEAINFINDREKPLALYVFSRNNKLIKRVIDETSSGGVTGNDVIMHF
                     TVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPCLLKGLKGESVNKLRYPPNSESKVSW
                     AKFFLLKQFNKGRLGMLLFVCLVAVAAVIVKKYQALPRGKALLASLIVHRRRWSSKH"
     exon            275..506
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            507..592
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            593..801
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            802..919
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1061
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1228
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1328
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1564
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1677
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..3246
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3128..3133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /note="hexamer: AATAAA"
     polyA_site      3146
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
                     /note="major polyA site"
     polyA_site      3246
                     /gene="Aldh3a2"
                     /gene_synonym="Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4;
                     Aldh4-r; FALDH"
ORIGIN      
        1 agtaggcgga taggacccag cagcggaaag tggcagtgag ctgtggcatc atccatagca
       61 gctccttact ggtactgtgc tccctcacct gcctcgctcc gcgttctcct caggcccggc
      121 catggagcgc caggtcctac ggcttcgcca ggcgttccgg tccggccgat ctcggccgct
      181 gcgcttccga ttgcagcagc ttgaggccct gcggaggatg gtgcaagagc gcgagaagga
      241 aatcttagca gccatcgcgg cagacctgag caaaagtgaa ctcaatgcat acagtcatga
      301 agtcattacc atccttggag agattgattt tatgttgggg aatcttcctg aattggcttc
      361 tgcgagaccg gctaagaaga acctgctaac catgatggat gaggcctacg ttcagcccga
      421 gcctctggga gtcgtactga ttattggagc ttggaattac cctttcgttc ttaccatgca
      481 accgctggtg ggagccattg ctgcaggaaa tgctgccatt gttaagccct cagaactcag
      541 tgaaaacacg gccaagatct tggctgaact cctccctcag tacttagacc aggacctgta
      601 tgcgattgtt aatggcggta tcccggaaac cacggagctt ctgaagcagc ggtttgacca
      661 cattctctat acagggaaca ctgcagttgg aaaaattgtc atggaagctg ctgccaagca
      721 tctgacccct gtgaccctgg aactcggcgg gaaaagccct tgttacattg acagagactg
      781 tgatctggac gtggcttgca gacgcatagc ctggggaaag tacatgaatt gtggtcaaac
      841 ctgcattgct cctgactata tcctgtgcga agcctccctc cagaatcaaa tcgtacagaa
      901 gattaaggaa acggtgaagg acttttatgg ggaaaacata aaggcttctc ctgactatga
      961 aaggatcatc aatcttcgtc actttaagag gttacaaagt ctgcttaaag gccagaaaat
     1021 agctttcggt ggagagatgg atgaggccac acgctactta gccccaacca tacttacaga
     1081 tgttgatcct aactccaagg tgatgcaaga agaaattttt ggaccaattc ttccaatagt
     1141 gtctgtgaaa aatgtagacg aagccataaa tttcataaat gaccgtgaaa agcccctggc
     1201 tctctacgta ttttctcgta acaataagct catcaaacgg gtgatagatg agacctccag
     1261 tggtggagtc accggcaatg atgtcatcat gcacttcact gttaattctc tgccctttgg
     1321 aggtgtgggt gccagtggaa tgggggcgta tcatggaaaa tacagttttg ataccttttc
     1381 tcatcagcgc ccctgcttgt taaaagggtt aaagggggaa agcgtcaaca agctcaggta
     1441 cccgcccaac agcgagtcca aggtcagctg ggccaagttc ttcctgctga agcagttcaa
     1501 caaaggaagg ctggggatgc tgttgtttgt gtgcctggtt gctgttgcag ctgtgattgt
     1561 caagaaatac caagctctgc cgaggggaaa agccctgttg gcttctctga tagttcatag
     1621 acggcgctgg tccagtaagc actgacggtc aggccccagc tgtctgttga gagtgaggat
     1681 cagctgtaat gacttccttg ttgcctctcc tgaagtatca ctctactaaa tggttaacaa
     1741 accaatactt ttaaaattgt acccaaacca ggaaattcac agatgtactg caatcaaacc
     1801 taagctgttg ccacaaacca ctaatgaaac tcagtgtttg agccaaatct ccgcaattga
     1861 gagcagtgca agtgctgaga ggatgtagac tgggctgggg cgagaacatg tcacactaga
     1921 tcccagtcca cgatgatgag tcagggagac tcgataactg ctccttggcc attcattttc
     1981 ctccagccca tagctctgcc cactccagtg tcaaacaccg cccaggcttt ccagctgacc
     2041 tctgttatct tgagagctga ggctaggtcc tcccagctac tgttaggcat tgaggtacta
     2101 aaactgcagg tgggtatgtc catctcatcc attgtggctt gagaccggcc ttcaggagtc
     2161 cgctctccat ttaaacatcc tttcttattc atagcgcacc acccaaagtc tgtgtgtttg
     2221 tgacagtctg tggggactgt cccagtgcct ttgtgatgac ctaaactgca ctgagtctct
     2281 tgccaagaag caatgctttt tttgtgaagg ccactcagag catcttgcag tcacagctgt
     2341 tcctgagcct gaggccagaa gattccctaa cccaggactt tgaagccaac ctaggcaaca
     2401 tgatggggac cctccccatt cttcataaaa atcccctcaa gatcctcaag ttgaatgttt
     2461 tgtagatctt caaggataag ccttctgctt attctcctag cacaatgcaa ggaaatttta
     2521 ctttttaaat cttagagaga ttcctacaga tctataaagc atggagccat tcctgtagtg
     2581 aagggggggt tattataccc cagggcttca gaactcacag gacagggatt gctggagaac
     2641 actgcgagct gtggagcaca cttaagggat gggatggtca gaggcgctcc cgagcaagcg
     2701 gggcatcatt ctcccttaga tcctagtgtg gctaagcagg gatgtggcag agagatctgt
     2761 gtggatctgg cttcctgctg ctggggcctg gctgggccca aagctccaag cctcactgcc
     2821 ttcctggggt cctaattaac tcggcctact caatgagaac gtaacatgct tattgaatgt
     2881 atagccgtgt ttgctgagta acctgtccca ccgttgaggc tatctgaagt gtattgtatg
     2941 aaggaagtat caagaacaaa tcattggccc gttatagcaa atagttgctt aagtagcagt
     3001 tgtcatagac taatcataaa atattttgca caaaatttca atgttgaact tgcacttact
     3061 gttgttatag taaattataa atcacagctt ctagctaggc caaaatactt actctactga
     3121 tcttcaaaat aaatgtattt cataaattat tgtgtgttaa ttttgacctc agaaatggag
     3181 atatgatgca aagttccttt gtaaatccat ttttcctttc tatccctcaa ggatgtcgtt
     3241 tgctaa
//
