LOCUS       NM_001112725            1597 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aldehyde dehydrogenase family 3, subfamily A1
            (Aldh3a1), transcript variant 2, mRNA.
ACCESSION   NM_001112725
VERSION     NM_001112725.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1597)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1597)
  AUTHORS   Son,J., Du,W., Esposito,M., Shariati,K., Ding,H., Kang,Y. and
            Accili,D.
  TITLE     Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of
            beta-cell failure
  JOURNAL   Nat Commun 14 (1), 558 (2023)
   PUBMED   36732513
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1597)
  AUTHORS   Prokopuk,L., Jarred,E.G., Blucher,R.O., McLaughlin,E.A.,
            Stringer,J.M. and Western,P.S.
  TITLE     An essential role for Polycomb Repressive Complex 2 in the mouse
            ovary
  JOURNAL   Reproduction 163 (3), 167-182 (2022)
   PUBMED   35084365
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1597)
  AUTHORS   Sunny,S.S., Lachova,J., Dupacova,N., Zitova,A. and Kozmik,Z.
  TITLE     Generation and characterization of Aldh3-Cre transgenic mice as a
            tool for conditional gene deletion in postnatal cornea
  JOURNAL   Sci Rep 10 (1), 9083 (2020)
   PUBMED   32493941
  REMARK    GeneRIF: Generation and characterization of Aldh3-Cre transgenic
            mice as a tool for conditional gene deletion in postnatal cornea.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1597)
  AUTHORS   Zieman,A.G., Poll,B.G., Ma,J. and Coulombe,P.A.
  TITLE     Altered keratinocyte differentiation is an early driver of keratin
            mutation-based palmoplantar keratoderma
  JOURNAL   Hum Mol Genet 28 (13), 2255-2270 (2019)
   PUBMED   31220272
REFERENCE   6  (bases 1 to 1597)
  AUTHORS   Vasiliou,V., Puga,A. and Nebert,D.W.
  TITLE     Negative regulation of the murine cytosolic aldehyde
            dehydrogenase-3 (Aldh-3c) gene by functional CYP1A1 and CYP1A2
            proteins
  JOURNAL   Biochem Biophys Res Commun 187 (1), 413-419 (1992)
   PUBMED   1520328
REFERENCE   7  (bases 1 to 1597)
  AUTHORS   McCaffery,P., Tempst,P., Lara,G. and Drager,U.C.
  TITLE     Aldehyde dehydrogenase is a positional marker in the retina
  JOURNAL   Development 112 (3), 693-702 (1991)
   PUBMED   1935685
REFERENCE   8  (bases 1 to 1597)
  AUTHORS   Holmes,R.S., Popp,R.A. and VandeBerg,J.L.
  TITLE     Genetics of ocular NAD+-dependent alcohol dehydrogenase and
            aldehyde dehydrogenase in the mouse: evidence for genetic identity
            with stomach isozymes and localization of Ahd-4 on chromosome 11
            near trembler
  JOURNAL   Biochem Genet 26 (3-4), 191-205 (1988)
   PUBMED   3408474
REFERENCE   9  (bases 1 to 1597)
  AUTHORS   Mather,P.B. and Holmes,R.S.
  TITLE     Biochemical genetics of aldehyde dehydrogenase isozymes in the
            mouse: evidence for stomach- and testis-specific isozymes
  JOURNAL   Biochem Genet 22 (11-12), 981-995 (1984)
   PUBMED   6543304
REFERENCE   10 (bases 1 to 1597)
  AUTHORS   Lush,I.E.
  TITLE     Genetic variation of some aldehyde-oxidizing enzymes in the mouse
  JOURNAL   Anim Blood Groups Biochem Genet 9 (2), 85-96 (1978)
   PUBMED   742739
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144241.1, EL959277.1, EL957097.1, EL963960.1, EL959139.1 and
            EL961165.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and uses
            an alternate in-frame splice site in the 3' coding region compared
            to variant 3. The encoded isoform (1) is shorter than isoform 2.
            Both variants 1 and 2 encode the same isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144241.1, SRR5189676.105727.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               AK144241.1         4-449
            447-632             EL959277.1         435-620
            633-684             EL957097.1         383-434
            685-701             AK144241.1         688-704
            702-706             EL963960.1         183-187
            707-958             AK144241.1         710-961
            959-1032            EL963960.1         439-512
            1033-1043           AK144241.1         1036-1046
            1044-1111           EL959139.1         323-390
            1112-1589           AK144241.1         1115-1592
            1590-1597           EL961165.1         499-506
FEATURES             Location/Qualifiers
     source          1..1597
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.96 cM"
     gene            1..1597
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /note="aldehyde dehydrogenase family 3, subfamily A1"
                     /db_xref="GeneID:11670"
                     /db_xref="MGI:MGI:1353451"
     exon            1..40
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            41..207
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1407
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /EC_number="1.2.1.5"
                     /note="isoform 1 is encoded by transcript variant 2;
                     aldehyde dehydrogenase, dimeric NADP-preferring; aldehyde
                     dehydrogenase 4; aldehyde dehydrogenase family 3 member
                     A1; dioxin-inducible aldehyde dehydrogenase 3; alcohol
                     dehydrogenase family 3, subfamily A1; aldehyde
                     dehydrogenase 3, stomach cytosolic (class 3)"
                     /codon_start=1
                     /product="aldehyde dehydrogenase, dimeric NADP-preferring
                     isoform 1"
                     /protein_id="NP_001106196.1"
                     /db_xref="CCDS:CCDS24808.1"
                     /db_xref="GeneID:11670"
                     /db_xref="MGI:MGI:1353451"
                     /translation="MSNISSIVNRARDAFNSGKTRPLQFRVEQLEALQRMINENLKGI
                     SKALASNLRKNEWTSYYEEVAHVLDEIDFTIKGLSDWAEDEPVAKTRQTQEDDLYIHS
                     EPLGVVLVIGAWNYPFNLTIQPMVGAIAAGNAVVLKPSEVSDHMADLLSTLIPQYMDK
                     DLYPVIKGGVPETTELLKEKFDHIMYTGSTAVGKIVMAAAAKHLTPVTLELGGKSPCY
                     VDKDCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNEIVEKLKKSLKDFYGEDA
                     KQSHDYGRIINDRHFQRVINLIDSKKVAHGGTWDQPSRYIAPTILVDVDPQSPVMQEE
                     IFGPVMPIVCVRSLDEAIKFINQREKPLALYVFSNNDKVIKKMIAETSSGGVTANDVI
                     VHITVPTLPFGGVGNSGMGAYHGKKSFETFSHRRSCLVRSLRNEEANKARYPPSPAKM
                     PRH"
     exon            208..439
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            440..525
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            526..734
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..852
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            853..994
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1161
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1261
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1392
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1597
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1575..1580
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /note="hexamer: AATAAA"
     polyA_site      1597
                     /gene="Aldh3a1"
                     /gene_synonym="Ahd-4; Ahd4; Aldh; Aldh3"
                     /note="major polyA site"
ORIGIN      
        1 attccaggag ttccagctgc tggagaggac tgtgtagaag ttaccatgag caatatcagt
       61 agcatcgtga accgggcccg tgatgccttt aactcaggca agactcgacc gctgcagttc
      121 cgggttgagc agctggaggc gttgcagcgc atgatcaacg agaacttgaa aggcatctcc
      181 aaggcgctgg cctctaacct gcgcaagaat gaatggacct cctactacga ggaggtggct
      241 cacgtgctgg acgaaatcga tttcacgatt aaggggctct ccgattgggc tgaggacgag
      301 cctgtggcaa agactcgtca gacccaggaa gatgacctct acatccactc ggagcccctg
      361 ggcgtggtcc ttgtcatagg tgcttggaac tacccattca acctcaccat tcagcccatg
      421 gtgggtgcca tcgctgcagg aaatgctgtg gtcctcaagc cctcggaagt gagtgatcac
      481 atggcagacc tgctttcaac acttatccct cagtatatgg acaaggatct gtacccagtg
      541 atcaaagggg gtgtccctga aaccacggag ctgctcaaag agaagtttga ccacatcatg
      601 tacacaggga gcacggctgt aggaaagatc gtcatggcgg ctgccgccaa gcatctgacc
      661 cctgtcacct tggagcttgg aggaaagagc ccttgttacg tagacaagga ctgtgatcta
      721 gatgtggctt gccggcgtat tgcttgggga aagtttatga acagtggcca gacctgtgtg
      781 gccccagact acatcctctg tgacccctcc attcagaatg aaattgtgga gaagctcaaa
      841 aagtcactga aagatttcta tggggaagat gctaagcagt cccatgacta tgggaggatc
      901 atcaacgacc ggcacttcca gcgggtcata aatctgattg acagcaagaa agtagcccat
      961 ggaggcacct gggatcagcc ttcacgatac atagctccca ccatcctagt ggatgtggac
     1021 ccccagtccc cggtgatgca ggaggagatc tttgggccgg tgatgcccat tgtgtgtgtt
     1081 cgaagcttgg atgaggccat taaatttatc aaccagcgcg agaagcccct ggcactctat
     1141 gtgttctcca acaatgacaa ggtgatcaag aaaatgatcg cagagacatc aagcggtgga
     1201 gtgacagcca atgacgtcat tgttcacatc actgtgccca ctttgccctt tgggggtgtg
     1261 gggaacagcg gcatgggggc ctaccatggc aagaaaagct tcgagacctt ttcccaccgc
     1321 cgctcttgcc tggtgaggtc tctgcggaat gaagaagcta acaaggccag gtatccccca
     1381 agcccagcca agatgccccg gcattgagag ggctacttca cctgacactt gttttgctgg
     1441 ctgtcctgtc cttgaagaat tgctcacgga gcctcatcct ggcttctctc ccacctgctg
     1501 ccccatgcat gctcaactac ccgaaggctc tcacctcccc cctcttgttc tgctgtttgc
     1561 tgagcacaga gaccaataaa aaagcctcta aagaaaa
//
