LOCUS       NM_009656               3883 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 2, mitochondrial (Aldh2),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_009656
VERSION     NM_009656.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3883)
  AUTHORS   Wei,Y., Gao,S., Li,C., Huang,X., Xie,B., Geng,J., Dai,H. and
            Wang,C.
  TITLE     Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung Fibrosis
            through Mitochondrial Dysfunction and Aging in Fibroblasts
  JOURNAL   Am J Pathol 194 (8), 1458-1477 (2024)
   PUBMED   38777148
  REMARK    GeneRIF: Aldehyde Dehydrogenase 2 Deficiency Aggravates Lung
            Fibrosis through Mitochondrial Dysfunction and Aging in
            Fibroblasts.
REFERENCE   2  (bases 1 to 3883)
  AUTHORS   Xu,C., Zhang,L., Xu,S., Wang,Z., Han,Q., Lv,Y., Wang,X., Zhang,X.,
            Zhang,Q., Zhang,Y., He,S., Yuan,Q., Bian,Y., Li,C., Wang,J., Xu,F.,
            Cao,Y., Pang,J. and Chen,Y.
  TITLE     Neutrophil ALDH2 is a new therapeutic target for the effective
            treatment of sepsis-induced ARDS
  JOURNAL   Cell Mol Immunol 21 (5), 510-526 (2024)
   PUBMED   38472357
  REMARK    GeneRIF: Neutrophil ALDH2 is a new therapeutic target for the
            effective treatment of sepsis-induced ARDS.
REFERENCE   3  (bases 1 to 3883)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3883)
  AUTHORS   Nie,X., Fan,J., Dai,B., Wen,Z., Li,H., Chen,C. and Wang,D.W.
  TITLE     LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy
            Through ALDH2
  JOURNAL   Circ Res 134 (4), 425-441 (2024)
   PUBMED   38299365
  REMARK    GeneRIF: LncRNA CHKB-DT Downregulation Enhances Dilated
            Cardiomyopathy Through ALDH2.
REFERENCE   5  (bases 1 to 3883)
  AUTHORS   Hsu,L.A., Yeh,Y.H., Chang,C.J., Chen,W.J., Tsai,H.Y. and Chang,G.J.
  TITLE     Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and Atrial
            Fibrillation Susceptibility: Unraveling the Connection
  JOURNAL   Int J Mol Sci 25 (4), 2186 (2024)
   PUBMED   38396862
  REMARK    GeneRIF: Aldehyde Dehydrogenase 2 (ALDH2) Deficiency, Obesity, and
            Atrial Fibrillation Susceptibility: Unraveling the Connection.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3883)
  AUTHORS   Fijneman,R.J. and Demant,P.
  TITLE     A gene for susceptibility to small intestinal cancer, ssic1, maps
            to the distal part of mouse chromosome 4
  JOURNAL   Cancer Res 55 (14), 3179-3182 (1995)
   PUBMED   7606739
REFERENCE   7  (bases 1 to 3883)
  AUTHORS   Chang,C. and Yoshida,A.
  TITLE     Cloning and characterization of the gene encoding mouse
            mitochondrial aldehyde dehydrogenase
  JOURNAL   Gene 148 (2), 331-336 (1994)
   PUBMED   7958964
REFERENCE   8  (bases 1 to 3883)
  AUTHORS   Caubin,J., Iglesias,T., Bernal,J., Munoz,A., Marquez,G.,
            Barbero,J.L. and Zaballos,A.
  TITLE     Isolation of genomic DNA fragments corresponding to genes modulated
            in vivo by a transcription factor
  JOURNAL   Nucleic Acids Res 22 (20), 4132-4138 (1994)
   PUBMED   7937138
REFERENCE   9  (bases 1 to 3883)
  AUTHORS   Chen,M., Achkar,C. and Gudas,L.J.
  TITLE     Enzymatic conversion of retinaldehyde to retinoic acid by cloned
            murine cytosolic and mitochondrial aldehyde dehydrogenases
  JOURNAL   Mol Pharmacol 46 (1), 88-96 (1994)
   PUBMED   8058062
REFERENCE   10 (bases 1 to 3883)
  AUTHORS   McCaffery,P., Tempst,P., Lara,G. and Drager,U.C.
  TITLE     Aldehyde dehydrogenase is a positional marker in the retina
  JOURNAL   Development 112 (3), 693-702 (1991)
   PUBMED   1935685
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK165032.1, AK163452.1 and AW050084.1.
            
            On May 5, 2015 this sequence version replaced NM_009656.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163452.1, AK165032.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2207              AK165032.1         2-2208
            2208-3389           AK163452.1         1974-3155
            3390-3883           AW050084.1         1-494               c
FEATURES             Location/Qualifiers
     source          1..3883
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 61.86 cM"
     gene            1..3883
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /note="aldehyde dehydrogenase 2, mitochondrial"
                     /db_xref="GeneID:11669"
                     /db_xref="MGI:MGI:99600"
     exon            1..463
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            464..568
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            569..709
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            710..789
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            790..901
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1030
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1144
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1247
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1432
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1597
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1755
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1870
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..3867
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2168..2173
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /note="hexamer: AATAAA"
     polyA_site      2188
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /note="major polyA site"
     polyA_site      2217
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
     regulatory      3247..3252
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /note="hexamer: CATAAA"
     polyA_site      3271
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
     regulatory      3836..3841
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /note="hexamer: AATAAA"
     regulatory      3848..3853
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
                     /note="hexamer: AATACA"
     polyA_site      3854
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
     polyA_site      3867
                     /gene="Aldh2"
                     /gene_synonym="Ahd-5; AHD-M1; Ahd5; ALDH-E2; ALDHI"
ORIGIN      
        1 attctcttcg ccgccatatc tgcacagatg tgagccttag gcgccagcca ccctgctagg
       61 agcgcacacc actctggcta ggctttctca gggttctgca aactccatct ctgacttggc
      121 tttgggagcc aggggtcgcg ccccttaggc cgtgaggggc tgggactccc tgaccacgcc
      181 cccgtgtctc cgcctcccat tggcggctgc agggggcgga ggcgaggact tgttcttcaa
      241 cgctgcagtc gccctccgat cggcaaggct tctctcggct ccgttcggct cggctcgccc
      301 atttcagttc agttcgggtc agttaagctc cgctcagttc agcatgctgc gcgccgcact
      361 caccactgtc cgccgcggac cgcgcctgag ccgcctgttg tccgccgccg ccaccagcgc
      421 ggtgccagcc cccaaccatc agcctgaggt cttctgcaac cagatcttca ttaacaatga
      481 gtggcacgac gccgtcagca ggaaaacatt tcccaccgtc aacccttcca caggggaggt
      541 catctgccag gtggccgaag ggaacaagga ggacgtagac aaggcagtga aggctgctcg
      601 tgcagccttc cagctgggct cgccctggcg ccgcatggat gcatctgacc ggggccggct
      661 gttgtaccga ttggcggatc tcattgaacg ggaccggacc tacctagcgg ccttggagac
      721 cctggacaac ggcaagcctt atgtcatctc gtacctggtg gatttggaca tggtcctgaa
      781 atgtctccgc tattacgctg gctgggctga caagtaccat gggaaaacca ttcccatcga
      841 cggcgacttc ttcagctata cccgccatga gcctgtgggc gtgtgtggac agatcattcc
      901 gtggaacttc ccgctcctga tgcaagcatg gaaactgggc ccagccctgg caaccgggaa
      961 cgtggtggtg atgaaggtgg ccgagcagac accgctcacc gcgctctacg tggccaactt
     1021 gatcaaggag gcaggctttc cccctggcgt ggtcaatatc gttcccggat tcggccctac
     1081 cgccggggct gccatcgcat cccatgaggg tgtggacaaa gtggcgttca caggctccac
     1141 ggaggttggt cacctaatcc aggtggccgc cgggagcagc aacctcaaga gagtaaccct
     1201 ggagctgggg ggaaagagtc ccaacatcat catgtccgac gctgacatgg actgggctgt
     1261 ggagcaggcc cactttgccc tgttcttcaa ccagggccag tgctgctgcg caggctcccg
     1321 gaccttcgtg caggagaatg tgtatgacga attcgtggaa cgcagcgtgg ctcgggccaa
     1381 gtctcgggtg gtggggaacc ccttcgacag ccggacggag caggggcctc aggtggatga
     1441 aactcagttt aagaagatcc tcggctacat caaatcggga caacaagaag gggcgaagct
     1501 gctgtgtggt gggggcgctg ccgcggaccg tggctacttt atccagccca ccgtgttcgg
     1561 ggacgtaaaa gacggcatga ccattgccaa ggaggagatc tttggaccag tgatgcaaat
     1621 cctcaaattc aagaccatcg aggaggttgt ggggcgggcc aatgattcta agtatgggct
     1681 ggcagccgcc gtcttcacaa aggacctgga taaagccaat tacctgtccc aagctctgca
     1741 ggctggcact gtgtggatca actgctacga tgtgtttggg gcccagtctc catttggggg
     1801 ctataagatg tcagggagtg gcagggagct gggcgagtat ggcctgcagg cgtacacaga
     1861 agtgaagacg gttactgtca aagtgccaca gaagaactcg taaagcggca tgcctgcttc
     1921 ctcagcccgc acccgaaaac ccaacaagat atactgagaa aaaccgccac acacactgcg
     1981 cctccaaaga gaaacccctt caccaaagtg tcttgggtca agaaagaatt ttataaacag
     2041 ggcggggctg gtggggggga aagctcctga taaactgggt aggggatgaa gctcaatgca
     2101 gaccgatcac gcgtccagat gtgcaggatg ctgccttcaa cctgcagtcc ctaagcagca
     2161 aatgagcaat aaaaatcagc agatcaaagc cacggggtca gttctctaag acgtaaattc
     2221 tgagtcttat ctctgttgca ttccgtaact ctctgctttg ggaggagaca aggccgtcct
     2281 tagaattgaa ttagctctgt ggaacactag cgccttggtg tttactggtc agaagtcatg
     2341 aaaggcagga cccctctcta ttcctggata cacgggacgc caggatgtcc ccactatttg
     2401 gtgatatcat gtatatctca ttaccctcat ccccatcttg gtacctggga tcttggttct
     2461 cacaagtaat tctaggctga cgaggaggga tgtaagctaa agggagggga gtcactattc
     2521 ttggctgcag ctacattttg gaatttcaca ctggcctatc tcacaggcca gaggaggtag
     2581 tgacacccgt ttgatccttt ccaagggtga gccaggttag gtttcaacca agggacctca
     2641 cggctcggca tcagttgcat gctgctaact aacctggagt cgattcagcc aaaagacagt
     2701 ttccagaagt ggctctgttc tcccaatctg ttctgcggcc tctttgaggc acagagcaga
     2761 gcagagccat gtcatgtgca cagtgcaagg tctgcctctc gaactaccag aaccaagaga
     2821 gattggaggt attagtgaca gtggcctgat ggaggtggca ggtgatggcc cgtgaaggta
     2881 gattttcagg gaataagaga atgtggcagt gactggcagc tgcaatgcag actctggttc
     2941 aggctatggt cactgcagat gcctggatgt gtgacagatg tgatgacatt gctgaaagac
     3001 agagggaccc actcccagtg gaaggccaag agagctcttg agcagggctc cagttacgtg
     3061 agctttctcc ctcttgtacc agaaggttcc attcctagag gttttagcta cctgtgacct
     3121 ctgccctgtg tataaatggg gttactgtga ctatcccaac cctgccctgt cctaaagtac
     3181 cttcaagggc caccttgtgc ccaacctgta gattattccc tatacagaaa tgctcatgat
     3241 gtttggcata aaaaaaaaat taagccagca attagcaata gtcattgtga gaagttacac
     3301 aactcttggt gccgctacgc ttgtgttttg gggtgttgag ttagctctgc atgggtgctg
     3361 caatactcaa tcctggaagc ccaggagcca agatggttgc tcgtagctga taggtgggca
     3421 aatatgccac gtgggtacaa cggctgcagg catgatgctc acatcgggca cagggccgca
     3481 ccgatgcatg cagcctggac cagtgtgtgc ttattttcag aatttccgtt tatactctta
     3541 tgctatgcat gacgattagc tgcctggtac ctgccctgag cagggataag caggtcaagt
     3601 ccaaggtcca caggagctgg gaagcttagg ggcgaaggtc acagatctta ctcacctagt
     3661 gagtgaacaa ggcgtggaga gcaagctgcc atcacaggca caagaaacgg acggtgagct
     3721 tagctttaga actagccagt cagaggcaga gctgagggta gaaggctgat gaagccctga
     3781 agttgtcctt cgacctccat atacacatcc ctgtatgtgc atgcgcactc aatgaaataa
     3841 ataagtaaat acaattttta aagatcaaaa aaaaaaaaaa aaa
//
