LOCUS       NM_153543               6030 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 1 family, member L2 (Aldh1l2),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_153543
VERSION     NM_153543.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6030)
  AUTHORS   Cheng,J., Yang,S., Shou,D., Chen,J., Li,Y., Huang,C., Chen,H. and
            Zhou,Y.
  TITLE     FOXO1 induced fatty acid oxidation in hepatic cells by targeting
            ALDH1L2
  JOURNAL   J Gastroenterol Hepatol 39 (10), 2197-2207 (2024)
   PUBMED   38923573
  REMARK    GeneRIF: FOXO1 induced fatty acid oxidation in hepatic cells by
            targeting ALDH1L2.
REFERENCE   2  (bases 1 to 6030)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6030)
  AUTHORS   Bouch,R.J., Zhang,J., Miller,B.C., Robbins,C.J., Mosher,T.H.,
            Li,W., Krupenko,S.A., Nagpal,R., Zhao,J., Bloomfeld,R.S., Lu,Y.,
            Nikiforov,M.A., Song,Q. and He,Z.
  TITLE     Distinct inflammatory Th17 subsets emerge in autoimmunity and
            infection
  JOURNAL   J Exp Med 220 (10) (2023)
   PUBMED   37367944
REFERENCE   4  (bases 1 to 6030)
  AUTHORS   Li,C., Teng,P., Sun,S., Cui,K., Yao,S., Fei,B., Ling,F. and
            Huang,Z.
  TITLE     Acetylation of aldehyde dehydrogenase ALDH1L2 regulates cellular
            redox balance and the chemosensitivity of colorectal cancer to
            5-fluorouracil
  JOURNAL   J Biol Chem 299 (9), 105090 (2023)
   PUBMED   37507016
  REMARK    GeneRIF: Acetylation of aldehyde dehydrogenase ALDH1L2 regulates
            cellular redox balance and the chemosensitivity of colorectal
            cancer to 5-fluorouracil.
REFERENCE   5  (bases 1 to 6030)
  AUTHORS   Hennequart,M., Pilley,S.E., Labuschagne,C.F., Coomes,J.,
            Mervant,L., Driscoll,P.C., Legrave,N.M., Lee,Y., Kreuzaler,P.,
            Macintyre,B., Panina,Y., Blagih,J., Stevenson,D., Strathdee,D.,
            Schneider-Luftman,D., Gronroos,E., Cheung,E.C., Yuneva,M.,
            Swanton,C. and Vousden,K.H.
  TITLE     ALDH1L2 regulation of formate, formyl-methionine, and ROS controls
            cancer cell migration and metastasis
  JOURNAL   Cell Rep 42 (6), 112562 (2023)
   PUBMED   37245210
REFERENCE   6  (bases 1 to 6030)
  AUTHORS   Krupenko,N.I., Sharma,J., Pediaditakis,P., Helke,K.L., Hall,M.S.,
            Du,X., Sumner,S. and Krupenko,S.A.
  TITLE     Aldh1l2 knockout mouse metabolomics links the loss of the
            mitochondrial folate enzyme to deregulation of a lipid metabolism
            observed in rare human disorder
  JOURNAL   Hum Genomics 14 (1), 41 (2020)
   PUBMED   33168096
  REMARK    GeneRIF: Aldh1l2 knockout mouse metabolomics links the loss of the
            mitochondrial folate enzyme to deregulation of a lipid metabolism
            observed in rare human disorder.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6030)
  AUTHORS   Poncet,N., Halley,P.A., Lipina,C., Gierlinski,M., Dady,A.,
            Singer,G.A., Febrer,M., Shi,Y.B., Yamaguchi,T.P., Taylor,P.M. and
            Storey,K.G.
  TITLE     Wnt regulates amino acid transporter Slc7a5 and so constrains the
            integrated stress response in mouse embryos
  JOURNAL   EMBO Rep 21 (1), e48469 (2020)
   PUBMED   31789450
REFERENCE   8  (bases 1 to 6030)
  AUTHORS   Levi,B.P., Yilmaz,O.H., Duester,G. and Morrison,S.J.
  TITLE     Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in
            the mouse hematopoietic and nervous systems
  JOURNAL   Blood 113 (8), 1670-1680 (2009)
   PUBMED   18971422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ130150.1, AK141954.1 and AC113014.9.
            
            On Jan 7, 2010 this sequence version replaced NM_153543.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034531.1, AK141954.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                CJ130150.1         1-38
            39-1451             AK141954.1         1-1413
            1452-1452           AC113014.9         155994-155994       c
            1453-5727           AK141954.1         1414-5688
            5728-6030           AC113014.9         134747-135049       c
FEATURES             Location/Qualifiers
     source          1..6030
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 41.27 cM"
     gene            1..6030
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /note="aldehyde dehydrogenase 1 family, member L2"
                     /db_xref="GeneID:216188"
                     /db_xref="MGI:MGI:2444680"
     exon            1..174
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2898
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /EC_number="1.5.1.6"
                     /note="aldehyde dehydrogenase 1L2; probable
                     10-formyltetrahydrofolate dehydrogenase ALDH1L2;
                     mitochondrial 10-FTHFDH; aldehyde dehydrogenase family 1
                     member L2, mitochondrial"
                     /codon_start=1
                     /product="mitochondrial 10-formyltetrahydrofolate
                     dehydrogenase"
                     /protein_id="NP_705771.2"
                     /db_xref="CCDS:CCDS24077.1"
                     /db_xref="GeneID:216188"
                     /db_xref="MGI:MGI:2444680"
                     /translation="MLWRGSQALRHFSTSRVYFKNKLKLALIGQSLFGQEVYSQLLKE
                     GHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKFPRWRLKGKTIKEVAEAYQSVGAEL
                     NVLPFCTQFIPMDVIDSPKHGSIIYHPSLLPRHRGASAINWTLIMGDKKAGFSVFWAD
                     DGLDTGPILLQRSCDVKPNDTVDSLYNRFLFPEGIKAMVEAVQLIADGKAPRTPQPEE
                     GATYEGIQKKENAEVSWDQPAEGLHNWIRGHDKVPGAWAEINGQMVTFYGSSLLTSSV
                     PSGEPLDIRGAKKPGLVTKNGLVLFGNDGKALMVRNLQFEDGKMIPASQYFSAGETSV
                     VELTAEELKVAETIKVIWARILSNTPVIEDSTDFFKSGASSMDVVRLVEEIRQSCGGL
                     QLQNEDVYMATKFGDFIQKVVRRLRGEDEEAEMVVDYVSKEVNGMTVKIPYQCFINGQ
                     FVDAEDGETYATVNPTDGTTICRVSYASLADVDRAVAAAKDAFENGEWGRMNARDRGR
                     LMYRLADLMEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTI
                     PINQARPNYNLTFTKKEPLGACAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTP
                     LTALKFAELTVKAGFPKGVINIIPGSGGVAGQRLSQHPDIRKLGFTGSTSVGKQIMKS
                     CAVSNLKKVSLELGGKSPLIIFSDCDLEKAVRMGMGAVFFNKGENCIAAGRLFVEEAI
                     HDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHRAHLEKLLQYCETGVQEGATLVYGGR
                     QVQRPGFFMEPTVFTGVEDHMYLAKEESFGPIMVISKFQNGDIDGVLQRANNTEYGLA
                     SGVFTRDINKAMYVSDKLEAGTVFINTYNKTDVAAPFGGMKQSGFGKDLGEEALNEYL
                     KIKTVTLEY"
     exon            175..319
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            320..554
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            555..720
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            721..822
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            823..912
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1047
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1173
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1265
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1413
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1533
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1661
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1812
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1883
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1989
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2077
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2171
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2271
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2370
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2536
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2537..2642
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2842
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     exon            2843..6030
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6008..6013
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /note="hexamer: AATAAA"
     polyA_site      6027
                     /gene="Aldh1l2"
                     /gene_synonym="D330038I09Rik; mtFDH"
                     /note="major polyA site"
ORIGIN      
        1 tgccattcga gggggcgggg ccgtgagcag agctggacag agctgaagcg aagcactcaa
       61 ccctctgcag ccctggtacc tacccactcc cgccgcccgc ctggcaatcg ctcgctcctc
      121 tacatcatgc tgtggcgggg tagccaggcg ctacggcact tctccaccag ccgggtttat
      181 ttcaaaaaca agctgaagtt ggcacttatt ggccagagcc tgttcggaca ggaagtctat
      241 agccagctcc tgaaagaggg ccaccgagta gtgggagtgt tcacagtgcc agacaaggat
      301 ggaaaggccg atccactggc tttggctgca gagaaagatg ggactcccgt gttcaagttc
      361 cctcgatgga gactcaaggg taaaaccatc aaggaggtag cagaagctta ccagtcggtg
      421 ggagccgagc tcaacgtgct ccccttctgc acacagttca tccccatgga tgtcattgac
      481 agcccaaagc atggctccat catctaccac ccctcactcc tacccaggca cagaggagct
      541 tctgccatca actggacact aatcatggga gataagaaag ctgggttttc tgttttctgg
      601 gcagatgatg gtttggatac aggacccatc cttcttcaga gatcgtgtga cgtcaagccc
      661 aatgacacag tggactcgct ttataaccgg ttcctttttc ctgaggggat caaggccatg
      721 gtagaagccg tccaactcat agctgatgga aaagcgcctc gcactcccca gccagaagag
      781 ggggcaacat atgaaggcat ccagaagaag gagaacgctg aggtttcttg ggaccagcct
      841 gctgaaggtt tgcataactg gattcgaggt catgacaagg tccctggagc ctgggcagag
      901 atcaatggac agatggtgac tttctacggc tcatcactgt tgactagttc tgtgccttct
      961 ggagaaccac tggacattag aggtgccaag aagcccggtc ttgtcaccaa aaatggcctt
     1021 gtcctttttg ggaatgatgg aaaagcactg atggtgagaa acctgcagtt tgaggacgga
     1081 aagatgattc cagcctccca gtacttttct gcgggtgaga catcagtggt agaacttacg
     1141 gccgaggagc tgaaggtggc agagaccatt aaggtcatct gggctcgaat tttaagcaac
     1201 acccctgtga ttgaggactc cacggacttc tttaaatctg gagcgagctc aatggatgtt
     1261 gtgaggctgg tggaagagat cagacagagt tgcggagggc ttcagctgca gaatgaagac
     1321 gtctacatgg ccaccaagtt tggagatttc atccaaaagg ttgtgcggag actgagagga
     1381 gaggacgaag aggcagagat ggtggtggat tacgtttcca aggaggtgaa cgggatgaca
     1441 gtgaaaatcc cctaccagtg tttcataaat ggacagtttg tggatgccga ggatggagag
     1501 acttacgcca ctgtcaaccc cacagatgga actacaatat gcagagtgtc ctacgcttct
     1561 ttagcggatg ttgacagagc agtagccgca gccaaggacg cctttgagaa cggcgaatgg
     1621 gggaggatga acgccagaga cagaggaaga ctcatgtaca gactcgctga cctaatggaa
     1681 gaaaaccaag aagagctggc caccatagaa gcgctggatt ccggggctgt ctacaccctg
     1741 gctctgaaga ctcacattgg aatgtctgtg cagacgttca gatacttcgc aggctggtgt
     1801 gacaaaattc agggttctac aattccaatc aaccaggccc ggccgaatta caacctgacc
     1861 ttcaccaaga aggagccact tggtgcctgt gccattatca ttccttggaa ctacccactg
     1921 atgatgctgg cctggaagag cgcagcgtgc ctggcggcag gcaacaccct ggtgctcaag
     1981 cctgcacagg tcacaccctt gacggctctg aagtttgcag agctgaccgt gaaagctggc
     2041 tttcccaagg gggtgattaa catcattcca ggctcagggg gtgtcgcagg acagaggctc
     2101 tctcagcacc ctgacatccg caagcttggc ttcactggat ccacctcagt gggcaaacag
     2161 atcatgaaaa gctgtgctgt gagcaacctg aagaaagttt cccttgagct tggtggcaaa
     2221 tccccactga taatattcag tgattgtgac cttgaaaagg ctgtacggat gggcatgggc
     2281 gcagtgtttt tcaataaagg agagaactgc attgcagctg ggcggctgtt tgtggaagag
     2341 gccatccacg acgaattcgt aaccagagtg gtggaagaga ttaaaaagat gaaaattgga
     2401 gatcccctgg acagatctac ggaccatggg ccccagaacc acagagcgca cttggaaaag
     2461 ctgctgcagt actgtgagac tggggtgcag gagggggcca cactggtgta tggaggaaga
     2521 caggtgcaga ggccaggctt cttcatggaa cccactgtgt tcacaggcgt ggaagatcac
     2581 atgtaccttg ccaaggagga atcctttggg cctatcatgg tcatttctaa attccaaaat
     2641 ggggacatcg atggggtgtt gcagagagca aataacactg aatatggctt ggcctcaggg
     2701 gtcttcacaa gagacatcaa caaagccatg tatgtgagtg acaagctaga ggcgggaacg
     2761 gttttcatta acacctacaa caagacagac gtggcagccc catttggtgg aatgaagcaa
     2821 tctggctttg gaaaagactt aggtgaggag gccctgaatg aatacctgaa aatcaaaaca
     2881 gtgacactcg agtattagag aaacctttga tagacagccc acttcaatgc ttcaggagct
     2941 gaagaccctg acggagatga ggaaggaggg gccgtctgga agccacaaag tagatactag
     3001 aaccaagaag agggttagac cacttgtatg agcatttacc tgactgaggg cctcaagaaa
     3061 ttccagtaca ctttttatca ccaaatggct taacctcttt ttaacaacat tgggtgctgt
     3121 atgtttttct aaagtatcaa agctccctcc caggaatgtc tatgctcttc taggtcaccc
     3181 gtcctgaaca tgctgacctc actcacaggc gcacttaaga gttctgggtc tcaatcccta
     3241 agacgtatat actgaacact gacaaccctt tcttagctgt gcattcaaac accagtttat
     3301 cctgcagaga atgtgacacc tgtcttcttc ctttctccta tgagaaggaa gattggtctt
     3361 tgtgcctttg actattttgt aacccactgt gacagacagg cagcttctga gcctttcttc
     3421 cacatttaca tacttgggac aaagtactgt aaagttcgga ggagaccctc ttattggcgt
     3481 catctttgat cctgtacttt aaatcctagt aaagtgcctg tgatggtcag tcgtggtcat
     3541 attataccag cttactgtgt gagttggggg aaaactaccc aacttgtctg agctctggcc
     3601 tcctcccgtg ttaaacagga gtagcagtgc cttccgcgga agcctcatta caaggactct
     3661 gtgcttcata attcatgtga atattccatt aaatgtgaat gttccttccc accactactc
     3721 tagaagcacg gccctaaatt gatgagattc gtgagcagct ccttagtcaa ggaagctaac
     3781 tgatggatga aatgaacttc ctatacttct caataatcaa ggctcagatt actcttccct
     3841 gcccattctt cttacacagt gcataacaca gcaggatgct gccaactgcc gtgcagtgaa
     3901 aaacgggcta ggcacagtgg ttcatgcctg caaccccaga ctcaggccag ggcagggcag
     3961 ggtccttatt gctgacctga ggtcaaccag gctatgcaga aagtgtgatg ccagcctggg
     4021 tcacactaag agaccttcta tcaaaaccag aaaaacaaaa ccaacattta aaatatgtca
     4081 gtggcaccag gaaaagggtc accttgtcct tggatgctta ctttgctgtc tccaggacat
     4141 gttgcttctc acgactgtat ctgctggctc tgctgctcac tggctgtgtg tggtcagggg
     4201 agtcagtgac ctcctgtctc caaagtctcc atttgttaca tggaagatga tggtaagctc
     4261 tgtgacttac ttggtgtagt ggttagaatg cgctcccagg gagctgcatc gtgcctcttc
     4321 aggatggcca ctgatcctgt gcggtgctca caaggtttcc cactgtgact caagtttgat
     4381 tatcaccact gacatgcaac cagacaaagg ggaattcctg agcacagaac tgatgtgcag
     4441 caatccatta atttcttgtg atgactaggg agatagtccc caaaataatg aagtggctgg
     4501 gctggaatgg ggtctagaga gtgtcagagg cagtactcat ggcataggac ctaggcactc
     4561 atgaccccaa ggtatggtga gttaaatgtt aaagtgttta tccaacaaca tggaaatgta
     4621 ctctgccata gtacatgagt caaagtaatg tgtggagggc cacagtgatg ctttgctctt
     4681 tcttgtgtgc tcagtctctc tgtgtctccc tccctccttc cctctctctc aactctcata
     4741 cctaatcaga gtattcatga cctccgagac atgctgcctt gacacgcact acagtctttc
     4801 tgcacttctg gctaggaagg ctcatcactc accccttcct aaactacaag tggacaagaa
     4861 tggtggtaag tccacaggtt agaatttgct agaaacacat tctgttttct tcagaaccac
     4921 ggatcaggaa tcaactgata cttaagccca agaactttac tgacacaaag ctgagaggaa
     4981 agagtttatt gacgctatat attccatccc aagtaaggcc atgtgccagg cactgagggc
     5041 ctcacacaga gcagcagata cacagcaatg tactgcaata cacaagctgg ttataatcac
     5101 cagagctcga tacaactaaa cacacaaata gaaacatgaa aactttgcat ataagatatt
     5161 taaaccctgt tttctgattc actttctaga gtgcagagaa aactactcaa aagacgtttt
     5221 aaaaaaagtg taactgccat acacaaatat gaagtttaca atttgataag ggtttgcatg
     5281 ttgtgagcat cggaagcact aattgaactc aacaggttac atacatacat aagtacatac
     5341 atgagtacac gcatacattg gccaataaag gaaaggctca gtgagaacca gccagtctcc
     5401 tctgaggatg acaggtacac aaagccctgg cgcacaccca ccaatgcccc tcccgtatct
     5461 gctggttgcc ttgatatttg gtatttggct tctatctctg tctctgcttc actgacttgt
     5521 gagagaccac tgtgtactta ggatatacac tgtttcaggt tctaagtgtc taccctgggc
     5581 tttctagact ttaaattgcc ttccttaagt tttgcttttt tgtttctgat ttcaggattt
     5641 atatggggcg ggggagtgtt attctcaatt atgttattaa acatgaaatt ctagtatgat
     5701 gcccttatga tttttgtcac aattagccac aatctttaat atgtatgtaa tttaccctca
     5761 tatatgattt gaggctaaat ctaacttttg tagaagtagc ctgtcctgac atcttgactc
     5821 attttacact gacttgagat atcagcttta tagtacgttt tcattctccc agacccatgc
     5881 acatgcagca ctaactgaac agaacaggtt acttacatac acacatatat aaacacatac
     5941 acaacatgtt tcaagttggg ttggatataa tcaagataaa ctgtataggt atatgaaatt
     6001 gtcaatgaat aaaaaatatt ctaaaaagtt
//
