LOCUS       NM_027406               3139 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 1 family, member L1 (Aldh1l1),
            transcript variant 1, mRNA.
ACCESSION   NM_027406 XM_915613 XM_923855
VERSION     NM_027406.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3139)
  AUTHORS   Zhang,Y., Li,D., Cai,Y., Zou,R., Zhang,Y., Deng,X., Wang,Y.,
            Tang,T., Ma,Y., Wu,F. and Xie,Y.
  TITLE     Astrocyte allocation during brain development is controlled by
            Tcf4-mediated fate restriction
  JOURNAL   EMBO J 43 (21), 5114-5140 (2024)
   PUBMED   39300210
REFERENCE   2  (bases 1 to 3139)
  AUTHORS   Fu,Y.W., Jin,S.Y., Li,J.T., Li,X.W., Gao,T.M. and Yang,J.M.
  TITLE     Mature astrocytes as source for astrocyte repopulation after
            deletion in the medial prefrontal cortex: Implications for
            depression
  JOURNAL   Glia 72 (9), 1646-1662 (2024)
   PUBMED   38801194
REFERENCE   3  (bases 1 to 3139)
  AUTHORS   Qiao,M., Huang,Q., Wang,X. and Han,J.
  TITLE     ZBTB21 suppresses CRE-mediated transcription to impair synaptic
            function in Down syndrome
  JOURNAL   Sci Adv 10 (27), eadm7373 (2024)
   PUBMED   38959316
REFERENCE   4  (bases 1 to 3139)
  AUTHORS   Zhou,X., Xiao,Q., Liu,Y., Chen,S., Xu,X., Zhang,Z., Hong,Y.,
            Shao,J., Chen,Y., Chen,Y., Wang,L., Yang,F. and Tu,J.
  TITLE     Astrocyte-mediated regulation of BLAWFS1 neurons alleviates
            risk-assessment deficits in DISC1-N mice
  JOURNAL   Neuron 112 (13), 2197-2217 (2024)
   PUBMED   38642554
REFERENCE   5  (bases 1 to 3139)
  AUTHORS   Liang,X.G., Hoang,K., Meyerink,B.L., Kc,P., Paraiso,K., Wang,L.,
            Jones,I.R., Zhang,Y., Katzman,S., Finn,T.S., Tsyporin,J., Qu,F.,
            Chen,Z., Visel,A., Kriegstein,A., Shen,Y., Pilaz,L.J. and Chen,B.
  TITLE     A conserved molecular logic for neurogenesis to gliogenesis switch
            in the cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 121 (20), e2321711121 (2024)
   PUBMED   38713624
REFERENCE   6  (bases 1 to 3139)
  AUTHORS   Anthony,T.E. and Heintz,N.
  TITLE     The folate metabolic enzyme ALDH1L1 is restricted to the midline of
            the early CNS, suggesting a role in human neural tube defects
  JOURNAL   J Comp Neurol 500 (2), 368-383 (2007)
   PUBMED   17111379
  REMARK    GeneRIF: These data provide the first evidence for localized
            differences in folate metabolism within the early neural tube and
            suggest that folate might modulate proliferation via effects on
            midline Aldh1l1(+) cells.
REFERENCE   7  (bases 1 to 3139)
  AUTHORS   Cook,R.J.
  TITLE     Disruption of histidine catabolism in NEUT2 mice
  JOURNAL   Arch Biochem Biophys 392 (2), 226-232 (2001)
   PUBMED   11488596
REFERENCE   8  (bases 1 to 3139)
  AUTHORS   Tang,J., Frankel,A., Cook,R.J., Kim,S., Paik,W.K., Williams,K.R.,
            Clarke,S. and Herschman,H.R.
  TITLE     PRMT1 is the predominant type I protein arginine methyltransferase
            in mammalian cells
  JOURNAL   J Biol Chem 275 (11), 7723-7730 (2000)
   PUBMED   10713084
REFERENCE   9  (bases 1 to 3139)
  AUTHORS   Champion,K.M., Cook,R.J., Tollaksen,S.L. and Giometti,C.S.
  TITLE     Identification of a heritable deficiency of the folate-dependent
            enzyme 10-formyltetrahydrofolate dehydrogenase in mice
  JOURNAL   Proc Natl Acad Sci U S A 91 (24), 11338-11342 (1994)
   PUBMED   7972060
REFERENCE   10 (bases 1 to 3139)
  AUTHORS   Giometti,C.S., Tollaksen,S.L. and Grahn,D.
  TITLE     Altered protein expression detected in the F1 offspring of male
            mice exposed to fission neutrons
  JOURNAL   Mutat Res 320 (1-2), 75-85 (1994)
   PUBMED   7506389
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122050.3.
            
            On Oct 4, 2017 this sequence version replaced NM_027406.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030730.1, SRR7652917.913868.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC122050.3         109008-109185
            179-328             AC122050.3         115417-115566
            329-563             AC122050.3         117457-117691
            564-729             AC122050.3         118041-118206
            730-831             AC122050.3         120834-120935
            832-921             AC122050.3         121580-121669
            922-1059            AC122050.3         122561-122698
            1060-1185           AC122050.3         124854-124979
            1186-1277           AC122050.3         127688-127779
            1278-1425           AC122050.3         128008-128155
            1426-1545           AC122050.3         128999-129118
            1546-1673           AC122050.3         130082-130209
            1674-1824           AC122050.3         134843-134993
            1825-1895           AC122050.3         136000-136070
            1896-2001           AC122050.3         138691-138796
            2002-2089           AC122050.3         141388-141475
            2090-2183           AC122050.3         147552-147645
            2184-2283           AC122050.3         148953-149052
            2284-2382           AC122050.3         150016-150114
            2383-2548           AC122050.3         152698-152863
            2549-2654           AC122050.3         155083-155188
            2655-2854           AC122050.3         156401-156600
            2855-3139           AC122050.3         157102-157386
FEATURES             Location/Qualifiers
     source          1..3139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 40.16 cM"
     gene            1..3139
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /note="aldehyde dehydrogenase 1 family, member L1"
                     /db_xref="GeneID:107747"
                     /db_xref="MGI:MGI:1340024"
     exon            1..178
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            179..328
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            329..563
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            564..729
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            730..831
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            832..921
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1059
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1185
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1277
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..1425
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1545
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1673
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1824
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1825..1895
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2001
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2002..2089
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2183
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2283
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2382
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2548
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2549..2654
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2655..2854
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     exon            2855..3139
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3110..3115
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /note="hexamer: AATAAA"
     polyA_site      3137
                     /gene="Aldh1l1"
                     /gene_synonym="1810048F20Rik; FDH; Fthfd; Neut2"
                     /note="major polyA site"
ORIGIN      
        1 ctgaccctaa ccctctctgc acaagacccg agcttgtgcg cccttctggg agcttgctgc
       61 ccctgtgctg actgctgaca gctgactgac gctcgcagct agcaggtact tctgggttgc
      121 tagcccagag ccctgggccg gtgaccctgt tttccctact tcccgtcttt gaccttgggt
      181 gccttccaac cttctgttgc catgaagatt gcagtaatcg ggcagagcct gtttggccag
      241 gaggtttact gccagctaag gaaggagggc catgaggtgg tgggtgtgtt caccatccca
      301 gacaaggatg ggaaagcaga tcccctgggc ctggaggccg agaaggatgg cgtgcccgtg
      361 tttaagttcc ctcggtggcg ggctcgagga caggctctgc ccgaggtcgt ggccaagtac
      421 caggctctgg gtgcagaact caacgtgctc cccttctgca gccagttcat acccatggag
      481 gtcatcaatg ccccccggca tggctccatc atctaccatc catctctgct gcccaggcac
      541 cgaggggcct cagccatcaa ctggaccctc attcatggag ataagaaagg aggcttcact
      601 atcttctggg ctgatgacgg tctggacact ggtgaccttc tgctgcagaa ggagtgtgac
      661 gtgcttccag atgacaccgt gagcacgctg tacaaccgtt tcctcttccc agagggcatc
      721 aaagggatgg ttcaggctgt gcgactgatt gcagagggca cagccccacg ccgtccccag
      781 cctgaggaag gagccaccta tgagggcatt cagaaaaagg agacagccat gatcaactgg
      841 gaccagccag cagaggccat tcacaactgg atccgtggga atgacaaggt gccaggtgcc
      901 tggacagagg cttgtgggca gaagctgacg tttttcaact cgacactcaa cacttcagga
      961 ctggtggctc agggagaagc tctacccatc ccaggagccc atcgtccagg cctagtcacc
     1021 aaagcgggac tcatcctctt tgggaatgat gatagaatgt tgctggtgaa gaatatccag
     1081 ctggaagatg gcaagatgat gccagcctcc cagttcttca aggggtctgc tagcagtgcc
     1141 ctggagctga ccgaggagga gctggccaca gcagaggccg tgcggagctc ttggatgcga
     1201 attctgccca atgtcccaga ggtagaagac tctacagatt tcttcaagtc aggagctgca
     1261 tccgtagatg ttgtgaggct ggtggaggag gtgaaggagc tgtgtgacgg gctggagtta
     1321 gaaaatgagg atgtttacat ggccaccacc ttcggggact tcatccagct cctagtgagg
     1381 aagttgagag gggaggacgg cgagagcgag tgtgtcatta actacgtgga aaaggcagtg
     1441 aagaaactga ctctccaaat gccctaccag ctcttcatag gcggcgagtt tgtggatgct
     1501 gagggcgcga agacctacag taccataaac ccaacggatg gaagtgtcat ctgccaggtg
     1561 tctctagctc aggtgagtga tgttgacaag gcggtggcag cagcgaagga ggcctttgag
     1621 aatggactgt ggggaaagat aaatgcgcgt gaccggggcc ggctcctgta caggttggcg
     1681 gacctcatgg agcagcacca ggaagagcta gccaccattg aggccctgga cgcaggtgcc
     1741 gtctacacgc tggccctgaa gacgcatgtg ggcatgtcca tccagacctt ccgatacttc
     1801 gctggctggt gtgataagat ccagggtgcc accatcccca tcaaccaggc tagacccaac
     1861 cgcaacctga ccttgaccaa gaaggaacct gttggggtct gtggtattgt catcccctgg
     1921 aactatccct taatgatgct gtcctggaag acagcagcct gcctggctgc cgggaacacc
     1981 gtggtgatca agcctgccca ggtgacccca ctcacagcct tgaagtttgc agagctgaca
     2041 ctgaaggctg gcattcccaa gggtgtggtc aacatcctcc caggatctgg ctcgctggtt
     2101 ggccagagac tctcagacca ccctgatgtg aggaaaatag ggttcacagg ctccacggag
     2161 gtgggaaaac acatcatgaa aagctgtgcc ctgagtaatg tgaagaaggt ctccctggag
     2221 ctgggtggaa agtcacccct tatcatcttt gctgactgtg acctcaacaa agctgtgcag
     2281 atgggcatga gctccgtttt cttcaacaaa ggggagaact gcattgcggc aggccggctc
     2341 tttgtggagg actccatcca tgaccagttt gtgcagaaag tggtggagga agtagggaag
     2401 atgaaaatcg gcaaccccct ggacagagat accaaccatg gcccgcagaa ccatgaggcc
     2461 cacctgagga agctggtgga gtattgccaa cgtggtgtga aggaaggggc cacactggtc
     2521 tgtggtggga accaagtccc aaggccaggc ttcttctttc agccaaccgt tttcacagac
     2581 gtggaggacc acatgtacat cgctaaggag gagtccttcg ggcccatcat gatcatctct
     2641 cggtttgctg atggggacgt ggatgcagtg ctatctcggg ccaatgctac agaatttggc
     2701 ctggcctctg gtgtcttcac tcgggatatc aacaaggccc tgtatgtcag tgacaaactg
     2761 caggcgggca ctgtgtttgt caacacatac aacaagaccg atgtggccgc accttttgga
     2821 ggattcaagc agtctggatt tggcaaagac ctgggagagg cggccctgaa tgagtacctg
     2881 cggatcaaga ctgtgacttt tgagtactga agccaagact gtgatacttc tcctgtaccc
     2941 tgttgacctc agggagtgct gaccctgtct ggtgacttag caccctcctg tccccagcac
     3001 tgctcctttc agctgctgga gctcttggcc tggacccctg ctggtgacag gacaccctct
     3061 gaacaatcag aagtggctcc aagtggagtg agcagtcatg tcccccatga ataaaaattg
     3121 tgagcagagg tcgcctaca
//
