LOCUS       NM_028270               2302 bp    mRNA    linear   ROD 02-JUL-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 1 family, member B1 (Aldh1b1),
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_028270
VERSION     NM_028270.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Sun,N., Cai,Q., Zhang,Y., Zhang,R.R., Jiang,J., Yang,H., Qin,C.F.
            and Cheng,G.
  TITLE     The aldehyde dehydrogenase ALDH1B1 exerts antiviral effects through
            the aggregation of the adaptor MAVS
  JOURNAL   Sci Signal 17 (818), eadf8016 (2024)
   PUBMED   38194477
  REMARK    GeneRIF: The aldehyde dehydrogenase ALDH1B1 exerts antiviral
            effects through the aggregation of the adaptor MAVS.
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Cerretelli,G., Zhou,Y., Muller,M.F., Adams,D.J. and Arends,M.J.
  TITLE     Acetaldehyde and defective mismatch repair increase colonic tumours
            in a Lynch syndrome model with Aldh1b1 inactivation
  JOURNAL   Dis Model Mech 16 (8) (2023)
   PUBMED   37395714
  REMARK    GeneRIF: Acetaldehyde and defective mismatch repair increase
            colonic tumours in a Lynch syndrome model with Aldh1b1
            inactivation.
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Mameishvili,E., Serafimidis,I., Iwaszkiewicz,S., Lesche,M.,
            Reinhardt,S., Bolicke,N., Buttner,M., Stellas,D.,
            Papadimitropoulou,A., Szabolcs,M., Anastassiadis,K., Dahl,A.,
            Theis,F., Efstratiadis,A. and Gavalas,A.
  TITLE     Aldh1b1 expression defines progenitor cells in the adult pancreas
            and is required for Kras-induced pancreatic cancer
  JOURNAL   Proc Natl Acad Sci U S A 116 (41), 20679-20688 (2019)
   PUBMED   31548432
  REMARK    GeneRIF: Overexpression of Aldh1b1 is associated with pancreatic
            cancer development.
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Oberbeck,N., Langevin,F., King,G., de Wind,N., Crossan,G.P. and
            Patel,K.J.
  TITLE     Maternal aldehyde elimination during pregnancy preserves the fetal
            genome
  JOURNAL   Mol Cell 55 (6), 807-817 (2014)
   PUBMED   25155611
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Ioannou,M., Serafimidis,I., Arnes,L., Sussel,L., Singh,S.,
            Vasiliou,V. and Gavalas,A.
  TITLE     ALDH1B1 is a potential stem/progenitor marker for multiple pancreas
            progenitor pools
  JOURNAL   Dev Biol 374 (1), 153-163 (2013)
   PUBMED   23142317
  REMARK    GeneRIF: ALDH1B1 is a potential stem/progenitor marker for multiple
            pancreas progenitor pools
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Singh,R., Hoogaars,W.M., Barnett,P., Grieskamp,T., Rana,M.S.,
            Buermans,H., Farin,H.F., Petry,M., Heallen,T., Martin,J.F.,
            Moorman,A.F., 't Hoen,P.A., Kispert,A. and Christoffels,V.M.
  TITLE     Tbx2 and Tbx3 induce atrioventricular myocardial development and
            endocardial cushion formation
  JOURNAL   Cell Mol Life Sci 69 (8), 1377-1389 (2012)
   PUBMED   22130515
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Levi,B.P., Yilmaz,O.H., Duester,G. and Morrison,S.J.
  TITLE     Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in
            the mouse hematopoietic and nervous systems
  JOURNAL   Blood 113 (8), 1670-1680 (2009)
   PUBMED   18971422
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ158368.1, AK153416.1 and AW555370.1.
            
            On Apr 11, 2007 this sequence version replaced NM_028270.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088396.1, BC086768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                CJ158368.1         2-100
            100-2295            AK153416.1         2-2197
            2296-2302           AW555370.1         1-7                 c
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 24.35 cM"
     gene            1..2302
                     /gene="Aldh1b1"
                     /gene_synonym="2700007F14Rik"
                     /note="aldehyde dehydrogenase 1 family, member B1"
                     /db_xref="GeneID:72535"
                     /db_xref="MGI:MGI:1919785"
     exon            1..148
                     /gene="Aldh1b1"
                     /gene_synonym="2700007F14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            149..2302
                     /gene="Aldh1b1"
                     /gene_synonym="2700007F14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2268..2273
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1b1"
                     /gene_synonym="2700007F14Rik"
                     /note="hexamer: ATTAAA"
     regulatory      2273..2278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1b1"
                     /gene_synonym="2700007F14Rik"
                     /note="hexamer: AATAAG"
     polyA_site      2294
                     /gene="Aldh1b1"
                     /gene_synonym="2700007F14Rik"
     polyA_site      2298
                     /gene="Aldh1b1"
                     /gene_synonym="2700007F14Rik"
                     /note="major polyA site"
ORIGIN      
        1 aggcggagct tagctggtga cggaaccaca ttggctggct agcggctgag cgaggcgggt
       61 ccgcacggct gctgaactga ccggagaacg ctgatactag aatttgagcc tgagcgcgat
      121 tcggagcctg agccccagac caccgcaggt cctcaggatg ctgactgccc gactcttgct
      181 gccccggctc ctctgcctcc agggcaggac tacctcttac tctacagcag ctgctctccc
      241 gaacccaatc ccaaacccag agatttgcta caacaagctg ttcatcaaca acgagtggca
      301 tgatgcggtc agcaaaaaga ccttccccac agtgaacccc actacaggtg aggtcattgg
      361 gcatgtggcc gaaggtgacc gggcagatgt ggatctggct gtaaaagcag cccgagaagc
      421 cttccgcctg gggtccccat ggcgcaggat ggatgcctca gagcggggcc ggctgctgaa
      481 ccgcctagct gatcttgtgg aacgagatcg agtgtacttg gcctcactgg agacgctaga
      541 taacgggaaa cctttccagg agtcttatgt cttggatctg gatgaagtca tcaaggtgta
      601 ccgttacttc gctggctggg ctgacaagtg gcatggtaag accatcccta tggatggtga
      661 gcatttctgc ttcacccgac atgagccagt gggtgtctgt ggccagataa tcccttggaa
      721 cttcccactg gtcatgcagg gctggaagct ggccccggca ctcgccacgg gcaacactgt
      781 ggtcatgaag gtggcagagc agaccccact ctctgctctg tacttggcct ccctcatcaa
      841 agaggcgggg tttcccccag gagtggtgaa catcatcact ggctacggcc ccacggcggg
      901 agctgccatc gctcagcaca tggatgtgga taaagtcgcc ttcacgggct ccactgaggt
      961 aggccacctg attcagaagg cagctggcga gtctaacctc aagagagtca ccctggagct
     1021 gggtgggaag agccccagca ttgtgctggc agacgctgac atggagcatg ccgtagatca
     1081 gtgtcacgaa gcccttttct tcaacatggg ccagtgctgc tgtgcaggct cccggacatt
     1141 cgtggaagag tccatctacc gtgagtttct cgagagaact gtggagaagg ccaagcagag
     1201 gaaagtgggg aacccctttg agttggacac ccagcaggga cctcaggtgg acaaggagca
     1261 gtttgaacga atcctgggct acatccggct gggacagaag gaaggggcaa agcttctctg
     1321 tggcggggag cgtttggggg agcgcggctt cttcatcaaa cccacagtct tcggggacgt
     1381 tcaggatggc atgaggatcg ccaaggagga gatctttggg cccgtgcagc ctctgttcaa
     1441 gttcaagaag atcgaggaag taatccagag agccaacaac accaggtatg gcctggctgc
     1501 ggctgtgttc acccgagacc tggacaaggc catctacttc acgcaggccc tgcaagctgg
     1561 gacggtgtgg gtgaacacct ataacattgt cacctgccac acgccattcg gaggctttaa
     1621 ggaatctggc aatggcaggg agctggggga ggacgggctc agagcctaca cggaggtgaa
     1681 gactgtcacc atcaaggttc ccgagaagaa ttcctgagat tggccatctt ggaggcccag
     1741 ccctgtcctg cagctccgtg acatctagcc agtggagggc aaaatctgat ttcagcctga
     1801 gttcccagtg aagtgttaca agaagtgtca accaataaag tagtccagcc agagcttttc
     1861 tacttaaagc agagacggtg gctgggccca gagtgcagcc catttcatcc ctcggtccca
     1921 cctctctgat gagttatagc caagaagcct taggagtctc cataaggcat attcaaaacc
     1981 actgactggc cataaaaagg agtgatgggc tgatcccggg gccacaggga tcctcaaaaa
     2041 cagaacgatc agtgaaggac gccggcccca catcgatcag tgtttggctg ggacccgggg
     2101 gaggggaatg gggaaggacc actcgtggat gtggggctcc tcttggggga ggttttgaaa
     2161 atgttgtgga attgggcaat ggacacagtt ggacaacttt gcagtcatac tgatttacta
     2221 tcaaattatg cacttaatta aggtatggga attaatttca cttgaaaatt aaaataagct
     2281 cagtgtccta tttgcaaatc tg
//
