LOCUS       NM_011921               2059 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus aldehyde dehydrogenase family 1, subfamily A7
            (Aldh1a7), mRNA.
ACCESSION   NM_011921
VERSION     NM_011921.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2059)
  AUTHORS   Jang,C., Hui,S., Lu,W., Cowan,A.J., Morscher,R.J., Lee,G., Liu,W.,
            Tesz,G.J., Birnbaum,M.J. and Rabinowitz,J.D.
  TITLE     The Small Intestine Converts Dietary Fructose into Glucose and
            Organic Acids
  JOURNAL   Cell Metab 27 (2), 351-361 (2018)
   PUBMED   29414685
REFERENCE   2  (bases 1 to 2059)
  AUTHORS   Bourke,L.M., Del Monte-Nieto,G., Outhwaite,J.E., Bharti,V.,
            Pollock,P.M., Simmons,D.G., Adam,A., Hur,S.S., Maghzal,G.J.,
            Whitelaw,E., Stocker,R., Suter,C.M., Harvey,R.P. and Harten,S.K.
  TITLE     Loss of Rearranged L-Myc Fusion (RLF) results in defects in heart
            development in the mouse
  JOURNAL   Differentiation 94, 8-20 (2017)
   PUBMED   27930960
REFERENCE   3  (bases 1 to 2059)
  AUTHORS   Harten,S.K., Oey,H., Bourke,L.M., Bharti,V., Isbel,L., Daxinger,L.,
            Faou,P., Robertson,N., Matthews,J.M. and Whitelaw,E.
  TITLE     The recently identified modifier of murine metastable epialleles,
            Rearranged L-Myc Fusion, is involved in maintaining epigenetic
            marks at CpG island shores and enhancers
  JOURNAL   BMC Biol 13, 21 (2015)
   PUBMED   25857663
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2059)
  AUTHORS   Yoval-Sanchez,B., Pardo,J.P. and Rodriguez-Zavala,J.S.
  TITLE     New insights into the half-of-the-sites reactivity of human
            aldehyde dehydrogenase 1A1
  JOURNAL   Proteins 81 (8), 1330-1339 (2013)
   PUBMED   23444097
REFERENCE   5  (bases 1 to 2059)
  AUTHORS   Ioannou,M., Serafimidis,I., Arnes,L., Sussel,L., Singh,S.,
            Vasiliou,V. and Gavalas,A.
  TITLE     ALDH1B1 is a potential stem/progenitor marker for multiple pancreas
            progenitor pools
  JOURNAL   Dev Biol 374 (1), 153-163 (2013)
   PUBMED   23142317
REFERENCE   6  (bases 1 to 2059)
  AUTHORS   Maly,I.P., Crotet,V. and Toranelli,M.
  TITLE     The so-called 'testis-specific aldehyde dehydrogenase' corresponds
            to type 2 retinaldehyde dehydrogenase in the mouse
  JOURNAL   Histochem Cell Biol 119 (2), 169-174 (2003)
   PUBMED   12610736
REFERENCE   7  (bases 1 to 2059)
  AUTHORS   Ogino,Y., Suzuki,K., Haraguchi,R., Satoh,Y., Dolle,P. and Yamada,G.
  TITLE     External genitalia formation: role of fibroblast growth factor,
            retinoic acid signaling, and distal urethral epithelium
  JOURNAL   Ann N Y Acad Sci 948, 13-31 (2001)
   PUBMED   11795391
REFERENCE   8  (bases 1 to 2059)
  AUTHORS   Swindell,E.C., Thaller,C., Sockanathan,S., Petkovich,M.,
            Jessell,T.M. and Eichele,G.
  TITLE     Complementary domains of retinoic acid production and degradation
            in the early chick embryo
  JOURNAL   Dev Biol 216 (1), 282-296 (1999)
   PUBMED   10588879
REFERENCE   9  (bases 1 to 2059)
  AUTHORS   Hsu,L.C., Chang,W.C., Hoffmann,I. and Duester,G.
  TITLE     Molecular analysis of two closely related mouse aldehyde
            dehydrogenase genes: identification of a role for Aldh1, but not
            Aldh-pb, in the biosynthesis of retinoic acid
  JOURNAL   Biochem J 339 (Pt 2) (Pt 2), 387-395 (1999)
   PUBMED   10191271
REFERENCE   10 (bases 1 to 2059)
  AUTHORS   Hue,L. and Hers,H.G.
  TITLE     The conversion of (4- 3 H)fructose and of (4- 3 H)glucose to liver
            glycogen in the mouse. An investigation of the glyceraldehyde
            crossroads
  JOURNAL   Eur J Biochem 29 (2), 268-275 (1972)
   PUBMED   4343087
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162458.4.
            
            On Mar 31, 2023 this sequence version replaced NM_011921.2.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032880.1, U96401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC162458.4         84981-85090         c
            111-215             AC162458.4         84492-84596         c
            216-356             AC162458.4         79812-79952         c
            357-486             AC162458.4         76720-76849         c
            487-548             AC162458.4         75230-75291         c
            549-677             AC162458.4         73455-73583         c
            678-791             AC162458.4         72215-72328         c
            792-894             AC162458.4         66932-67034         c
            895-1079            AC162458.4         65684-65868         c
            1080-1244           AC162458.4         59745-59909         c
            1245-1402           AC162458.4         57432-57589         c
            1403-1477           AC162458.4         53870-53944         c
            1478-2059           AC162458.4         50488-51069         c
FEATURES             Location/Qualifiers
     source          1..2059
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.95 cM"
     gene            1..2059
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /note="aldehyde dehydrogenase family 1, subfamily A7"
                     /db_xref="GeneID:26358"
                     /db_xref="MGI:MGI:1347050"
     exon            1..110
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1550
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /EC_number="1.2.1.3"
                     /note="aldehyde dehydrogenase family 1, subfamily A4;
                     ALHDII; ALDH-E1; ALDH class 1; aldehyde dehydrogenase
                     family 1 member A7; aldehyde dehydrogenase
                     phenobarbital-inducible; Aldehyde dehydrogenase 1
                     (phenobarbitol inducible)"
                     /codon_start=1
                     /product="aldehyde dehydrogenase, cytosolic 1"
                     /protein_id="NP_036051.1"
                     /db_xref="CCDS:CCDS29696.1"
                     /db_xref="GeneID:26358"
                     /db_xref="MGI:MGI:1347050"
                     /translation="MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSSKKFPVLNPA
                     TEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLL
                     LATMESMNAGKVFAHAYLLDVEISIKALQYFAGWADKIHGQTIPSDGNIFTYTRREPI
                     GVCGQIIPWNGPLIIFTWKLGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGV
                     VNIVPGYGPTAGGAISSHMDIDKVSFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPC
                     IVFADADLDSAVEFAHQGVFFHQGQICVAASRLFVEESIYDEFVRRSVERAKKYILGN
                     PLNSGINQGPQIDKEQHNKILGLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTD
                     EMRIAKEEIFGPVQQIMKFKSMDDVIKRANNTTYGLAAGVFTKDLDKAITVSSALQAG
                     MVWVNCYLAVPVQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMQISQKNS"
     exon            111..215
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            216..356
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            357..486
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            487..548
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            549..677
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            678..791
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            792..894
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1079
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1244
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1402
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1477
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     exon            1478..2059
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2039..2044
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /note="hexamer: AATAAA"
     polyA_site      2059
                     /gene="Aldh1a7"
                     /gene_synonym="Ahd2-like; Aldh-pb; Aldh1a4; Aldhpb"
                     /note="major polyA site"
ORIGIN      
        1 attttgctga gcctgtcact tgtgttccag gagccaaacc agcaatgtct tcacctgcac
       61 aacctgcagt ccctgccccg ctggccaact tgaagattca acataccaag atctttataa
      121 acaatgaatg gcatgattcg gtgagcagca agaaatttcc tgtccttaac cctgcaactg
      181 aggaggtcat ctgccacgtg gaagaagggg acaaggctga tgttgacaaa gctgtgaagg
      241 ccgcaagaca ggctttccag attggctccc catggcgcac catggatgct tcagagaggg
      301 gccgcctgct gaacaagctg gctgacttaa tggagagaga tcgtctgctg ctggctacaa
      361 tggaatcgat gaatgctggg aaagtctttg ctcatgcata cctgttggat gtagagatca
      421 gcataaaagc attacagtac ttcgcaggct gggctgacaa gatccatggc caaacaatac
      481 ccagtgatgg aaacatattc acttatacaa ggcgtgaacc tattggggtg tgtggccaaa
      541 tcatcccttg gaatggtcca ttgattatat tcacttggaa gttaggccct gcccttagct
      601 gtgggaacac tgtggttgtc aagccagcag agcaaactcc tctcacagct cttcacatgg
      661 catctttaat aaaagaggca gggtttcctc ctggcgtggt gaacattgtc cctggttatg
      721 ggccaactgc agggggagcc atctcctccc acatggacat cgacaaagtg tccttcacag
      781 gatcaacaga ggttggcaaa ttaatcaagg aagctgcagg gaaaagcaat ctgaagagag
      841 tcaccctgga gctgggggga aagagccctt gcattgtgtt tgcagatgcc gacttggaca
      901 gtgctgttga gtttgcacac caaggagtgt tcttccacca gggtcagatt tgtgttgcag
      961 cgtccaggct ttttgttgag gaatcaattt acgatgagtt tgtgaggagg agtgtggagc
     1021 gggctaagaa atacattcta ggaaatcctc tgaactccgg aataaatcaa ggtcctcaga
     1081 ttgacaagga acaacacaat aaaatacttg gtctcattga gagtgggaag aaagaaggag
     1141 ccaagctgga gtgtggtgga ggtcgctggg ggaacaaagg cttctttgtc caacccacag
     1201 tcttctccaa tgtgactgat gagatgcgca ttgccaaaga ggagatattt ggaccagtgc
     1261 aacaaatcat gaagtttaaa tctatggatg atgtgatcaa gagagcaaac aacactacct
     1321 atggtttagc agcaggagtc ttcactaaag acctggataa ggccatcact gtgtcatctg
     1381 ctctgcaggc tgggatggtg tgggtgaact gctatttggc tgtccctgtc caatgcccat
     1441 ttggtggatt caagatgtct ggaaatgggc gagaactggg cgaacatggt ctttatgaat
     1501 acactgagct caagacagtt gcaatgcaaa tatctcagaa gaactcataa agaagccagc
     1561 agagtgaaga gaaactctca gcagtggctg tacatctcat acagtcacca gaaagtggtg
     1621 ttttgctata agttcttctt ctgttgagtt ctttaaacgt aaggaattca tcagtattac
     1681 tgttaatcat agaaaagacg tagcttaatc tggcagaatc agagtcttct aatccgtgaa
     1741 cccaattcat atcccagaac aaaaggatac attaaggtgc aagctctctg taactctgtc
     1801 atgataaggt gctttccatt gtagctactt gtctagagta cacacttggc aaggaggacc
     1861 agtcctgatt taagctctgt cccacactga ttccttgaac tacgtaccat gcatgataac
     1921 tgaaaagtta gctgctctat tcctcggggt tattcctctg agtgttgtga aatattttcc
     1981 agaatgccat gactgcttgt caaatgaaat gcctccctgt aattcgaatg caaagcttaa
     2041 taaaggcaat ctcgcatga
//
