LOCUS       NM_053080               3423 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus aldehyde dehydrogenase family 1, subfamily A3
            (Aldh1a3), mRNA.
ACCESSION   NM_053080
VERSION     NM_053080.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3423)
  AUTHORS   Shigesawa,I., Nakamura,A., Yamauchi,Y., Kawata,S., Miyazaki,A.,
            Nomoto,H., Kameda,H., Terauchi,Y. and Atsumi,T.
  TITLE     Effects of glucokinase haploinsufficiency on the pancreatic
            beta-cell mass and function of long-term high-fat, high-sucrose
            diet-fed mice
  JOURNAL   J Diabetes Investig 15 (12), 1732-1742 (2024)
   PUBMED   39305123
REFERENCE   2  (bases 1 to 3423)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3423)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3423)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   5  (bases 1 to 3423)
  AUTHORS   Queen,R., Crosier,M., Eley,L., Kerwin,J., Turner,J.E., Yu,J.,
            Alqahtani,A., Dhanaseelan,T., Overman,L., Soetjoadi,H., Baldock,R.,
            Coxhead,J., Boczonadi,V., Laude,A., Cockell,S.J., Kane,M.A.,
            Lisgo,S. and Henderson,D.J.
  TITLE     Spatial transcriptomics reveals novel genes during the remodelling
            of the embryonic human arterial valves
  JOURNAL   PLoS Genet 19 (11), e1010777 (2023)
   PUBMED   38011284
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3423)
  AUTHORS   Toresson,H. and Campbell,K.
  TITLE     A role for Gsh1 in the developing striatum and olfactory bulb of
            Gsh2 mutant mice
  JOURNAL   Development 128 (23), 4769-4780 (2001)
   PUBMED   11731457
REFERENCE   7  (bases 1 to 3423)
  AUTHORS   Grun,F., Hirose,Y., Kawauchi,S., Ogura,T. and Umesono,K.
  TITLE     Aldehyde dehydrogenase 6, a cytosolic retinaldehyde dehydrogenase
            prominently expressed in sensory neuroepithelia during development
  JOURNAL   J Biol Chem 275 (52), 41210-41218 (2000)
   PUBMED   11013254
REFERENCE   8  (bases 1 to 3423)
  AUTHORS   Suzuki,R., Shintani,T., Sakuta,H., Kato,A., Ohkawara,T., Osumi,N.
            and Noda,M.
  TITLE     Identification of RALDH-3, a novel retinaldehyde dehydrogenase,
            expressed in the ventral region of the retina
  JOURNAL   Mech Dev 98 (1-2), 37-50 (2000)
   PUBMED   11044606
REFERENCE   9  (bases 1 to 3423)
  AUTHORS   Mic,F.A., Molotkov,A., Fan,X., Cuenca,A.E. and Duester,G.
  TITLE     RALDH3, a retinaldehyde dehydrogenase that generates retinoic acid,
            is expressed in the ventral retina, otic vesicle and olfactory pit
            during mouse development
  JOURNAL   Mech Dev 97 (1-2), 227-230 (2000)
   PUBMED   11025231
REFERENCE   10 (bases 1 to 3423)
  AUTHORS   Li,H., Wagner,E., McCaffery,P., Smith,D., Andreadis,A. and
            Drager,U.C.
  TITLE     A retinoic acid synthesizing enzyme in ventral retina and
            telencephalon of the embryonic mouse
  JOURNAL   Mech Dev 95 (1-2), 283-289 (2000)
   PUBMED   10906479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK147006.1 and BC038646.1.
            
            On Mar 21, 2008 this sequence version replaced NM_053080.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058277.1, AK147006.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3387              AK147006.1         2-3388
            3388-3423           BC038646.1         2209-2244
FEATURES             Location/Qualifiers
     source          1..3423
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 35.73 cM"
     gene            1..3423
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /note="aldehyde dehydrogenase family 1, subfamily A3"
                     /db_xref="GeneID:56847"
                     /db_xref="MGI:MGI:1861722"
     exon            1..164
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1604
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /EC_number="1.2.1.36"
                     /note="aldehyde dehydrogenase-6; aldehyde dehydrogenase
                     family 1 member A3; RALDH-3"
                     /codon_start=1
                     /product="retinaldehyde dehydrogenase 3"
                     /protein_id="NP_444310.3"
                     /db_xref="CCDS:CCDS21345.1"
                     /db_xref="GeneID:56847"
                     /db_xref="MGI:MGI:1861722"
                     /translation="MATTNGAVENGQPDGKPPALPRPIRNLEVKFTKIFINNDWHESK
                     SGRKFATYNPSTLEKICEVEEGDKPDVDKAVEAAQAAFQRGSPWRRLDALSRGQLLHQ
                     LADLVERDRAILATLETMDTGKPFLHAFFVDLEGCIKTFRYFAGWADKIQGRTIPTDD
                     NVVCFTRHEPIGVCGAITPWNFPLLMLAWKLAPALCCGNTVVLKPAEQTPLTALYLAS
                     LIKEVGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVREAASRSNLKR
                     VTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYGEFVRRS
                     VEFAKKRPVGDPFDAKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDRGLF
                     IKPTVFSDVTDNMRIAKEEIFGPVQPILKFKNLEEVIKRANSTDYGLTAAVFTKNLDK
                     ALKLAAALESGTVWINCYNAFYAQAPFGGFKMSGNGRELGEYALAEYTEVKTVTIKLE
                     EKNP"
     exon            165..269
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            270..410
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            411..540
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            541..602
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            603..731
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            732..845
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..948
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1133
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1298
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1456
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1531
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     exon            1532..3401
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3380..3385
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /note="hexamer: AATAAA"
     polyA_site      3401
                     /gene="Aldh1a3"
                     /gene_synonym="ALDH6; RALDH3; V1"
                     /note="major polyA site"
ORIGIN      
        1 aggctgcgca ccgcccaggc caagctggtg cgtcggggac acggaccgga gagtgcgaac
       61 cagttatggc taccaccaac ggggctgtgg aaaacggaca gccggatggg aaaccgcctg
      121 ccttgccgcg ccccatccgc aacttggagg tcaagttcac caagatattt atcaacaacg
      181 actggcacga atccaagagt ggaagaaagt ttgccacata taacccttca acactagaga
      241 aaatatgtga ggtggaagaa ggagataagc ccgatgtgga caaggctgtg gaggccgctc
      301 aagctgcctt ccagcgggga tccccgtggc gccggctgga tgcactgagc agaggccagt
      361 tgctgcatca gctggctgac cttgtagaaa gggaccgagc gatcctggct actctggaga
      421 ccatggacac cggcaagcca ttccttcatg cctttttcgt cgacctggaa ggctgtatta
      481 agaccttcag atattttgcc gggtgggcag acaaaatcca gggcaggacc atccccacag
      541 atgacaacgt tgtgtgcttc accaggcatg agcccatcgg ggtgtgtggg gccattacac
      601 catggaactt ccccctgctg atgctggcct ggaaactggc tcctgccctg tgctgtggga
      661 acaccgtggt cctgaagcca gctgagcaga cccctctcac ggctctgtac ctagcctctc
      721 tcatcaaaga ggtcgggttc cctccgggtg tggtgaacat tgtaccaggc tttgggccca
      781 ctgtgggagc agcaatttcc tcccatccgc agatcaacaa gatagccttc accggctcca
      841 cagaggttgg aaagctggtc agagaagccg cctcccggag caacctgaag agggtcacac
      901 tggagctagg aggcaagaac ccgtgcatcg tgtgtgcaga tgctgacttg gacttggccg
      961 tcgagtgtgc tcaccaggga gtgttcttca accaaggcca gtgctgtaca gcggcctcca
     1021 gggtgttcgt ggaagagcag gtctacgggg agtttgtgag gaggagtgtg gagttcgcca
     1081 agaagaggcc agttggagac cccttcgatg ccaaaacgga gcaggggcct cagatcgacc
     1141 aaaagcagtt tgacaaaatc ctcgagctga ttgagagtgg gaagaaggaa ggggccaagc
     1201 tagaatgtgg ggggtcagcc atggaggaca gagggctgtt catcaaaccc acggtcttct
     1261 cagatgttac ggacaacatg aggattgcca aagaggagat tttcggacca gtgcagccga
     1321 tcctgaagtt caaaaacctg gaggaggtga tcaagagagc gaatagcacc gactatggac
     1381 tcacagcagc agtgttcacc aaaaacctgg acaaagcact gaagctggct gctgcgctcg
     1441 agtcggggac agtctggatc aactgctaca atgcatttta tgcacaggct ccatttggtg
     1501 gcttcaaaat gtctgggaat ggcagagaac taggagaata tgctctggct gaatatacag
     1561 aagtgaaaac tgtcaccatc aaactcgagg agaagaaccc ctgaggaaca ggccggcttc
     1621 ttcctcaaaa gctggacagc tgaccgtggc aactccagcc tgccacgagc agaaagcagg
     1681 atgacagtgc tcagcttccc aggaccctct cttctggaca cccgatctac tggagttcaa
     1741 tggttttgac tttcctctca ctcacacgca tgctttatgg accaaactgt gggcagacgg
     1801 ataggatatg ggaaactgga gggctgcctg gagaggaact cttacccagc tctgactttg
     1861 cctttagact aagtgcagga caccgcaaag acagccagtg ctcttaacta tgagacagta
     1921 gtcactggag tgtcccacgg ttaatttaaa tgctttttga ccccaggagg aatatagaat
     1981 gagctcacta aatgttctgt gagcaaatct ggtctttggg gtctctttgg ggtcatctgt
     2041 gcacacaagt ccctccttgt tctgaggggg aaagtgggat tattcacaac aaaggattag
     2101 tgttgaggtg aagggacaat ttcagggacc cagtgtgggg agcttagcga agctgccatg
     2161 gaaaggcccc agaagccttt ggtgtgcagg ggtgcgggtc ctaagggctg catatgggca
     2221 ctgaccatgg ggttcacctt gaaaacaatc ctgactttgg aatgaccaaa tcaacatccc
     2281 aaagagtttg ccctatagtt atgagatggt cttccacgac ataggcccat ctaaggcaga
     2341 caacgtgtca cctttgccac tgagggctca tgttagaact accatggcag agcaaaccct
     2401 gggcaatgga gcctcacatt tgaccctcag agccaccatt cactttttca aatacccgtt
     2461 tctaccacat tcaataacgg gcacgcccac ttcctttttc tcttctccag ctccattacc
     2521 tgttttagat tagtgaagtt catgccagca agaaatagct gccactgcat agttctgtag
     2581 tcttcaaaat cccgtctggg ctttcattta tgattggcta acaagtaaca cctggatccc
     2641 acaagggacc accaagtgac ctgggtacct cagtcatgtt aaaacatgtt ttcctttcct
     2701 ctttgatgta tgcatatgat gcgcaatttc atgtttgaac ttggaaaact aaaacgatcc
     2761 ccataaagct ttaagggtag aaccacactc tttgggttga ctgctgtttg ggtaactttc
     2821 actgtcagta aacatgcacc tgcctaatta gatgtgaggc ttacatttga ggataaagtt
     2881 gggctgagca agcgtgagaa ttaagtcttc tatctgaacc agtgtgaggt agagaatgtg
     2941 gggcgtgaat cggggctctc agccctgtcg gagacaagca atattccatc caccttcttt
     3001 cctccctcaa cacttatact accataacta gttaagtcag gatttggctt cggacactga
     3061 attttgggta tctcaataac tctaggcact acccttcacc atagtacact agagggttgc
     3121 tattcttcca ttgtacaata atgcctttaa tatgaaatgt tacattattt ataattggta
     3181 tcattaatgt atctttttat agctgtaagt acacggaggt agtgtattta accttctgta
     3241 atatactgta cttagaaatg aaaatctata taatgttaga tctcacttct tttaaggttt
     3301 acccctgtgg tatggttttt aaatcaattg gattggggat tttgatctta agttcagatt
     3361 gtgtgttcag caatgaaaaa ataaagttgg acacagagaa aaaaaaaaaa aaaaaaaaaa
     3421 aaa
//
