LOCUS       NM_009022               2264 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus aldehyde dehydrogenase family 1, subfamily A2
            (Aldh1a2), mRNA.
ACCESSION   NM_009022
VERSION     NM_009022.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2264)
  AUTHORS   Matsuoka,R., Kitajima,K., Nii,T., Zou,Z., Tanaka,K., Joo,K.,
            Ohkawa,Y., Ohga,S. and Meno,C.
  TITLE     Hyperglycaemia induces diet-dependent defects of the left-right
            axis by lowering intracellular pH
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1871 (1), 167550 (2025)
   PUBMED   39442590
REFERENCE   2  (bases 1 to 2264)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   3  (bases 1 to 2264)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   4  (bases 1 to 2264)
  AUTHORS   Longtine,C., Eliason,C.M., Mishkind,D., Lee,C., Chiappone,M.,
            Goller,F., Love,J., Kingsley,E.P., Clarke,J.A. and Tabin,C.J.
  TITLE     Homology and the evolution of vocal folds in the novel avian voice
            box
  JOURNAL   Curr Biol 34 (3), 461-472 (2024)
   PUBMED   38183987
REFERENCE   5  (bases 1 to 2264)
  AUTHORS   Langner,E., Cheng,T., Kefaloyianni,E., Gluck,C., Wang,B. and
            Mahjoub,M.R.
  TITLE     Cep120 is essential for kidney stromal progenitor cell growth and
            differentiation
  JOURNAL   EMBO Rep 25 (1), 428-454 (2024)
   PUBMED   38177914
REFERENCE   6  (bases 1 to 2264)
  AUTHORS   Moss,J.B., Xavier-Neto,J., Shapiro,M.D., Nayeem,S.M., McCaffery,P.,
            Drager,U.C. and Rosenthal,N.
  TITLE     Dynamic patterns of retinoic acid synthesis and response in the
            developing mammalian heart
  JOURNAL   Dev Biol 199 (1), 55-71 (1998)
   PUBMED   9676192
REFERENCE   7  (bases 1 to 2264)
  AUTHORS   Niederreither,K., McCaffery,P., Drager,U.C., Chambon,P. and
            Dolle,P.
  TITLE     Restricted expression and retinoic acid-induced downregulation of
            the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse
            development
  JOURNAL   Mech Dev 62 (1), 67-78 (1997)
   PUBMED   9106168
REFERENCE   8  (bases 1 to 2264)
  AUTHORS   Sapin,V., Ward,S.J., Bronner,S., Chambon,P. and Dolle,P.
  TITLE     Differential expression of transcripts encoding retinoid binding
            proteins and retinoic acid receptors during placentation of the
            mouse
  JOURNAL   Dev Dyn 208 (2), 199-210 (1997)
   PUBMED   9022057
REFERENCE   9  (bases 1 to 2264)
  AUTHORS   Zhao,D., McCaffery,P., Ivins,K.J., Neve,R.L., Hogan,P., Chin,W.W.
            and Drager,U.C.
  TITLE     Molecular identification of a major retinoic-acid-synthesizing
            enzyme, a retinaldehyde-specific dehydrogenase
  JOURNAL   Eur J Biochem 240 (1), 15-22 (1996)
   PUBMED   8797830
REFERENCE   10 (bases 1 to 2264)
  AUTHORS   McCaffrery,P., Posch,K.C., Napoli,J.L., Gudas,L. and Drager,U.C.
  TITLE     Changing patterns of the retinoic acid system in the developing
            retina
  JOURNAL   Dev Biol 158 (2), 390-399 (1993)
   PUBMED   8393814
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ166631.1, BC075704.1 and AK078553.1.
            
            On Mar 28, 2009 this sequence version replaced NM_009022.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK078553.1, BC075704.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                CJ166631.1         2-34
            34-2257             BC075704.1         1-2224
            2258-2264           AK078553.1         2199-2205
FEATURES             Location/Qualifiers
     source          1..2264
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 39.85 cM"
     gene            1..2264
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /note="aldehyde dehydrogenase family 1, subfamily A2"
                     /db_xref="GeneID:19378"
                     /db_xref="MGI:MGI:107928"
     exon            1..175
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..1615
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /EC_number="1.2.1.36"
                     /note="RALDH 2; RALDH(II); aldehyde dehydrogenase family 1
                     member A2; retinaldehyde-specific dehydrogenase type 2;
                     alcohol dehydrogenase family 1, subfamily A7;
                     retinaldehyde dehydrogenase 2; alcohol dehydrogenase
                     family 1, subfamily A2"
                     /codon_start=1
                     /product="retinal dehydrogenase 2"
                     /protein_id="NP_033048.2"
                     /db_xref="CCDS:CCDS52852.1"
                     /db_xref="GeneID:19378"
                     /db_xref="MGI:MGI:107928"
                     /translation="MTSSEIAMPGEVKADPAALMASLQLLPSPTPNLEIKYTKIFINN
                     EWQNSESGRVFPVCNPATGEQVCEVQEADKVDIDKAVQAARLAFSLGSVWRRMDASER
                     GRLLDKLADLVERDRATLATMESLNGGKPFLQAFYIDLQGVIKTLRYYAGWADKIHGM
                     TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFTWKIAPALCCGNTVVIKPAEQTPLS
                     ALYMGALIKEAGFPPGVVNILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAG
                     RSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYE
                     EFVKRSVERAKRRIVGSPFDPTTEQGPQIDKKQYNKVLELIQSGVAEGAKLECGGKGL
                     GRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVF
                     TNDINKALMVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKT
                     VTVKIPQKNS"
     exon            176..280
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..421
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            422..551
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..613
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            614..742
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            743..856
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            857..959
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1144
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1309
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1310..1467
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1542
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1631
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..2264
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2236..2241
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /note="hexamer: AATAAA"
     polyA_site      2257
                     /gene="Aldh1a2"
                     /gene_synonym="Aldh1a7; Raldh1; Raldh2"
                     /note="major polyA site"
ORIGIN      
        1 atacagcgag cgcgccccgg ccgcgcagcg ccccgcgcac acccacccgt ggccgcccat
       61 gacttccagc gagatcgcca tgccgggcga ggtgaaggcc gaccccgccg cgctcatggc
      121 ctcgctgcag ctcctgccgt cgcccacgcc caacctcgag atcaagtaca ccaagatctt
      181 tattaacaat gaatggcaga actcagagag tgggagagtg ttccctgtct gtaatccagc
      241 cacaggagag caagtgtgtg aagttcaaga agcagacaag gtggatatag acaaggcagt
      301 gcaagcagcc cgccttgcct tctctcttgg ttctgtgtgg agaaggatgg atgcgtctga
      361 aagaggacgt ctgttggaca agcttgcaga cttggtggaa cgggacaggg caactcttgc
      421 aactatggaa tccctaaatg gcggtaagcc attcctgcaa gctttttaca tcgatttgca
      481 gggagtcatc aaaaccctga ggtattatgc aggctgggct gataaaattc acggaatgac
      541 cattcctgta gatggagact attttacttt cacaagacac gagcccattg gagtgtgtgg
      601 acagatcatc ccgtggaact tccccctgct gatgttcacc tggaaaattg ctcccgcatt
      661 gtgctgtggt aacaccgtgg tcatcaaacc cgctgagcag acaccgctca gtgcactgta
      721 tatgggagcc ctcatcaagg aggctggctt tccacccgga gtcgtcaata tcctgccagg
      781 gtatgggcca acagcagggg cagcaatcgc ttctcacatc ggcatagaca agattgcatt
      841 cacaggctct actgaggttg gaaagcttat tcaagaagca gctggaagaa gtaacctgaa
      901 gagagtgacc ctggaactcg gagggaagag ccctaatatt atttttgcag atgctgactt
      961 ggactacgct gtggagcagg ctcaccaggg tgtgttcttc aaccaaggcc agtgctgcac
     1021 cgcagggtct cgcatctttg tggaagaatc catctatgag gaatttgtga aaagaagtgt
     1081 ggaaagggcc aagaggcgca ttgtggggag cccctttgat cccacaactg agcagggtcc
     1141 tcagatcgat aagaaacaat acaacaaagt cctggagctt atccagagcg gtgtggctga
     1201 gggcgccaag ctggagtgcg gaggcaaagg gctgggaagg aagggcttct tcattgagcc
     1261 caccgtgttc tccaacgtca ctgatgacat gcggattgcc aaggaggaga tctttggtcc
     1321 tgttcaagaa attttgaggt ttaagactat ggatgaagtt atagaaagag ccaataactc
     1381 agactttgga cttgtagcag ctgtcttcac taatgacatc aacaaggctc tcatggtatc
     1441 ctccgcaatg caagctggga cagtttggat caattgttac aatgccttaa atgcgcagag
     1501 cccctttggg gggttcaaga tgtctggaaa tgggagagaa atgggtgagt ttggcttacg
     1561 ggagtattca gaagtaaaga ccgtgacggt gaagatcccc cagaagaact cctaagaggc
     1621 cgaggctgaa gagcaccggt gtgccaagac tgccacgttt ctcccggcct cctccgtcat
     1681 accccgtggt ccccttgtcc attcaccact cttgcctcac aacaagtgag cttcagcctg
     1741 cagaggggga ggtgtgaagc aagcctgact ctccttccct ccaaccccac cctctttctg
     1801 ccttccaatg aaccccattt ggtgtgggca gcactggctt ccttcccttc tctcctgagc
     1861 tgccaaatcg aagccagtct ctaacctggg tgaataccgt ttatttaaaa atgccaaaca
     1921 tagcctagat atagaatatg gtcatgtatc tatcgccttc tctatttaat agttttctgc
     1981 tttctaacca aaccagtttt tagttttcta tttataacct gcctgtccac gatgttttta
     2041 agcaagctct ccatactgtt actgacagag ccctgacagt ggctttgagt ccttccagca
     2101 ggctctctgt tcctcctaca gtgcacccat gtgaacacac gattaaccag ctagctccct
     2161 tcaacccaca gtatagaatg tgaaaatgaa gatttatgac ttttaattta cttcaaaaag
     2221 aaacctcgtg ctagcaataa agcatttata ttgtgtacac cttg
//
