LOCUS       NM_001361505            2589 bp    mRNA    linear   ROD 25-FEB-2025
DEFINITION  Mus musculus aldehyde dehydrogenase family 1, subfamily A1
            (Aldh1a1), transcript variant 3, mRNA.
ACCESSION   NM_001361505
VERSION     NM_001361505.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2589)
  AUTHORS   Jasmine, Baraiya,D.H., Kavya,T.T., Mandal,A., Chakraborty,S.,
            Sathish,N., Francis,C.M.R. and Binoy Joseph,D.
  TITLE     Epithelial and mesenchymal compartments of the developing bladder
            and urethra display spatially distinct gene expression patterns
  JOURNAL   Dev Biol 520, 155-170 (2025)
   PUBMED   39798644
REFERENCE   2  (bases 1 to 2589)
  AUTHORS   Lai,W., Zhao,Y., Chen,Y., Dai,Z., Chen,R., Niu,Y., Chen,X.,
            Chen,S., Huang,G., Shan,Z., Zheng,J., Hu,Y., Chen,Q., Gong,S.,
            Kang,S., Guo,H., Ma,X., Song,Y., Xia,K., Wang,J., Zhou,L., So,K.F.,
            Wang,K., Qiu,S., Zhang,L., Chen,J. and Shi,L.
  TITLE     Autism patient-derived SHANK2BY29X mutation affects the development
            of ALDH1A1 negative dopamine neuron
  JOURNAL   Mol Psychiatry 29 (10), 3180-3194 (2024)
   PUBMED   38704506
  REMARK    GeneRIF: Autism patient-derived SHANK2B[Y29X] mutation affects the
            development of ALDH1A1 negative dopamine neuron.
REFERENCE   3  (bases 1 to 2589)
  AUTHORS   Souali-Crespo,S., Condrea,D., Vernet,N., Feret,B., Klopfenstein,M.,
            Grandgirard,E., Alunni,V., Cerciat,M., Jung,M., Mayere,C., Nef,S.,
            Mark,M., Chalmel,F. and Ghyselinck,N.B.
  TITLE     Loss of NR5A1 in mouse Sertoli cells after sex determination
            changes cellular identity and induces cell death by anoikis
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078651
REFERENCE   4  (bases 1 to 2589)
  AUTHORS   Steingruber,L., Krabichler,F., Franzmeier,S., Wu,W., Schlegel,J.
            and Koch,M.
  TITLE     ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1 control
            myogenic differentiation of skeletal muscle satellite cells by
            retinoic acid-dependent and -independent mechanisms
  JOURNAL   Cell Tissue Res 394 (3), 515-528 (2023)
   PUBMED   37904003
  REMARK    GeneRIF: ALDH1A1 and ALDH1A3 paralogues of aldehyde dehydrogenase 1
            control myogenic differentiation of skeletal muscle satellite cells
            by retinoic acid-dependent and -independent mechanisms.
REFERENCE   5  (bases 1 to 2589)
  AUTHORS   Tixi,W., Maldonado,M., Chang,Y.T., Chiu,A., Yeung,W., Parveen,N.,
            Nelson,M.S., Hart,R., Wang,S., Hsu,W.J., Fueger,P., Kopp,J.L.,
            Huising,M.O., Dhawan,S. and Shih,H.P.
  TITLE     Coordination between ECM and cell-cell adhesion regulates the
            development of islet aggregation, architecture, and functional
            maturation
  JOURNAL   Elife 12, e90006 (2023)
   PUBMED   37610090
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2589)
  AUTHORS   McCaffery,P., Lee,M.O., Wagner,M.A., Sladek,N.E. and Drager,U.C.
  TITLE     Asymmetrical retinoic acid synthesis in the dorsoventral axis of
            the retina
  JOURNAL   Development 115 (2), 371-382 (1992)
   PUBMED   1425331
REFERENCE   7  (bases 1 to 2589)
  AUTHORS   McCaffery,P., Tempst,P., Lara,G. and Drager,U.C.
  TITLE     Aldehyde dehydrogenase is a positional marker in the retina
  JOURNAL   Development 112 (3), 693-702 (1991)
   PUBMED   1935685
REFERENCE   8  (bases 1 to 2589)
  AUTHORS   Engler,P., Haasch,D., Pinkert,C.A., Doglio,L., Glymour,M.,
            Brinster,R. and Storb,U.
  TITLE     A strain-specific modifier on mouse chromosome 4 controls the
            methylation of independent transgene loci
  JOURNAL   Cell 65 (6), 939-947 (1991)
   PUBMED   2044153
REFERENCE   9  (bases 1 to 2589)
  AUTHORS   Holmes,R.S.
  TITLE     Genetics and ontogeny of aldehyde dehydrogenase isozymes in the
            mouse: localization of Ahd-1 encoding the mitochondrial isozyme on
            chromosome 4
  JOURNAL   Biochem Genet 16 (11-12), 1207-1218 (1978)
   PUBMED   751648
REFERENCE   10 (bases 1 to 2589)
  AUTHORS   Theriault,L.L., Dungan,D.D., Simons,S., Keen,C.L. and Hurley,L.S.
  TITLE     Lipid and myelin abnormalities of brain in the crinkled mouse
  JOURNAL   Proc Soc Exp Biol Med 155 (4), 549-553 (1977)
   PUBMED   896803
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152162.9 and AC167167.3.
            
            Transcript Variant: This variant (3) differs in the 5' UTR compared
            to variant 1. All five variants encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660825.174633.1,
                                           SRR1660815.278542.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC152162.9         64596-64834
            240-369             AC152162.9         65408-65537
            370-471             AC152162.9         125112-125213
            472-572             AC152162.9         131777-131877
            573-652             AC152162.9         174011-174090
            653-757             AC167167.3         49706-49810         c
            758-898             AC167167.3         42703-42843         c
            899-1028            AC167167.3         40625-40754         c
            1029-1090           AC167167.3         38993-39054         c
            1091-1219           AC167167.3         37270-37398         c
            1220-1333           AC167167.3         35898-36011         c
            1334-1436           AC167167.3         31567-31669         c
            1437-1621           AC167167.3         29873-30057         c
            1622-1786           AC167167.3         26210-26374         c
            1787-1944           AC167167.3         23898-24055         c
            1945-2019           AC167167.3         20585-20659         c
            2020-2589           AC167167.3         17260-17829         c
FEATURES             Location/Qualifiers
     source          1..2589
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 13.91 cM"
     gene            1..2589
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /note="aldehyde dehydrogenase family 1, subfamily A1"
                     /db_xref="GeneID:11668"
                     /db_xref="MGI:MGI:1353450"
     exon            1..239
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            240..369
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            370..471
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            472..572
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            573..652
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     CDS             587..2092
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /EC_number="1.2.1.3"
                     /EC_number="1.2.1.19"
                     /EC_number="1.2.1.36"
                     /EC_number="1.2.1.28"
                     /note="retinal dehydrogenase 1; RALDH 1; aldehyde
                     dehydrogenase, cytosolic; aldehyde dehydrogenase family 1
                     member A1; alcohol dehydrogenase family 1, subfamily A2;
                     aldehyde dehydrogenase 1, liver cytosolic (class 1);
                     alcohol dehydrogenase family 1, subfamily A1;
                     3-deoxyglucosone dehydrogenase"
                     /codon_start=1
                     /product="aldehyde dehydrogenase 1A1"
                     /protein_id="NP_001348434.1"
                     /db_xref="CCDS:CCDS29695.1"
                     /db_xref="GeneID:11668"
                     /db_xref="MGI:MGI:1353450"
                     /translation="MSSPAQPAVPAPLADLKIQHTKIFINNEWHNSVSGKKFPVLNPA
                     TEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLL
                     LATMEALNGGKVFANAYLSDLGGCIKALKYCAGWADKIHGQTIPSDGDIFTYTRREPI
                     GVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAEQTPLTALHLASLIKEAGFPPGV
                     VNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPC
                     IVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVKRSVERAKKYVLGN
                     PLTPGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTD
                     EMRIAKEEIFGPVQQIMKFKSVDDVIKRANNTTYGLAAGLFTKDLDKAITVSSALQAG
                     VVWVNCYMMLSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS"
     exon            653..757
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..898
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1028
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1090
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1219
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1333
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1436
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1621
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1786
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1944
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..2019
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     exon            2020..2589
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /note="hexamer: AATAAA"
     polyA_site      2588
                     /gene="Aldh1a1"
                     /gene_synonym="Ahd-2; Ahd2; ALDH-E1; Aldh1; Aldh1a2;
                     ALHDII; E1; Raldh1"
                     /note="major polyA site"
ORIGIN      
        1 agtatgtcct aagaaactgg aactatctca cagcagagac agagcccaga agtgagcctg
       61 cctgggggaa cagccaaaaa gaacatccag gcctggaaga caagctgagg ggtggataga
      121 actgtgtggg gaggagtctg gtgctgactg gtgaattcag aagcaggaaa gagggacaga
      181 gtggatttta caaccagaat aaagctggga aatgcccccg tgaatggagc caaagaaagg
      241 ttggagtttg gggtatggtg tgtatttgaa gattcaaact ccacgtggtc ttcaggagct
      301 caaacactct cacacagaac agaaaggaag tctccaaaac gaatgtgaaa ttgacaaatc
      361 accgcactgc ttcaggaccc cagcccatgg aatgctgtga tcaacattca gagtcgatca
      421 tcctacatca attaccctaa tctaggaaat cccacagagc caggaccaaa gggaccactt
      481 tccactgggt gtcccagtgc ctatcacact ttagtaggac ttgaggacaa atcgtgtctt
      541 gttcttggaa gaagcatcct ggctaagtgg ctgagccaaa ccagcaatgt cttcgcctgc
      601 acaacctgca gtccctgccc cactggccga cttgaagatt caacatacca agatcttcat
      661 aaacaatgaa tggcacaatt cagtgagcgg caagaaattt ccagttctta accctgcaac
      721 tgaggaggtc atctgccacg tggaagaagg ggacaaggct gatgttgaca aagctgtgaa
      781 ggctgcaaga caggctttcc agattggctc tccatggcgc accatggatg cttcagagag
      841 gggccgcctg ctgaacaagc tggctgactt aatggagaga gatcgtctgc tgctggctac
      901 aatggaggca ctcaatggtg ggaaagtctt tgccaatgca tacttgtcgg atttaggagg
      961 ctgcataaaa gcattaaagt actgtgcagg ctgggctgac aagattcatg gtcaaacaat
     1021 accaagtgat ggagacattt tcacttatac aagacgtgaa cctattggag tgtgtggcca
     1081 aatcatcccc tggaattttc caatgctcat gttcatttgg aagataggcc ctgcccttag
     1141 ctgtgggaat accgtggttg tcaagccagc agagcaaact cctctcacgg ctcttcacct
     1201 ggcatcttta ataaaagagg cagggtttcc tcctggcgtg gtaaacattg tccctggtta
     1261 tgggccaact gcaggggcag ccatctcctc tcacatggat gtcgacaagg tggccttcac
     1321 tggatcaaca caggttggca agttaatcaa ggaagctgca gggaaaagca atctgaagag
     1381 agtcaccctg gagctggggg gaaagagccc ttgcattgtg tttgcagatg ccgacttgga
     1441 cattgctgtt gagtttgcac accatggagt gttttatcat caaggccaat gttgtgtcgc
     1501 agcatcccgg atttttgttg aggagtcagt ttatgatgag tttgtgaaaa ggagtgttga
     1561 gcgagctaag aaatatgttc ttggaaatcc tctgacccca ggaataaatc aaggccctca
     1621 gattgacaag gaacaacatg ataaaatact cgatctcatt gagagtggga agaaagaagg
     1681 agccaaactg gagtgtggtg gaggacgctg ggggaacaaa ggcttctttg tgcagcccac
     1741 agtgttctcc aacgtgactg atgagatgcg cattgccaaa gaggagatat ttggaccagt
     1801 gcaacaaatc atgaagttta agtctgtaga tgatgtgatc aagagagcaa acaatactac
     1861 ctatggttta gcagcaggac tcttcactaa agacctggat aaggccatca ctgtgtcatc
     1921 tgctctgcag gctggggtgg tgtgggttaa ctgctatatg atgttgtcag cccagtgccc
     1981 cttcggtgga ttcaagatgt ctggaaatgg aagagaactg ggtgaacatg gtctttatga
     2041 atacactgag ctcaagacag tcgcaatgaa gatatctcag aagaactcct aaagaagcca
     2101 gcagagtaaa gagaaactct cagcagtggc tacacatctc ctatagtaac cagcatagtc
     2161 gtgttttatt ataatttctt ctccagttga tttcttaagc aaaaggaatt catcagtgtt
     2221 actgtcactc ataaaaaaca tgtggcttaa tccaacagat tcattcacct tctaatatgt
     2281 gaccccagtt cttatccaag aatagaagga tagatataag cgcaagctct ctgtaactcc
     2341 gtcatgacca ggtgctttcc attgtagcta cttatctaac atactcattt ggtgaggagg
     2401 actagttgtg acttaagctc tgtccctcag tgactccttg aagtactcac cacacataat
     2461 gactgcagag tcagctgctc tgttccccag gtgttgtgaa atattttcta gaatgtcatg
     2521 cctgcttgtc aaatgaaatg cctagctgta attagaacgc aaagcttaat aaaggcaccc
     2581 ttgcatgat
//
