LOCUS       NM_145954               2572 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus aldehyde dehydrogenase 16 family, member A1
            (Aldh16a1), mRNA.
ACCESSION   NM_145954
VERSION     NM_145954.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2572)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2572)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2572)
  AUTHORS   Charkoftaki,G., Chen,Y., Han,M., Sandoval,M., Yu,X., Zhao,H.,
            Orlicky,D.J., Thompson,D.C. and Vasiliou,V.
  TITLE     Transcriptomic analysis and plasma metabolomics in Aldh16a1-null
            mice reveals a potential role of ALDH16A1 in renal function
  JOURNAL   Chem Biol Interact 276, 15-22 (2017)
   PUBMED   28254523
  REMARK    GeneRIF: ALDH16A1 is expressed in proximal and distal convoluted
            tubule cells in the cortex of the kidney and in zone 3 hepatocytes.
            RNA-seq and gene ontology enrichment analyses showed that cellular
            lipid and lipid metabolic processes are up-regulated.
REFERENCE   4  (bases 1 to 2572)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2572)
  AUTHORS   Levi,B.P., Yilmaz,O.H., Duester,G. and Morrison,S.J.
  TITLE     Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in
            the mouse hematopoietic and nervous systems
  JOURNAL   Blood 113 (8), 1670-1680 (2009)
   PUBMED   18971422
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161198.1 and AV231409.1.
            
            On Jun 5, 2018 this sequence version replaced NM_145954.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144967.1, AK151691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2568              AK161198.1         41-2608
            2569-2572           AV231409.1         225-228
FEATURES             Location/Qualifiers
     source          1..2572
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 29.15 cM"
     gene            1..2572
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /note="aldehyde dehydrogenase 16 family, member A1"
                     /db_xref="GeneID:69748"
                     /db_xref="MGI:MGI:1916998"
     exon            1..145
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            146..248
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            249..375
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            376..554
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            555..632
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            633..814
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            815..967
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1153
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1249
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1386
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1492
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1623
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1624..1791
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1993
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2179
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2302
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2572
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2546..2551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2570
                     /gene="Aldh16a1"
                     /gene_synonym="2410004H02Rik"
                     /note="major polyA site"
ORIGIN      
        1 aagttcctct aggtagaccg tccagcaatc cctcgcggaa ggctccggga gagcgatggc
       61 ggctacgcgt gtacagccca gtacccggga gattttcacg acgctggagt acggaccggt
      121 gccggagagc cacgcatgcg cactggcctg gctggacacc cacaaccgcc tcttgggcca
      181 ccatgtcaat gggatgtggc tgaagccaga acacaggaat ccagcgcctt gccaggatcc
      241 catcacagga gaaaacctgg ccagctgctt gcaagcagag gctgaggaca tcgctgcagc
      301 tgtggaggct gcaaagatag cattcaaggc ctggagccaa ctccctggag ctgctcgggg
      361 acaacaccta acccggctgg ccaaggtcgt tcagaagcac cagcgactgc tgtggaccct
      421 ggaatccctg gtcactggac gggctgttcg agaggttcga gatggagatg tgccactggc
      481 ccagcaactg ctccagtacc atgcagtcca ggcacatgcc cagggtgacg cactggcaga
      541 ctggcagccc gtgggagtca ttggcctcat cctgccgact cctttctctt tcttggacat
      601 gatgtggagg gtctgccctg ccttggctat gggctgcacc gtggtggccc tcgtgccccc
      661 agccttcccg acacctctcc tcctggctca gctggcagga gagcttggct ctttcccagg
      721 gatcctcaat gtggtatgtg gccctgcctc gctggggcct gtcctggcct cccaacctgg
      781 agtccagaag gtggctttct gcggagccgt ggaggaagga cgtgttctgc gacggactct
      841 agcaggcagg ggagctgagc tgggcctggc cctgggcaca gagtcactgt tgctattgat
      901 ggactccgca gatgtggact cagctgtgga gggtgtcgtg gatgccgtct ggtcagaccg
      961 cagcctgggg gggctcaggc tcctcatcca ggaatctgta tgggatgaag ctatgaggcg
     1021 actccaggcc agaatggcac agatacggag tgggagagga ctggatgggg ctgtggacat
     1081 gggggctcga ggagctgctg cccgagacct ggcccagagc tttgtggatg aggcccaaag
     1141 ccaaggggga caggtattcc aagctggtga tgtgccctcc agtagcccat tcttctctcc
     1201 agccttggtt tctggtctgc ctccagcagc cccatgtgcc caggccgagg taccgtggcc
     1261 tgtggttatg gcttctcctt tccgcacagt caaggaggca ctagccctgg ccaatggaac
     1321 accccgggga ggcagcgcca gcgtgtggag tgaaaggcta gggcaagccc tggagctggg
     1381 ctatgggctc caggtgggca cagtgtggat caatgctcat ggcctccgag accctgcggt
     1441 gccgacaggg ggctgcaagg agagtgggtc ttcctggcac ggaggcccag atggcctgta
     1501 tgagtacctg cagcccttgg ggacaccttc ccaggagtcc ttcctttgtg agaatatcaa
     1561 ctacgacaca tttggccttg ctgcgtcctc cattctgccg tcagggccag aaacagggcc
     1621 tagcccagcc cctccctatg ggctgtttgt cggaggccgt ttccagtctc ctgggaccca
     1681 gagctccagg cccatccaag attcttcagg caaagtctcc agctatgtag ctgagggtgg
     1741 agccaaggat atccgaggtg ctgtagaggc tgctcatcag gctgcccctg gctggggagc
     1801 ccagtcccca agagcccgag caggcctgct gtgggccctg gcggctgctc tggagcgcag
     1861 gaagccagtg ctgacctcac aactagaaag gcacggagca gcgcctacag ttgccaagat
     1921 tgaagtagaa ctgagtgtga ggcgactcca gacatggggc acccgggttc aggaccaagg
     1981 ccagacacta caggtaacag gattgagagg ccctgtgctc cggcttcgag aaccattggg
     2041 agtgctggcc gtggtgtgcc cggatgagtg gcccctgctg gcttttgtgt cactactggc
     2101 ccctgcactg gcccatggca atgccgtggt cttagtaccc agtggggcat gtcctctgct
     2161 ggccttggag gtctgccagg atatagctcc tctgtttcct gctggcctgg tgagtgtagt
     2221 gacaggggat cgcgaccacc tgacccgctg tctggcctta catcaggatg tccaagccct
     2281 gtggtacttc ggctcggccc agggctccca gtttgtggaa tgggcctctg caggaaacct
     2341 caagtctgtg tgggtaaaca ggggcttccc aagggcctgg gatgtggagg tccagggggc
     2401 aggacaggag ctgagtcttc acgcagcacg aacaaaggcc ctgtggctgc caatggggga
     2461 ctgatgccga agccacccac tccatctttg atgctcagga gcaccaagtg cttggaacgt
     2521 ttctctcaga tttcccatgg cttctaataa actgagtgac tttaactgtg ca
//
