LOCUS       NM_009655               5063 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus activated leukocyte cell adhesion molecule (Alcam),
            transcript variant 1, mRNA.
ACCESSION   NM_009655
VERSION     NM_009655.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5063)
  AUTHORS   Kc,R., Lopez de Boer,R., Lin,M., Vagnozzi,A.N., Jeannotte,L. and
            Philippidou,P.
  TITLE     Multimodal Hox5 activity generates motor neuron diversity
  JOURNAL   Commun Biol 7 (1), 1166 (2024)
   PUBMED   39289460
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5063)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   3  (bases 1 to 5063)
  AUTHORS   Mohamad,S.F., El Koussa,R., Ghosh,J., Blosser,R., Gunawan,A.,
            Layer,J., Zhang,C., Karnik,S., Dave,U., Kacena,M.A. and Srour,E.F.
  TITLE     Osteomacs promote maintenance of murine hematopoiesis through
            megakaryocyte-induced upregulation of Embigin and CD166
  JOURNAL   Stem Cell Reports 19 (4), 486-500 (2024)
   PUBMED   38458190
  REMARK    GeneRIF: Osteomacs promote maintenance of murine hematopoiesis
            through megakaryocyte-induced upregulation of Embigin and CD166.
REFERENCE   4  (bases 1 to 5063)
  AUTHORS   Baek,S.M., Kim,M.N., Kim,E.G., Lee,Y.J., Park,C.H., Kim,M.J.,
            Kim,K.W. and Sohn,M.H.
  TITLE     Activated Leukocyte Cell Adhesion Molecule Regulates the Expression
            of Interleukin-33 in RSV Induced Airway Inflammation by Regulating
            MAPK Signaling Pathways
  JOURNAL   Lung 202 (2), 127-137 (2024)
   PUBMED   38502305
  REMARK    GeneRIF: Activated Leukocyte Cell Adhesion Molecule Regulates the
            Expression of Interleukin-33 in RSV Induced Airway Inflammation by
            Regulating MAPK Signaling Pathways.
REFERENCE   5  (bases 1 to 5063)
  AUTHORS   Warin,J., Vedrenne,N., Tam,V., Zhu,M., Yin,D., Lin,X.,
            Guidoux-D'halluin,B., Humeau,A., Roseiro,L., Paillat,L.,
            Chedeville,C., Chariau,C., Riemers,F., Templin,M., Guicheux,J.,
            Tryfonidou,M.A., Ho,J.W.K., David,L., Chan,D. and Camus,A.
  TITLE     In vitro and in vivo models define a molecular signature reference
            for human embryonic notochordal cells
  JOURNAL   iScience 27 (2), 109018 (2024)
   PUBMED   38357665
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5063)
  AUTHORS   Fraboulet,S., Schmidt-Petri,T., Dhouailly,D. and Pourquie,O.
  TITLE     Expression of DM-GRASP/BEN in the developing mouse spinal cord and
            various epithelia
  JOURNAL   Mech Dev 95 (1-2), 221-224 (2000)
   PUBMED   10906467
REFERENCE   7  (bases 1 to 5063)
  AUTHORS   Nevrivy,D.J., Peterson,V.J., Avram,D., Ishmael,J.E., Hansen,S.G.,
            Dowell,P., Hruby,D.E., Dawson,M.I. and Leid,M.
  TITLE     Interaction of GRASP, a protein encoded by a novel retinoic
            acid-induced gene, with members of the cytohesin family of guanine
            nucleotide exchange factors
  JOURNAL   J Biol Chem 275 (22), 16827-16836 (2000)
   PUBMED   10828067
REFERENCE   8  (bases 1 to 5063)
  AUTHORS   Sekine-Aizawa,Y., Omori,A. and Fujita,S.C.
  TITLE     MuSC, a novel member of the immunoglobulin superfamily, is
            expressed in neurons of a subset of cranial sensory ganglia in the
            mouse embryo
  JOURNAL   Eur J Neurosci 10 (9), 2810-2824 (1998)
   PUBMED   9758151
REFERENCE   9  (bases 1 to 5063)
  AUTHORS   Bowen,M.A., Bajorath,J., D'Egidio,M., Whitney,G.S., Palmer,D.,
            Kobarg,J., Starling,G.C., Siadak,A.W. and Aruffo,A.
  TITLE     Characterization of mouse ALCAM (CD166): the CD6-binding domain is
            conserved in different homologs and mediates cross-species binding
  JOURNAL   Eur J Immunol 27 (6), 1469-1478 (1997)
   PUBMED   9209500
REFERENCE   10 (bases 1 to 5063)
  AUTHORS   Kanki,J.P., Chang,S. and Kuwada,J.Y.
  TITLE     The molecular cloning and characterization of potential chick
            DM-GRASP homologs in zebrafish and mouse
  JOURNAL   J Neurobiol 25 (7), 831-845 (1994)
   PUBMED   8089660
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154383.2, AK031391.1, AK161090.1 and BE654940.1.
            
            On Sep 8, 2016 this sequence version replaced NM_009655.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030851.1, AK031391.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                AC154383.2         158309-158392       c
            85-3126             AK031391.1         1077-4118
            3127-4100           AK161090.1         957-1930
            4101-4956           AK161090.1         1932-2787
            4957-5063           BE654940.1         11-117              c
FEATURES             Location/Qualifiers
     source          1..5063
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 32.88 cM"
     gene            1..5063
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="activated leukocyte cell adhesion molecule"
                     /db_xref="GeneID:11658"
                     /db_xref="MGI:MGI:1313266"
     exon            1..689
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             617..2368
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; CD166 antigen"
                     /codon_start=1
                     /product="CD166 antigen isoform 1 precursor"
                     /protein_id="NP_033785.1"
                     /db_xref="CCDS:CCDS37356.1"
                     /db_xref="GeneID:11658"
                     /db_xref="MGI:MGI:1313266"
                     /translation="MASKVSPSCRLVFCLLISAAVLRPGLGWYTVNSAYGDTIVMPCR
                     LDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLSLSENYTLSIAN
                     AKISDEKRFVCMLVTEDNVFEAPTLVKVFKQPSKPEIVNKAPFLETDQLKKLGDCISR
                     DSYPDGNITWYRNGKVLQPVEGEVAILFKKEIDPGTQLYTVTSSLEYKTTRSDIQMPF
                     TCSVTYYGPSGQKTIYSEQEIFDIYYPTEQVTIQVLPPKNAIKEGDNITLQCLGNGNP
                     PPEEFMFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKRNMAASTTITVHYLDL
                     SLNPSGEVTKQIGDTLPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVC
                     ETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIHWTIT
                     GSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEH
                     DEADDISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLG
                     NMEENKKLEENNHKTEA"
     exon            690..790
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            791..1010
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1075
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1163
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1346
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1347..1474
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1607
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1720
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1721..1856
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..1990
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..2123
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2162
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2280
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2281..2392
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..5043
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2562..2567
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="hexamer: AATAAA"
     regulatory      2568..2573
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="hexamer: ATTACA"
     polyA_site      2587
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="major polyA site"
     polyA_site      2600
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
     regulatory      3835..3840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="hexamer: AATAAA"
     polyA_site      3856
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
     regulatory      3984..3989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="hexamer: AATAAA"
     polyA_site      4003
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
     regulatory      4936..4941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="hexamer: AATAAA"
     polyA_site      4959
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
     regulatory      5023..5028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
                     /note="hexamer: AATAAA"
     polyA_site      5043
                     /gene="Alcam"
                     /gene_synonym="BEN; CD166; DM-GRASP; MuSC; SC1"
ORIGIN      
        1 gaggagcggg aggagcagga ggagcgggag gagcgggagg aggagacagg cagcttacac
       61 acgccttccc gtcctccact cagagcagcc ggagcccgcg gccgccgcca ctgctccagc
      121 tgccgccgct acagcctctg cctcggctgc cacctgagga gacccaccgt cgggaccccg
      181 cggcgctgcc ccgccgaccc ttctctgctc ccggtgatcc gtgcacggtg caactctcat
      241 cactcttctt atcctctcct ttgcaagaag agaaactact agaagacagc atccaaaaag
      301 aaaccgcgtc taccttgact gactactgaa gcgtctcctg gaataagagg gtcgcccgtc
      361 ctgggagtag ctgccagaga cactgaggaa gggtgtggag ggggggaggg aggagttgcg
      421 ggttccgcgt ggaggaaagt tgcgtgtggc acagacccga cggcgcagcg ccacagtccc
      481 cgggggaccg tgtgtcttgg aaaaaagtcg ctgtccccct aaggcgagac ccacaagcga
      541 gcgggccccg tgggcccggg gacgacgccc cctcctgcgg cgtggacttt gtcggtggcc
      601 ttctaggagg aggaatatgg catctaaggt gtccccttct tgccgtctgg ttttctgcct
      661 cttgatctcc gccgcggtcc tcagaccagg ccttggatgg tacactgtca actcagcata
      721 tggagacacc attgtcatgc cttgccgtct cgatgtacct cagaacctca tgtttggcaa
      781 atggaaatat gaaaagcccg atgggtcccc agtatttatt gcattccgat cttctacgaa
      841 gaaaagtgtg cagtatgatg atgtcccaga gtacaaggac agactgagcc tctcagaaaa
      901 ctacactttg tctatcgcca atgctaagat cagtgatgag aagagatttg tgtgcatgct
      961 agtgaccgag gacaatgtgt ttgaagcacc taccctagtc aaggtgttca agcaaccatc
     1021 taaacctgaa attgtaaaca aagcaccctt tcttgaaaca gatcagctga aaaagttagg
     1081 tgactgcatt tcaagagaca gttacccaga tggcaacatc acatggtaca ggaatggcaa
     1141 agtgctgcaa cctgtggaag gagaggtggc catacttttt aaaaaggaaa ttgatccagg
     1201 aactcagttg tataccgtga cttcctcctt ggagtacaag acaaccagat ctgacataca
     1261 aatgccattc acctgttctg tgacatatta tggaccctcc ggccagaaaa caatttattc
     1321 cgaacaagaa atctttgata tttactatcc tacagagcag gtgacaatac aagtgctgcc
     1381 accaaaaaat gccatcaaag aaggggacaa catcaccctt cagtgtttgg ggaatggcaa
     1441 cccacctcct gaggagttca tgttttactt accaggacag cctgaaggca taagaagctc
     1501 aaacacttac acactgacag atgtgagacg caatgccaca ggggactaca aatgctcact
     1561 cattgacaaa aggaacatgg cggcttcaac gaccatcaca gttcactact tggatttatc
     1621 cttaaaccca agtggggagg tgaccaagca gattggcgat accctgcctg tgtcatgcac
     1681 aatatctgca agtaggaacg cgactgtggt gtggatgaag gataacatcc ggctccggtc
     1741 cagcccttcc ttttccagtc ttcattatca ggatgctggg aactatgtct gtgaaactgc
     1801 tcttcaggag gttgagggac tgaagaaaag ggagtcgctg accctcattg tagaagggaa
     1861 acctcaaatc aaaatgacta agaaaactga ccccagtgga ctgtctaaaa ctataatctg
     1921 ccacgtggaa gggtttccaa agccagctat acattggacc attaccggca gtgggagcgt
     1981 cataaaccaa acagaggagt ctccttatat taatggcagg tattatagta aaattatcat
     2041 ttcccctgag gagaatgtaa cattaacttg cacagcagaa aaccaactgg agagaacagt
     2101 aaactccctg aatgtctctg cgataagtat tccagagcac gatgaggcag acgatataag
     2161 tgatgaaaac agagaaaagg tgaatgacca ggcaaaactg attgtgggaa ttgtcgttgg
     2221 tctcctcctc gctgccctcg ttgctggtgt cgtctactgg ctgtacatga agaagtccaa
     2281 aactgcatca aaacatgtaa acaaggacct tggtaatatg gaggaaaata aaaagctgga
     2341 agaaaacaat cacaaaacag aagcctaaga gaggagcgga ttggatagcc tgaggaaaaa
     2401 aacatataag caaattgaag catgaacgtg gattgtattt aagacatata caaagacaaa
     2461 tgacagcaat tcatggttca agtataaagc agttcattct accaagctgt cacaggatct
     2521 tagagaatta tctcaagtaa aacagtgaaa taaagttata aaataaaatt acaagatttg
     2581 gcagccatga taataggtca tatgttgtat ttcgtttgat tttttttctg taaatgtctg
     2641 cactaagggt ttctttcagt ttgcctttta tgtaaatttt ttacgtagct atttttatac
     2701 actgtaagct ttgttctggg agtggctgtt aattggatgt ataatgtaac gttttatttc
     2761 aattgtttat atggatagtc tgagcaggta cggttctgat tctgattgct atcaataaca
     2821 ccccatactt tctttgaaca tactttgacc tgaagctcaa aggtggcagt tgtgagattg
     2881 ggacacatat cttgcccaat cagaagctgt ttcttatctt gagagttagg agcaccatag
     2941 gatatgatgg tctatgtgct gccaacaggc tccccgaagc gagtcacaaa cacatacagc
     3001 aacactactt gagaatggta ctcccaaact gacaattttt tcttttctga aaaagatata
     3061 cacatagtgt gtatcacatt tacttattga cacttactaa gaaatgacat tctgttaaaa
     3121 aaaattagga aaaaaatatg gaaaaaaaat atcagagaaa agtgtcagag aaagttggaa
     3181 gctcatatcc ccatagtcgc agatcacgat gtaaatcact gtaattaaaa ttggtgttaa
     3241 atcctttggg ttttccactg ccttaaaatg atacttattt ccttaaaaaa gaaaataaaa
     3301 taagagatat cagtcagaat tgcagatttt taacagtggt cattattaaa gctgtgttat
     3361 tttccacaga atatagaata tatatttttt tcgtgtgtgt ttttgttaac tacgctacag
     3421 atattgaatg caccttgaga taatttagtg tttttaactg gtacataatt tatcaagcag
     3481 tacatgaaag tgtaataata aaatgtctat gtatctttag ttacattcag atttgtaact
     3541 ttataaacat gttttctgcc tgaggtactt tttaaggagg tagtgtacat gggacctttt
     3601 tgaagtagac tggataaggg ccagtagcga cttgcgacta gactttaaac tttgctcttt
     3661 caggtggagg cttcgtttct gggatcccac tgcaccgcca tttcttccca gatttatgtg
     3721 tataacttaa actggaaaaa aagaaaaaga aaaatatgac tattagattt ccaggtatag
     3781 aactgtgttc tttgagaggg aaaagaaata tggtgtttcc ttttagacac aaacaataaa
     3841 attattttga aggcaatgag aaactaatca aagactaatc tctgttggag gttgggaata
     3901 atgttttgcc acttctgcag actgagagac gtgtcattgg acatgtgtaa ccatttgata
     3961 tctgagcaat agtgtctcag tttaataaaa gcttcctata gtacattggt atggattaaa
     4021 tacataaaat attctattag acttcatgct gtaaagagaa catgttattt tgcctctaaa
     4081 ctttgattta ttgaagtttt atttggcaag aaaaaagaaa ttgaatcttg atcaatattt
     4141 aaaccaaagg gaaaagggaa aaccaaaacc aaaccaaagt tctttgtttt gcctggttac
     4201 gacattcagt ttatctgtgt aaatattatg attttttttg ttttgttttc tctttagaat
     4261 tttgttaaag aaattctaaa agttttaaac acctgctttc cacaataagc catgaacact
     4321 acagtgagat tagttcccta ttaatacttc attttctttc tttctttctt tctttctttc
     4381 tttctttctt tctttctttc tcttgtctct tctctctctc tcctttttct tttttctttt
     4441 tcttttcttt ttgttttttg tttttttttg tgggagatca aaggtttaaa gtcttactct
     4501 taagatgtgt ttgcagaaag aaggaacaag gcatcgggag agcgtttact cctagtccta
     4561 ccagtaaggc gtccacttgc aatggtaact gagtccacaa acagctgtta gaacctagac
     4621 agcagcatga ctggctcaga gctcttgccc atgagcagat gtttacaaga gaggaaaaga
     4681 ttgcttgcta cgactgcatc agcgtctgca cctgcgtaag gaggaagctc actcactcaa
     4741 gagcacctcc atgtaccgcg tcacactgga aggaggctaa gtctcagtct tcaagttctg
     4801 gactttcttc tctccagtgg cacttgttgg caactagata caggtttcta accggttcac
     4861 ggttcacccc ctatatgtaa ttataggaat tgtatgtgga aatggattaa catacccctt
     4921 tatgcctaaa aaaaaaataa aaaaatatgt cttcacatat ccctcatagc tgtctgcctc
     4981 ttgtctgcaa taggatgttc atgtacaaaa gtggttttct ttaataaaag gtggaaacat
     5041 tgaaaaaaaa aaaaaaaaaa aaa
//
