LOCUS       NM_008525               4536 bp    mRNA    linear   ROD 17-DEC-2022
DEFINITION  Mus musculus aminolevulinate, delta-, dehydratase (Alad),
            transcript variant 1, mRNA.
ACCESSION   NM_008525 XM_910240
VERSION     NM_008525.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4536)
  AUTHORS   Sampaio TB, Marcondes Sari MH, Pesarico AP and Nogueira CW.
  TITLE     delta-Aminolevulinate Dehydratase Activity is Stimulated in a MPTP
            Mouse Model of Parkinson's Disease: Correlation with
            Myeloperoxidase Activity
  JOURNAL   Cell Mol Neurobiol 37 (5), 911-917 (2017)
   PUBMED   27650074
  REMARK    GeneRIF: this study demonstrated for the first time the involvement
            of striatal delta-ALA-D activity in the
            1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model and its
            correlation with the MPO activity.
REFERENCE   2  (bases 1 to 4536)
  AUTHORS   Nakahara M, Tateyama H, Araki M, Nakagata N, Yamamura K and Araki
            K.
  TITLE     Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from
            MSM/Ms mice
  JOURNAL   Mamm Genome 24 (5-6), 228-239 (2013)
   PUBMED   23604909
REFERENCE   3  (bases 1 to 4536)
  AUTHORS   Desgardin AD, Abramova T, Rosanwo TO, Kartha S, Shim EH, Jane SM
            and Cunningham JM.
  TITLE     Regulation of delta-aminolevulinic acid dehydratase by kruppel-like
            factor 1
  JOURNAL   PLoS One 7 (10), e46482 (2012)
   PUBMED   23056320
  REMARK    GeneRIF: Similar to its role at the beta-globin promoter, KLF1
            induces factor recruitment and chromatin changes at the Alad1b
            promoter in a temporally-specific manner
REFERENCE   4  (bases 1 to 4536)
  AUTHORS   Bardag-Gorce F and French SW.
  TITLE     Delta-aminolevulinic dehydratase is a proteasome interacting
            protein
  JOURNAL   Exp Mol Pathol 91 (2), 485-489 (2011)
   PUBMED   21640720
  REMARK    GeneRIF: The data supports the hypothesis that ALAD, an important
            enzyme for heme synthesis, is also important as a proteasome
            interacting protein.
REFERENCE   5  (bases 1 to 4536)
  AUTHORS   Tallack MR, Whitington T, Yuen WS, Wainwright EN, Keys JR, Gardiner
            BB, Nourbakhsh E, Cloonan N, Grimmond SM, Bailey TL and Perkins AC.
  TITLE     A global role for KLF1 in erythropoiesis revealed by ChIP-seq in
            primary erythroid cells
  JOURNAL   Genome Res 20 (8), 1052-1063 (2010)
   PUBMED   20508144
  REMARK    Erratum:[Genome Res. 2010 Dec;20(12):1748]
REFERENCE   6  (bases 1 to 4536)
  AUTHORS   Pilz A, Moseley H, Peters J and Abbott C.
  TITLE     Comparative mapping of mouse chromosome 4 and human chromosome 9:
            Lv, Orm, and Hxb are closely linked on mouse chromosome 4
  JOURNAL   Mamm Genome 3 (5), 247-249 (1992)
   PUBMED   1379092
REFERENCE   7  (bases 1 to 4536)
  AUTHORS   Fletcher C, Norman DJ and Heintz N.
  TITLE     Genetic mapping of meander tail, a mouse mutation affecting
            cerebellar development
  JOURNAL   Genomics 9 (4), 647-655 (1991)
   PUBMED   2037292
REFERENCE   8  (bases 1 to 4536)
  AUTHORS   Roberts M, Alexander J and Blackwell JM.
  TITLE     Genetic analysis of Leishmania mexicana infection in mice: single
            gene (Scl-2) controlled predisposition to cutaneous lesion
            development
  JOURNAL   J Immunogenet 17 (1-2), 89-100 (1990)
   PUBMED   2212703
REFERENCE   9  (bases 1 to 4536)
  AUTHORS   Bishop TR, Hodes ZI, Frelin LP and Boyer SH.
  TITLE     Cloning and sequence of mouse erythroid delta-aminolevulinate
            dehydratase cDNA
  JOURNAL   Nucleic Acids Res 17 (4), 1775 (1989)
   PUBMED   2922298
REFERENCE   10 (bases 1 to 4536)
  AUTHORS   Francke,U.
  TITLE     Regional localization of the human genes for malate dehydrogenase-1
            and isocitrate dehydrogenase-1 on chromosome 2 by interspecific
            hybridization using human cells with the balanced reciprocal
            translocation t(1;2) (q32;q13)
  JOURNAL   Cytogenet Cell Genet 14 (3-6), 308-312 (1975)
   PUBMED   1192808
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL732594.5, AK032908.1 and CB524263.1.
            
            [WARNING] On May 10, 2023 this sequence was replaced by
            NM_008525.5.
            
            On Feb 14, 2013 this sequence version replaced NM_008525.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript from the same
            strain was available for the full length of the gene. The extent of
            this transcript is supported by transcript alignments and
            orthologous data.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055930.1, SRR10223970.6379.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-145               AL732594.5         112574-112718       c
            146-1351            AK032908.1         2-1207
            1352-1774           CB524263.1         247-669
            1775-4536           AL732594.5         98639-101400        c
FEATURES             Location/Qualifiers
     source          1..4536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.17 cM"
     gene            1..4536
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /note="aminolevulinate, delta-, dehydratase"
                     /db_xref="GeneID:17025"
                     /db_xref="MGI:MGI:96853"
     exon            1..204
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            205..391
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            392..442
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            443..539
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            540..675
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            676..759
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            760..848
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            849..904
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            905..992
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1079
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1209
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..4536
                     /gene="Alad"
                     /gene_synonym="ALADH; Lv"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctcagcgt ggatctggcc gcgcgagctg accagtgatc cggagactgc cccgaaggga
       61 gcgtaagctg cattcccgga ggggcgggcg gtacgggagc cgcttccggg tgagccgccc
      121 cgcccccacg tgggcttgcg cttttagagc gggagagcgc ggtgtccaga gcccggctcg
      181 gagcggcggc gagcagcgtc cttgagctga ggctgcagca gacacccagg agccgccact
      241 ccatccagca gacttctctg tgttccactg ccccgaccat gcaccaccag tctgttctgc
      301 acagcggcta ctttcaccca ctgcttcgga gctggcagac tgctgcctcc accgtcagtg
      361 cctccaacct catctatccc atctttgtca cggatgttcc tgatgatgtc cagcctatcg
      421 ccagcctccc aggagtggcc aggtatggcg taaaccagct agaagagatg ctgagacctc
      481 tggtggaagc tggcctgcgc tgtgtcctga tctttggcgt ccccagcaga gttcccaagg
      541 atgaacaggg ctctgcagct gactctgagg actccccaac tattgaggct gtccgtctgc
      601 tgaggaagac cttcccttcc ctcctagtgg cctgtgacgt ctgcttgtgc ccctacacct
      661 cccatggcca ctgtggcctc ctgagtgaaa atggagcatt cctagcagag gagagccgac
      721 agcggttggc agaggtggca ctggcctatg ccaaggcagg ctgtcaggtt gtagctccgt
      781 cagacatgat ggacggacga gttgaggcca tcaaggctgc cctgctaaaa catggacttg
      841 gcaacagggt ctctgtgatg agctatagtg ccaaatttgc ctcctgtttc tacggtcctt
      901 tccgggatgc agctcagtca agcccagctt ttggagaccg acgctgttat cagctgcctc
      961 ctggtgcccg tggcctggcc ctccgagcag tggcccgaga cattcaagaa ggagctgaca
     1021 tgctcatggt gaagccggga ttgccctacc tggacatggt gcgagaggtg aaggacaagc
     1081 accccgagct ccccctcgca gtataccagg tgtctggaga gtttgccatg ttgtggcacg
     1141 gagcccaggc cggggccttt gatctcagga ctgctgtact ggagaccatg acggccttcc
     1201 gcagagccgg tgccgacatc atcatcacct actttgcacc gcagctgttg aagtggctga
     1261 aggaagaatg aagaaaaagt gtcggacttg atcttgacca agctccctgg gccttacaga
     1321 agggggaaag taaatgcgct gttagaactg tgccctgtgc cctcttcctg cccacgctgc
     1381 tggcagggtg cagcgccctg ggtggtttgc cagcatgcta aactcccact cacagctgca
     1441 gcctaccagg ccctccaagt ttcccactct ggctcagccc agagaccctc ctccctgctc
     1501 tgctgaggtg tggccttagc ttggcagaac ccaagagcct caggcaccgg cttggagctt
     1561 tgggacaaga ggagagcagt tggagcttga aacctaaaga gttattcatt aatgaggatc
     1621 aaaccccaga agcagcaggg attcctggcc acaggagatg ccagcatcag aaagtctgtc
     1681 tgcacaagtc agttcctgag aacctctgcc cagggcagat ggacacagca ggatgcacag
     1741 cagcatacgt ctctgtagga tgtatgcaga gaaaggggag cgtaacaaag caggtgaatc
     1801 gatacttgct aagaagggga agtccaagac agctgtccct gagttgaaac cttaaaggga
     1861 caaagaggac cagcagacgt gctcagagac ccctttggta ggaggagctt ggcagggcta
     1921 gagggcaggc gacgaagagg aacgtggata acagagggga ggttggaata gttcgttccc
     1981 cgacttagca gggacctaaa gttttgtttt gcatctgtgg gacagccatc ttaaagattt
     2041 gggcgtttgg tttagttttc tccactaagt atccctggcc tcacccacct aggcaagcac
     2101 tctgccactg aactgtacct atagccttca aggcacgttc tggagaccag actagatgtg
     2161 ttgcgggagg tagataaggg aacaagagag agtgaggttg tctttgtggg tttctgaagt
     2221 tgcccagctg gttttagttc attcatctga catgacaccc gtactgcggc taatgaaggt
     2281 tagggccagt ttgcaggcac acctgacttt agaggtggag gccctactct agctctgact
     2341 ctaacgcgat gtcattctta aggtgcagaa ttagttagag ttaataactg gcaactcctg
     2401 caatcagact ggtccaatac ttggtggctt tcttttaaag ctgtgaataa ctcaagagct
     2461 gatcttccta cttctcagcc ttctggaagg tagccaccaa aatcaaatca gccctaaact
     2521 gtctctttct tggatcctga gcatagattt accatctaga acccagatca ctaatttaaa
     2581 acctgctatc atcaggccag gggtatacca gactagactt gtactatctt ggctgttata
     2641 cagcctctga gctctgtggt taaaatggtt cgtgtgttag ggaagccatc accaagctgt
     2701 taagagagcc aggagacatg ctaccctgca tgtgccaagg ccctaatgtg tccaggccca
     2761 atggcaaatg ggaaggtcac caggtcccga cctttgaagg atcagaaaac agtcccctga
     2821 aggactgatg tttggatgaa cagctaaagc tgagacataa ttgaccaaga gccttccagg
     2881 gaaagaacca ttgtgcaaag ttcctggagc cgaagtggag ctggatgagc acggggctgg
     2941 tgtggcccgc acaccaggaa gaatacagga acaggtggcc tggacatctc agtctaagcc
     3001 gtacaggggc ttcgatgcca cactcctcca cctttatccc aagatcaaag ggcacctcaa
     3061 ggatgccagc aggggaatga ccatgttgtg ggttttcact tagtaacacc atggcattat
     3121 gcagatgaga tgtttgaatt ccatggtgac catagggatg caaaaaagga gattatttag
     3181 agtatagttt agacctgctt ctctgaatgg caagtggcct gaccatttaa tggagaaagc
     3241 agactcaagg tagaacccta agtttagctt gagtccttgg caatgagaaa ggcacccccc
     3301 actaaggcta ctcacatttt cggcagaact gggttaaagg ttaaaaggaa aaccagatgt
     3361 aacattctga cccagctcca aagccccgac ccttaaccac tcatgacacc tcccagtaag
     3421 ggacagtgag aaagatggct ggcctctgct gtgtgactaa ctggtatggg aggaggacct
     3481 tggagcccat tttcccctgg agctgggtct tgtcacctga agtgtccact tggtggcagc
     3541 cacctacatc tttgcaaaca aagcaggcac agacagacat ggcttacacc taagggcttc
     3601 ctgcacagaa gggcttcctg gacttcaaga ctaacctaag ctgcagaata agatccttct
     3661 ttaaaatcgg gaagagactt gagagtcatc tgaaagggtt gtaactgacc tgtgccacat
     3721 ccatagagaa ctagattttc agtctggcaa ggatattatc agcctcccag atacctggca
     3781 gtgggtgtcc agggacttga tgagacttgg ttttctcatt cccctctcaa atgtgccagt
     3841 ttaggctgta gtttcaccct ttggcaggca tcataatcag ccatttaact ccttaagagt
     3901 ggagaacacc cagtttccag ctagccatcc catatagact gccagtctag cacaggaagg
     3961 gcctagtgat ttgtggcagt cttgagtctg ggtactcttg gttgcaggga ctgaaactca
     4021 ggtcaataga aaaagaaact gaactggttc gcatgcctaa atcttggtaa tgtcaattat
     4081 gtgtgtcccc aagtcaaagg ctttgatctt ttggccttgg ggagacttta ttgttggata
     4141 agccttccca gccaacaact tgatccctca ctgaaataac ccctaagatt tgtaatccca
     4201 gagaaagacc cattctgtcc tgtccctgcc ataacaactc tggagatctg tgattgttct
     4261 gcgtaggtca catgtctgcc aattggctca ctcagtatga actggacagg gatgggtgac
     4321 atggttgacc tgccccccca ttacataaaa ggctgacaag gccttggctc tggtaccaaa
     4381 tggtcctctg cctggaatgc cttctctcta aatccatgtg tctcctttta tgttcggacc
     4441 tcagctgacc tgtcacttcc tcaaacctga tccagcaatc tctctaaact caccctctgt
     4501 attcggatta gtgaatacaa caagtcaaaa taacag
//
