LOCUS       NM_001302266            2159 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus AKT interacting protein (Aktip), transcript variant 3,
            mRNA.
ACCESSION   NM_001302266 XM_006530670
VERSION     NM_001302266.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2159)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2159)
  AUTHORS   La Torre,M., Centofante,E., Nicoletti,C., Burla,R., Giampietro,A.,
            Cannistra,F., Schirone,L., Valenti,V., Sciarretta,S., Musaro,A. and
            Saggio,I.
  TITLE     Impact of diffused versus vasculature targeted DNA damage on the
            heart of mice depleted of telomeric factor Ft1
  JOURNAL   Aging Cell 22 (12), e14022 (2023)
   PUBMED   37960940
  REMARK    GeneRIF: Impact of diffused versus vasculature targeted DNA damage
            on the heart of mice depleted of telomeric factor Ft1.
REFERENCE   3  (bases 1 to 2159)
  AUTHORS   La Torre,M., Merigliano,C., Maccaroni,K., Chojnowski,A., Goh,W.I.,
            Giubettini,M., Verni,F., Capanni,C., Rhodes,D., Wright,G.,
            Burke,B., Soddu,S., Burla,R. and Saggio,I.
  TITLE     Combined alteration of lamin and nuclear morphology influences the
            localization of the tumor-associated factor AKTIP
  JOURNAL   J Exp Clin Cancer Res 41 (1), 273 (2022)
   PUBMED   36096808
  REMARK    GeneRIF: Combined alteration of lamin and nuclear morphology
            influences the localization of the tumor-associated factor AKTIP.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2159)
  AUTHORS   Burla,R., La Torre,M., Zanetti,G., Bastianelli,A., Merigliano,C.,
            Del Giudice,S., Vercelli,A., Di Cunto,F., Boido,M., Verni,F. and
            Saggio,I.
  TITLE     p53-Sensitive Epileptic Behavior and Inflammation in Ft1
            Hypomorphic Mice
  JOURNAL   Front Genet 9, 581 (2018)
   PUBMED   30546381
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2159)
  AUTHORS   La Torre,M., Merigliano,C., Burla,R., Mottini,C., Zanetti,G., Del
            Giudice,S., Carcuro,M., Virdia,I., Bucciarelli,E., Manni,I.,
            Vinciguerra,G.R., Piaggio,G., Riminucci,M., Cumano,A.,
            Bartolazzi,A., Verni,F., Soddu,S., Gatti,M. and Saggio,I.
  TITLE     Mice with reduced expression of the telomere-associated protein Ft1
            develop p53-sensitive progeroid traits
  JOURNAL   Aging Cell 17 (4), e12730 (2018)
   PUBMED   29635765
REFERENCE   6  (bases 1 to 2159)
  AUTHORS   Lesche,R. and Ruther,U.
  TITLE     Close linkage of p130 and Ft1 is conserved among mammals
  JOURNAL   Mamm Genome 9 (3), 253-255 (1998)
   PUBMED   9501314
REFERENCE   7  (bases 1 to 2159)
  AUTHORS   Lesche,R., Peetz,A., van der Hoeven,F. and Ruther,U.
  TITLE     Ft1, a novel gene related to ubiquitin-conjugating enzymes, is
            deleted in the Fused toes mouse mutation
  JOURNAL   Mamm Genome 8 (12), 879-883 (1997)
   PUBMED   9383278
REFERENCE   8  (bases 1 to 2159)
  AUTHORS   Heymer,J., Kuehn,M. and Ruther,U.
  TITLE     The expression pattern of nodal and lefty in the mouse mutant Ft
            suggests a function in the establishment of handedness
  JOURNAL   Mech Dev 66 (1-2), 5-11 (1997)
   PUBMED   9376323
REFERENCE   9  (bases 1 to 2159)
  AUTHORS   Volkmann,A., Doffinger,R., Ruther,U. and Kyewski,B.A.
  TITLE     Insertional mutagenesis affecting programmed cell death leads to
            thymic hyperplasia and altered thymopoiesis
  JOURNAL   J Immunol 156 (1), 136-145 (1996)
   PUBMED   8598454
REFERENCE   10 (bases 1 to 2159)
  AUTHORS   van der Hoeven,F., Schimmang,T., Volkmann,A., Mattei,M.G.,
            Kyewski,B. and Ruther,U.
  TITLE     Programmed cell death is affected in the novel mouse mutant Fused
            toes (Ft)
  JOURNAL   Development 120 (9), 2601-2607 (1994)
   PUBMED   7956835
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC034861.1, AK146459.1, AC122441.6 and Z67963.1.
            
            On Oct 10, 2014 this sequence version replaced XM_006530670.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034861.1, AK146459.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                BC034861.1         1-14
            15-1424             AK146459.1         6-1415
            1425-1426           AC122441.6         162094-162095       c
            1427-2079           AK146459.1         1416-2068
            2080-2159           Z67963.1           2094-2173
FEATURES             Location/Qualifiers
     source          1..2159
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 44.25 cM"
     gene            1..2159
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="AKT interacting protein"
                     /db_xref="GeneID:14339"
                     /db_xref="MGI:MGI:3693832"
     exon            1..128
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            129..240
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1077
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="isoform 1 is encoded by transcript variant 3; fused
                     toes protein; thymoma viral proto-oncogene 1 interacting
                     protein"
                     /codon_start=1
                     /product="AKT-interacting protein isoform 1"
                     /protein_id="NP_001289195.1"
                     /db_xref="CCDS:CCDS22519.1"
                     /db_xref="GeneID:14339"
                     /db_xref="MGI:MGI:3693832"
                     /translation="MNPLWSMSAGSVRKRAEGEEKTLAGDVKTSPPRSAPKKQLPSIP
                     KNALPIAKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRS
                     ALVWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLLFDIPVFHPLVDPTSGELDV
                     KRAFAKWRRNHNHIWQVLMYARRVFYKIDTTSPLNPEAAVLYEKDIQLFKSKVVDSVK
                     VCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPDEQHNKSVHVAGLSWVK
                     PGSVQPFSKEEKTVAT"
     exon            241..446
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            447..511
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            512..612
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            613..701
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            702..800
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            801..908
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            909..969
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     exon            970..2149
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1730..1735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="hexamer: AATAAA"
     regulatory      1738..1743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="hexamer: AATAAA"
     polyA_site      1760
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="major polyA site"
     polyA_site      1769
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="major polyA site"
     regulatory      2057..2062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="hexamer: AATAAA"
     polyA_site      2081
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="Aktip"
                     /gene_synonym="AL023020; Fif; Ft; Ft1; Fts"
ORIGIN      
        1 cgctgagggc agggcggggc ggggctctgc gggagaggag cggcaggggc cgggctgcag
       61 gacagccgga gatgctgttg gcccgcggtg gcgctcggcc cccagcgctc cgcaccgagg
      121 gcatccaggc agtgtgaatg ctgaggacag aagagtttga tgacacagcg ctgaagttct
      181 ttgtgtggag cacacgtaat gaaccctttg tggagcatgt ctgcaggctc tgtgcgcaaa
      241 cgagctgaag gtgaagagaa gacattagca ggagatgtga aaaccagtcc tccacgaagt
      301 gcacccaaaa aacagctacc ttctattccc aaaaatgctc tacccatagc gaagcctacg
      361 tctcctgccc cagcagcgca gtcaacaaac ggcacccatg cctcttatgg acccttctac
      421 ctggaatatt cgcttcttgc agaatttact ctggtagtga agcagaagct gccaggagtc
      481 tacgtacagc catcttaccg ctctgcatta gtgtggtttg gagtaatatt catacggcac
      541 gggctgtatc aggatggcgt attcaaattt acggtgtata ttcctgataa ctatcctgat
      601 ggcgactgtc cgcgcttgct gtttgatatt cccgtctttc acccactagt tgatcccacc
      661 tcgggtgagc tggatgtgaa aagagcgttc gcaaagtgga ggcggaacca taaccatata
      721 tggcaggtgt taatgtatgc gaggagagtc ttctacaaga tcgacacgac gagccccctg
      781 aacccagagg ccgcagtgct gtatgaaaaa gacattcaac tttttaaaag taaagtggtc
      841 gacagtgtta aagtgtgtac tgcccgtctt tttgaccagc ccaagataga agacccctac
      901 gccattagct tttctccgtg gaacccttct gtacatgatg aggccagaga aaagatgctg
      961 actcagaaga agcctgatga acagcacaat aaaagtgttc atgttgctgg cctgtcatgg
     1021 gtaaagcctg gctcagtaca acctttcagt aaagaagaga aaacagtagc aacctaagag
     1081 atggtggatc tggtgcaccg tgcactttcc tgctggactc tggcctagtt aaagctgact
     1141 aatggcaaag gactgcctga agagtaaact tcgtgaaccg tgactggcta tcagtgttgt
     1201 gtatgcgtag gttctaacag caggttatgg agacctctca ttaagtagag ttacttctgt
     1261 cggaagtgtc agggtggatc tagttcagta ctccaaatta ttggggacct tgaggcttaa
     1321 gtatttttct gaatatgtta gaggtaagtt gtgtttactt aaactaacag aacagagaga
     1381 ctgtaatgag tacaatgagt accatgtaat agtttggagt tggtagtttc agctgtacat
     1441 atgttaggcc atgaagaagg gtgtagagga cagactccga gtgcagcact ttcaagtaga
     1501 agcctggctt cccagcttca gcctgctgac ttgctgtaaa catctatctc agaagcatta
     1561 ggaacgtagg cagaaccagg atgcttcatc atagggtttt ttttttttaa tttttttttt
     1621 aaggcaaatt actgtatttt tatggcagga agaagaaaaa agtgttcaaa cggtttctga
     1681 tgaagtcagg tatttaaatg gtgaatgact gatgtgttag tggagatgaa ataaaccaat
     1741 aaatgattga ttgtcattta tgcaggaaag taatgctcct tttcaatata actaaacaga
     1801 gactaattta taagtgcttt attgaaaaat acacatattt tcatataaaa ttacagtagc
     1861 ggtactaagg ttttctaagt actctgcaca gcactactct gtggtggggg ggggagtgcc
     1921 aggcttgtag gtcctcagct gggtgctgta gagcagcatg aagttaccta gtaacttggt
     1981 ttatcatgat ccaatttaca attgaatttt ttccttagga ttattaatcc aacttaaaaa
     2041 aacgacaata atgattaata aagatatgcg tagataatca atagctgtta aataattttc
     2101 taatttgtat aaatggtact atgtactaat aaaaacctca cttctccaaa aaaaaaaaa
//
