LOCUS       NM_011785               6789 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus thymoma viral proto-oncogene 3 (Akt3), mRNA.
ACCESSION   NM_011785
VERSION     NM_011785.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6789)
  AUTHORS   Shen,Y., Zhu,W., Li,S., Zhang,Z., Zhang,J., Li,M., Zheng,W.,
            Wang,D., Zhong,Y., Li,M., Zheng,H. and Du,J.
  TITLE     Integrated analyses of 5 mC, 5hmC methylation and gene expression
            reveal pathology-associated AKT3 gene and potential biomarkers for
            Alzheimer's disease
  JOURNAL   J Psychiatr Res 178, 367-377 (2024)
   PUBMED   39197298
  REMARK    GeneRIF: Integrated analyses of 5 mC, 5hmC methylation and gene
            expression reveal pathology-associated AKT3 gene and potential
            biomarkers for Alzheimer's disease.
REFERENCE   2  (bases 1 to 6789)
  AUTHORS   Zhang,L., Altemus,J., Ding,L., Cherepanova,O., Byzova,T.V. and
            Podrez,E.A.
  TITLE     Enhanced Akt3 kinase activity reduces atherosclerosis in
            hyperlipidemic mice in a gender-dependent manner
  JOURNAL   J Biol Chem 299 (12), 105425 (2023)
   PUBMED   37926285
  REMARK    GeneRIF: Enhanced Akt3 kinase activity reduces atherosclerosis in
            hyperlipidemic mice in a gender-dependent manner.
REFERENCE   3  (bases 1 to 6789)
  AUTHORS   Li,P., Hao,X., Liu,J., Zhang,Q., Liang,Z., Li,X. and Liu,H.
  TITLE     miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated mTOR in
            SiO2-Induced Lung Fibrosis
  JOURNAL   Int J Mol Sci 24 (14), 11440 (2023)
   PUBMED   37511199
  REMARK    GeneRIF: miR-29a-3p Regulates Autophagy by Targeting Akt3-Mediated
            mTOR in SiO2-Induced Lung Fibrosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6789)
  AUTHORS   Bertol,J.W., Johnston,S., Ahmed,R., Xie,V.K., Hubka,K.M., Cruz,L.,
            Nitschke,L., Stetsiv,M., Goering,J.P., Nistor,P., Lowell,S.,
            Hoskens,H., Claes,P., Weinberg,S.M., Saadi,I., Farach-Carson,M.C.
            and Fakhouri,W.D.
  TITLE     TWIST1 interacts with beta/delta-catenins during neural tube
            development and regulates fate transition in cranial neural crest
            cells
  JOURNAL   Development 149 (15) (2022)
   PUBMED   35781329
REFERENCE   5  (bases 1 to 6789)
  AUTHORS   Wang,B., Zhang,M., Guo,J., Liu,Z., Zhou,R., Guo,F., Li,K. and Mu,Y.
  TITLE     The Effects of Flavonoid Apigenin on Male Reproductive Health:
            Inhibition of Spermatogonial Proliferation through Downregulation
            of Prmt7/Akt3 Pathway
  JOURNAL   Int J Mol Sci 22 (22), 12209 (2021)
   PUBMED   34830091
  REMARK    GeneRIF: The Effects of Flavonoid Apigenin on Male Reproductive
            Health: Inhibition of Spermatogonial Proliferation through
            Downregulation of Prmt7/Akt3 Pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6789)
  AUTHORS   Brodbeck,D., Hill,M.M. and Hemmings,B.A.
  TITLE     Two splice variants of protein kinase B gamma have different
            regulatory capacity depending on the presence or absence of the
            regulatory phosphorylation site serine 472 in the carboxyl-terminal
            hydrophobic domain
  JOURNAL   J Biol Chem 276 (31), 29550-29558 (2001)
   PUBMED   11387345
REFERENCE   7  (bases 1 to 6789)
  AUTHORS   Di Cunto,F., Imarisio,S., Hirsch,E., Broccoli,V., Bulfone,A.,
            Migheli,A., Atzori,C., Turco,E., Triolo,R., Dotto,G.P., Silengo,L.
            and Altruda,F.
  TITLE     Defective neurogenesis in citron kinase knockout mice by altered
            cytokinesis and massive apoptosis
  JOURNAL   Neuron 28 (1), 115-127 (2000)
   PUBMED   11086988
REFERENCE   8  (bases 1 to 6789)
  AUTHORS   Murthy,S.S., Tosolini,A., Taguchi,T. and Testa,J.R.
  TITLE     Mapping of AKT3, encoding a member of the Akt/protein kinase B
            family, to human and rodent chromosomes by fluorescence in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 38-40 (2000)
   PUBMED   10773662
REFERENCE   9  (bases 1 to 6789)
  AUTHORS   Datta,S.R., Brunet,A. and Greenberg,M.E.
  TITLE     Cellular survival: a play in three Akts
  JOURNAL   Genes Dev 13 (22), 2905-2927 (1999)
   PUBMED   10579998
  REMARK    Review article
REFERENCE   10 (bases 1 to 6789)
  AUTHORS   Brodbeck,D., Cron,P. and Hemmings,B.A.
  TITLE     A human protein kinase Bgamma with regulatory phosphorylation sites
            in the activation loop and in the C-terminal hydrophobic domain
  JOURNAL   J Biol Chem 274 (14), 9133-9136 (1999)
   PUBMED   10092583
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130843.3, CD578931.1, AC163009.2, AK052953.1 and BF455585.1.
            
            On Apr 10, 2018 this sequence version replaced NM_011785.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066861.1, SRR9219381.134313.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC130843.3         102891-102910       c
            21-361              CD578931.1         1-341
            362-475             AC163009.2         15362-15475
            476-607             AC163009.2         21339-21470
            608-673             AC163009.2         38171-38236
            674-742             AC163009.2         39595-39663
            743-865             AC163009.2         51104-51226
            866-994             AC163009.2         58975-59103
            995-1410            AK052953.1         107-522
            1411-6306           AC163009.2         92998-97893
            6307-6789           BF455585.1         1-483               c
FEATURES             Location/Qualifiers
     source          1..6789
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 82.66 cM"
     gene            1..6789
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /note="thymoma viral proto-oncogene 3"
                     /db_xref="GeneID:23797"
                     /db_xref="MGI:MGI:1345147"
     exon            1..92
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1486
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /EC_number="2.7.11.1"
                     /note="RAC-PK-gamma; protein kinase Akt-3; protein kinase
                     B gamma; PKB gamma"
                     /codon_start=1
                     /product="RAC-gamma serine/threonine-protein kinase"
                     /protein_id="NP_035915.3"
                     /db_xref="CCDS:CCDS35799.1"
                     /db_xref="GeneID:23797"
                     /db_xref="MGI:MGI:1345147"
                     /translation="MSDVTIVKEGWVQKRGEYIKNWRPRYFLLKTDGSFIGYKEKPQD
                     VDLPYPLNNFSVAKCQLMKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAI
                     QAVADRLQRQEEERMNCSPTSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFG
                     KVILVREKASGKYYAMKILKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTK
                     DRLCFVMEYVNGGELFFHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLEN
                     LMLDKDGHIKITDFGLCKEGITDAATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGV
                     VMYEMMCGRLPFYNQDHEKLFELILMEDIKFPRTLSSDAKSLLSGLLIKDPNKRLGGG
                     PDDAKEIMRHSFFSGVNWQDVYDKKLVPPFKPQVTSETDTRYFDEEFTAQTITITPPE
                     KYDDDGMDGMDNERRPHFPQFSYSASGRE"
     exon            93..218
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            219..330
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            331..475
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            476..607
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            608..673
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            674..742
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            743..865
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            866..994
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1209
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1297
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1400
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..6774
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1733..1738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /note="hexamer: ATTATA"
     polyA_site      1755
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /note="major polyA site"
     regulatory      4712..4717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /note="hexamer: AATAAA"
     polyA_site      4734
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /note="major polyA site"
     regulatory      6752..6757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /note="hexamer: AATAAA"
     polyA_site      6774
                     /gene="Akt3"
                     /gene_synonym="D930002M15Rik; Nmf350"
                     /note="major polyA site"
ORIGIN      
        1 gcaaagcacc atttctccaa gttggggggc tcagagggga gccatcatga gcgatgttac
       61 cattgtgaaa gaaggttggg ttcagaagag gggagaatat ataaaaaact ggaggccaag
      121 atacttcctt ttgaagacag atggctcatt cataggctat aaggagaaac ctcaagatgt
      181 ggacttacct tatcccctca acaacttctc agtggcaaaa tgtcagttaa tgaaaacaga
      241 acgaccaaag ccaaatacat ttattatcag atgtcttcag tggaccactg ttatagagag
      301 aacatttcat gtagatacac cagaggaaag agaagagtgg acggaagcta tccaagccgt
      361 agccgaccga ttgcagaggc aagaggagga gaggatgaat tgtagcccaa cctcacagat
      421 tgataatata ggagaagaag agatggatgc gtctacaacc catcataaaa gaaagacgat
      481 gaatgatttt gactatttga aactactagg taaaggcact tttgggaaag ttattttggt
      541 tcgagagaag gcaagtggaa aatactatgc tatgaagatt ctgaagaaag aagtcattat
      601 tgcaaaggat gaagtggcac acactcttac tgaaagcaga gtactaaaga acaccagaca
      661 tccattttta acatccttga aatattcctt ccagacaaaa gaccgtttgt gttttgtgat
      721 ggaatatgtt aatggcggag agctgttttt ccatttgtcg agagagcgag tgttctctga
      781 ggaccgcaca cgtttctatg gtgcagaaat tgtctctgct ttggactatc tacattctgg
      841 aaagattgtg taccgtgatc tcaagttgga gaatttgatg ctagataagg atggccatat
      901 aaaaattacg gattttgggc tttgcaaaga agggatcaca gatgcagcta ccatgaagac
      961 attctgtggc acaccagagt acctggcacc agaggtatta gaagataatg actatggccg
     1021 agccgtggac tggtggggct taggtgttgt catgtatgaa atgatgtgtg gaaggttgcc
     1081 tttctacaac caggatcatg agaaactctt tgaattaata ctaatggaag acattaaatt
     1141 cccccgaaca ctctcttcag atgcaaaatc attgctttca gggctcttga taaaggatcc
     1201 aaataaacgc cttggtggag ggccagatga tgcaaaagaa atcatgaggc atagtttttt
     1261 ttctggagta aactggcaag atgtatatga caaaaagctt gtacctcctt ttaagcctca
     1321 agtaacatct gaaacagaca cccgatattt tgatgaagaa tttacagctc agactattac
     1381 aataacacca cctgaaaagt atgacgacga cggcatggac ggcatggaca acgagcggcg
     1441 gccacacttc cctcagttct cctactctgc aagcggacgg gaataagttc ctttcagtct
     1501 gtttctacac tgtcatctta gactttgcct gagactgatt cctggacatc tctaccagtc
     1561 ctcgctctta cagttagcag gggcaccttc tgacatccct gaccagccaa gggtcttcac
     1621 cctcaccacc tttcactcac atgaaaccat atacacagac actccagttt tgtttttgca
     1681 tgaaattgta tctcagtcta aggtctcatg ctgttgctgc tactgtctta ctattatagc
     1741 aaccttcaga agtaatttca caatctttgg gagtcatgag cccattgttc atttgtgcat
     1801 caagtgtcat cttttggttt ttggttttcc ctagcagtga aggctaaatg agatacactg
     1861 attctaggta cattgttaac tttctaggag ataaatcaag aactaattag actaagaaga
     1921 tttagtttat atttctgaac aagcaattgt tgaagggtgg tggtgtgtgt atgtaagagt
     1981 ttagcagtgt atgtctgacc agcacatgaa gtgtgtatca ctgacatttg gctggaaaat
     2041 cttaggaaac attgagagga ctgaagggcc aatgagatac acattttttt tttttaaatc
     2101 ctgctggcta ttgtggagga agcccagtgc cacccatgga tgcccaggtt tcaagggcaa
     2161 atggacattg ttcaaccaag tactgacggt gcagagtccc ctagagagtc ttaggatcta
     2221 ctttgtacca gagagtattt tcccctgggc ttggcaacct ttttcccttc tttatattta
     2281 tcacctctga tggctgaaga atgtagacag tataatgatc ctgctgtcgc caaaatctat
     2341 acaccaaggt gaacaggtgt ttgccttacc agttttggag tttttacttt cagttatagg
     2401 taaattagct ttttctcaga tgttaaaacc ttgaatgtcc tttatggttt tgtttatatt
     2461 acagtagtat ttatttttta gtggtaagaa ttgtgttgtc atgttagcaa gcgcagctcc
     2521 aattcacaga tcattgcctg cgttttcttt tgacccatgt gcaaggaatg tacacaccca
     2581 ttagaatcat gcactttttc tcctatgtta aaaacaatgg taaggctctg ggactgtatc
     2641 tgttggttag aatctggcta gaatctctgg gagaagagat gctgtgattt aaccccttgg
     2701 agctgaaatg agagcatccc caactaccca gtgccaaggg atggatgtga gaggatagtc
     2761 tggcagaaag taatggagaa agctgagacc caaatgatga tgagaaatga actctactcg
     2821 gcaaaatgaa cacatcacaa gtattcacac aataggaagt aaaggataag aagctgatgt
     2881 gtttattctt atcaaggtac attcattact gaatcaagcc atcagggaaa acaacaaaac
     2941 aaaacacctc tagcttttat ttttctgtac atattcatgt ctcccaaccc aaacatttct
     3001 cactgagagg ggacatgtat gcaaacctca tctttctcct tcattaatga tgatcttcag
     3061 attaaccctt tggtgctagg agctgacact ttccaaagca gactatgacg tccaaggatc
     3121 aaagcctctc ttgcagcaag caagagcaac tgctgctcca aggcgtgatc atggaagtgg
     3181 aagaccacag tgtgacacag tggtactgca ttgtcttttt cagtaggaag tcatgttctc
     3241 atgcaagtgt cttggcctct aggctcagac ttagagaagc agagccgctg ctggcagtgg
     3301 ctggccgctg ggactgctgg ggtgtaaagg gcattttcct aaggcagcta agacagactc
     3361 agacatagat ttttgtccta atttttcatg tttctacctg ggtgagttta ccctcagtgg
     3421 gaagtaggaa gttaaacagg tgtattctta catctgctgt cttctgtttt cctacataga
     3481 agtatgttga atgttgcaca ttgacaagga agtagattag atggtaagtc cttttaagtt
     3541 accctgcatc cattctgtaa gaaaggagga ggagaggaag aaaagcaagc tgagcctggc
     3601 cgatgttcag aacatttact ccctcagagg gagcagacac tgtacactaa gcacacagct
     3661 tcttttgttt tgtctctcct tccaagtctt aaggtaattt catgaccttg gccaaggata
     3721 ctttgtgaag attaatgagg ggacattgac aatgcctcag gctggccact cctcacactg
     3781 gcccttggtc cccagccatt caaggggtta ctcatcccat ccctgactac ctgagtgtca
     3841 ctacaggtgg gttcttggct ttgagttcaa gaattctttc cttacaccct ccaccagatg
     3901 tcagtggaaa ggcagaagta gaaccgaggt gtgggaggag attctaaaag cttgtgttgc
     3961 ccaggcctct agcttagggt tctggcaatt gagacggcct gaaacctgac agcatcatgt
     4021 ccgggcagct ctggctttgt gagtccagct cctaccaact ccaccttgac ctcttgtctc
     4081 catgcagggc tgtctgggag gaaactggcc acttctgctc agactgctgc cagcgctctc
     4141 acagctttgc tctctacact aatgacatag attattccag tattgttccc atttcccacc
     4201 tgacctccag cttctcggag ctgacttctt gcaggggcca catgcttctt tccctcacta
     4261 actgcagggt ctccaccaca cctcagtgta cacactttgc tgctaccgtc tgtactgtct
     4321 acatcacggt tcccttagct tgctcctggt agtgcattac aggcaagcat gaaatgtaaa
     4381 gtatttattt aaataaaaag gaaacctctg aattggtcat cgagtcacct ccctgtagat
     4441 ttgtagtctg tgacatattt cgactttcta gtcctgctag atccatataa gatctggtca
     4501 tctggttaag ggtttgaagc agacatagct atgaacccgg atggtatcat cactgtcacg
     4561 gctggccaca ctacagatgt ttatgtcctt acgtttatga cccacagggt gtgaagtaac
     4621 ttccaagaac ctgattttgt acactgtcca ctctcagtat ctcacactct ctgataggga
     4681 cacacattac ttccttcgta cagacagctt aaataaagcc ctatgtcaat ctgctgcttc
     4741 tctgtttgtt gttgttggat atggctctgt aatttcagaa aactaaattt cctccttttc
     4801 tggaaaaatg attatagccc cagctgttat taaccaaccc tgtatgaagg tgtgatagga
     4861 aaagaggtaa atttctcttc cataaaacac atacggggtg tttttacttg accaagatgc
     4921 caatagcatg cttgtacaaa ctgataaagg gctaggtgtg gagtcactgg ccaccagcag
     4981 tagattttaa ggcacatcta ctaggatgcc agataaagag tagattgcag accctaaagg
     5041 tcttaataag aaagggtgtg ggcccagaat cctcaaggaa tgcagctcat cactaatgtc
     5101 ttcctgataa catactgtgc cacacccttc ctggcaaggg tgtctttaac ccttcatgtc
     5161 aatttgactt agacatgagt aattgatggc tagaatgtct ggattacatg gttttggacg
     5221 gggtgtcttt ctgattttta cctcataagc tacaattgta gaacttggct ttgctcttgt
     5281 gagttcaaca gagagaggaa tgacttttgg gaccagttag gcatgcatgt gtatttctca
     5341 cagccaaatt tggggacatt cttacatgtg ctgtcctcaa aatcaactgg ggttggcaga
     5401 tacatgaggc tgaaataaag tgacctctac aactctctaa aggtgctatt tttagaatat
     5461 tgtataattt attcctggta tacataaaac aattgaggac agttaaaacc tgtgacagct
     5521 ttatgtctag cacatttgat gaaacctgaa acttctgact cggaagttgt gctgttctag
     5581 gcttgcacct ttggcatgcc ccagagatga ggatggccca tgtgccatca tgctgccagc
     5641 acaccatggc ctaagctgta tgtttgtgaa gggcaggctg agcatgtgga caccatgcct
     5701 ccactgagag ccctgggctg ccgggcagcc gggcagctgg gctgcgggca gggagaggtg
     5761 aggtctcaca tgcaggcttg cccttagtgt ttcatccctc cctcagacgc catgaccatc
     5821 tcagcatccg ggctttatct ccatctgtct gtttggtttt tgtttttgtt tgttttgtgg
     5881 tactggggta ggaacccagg gcctcacaca tgctgggcaa gtgctctgcc accgagctac
     5941 accccagacc ttccagtgtc catttgtatt cctttgaagc atttgagggc ttgactgtat
     6001 agtagaaata ctattttaga ctaagaatat gatctgtgta cagatatttg atatactgtt
     6061 aagtaaattt tctaatttca catacatttg tttttaggct cctctcaaat actgctattg
     6121 aagacaaaaa tctgacacca tcgagccaaa gatgcctttt tggggggagg ggaggggttt
     6181 gctttgtgtt gttcagagaa tgggaagaaa aatgcagagt gcttcctgag tgcacacagt
     6241 tcgatgggaa atactggatg ctggctaaag gtagacatgg tcatgagcgg gaagaagcag
     6301 tggccggcag gaggaggggt ggtcttcagt ccacgttggc tgacttcaaa catgtgcctt
     6361 tcagtgtgtt ttgtcattgc tacaaaatga aaaggaaacg gaacaactca agtctttagg
     6421 aaggtcattt tattaatcca tgtgtatact ttagagacaa cgtaaatcag tgacttgaag
     6481 ctgttctgag cacacactcc caacgagccc tagccagttg atgctgaagc aagcactccc
     6541 tgtccatagc acagggacag accatggcat gaggaccagc cccccctgca gtccctggtg
     6601 gtgtctccct ggggaggttt cggtgcactg tggcacatta agtacaaatc agatgaatgt
     6661 aaatatctct ttgtaaatca tttatttcac tctgtttcat ccaggtcagc aatcagattg
     6721 tggcatgctg ggtaactgga aaaaaaatga taataaaaag taagtttaaa tagaaaaaaa
     6781 aaaaaaaaa
//
