LOCUS       NM_001110208            4562 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus thymoma viral proto-oncogene 2 (Akt2), transcript
            variant 1, mRNA.
ACCESSION   NM_001110208
VERSION     NM_001110208.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4562)
  AUTHORS   Zerbib,L., Ladraa,S., Fraissenon,A., Bayard,C., Firpion,M.,
            Venot,Q., Protic,S., Hoguin,C., Thomas,A., Fraitag,S., Duong,J.P.,
            Kaltenbach,S., Balducci,E., Lefevre,C., Villarese,P., Asnafi,V.,
            Broissand,C., Goudin,N., Nemazanyy,I., Autret,G., Tavitian,B.,
            Legendre,C., Arzouk,N., Minard-Colin,V., Chopinet,C., Dussiot,M.,
            Adams,D.M., Mirault,T., Guibaud,L., Isenring,P. and Canaud,G.
  TITLE     Targeted therapy for capillary-venous malformations
  JOURNAL   Signal Transduct Target Ther 9 (1), 146 (2024)
   PUBMED   38880808
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4562)
  AUTHORS   Huang,F., Zhao,N., Cai,P., Hou,M., Yang,S., Zheng,B., Ma,Q.,
            Jiang,J., Gai,X., Mao,Y., Wang,L., Hu,Z., Zha,X., Liu,F. and
            Zhang,H.
  TITLE     Active AKT2 stimulation of SREBP1/SCD1-mediated lipid metabolism
            boosts hepatosteatosis and cancer
  JOURNAL   Transl Res 268, 51-62 (2024)
   PUBMED   38244769
  REMARK    GeneRIF: Active AKT2 stimulation of SREBP1/SCD1-mediated lipid
            metabolism boosts hepatosteatosis and cancer.
REFERENCE   3  (bases 1 to 4562)
  AUTHORS   Herve,J., Haurogne,K., Allard,M., Sourice,S., Lindenbaum,P.,
            Bach,J.M. and Lieubeau,B.
  TITLE     Spontaneous Akt2 deficiency in a colony of NOD mice exhibiting
            early diabetes
  JOURNAL   Sci Rep 14 (1), 9100 (2024)
   PUBMED   38643275
  REMARK    GeneRIF: Spontaneous Akt2 deficiency in a colony of NOD mice
            exhibiting early diabetes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4562)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4562)
  AUTHORS   Wang,G., Feng,L., Liu,C., Han,Z. and Chen,X.
  TITLE     MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte Hypertrophy
            by Targeting AKT2
  JOURNAL   Int Heart J 65 (3), 528-536 (2024)
   PUBMED   38825497
  REMARK    GeneRIF: MiR-378 Inhibits Angiotensin II-Induced Cardiomyocyte
            Hypertrophy by Targeting AKT2.
REFERENCE   6  (bases 1 to 4562)
  AUTHORS   Altomare,D.A., Lyons,G.E., Mitsuuchi,Y., Cheng,J.Q. and Testa,J.R.
  TITLE     Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2
            kinase is activated by insulin
  JOURNAL   Oncogene 16 (18), 2407-2411 (1998)
   PUBMED   9620559
REFERENCE   7  (bases 1 to 4562)
  AUTHORS   Altomare,D.A., Kozak,C.A., Sonoda,G. and Testa,J.R.
  TITLE     Chromosome mapping of the mouse Akt2 gene and Akt2 pseudogene
  JOURNAL   Cytogenet Cell Genet 74 (4), 248-251 (1996)
   PUBMED   8976376
REFERENCE   8  (bases 1 to 4562)
  AUTHORS   Altomare,D.A., Guo,K., Cheng,J.Q., Sonoda,G., Walsh,K. and
            Testa,J.R.
  TITLE     Cloning, chromosomal localization and expression analysis of the
            mouse Akt2 oncogene
  JOURNAL   Oncogene 11 (6), 1055-1060 (1995)
   PUBMED   7566964
REFERENCE   9  (bases 1 to 4562)
  AUTHORS   Staal,S.P.
  TITLE     Molecular cloning of the akt oncogene and its human homologues AKT1
            and AKT2: amplification of AKT1 in a primary human gastric
            adenocarcinoma
  JOURNAL   Proc Natl Acad Sci U S A 84 (14), 5034-5037 (1987)
   PUBMED   3037531
REFERENCE   10 (bases 1 to 4562)
  AUTHORS   Iannetti,P., Balducci,L., Assensio,A.M., Battaglia,M.,
            D'Ambrosio,E. and Midulla,M.
  TITLE     [Herpetic meningoencephalitis in infants. Study of 7 cases]
  JOURNAL   Arch Fr Pediatr 35 (10), 1075-1084 (1978)
   PUBMED   219800
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ159088.1, AK158792.1, AK028871.1 and BM899551.1.
            
            On Sep 8, 2016 this sequence version replaced NM_001110208.1.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1-4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.121205.1,
                                           SRR1660817.7755.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 CJ159088.1         1-8
            9-3163              AK158792.1         2-3156
            3164-4517           AK028871.1         2369-3722
            4518-4562           BM899551.1         1-45                c
FEATURES             Location/Qualifiers
     source          1..4562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 15.94 cM"
     gene            1..4562
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /note="thymoma viral proto-oncogene 2"
                     /db_xref="GeneID:11652"
                     /db_xref="MGI:MGI:104874"
     exon            1..328
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            329..459
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            460..588
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            589..700
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            701..854
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            855..986
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1052
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1121
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1244
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1373
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1588
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1676
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1779
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            1780..4544
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4523..4528
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /note="hexamer: AATAAA"
     polyA_site      4540
                     /gene="Akt2"
                     /gene_synonym="2410016A19Rik; PKB; PKBbeta"
                     /note="major polyA site"
ORIGIN      
        1 tgcctcctag ttcctgcgct tgcggtctga tgttttctga ggccattccc ttggtctact
       61 acgtcagttc ctgtttgtgg ctggaaaagg cggtatttcc ggccagcggg tgggaggggg
      121 ctgtgagtgg gggctggggg ctggggggag ggggcggggg ggcccgcgct gcgcgagccg
      181 ttgggcctga ctccgagaag gcgtcgccgc cgccagcact gccgccgttg ctgccgccag
      241 ttcataaata aggagcggga acgagctcag cgtggcgatg ggcgggggta gagcccggcc
      301 ggagaggctg ggcggccgcc ggtgacagac gatactgtat ccgaggagcc tcctgcatgt
      361 cctgctgccc tgagctcact caagctaggt gacagcgtgt gaatgctgcc accatgaatg
      421 aggtatctgt catcaaagaa ggctggctcc acaaacgtgg tgaatacatc aagacctgga
      481 ggccacggta cttccttctg aagagtgatg gatctttcat tgggtataag gagaggcccg
      541 aggcccctga ccagacctta ccccccctga acaatttctc tgtagcagaa tgccagctga
      601 tgaagactga gaggccacga cccaacacct ttgtcatacg ctgcctgcag tggaccacag
      661 tcatcgagag gaccttccat gtagactctc cagatgagag ggaagagtgg atgcgggcta
      721 tccagatggt cgccaacagt ctgaagcagc ggggcccagg tgaggacgcc atggattaca
      781 agtgtggctc ccccagtgac tcttccacat ctgagatgat ggaggtagct gtcaacaagg
      841 cacgggccaa agtgaccatg aatgacttcg attatctcaa actcctcggc aagggcacct
      901 tcggcaaggt cattctggtt cgagagaagg ccactggccg ctattatgcc atgaagatcc
      961 tgcgcaagga ggtcatcatt gcaaaggatg aagtcgccca cacagtcaca gagagccggg
     1021 ttctgcagaa taccaggcac cccttcctta cagccctcaa gtatgccttc cagacccatg
     1081 accgcctatg ctttgtgatg gagtatgcca acgggggtga gctgtttttc cacctctctc
     1141 gggagcgagt cttcacggag gatcgggcgc gcttttatgg agcagagatt gtgtcagctc
     1201 tggagtattt gcactcgaga gatgtggtgt accgtgacat caagctggaa aaccttatgt
     1261 tggacaaaga tggccacatc aagatcactg actttggctt gtgcaaagag ggcatcagtg
     1321 atggagccac catgaaaacc ttctgtggta ccccggagta cttggcgcct gaggtgctag
     1381 aggacaatga ctatgggcga gcagtggact ggtgggggct gggtgtggtc atgtatgaga
     1441 tgatgtgtgg ccgcctgcca ttctacaacc aggaccacga gcgcctcttt gagctcattc
     1501 ttatggagga gatccgcttc ccgcgcacac tcgggccaga ggccaagtcc ctgctggctg
     1561 gactgctgaa gaaggaccca aagcagaggc tcggcggagg tcccagtgat gcgaaggagg
     1621 tcatggagca tagattcttc ctcagcatca actggcagga cgtggtacag aaaaagctcc
     1681 tgccaccctt caaacctcag gtcacttcag aagtggacac aaggtacttt gatgacgagt
     1741 tcaccgccca gtccatcaca atcacacccc cagaccgata tgacagcctg gacccgctgg
     1801 aactggacca gcggacgcac ttcccccagt tctcctactc agccagcatc cgagagtgag
     1861 cagccctctg ccaccacagg acacaagcat ggccgtcatc cactgcctgg gtggcttttt
     1921 aaaaaaaaaa ctttattttg ccttttggtt tgtgttccct tccctgtccc ctcatcccaa
     1981 atccagtttc ttcttcagtc cttgctcaga cttagtggtc ctggcggccc tctcctctgg
     2041 gctcccctct gttccaggtg agcgctgggg accgcccagg gacaggctgt tgggaggatg
     2101 gagagtgagg tcattcctca ccactagcct ccaagagggt gaagtgggga gccatggggt
     2161 cacatggatt tggaggcacg ccagcggagg acacatctag aagttcccct cactcccagc
     2221 acctcagctg ccttccatgc tgtcctctgg gcaatcttat ctgctgccac cccacctggg
     2281 gcacaaaagc agtaatgtcc agggacaggc agaagccttt ggaagctgag gggtctgggt
     2341 ttgcttctat ggagaatgga tcttcaaggg ggatccagga gcaggagctg ccttcctctt
     2401 cctcccaagc tactctcttg attctcaata aagcaggagg aatgttcggg ggcagccctc
     2461 ctgcccacag cccagtgcct taccagggct tccttctagc cagccttgcc tcccgctcgg
     2521 cccctttgga tggctccgtt ctctgcctgg ggcagaggga agccaacctt ggctgttaca
     2581 catctcacac caagacagta ttgggcccct tggacttgac tggggtctga ggggacagag
     2641 atggggatag gtgtctgata cacaatgggg tggagtctgc ctcatctcca gggcacctgt
     2701 tctggagcct taaagtgaat gtttgagtta gagttgtgtc agtgctgtgg gtgcgggtgt
     2761 gcacctgacc tagcagtgag catcccaggc tcctgggatg ctggtgccca cagctgtatg
     2821 cagcacttgt gtgagtgggc tcaggctcag ccccagcctg agtgtttgat cccacggggt
     2881 gcagtgagtg caggcgatgt gcctgctgct ctggccatgt ctctccctcc tcaatagctc
     2941 tgggtttttg gaaatgagtt ctcctggttt tgctctccca ccacaccccc agaataggtg
     3001 gatttcagaa aggcagtagg gtggggtggt tgggatggtt atgggggtca tctgtttttt
     3061 actttgtatg tgtgtatgtt tatctgagag ttttcgccca tccctgctgg cctttcctta
     3121 ctcctcgtat ttgtacggta caagcaataa agacactcat ttcagaccag ggcccagtcc
     3181 acatttcctt agccacccct tctgtcctgg tactggagtg ccagagtagc atgcaccatt
     3241 tattacctgc tctgccttat tctgaggtcc atggagccat ggggatggaa gagatggccg
     3301 tgagaaagtg ggtggtggat cccggctgca gagagcggcg ctgcagagga aaaggtggct
     3361 gggtggtttc tgttgggtag ggatggctcg gacccttaga agctgccaga ttgggggcag
     3421 cagtgctgag cggctctaaa caggaagcac gagcgctgtg gcagcagagg ggtggttcat
     3481 tcacttggcc tctgagccct aaacagcttc tgtgtggaac caggaagcct tagtgtcccc
     3541 aaatgccatc ataaaatctg tgacttaaca gggcttgtga ctcccagcag gaacacccgg
     3601 acatttgatt acagctgcac tggtctagga ctgaacccca tgctgaacct gtgggttgtg
     3661 gggctcactg gggtacttgc tcctttccca tacccaggtg ccaggcacac agggcctggt
     3721 gcagatggat ttgttccagg atttactaga agacggggca ccacaagcat ggcgatctga
     3781 gaactggaaa gcgggctgtg ggaaagcaag gccagtttag acacctgtcc caactgcaga
     3841 gaagactgcg tgcggcccag gttgggtgtc ccgtagctct gataggagaa ggtggagcct
     3901 tgctggggtg ttagagttca ctgtagtctt tcactctagc ctaggaaaaa gaaaaatgct
     3961 ttgcattccc ctgtcacagc acctcagtca ccttgtgtga ctcatctccc agcaggacac
     4021 gttcctgcct acctctggtt ttcagcagct ccgcgaaagg agctcacagt cagctgttcc
     4081 tgtagtgaac acacgtgtct acgctgctta gtgtgaggga caaagttttc ataaaagttt
     4141 tcactggaat cctttacaag gctcacttca aacatttcac aaggttttgt ttctccccaa
     4201 tctgtgtgtt tataagagca tcagggagaa gtgagccccc acaacccagg ctgcagtggc
     4261 atcactgtgc actttgccat gaacccttgg cctgcctttt gtgcatccct cattcttgcc
     4321 agctgcagcc gtgcctgggc tatgcccctt tgccaccata ccttaggaat tttgcagatg
     4381 tcctcagtct gctgggtcct tgaggaaatg agacttgggt atcaggggac tctgtggcct
     4441 tgtggtccca gttgcttcac aaggctgcat gggcgtgtac cttccatcac taagatctgc
     4501 tatcatcagt gctgtaatca aaaataaaaa taaggctcca tcttaaaaaa aaaaaaaaaa
     4561 aa
//
