LOCUS       NM_001409449            2647 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus thymoma viral proto-oncogene 1 (Akt1), transcript
            variant 4, mRNA.
ACCESSION   NM_001409449 XM_006515415
VERSION     NM_001409449.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2647)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2647)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   3  (bases 1 to 2647)
  AUTHORS   Chen,Y., Li,H., Wang,J., Yang,S., Su,Z., Wang,W., Rao,C. and Hou,L.
  TITLE     The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast
            proliferation during early development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39555938
REFERENCE   4  (bases 1 to 2647)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   5  (bases 1 to 2647)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Gu,L.J., Guo,J.N., Sun,S.M.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     Protein phosphatase 4 maintains the survival of primordial
            follicles by regulating autophagy in oocytes
  JOURNAL   Cell Death Dis 15 (9), 658 (2024)
   PUBMED   39245708
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2647)
  AUTHORS   Altomare,D.A., Lyons,G.E., Mitsuuchi,Y., Cheng,J.Q. and Testa,J.R.
  TITLE     Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2
            kinase is activated by insulin
  JOURNAL   Oncogene 16 (18), 2407-2411 (1998)
   PUBMED   9620559
REFERENCE   7  (bases 1 to 2647)
  AUTHORS   Cong,L.N., Chen,H., Li,Y., Zhou,L., McGibbon,M.A., Taylor,S.I. and
            Quon,M.J.
  TITLE     Physiological role of Akt in insulin-stimulated translocation of
            GLUT4 in transfected rat adipose cells
  JOURNAL   Mol Endocrinol 11 (13), 1881-1890 (1997)
   PUBMED   9415393
REFERENCE   8  (bases 1 to 2647)
  AUTHORS   Wada,H., Matsuo,M., Uenaka,A., Shimbara,N., Shimizu,K. and
            Nakayama,E.
  TITLE     Rejection antigen peptides on BALB/c RL male 1 leukemia recognized
            by cytotoxic T lymphocytes: derivation from the normally
            untranslated 5' region of the c-akt proto-oncogene activated by
            long terminal repeat
  JOURNAL   Cancer Res 55 (21), 4780-4783 (1995)
   PUBMED   7585504
REFERENCE   9  (bases 1 to 2647)
  AUTHORS   Bellacosa,A., Franke,T.F., Gonzalez-Portal,M.E., Datta,K.,
            Taguchi,T., Gardner,J., Cheng,J.Q., Testa,J.R. and Tsichlis,P.N.
  TITLE     Structure, expression and chromosomal mapping of c-akt:
            relationship to v-akt and its implications
  JOURNAL   Oncogene 8 (3), 745-754 (1993)
   PUBMED   8437858
REFERENCE   10 (bases 1 to 2647)
  AUTHORS   Cho,M., Villani,V. and D'Eustachio,P.
  TITLE     A linkage map of distal mouse chromosome 12
  JOURNAL   Mamm Genome 1 (1), 30-36 (1991)
   PUBMED   1794043
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124373.4.
            
            On Jul 18, 2022 this sequence version replaced XM_006515415.2.
            
            Summary: This gene encodes the founding member of the Akt
            serine-threonine protein kinase gene family that also includes Akt2
            and Akt3. This kinase is a major downstream effector of the
            phosphatidylinositol 3-kinase (PI3K) pathway that mediates the
            effects of various growth factors such as platelet-derived growth
            factor (PDGF), epidermal growth factor (EGF), insulin and
            insulin-like growth factor I (IGF-I). It is activated through
            recruitment to cellular membranes by PI3K lipid products and by
            phosphorylation by 3-phosphoinositide dependent kinase-1. It then
            further phosphorylates different downstream proteins in response to
            various extracellular signals and thus plays a pivotal role in
            mediating a variety of cellular processes, such as glucose
            metabolism, glycogen biosynthesis, protein synthesis and turn over,
            inflammatory response, cell survival (anti-apoptosis) and
            development. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.304193.1,
                                           SRR7345562.4704045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-239               AC124373.4         141324-141562       c
            240-378             AC124373.4         139134-139272       c
            379-507             AC124373.4         129798-129926       c
            508-619             AC124373.4         127168-127279       c
            620-767             AC124373.4         126747-126894       c
            768-899             AC124373.4         126164-126295       c
            900-965             AC124373.4         126016-126081       c
            966-1034            AC124373.4         125285-125353       c
            1035-1160           AC124373.4         124886-125011       c
            1161-1289           AC124373.4         124686-124814       c
            1290-1504           AC124373.4         124395-124609       c
            1505-1592           AC124373.4         124120-124207       c
            1593-1695           AC124373.4         122745-122847       c
            1696-2647           AC124373.4         121444-122395       c
FEATURES             Location/Qualifiers
     source          1..2647
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.2 cM"
     gene            1..2647
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /note="thymoma viral proto-oncogene 1"
                     /db_xref="GeneID:11651"
                     /db_xref="MGI:MGI:87986"
     exon            1..239
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            240..378
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     CDS             333..1775
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /EC_number="2.7.11.1"
                     /note="isoform 1 is encoded by transcript variant 4;
                     protein kinase B-alpha; RAC-alpha serine/threonine-protein
                     kinase; PKB alpha; Akt1m protein; related to A and C
                     kinases; AKT1 kinase; RAC-PK-alpha; proto-oncogene c-AKT;
                     tumor rejection antigen peptide pRLib"
                     /codon_start=1
                     /product="RAC-alpha serine/threonine-protein kinase
                     isoform 1"
                     /protein_id="NP_001396378.1"
                     /db_xref="GeneID:11651"
                     /db_xref="MGI:MGI:87986"
                     /translation="MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQD
                     VDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATA
                     IQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGT
                     FGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQ
                     THDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLK
                     LENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWG
                     LGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRL
                     GGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITIT
                     PPDQDDSMECVDSERRPHFPQFSYSASGTA"
     exon            379..507
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            508..619
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            620..767
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            768..899
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            900..965
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1034
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1160
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1289
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1504
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1592
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1695
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..2647
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2629..2634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /note="hexamer: AATAAA"
     polyA_site      2647
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgccgc gcctcggagt aggagcagga agtggccgag cggaggcctg ggcggggagc
       61 gcgcggggcc gggctggtcg cgcaggaggc ccacgccggc gagggtgcgg gcggccgctg
      121 cgtgaccttg ggtggccgct ccacggggcc aggtcgcggg agaggggcgc tgttggtgtg
      181 cgcagtgggg gccggtgcgc cctggggcct ggggctgccc gggcactcgg ccagcgagga
      241 cgctgcggcc aggccggctg ggctcagcct accgagaaga gactctgagc atcatccctg
      301 ggttacccct gtctctgggg gccacggata ccatgaacga cgtagccatt gtgaaggagg
      361 gctggctgca caaacgaggg gaatatatta aaacctggcg gccacgctac ttcctcctca
      421 agaacgatgg cacctttatt ggctacaagg aacggcctca ggatgtggat cagcgagagt
      481 ccccactcaa caacttctca gtggcacaat gccagctgat gaagacagag cggccaaggc
      541 ccaacacctt tatcatccgc tgcctgcagt ggaccacagt cattgagcgc accttccatg
      601 tggaaacgcc tgaggagcgg gaagaatggg ccaccgccat tcagactgtg gcagatggac
      661 tcaagaggca ggaagaagag acgatggact tccgatcagg ctcacccagt gacaactcag
      721 gggctgaaga gatggaggtg tccctggcca agcccaagca ccgtgtgacc atgaacgagt
      781 ttgagtacct gaagctactg ggcaagggca cctttgggaa ggtgattctg gtgaaagaga
      841 aggccacagg ccgctactat gccatgaaga tcctcaagaa ggaggtcatc gtcgccaagg
      901 atgaggttgc ccacacgctt actgagaacc gtgtcctgca gaactctagg catcccttcc
      961 ttacggccct caagtactca ttccagaccc acgaccgcct ctgctttgtc atggagtatg
     1021 ccaacggggg cgagctcttc ttccacctgt ctcgagagcg tgtgttctcc gaggaccggg
     1081 cccgcttcta tggtgcggag attgtgtctg ccctggacta cttgcactcc gagaagaacg
     1141 tggtgtaccg ggacctgaag ctggagaacc tcatgctgga caaggacggg cacatcaaga
     1201 taacggactt cgggctgtgc aaggagggga tcaaggacgg tgccactatg aagacattct
     1261 gcggaacgcc ggagtacctg gcccctgagg tgctggagga caacgactac ggccgtgcag
     1321 tggactggtg ggggctgggc gtggtcatgt acgagatgat gtgtggccgc ctgcccttct
     1381 acaaccagga ccacgagaag ctgttcgagc tgatcctcat ggaggagatc cgcttcccgc
     1441 gcacactcgg ccctgaggcc aagtccctgc tctccgggct gctcaagaag gaccctacac
     1501 agaggctcgg tgggggctcc gaggatgcca aggagatcat gcagcaccgg ttctttgcca
     1561 acatcgtgtg gcaggatgtg tatgagaaga agctgagccc acctttcaag ccccaggtca
     1621 cctctgagac tgacaccagg tatttcgatg aggagttcac agctcagatg atcaccatca
     1681 cgccgcctga tcaagatgac agcatggagt gtgtggacag tgagcggagg ccgcacttcc
     1741 cccagttctc ctactcagcc agtggcacag cctgaggcct ggggcagcgg ctggcagctc
     1801 cacgctcctc tgcattgccg agtccagaag ccccgcatgg atcatctgaa cctgatgttt
     1861 tgtttctcgg atgcgctggg gaggaacctt gccagcctcc aggaccaggg gaggatgttt
     1921 ctactgtggg cagcagccta cctcccagcc aggtcaggag gaaaactatc ctggggtttt
     1981 tcttaattta tttcatccag tttgagacca cacatgtggc ctcagtgccc agaacaatta
     2041 gattcatgta gaaaactatt aaggactgac gcgaccatgt gcaatgtggg ctcatgggtc
     2101 tgggtgggtc ccgtcactgc ccccattggc ctgtccaccc tggccgccac ctgtctctag
     2161 ggtccagggc caaagtccag caagaaggca ccagaagcac ccccctgtgg tatgctaact
     2221 ggccctctcc ctctgggcgg ggagaggtca cagctgcttc agccctaggg ctggatggga
     2281 tggccagggc tcaagtgagg ttgacagagg aacaagaatc cagtttgttg ctgtgtccca
     2341 tgctgttcag agacatttag gggattttaa tcttggtgac aggagagccc ctgccctccc
     2401 gcacccgctc ccgcgtggtg gctcttagcg ggtaccctgg gagcgcctgc ctcacgtgag
     2461 cccttctcct agcacttgtc cttttagatg ctttccctct cccgctgtcc gtcaccctgg
     2521 cctgtcccct cccggccaga cgctggccat tgctgcacca tgtcgttttt tacaacattc
     2581 agcttcagca tttttactat tataataaga aactgtccct ccaaattcaa taaaaattgc
     2641 ttttcaa
//
