LOCUS       NM_001165894            2606 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus thymoma viral proto-oncogene 1 (Akt1), transcript
            variant 2, mRNA.
ACCESSION   NM_001165894
VERSION     NM_001165894.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2606)
  AUTHORS   Shen,C.L., Tsai,Y.Y., Chou,S.J., Chang,Y.M. and Tarn,W.Y.
  TITLE     RBM4-mediated intron excision of Hsf1 induces BDNF for cerebellar
            foliation
  JOURNAL   Commun Biol 7 (1), 1712 (2024)
   PUBMED   39738787
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2606)
  AUTHORS   Basu,S., Mautner,L., Whiting,K., Hasenpusch-Theil,K., Borkowska,M.
            and Theil,T.
  TITLE     Identification of Pappa and Sall3 as Gli3 direct target genes
            acting downstream of cilia signaling in corticogenesis
  JOURNAL   Cereb Cortex 34 (12) (2024)
   PUBMED   39716738
REFERENCE   3  (bases 1 to 2606)
  AUTHORS   Chen,Y., Li,H., Wang,J., Yang,S., Su,Z., Wang,W., Rao,C. and Hou,L.
  TITLE     The Ednrb-Aim2-AKT axis regulates neural crest-derived melanoblast
            proliferation during early development
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39555938
REFERENCE   4  (bases 1 to 2606)
  AUTHORS   Dinesh,N.E.H., Baratang,N., Rosseau,J., Mohapatra,R., Li,L.,
            Mahalingam,R., Tiedemann,K., Campeau,P.M. and Reinhardt,D.P.
  TITLE     Fibronectin isoforms promote postnatal skeletal development
  JOURNAL   Matrix Biol 133, 86-102 (2024)
   PUBMED   39159790
REFERENCE   5  (bases 1 to 2606)
  AUTHORS   Dong,M.Z., Ouyang,Y.C., Gao,S.C., Gu,L.J., Guo,J.N., Sun,S.M.,
            Wang,Z.B. and Sun,Q.Y.
  TITLE     Protein phosphatase 4 maintains the survival of primordial
            follicles by regulating autophagy in oocytes
  JOURNAL   Cell Death Dis 15 (9), 658 (2024)
   PUBMED   39245708
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2606)
  AUTHORS   Altomare,D.A., Lyons,G.E., Mitsuuchi,Y., Cheng,J.Q. and Testa,J.R.
  TITLE     Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2
            kinase is activated by insulin
  JOURNAL   Oncogene 16 (18), 2407-2411 (1998)
   PUBMED   9620559
REFERENCE   7  (bases 1 to 2606)
  AUTHORS   Cong,L.N., Chen,H., Li,Y., Zhou,L., McGibbon,M.A., Taylor,S.I. and
            Quon,M.J.
  TITLE     Physiological role of Akt in insulin-stimulated translocation of
            GLUT4 in transfected rat adipose cells
  JOURNAL   Mol Endocrinol 11 (13), 1881-1890 (1997)
   PUBMED   9415393
REFERENCE   8  (bases 1 to 2606)
  AUTHORS   Wada,H., Matsuo,M., Uenaka,A., Shimbara,N., Shimizu,K. and
            Nakayama,E.
  TITLE     Rejection antigen peptides on BALB/c RL male 1 leukemia recognized
            by cytotoxic T lymphocytes: derivation from the normally
            untranslated 5' region of the c-akt proto-oncogene activated by
            long terminal repeat
  JOURNAL   Cancer Res 55 (21), 4780-4783 (1995)
   PUBMED   7585504
REFERENCE   9  (bases 1 to 2606)
  AUTHORS   Bellacosa,A., Franke,T.F., Gonzalez-Portal,M.E., Datta,K.,
            Taguchi,T., Gardner,J., Cheng,J.Q., Testa,J.R. and Tsichlis,P.N.
  TITLE     Structure, expression and chromosomal mapping of c-akt:
            relationship to v-akt and its implications
  JOURNAL   Oncogene 8 (3), 745-754 (1993)
   PUBMED   8437858
REFERENCE   10 (bases 1 to 2606)
  AUTHORS   Cho,M., Villani,V. and D'Eustachio,P.
  TITLE     A linkage map of distal mouse chromosome 12
  JOURNAL   Mamm Genome 1 (1), 30-36 (1991)
   PUBMED   1794043
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC066018.1.
            
            On Jul 18, 2022 this sequence version replaced NM_001165894.1.
            
            Summary: This gene encodes the founding member of the Akt
            serine-threonine protein kinase gene family that also includes Akt2
            and Akt3. This kinase is a major downstream effector of the
            phosphatidylinositol 3-kinase (PI3K) pathway that mediates the
            effects of various growth factors such as platelet-derived growth
            factor (PDGF), epidermal growth factor (EGF), insulin and
            insulin-like growth factor I (IGF-I). It is activated through
            recruitment to cellular membranes by PI3K lipid products and by
            phosphorylation by 3-phosphoinositide dependent kinase-1. It then
            further phosphorylates different downstream proteins in response to
            various extracellular signals and thus plays a pivotal role in
            mediating a variety of cellular processes, such as glucose
            metabolism, glycogen biosynthesis, protein synthesis and turn over,
            inflammatory response, cell survival (anti-apoptosis) and
            development. Alternatively spliced transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Sep 2009].
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the 3' coding region, which results in a frameshift, compared to
            variant 1. The resulting isoform (2) has a shorter and distinct
            C-terminus, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1605301.1, AK040758.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1704              BC066018.1         30-1733
            1705-2606           BC066018.1         1784-2685
FEATURES             Location/Qualifiers
     source          1..2606
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 61.2 cM"
     gene            1..2606
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /note="thymoma viral proto-oncogene 1"
                     /db_xref="GeneID:11651"
                     /db_xref="MGI:MGI:87986"
     exon            1..248
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            249..387
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            388..516
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            517..628
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            629..776
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            777..908
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            909..974
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1043
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1169
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..1298
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1513
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1514..1601
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1704
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..2606
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2588..2593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /note="hexamer: AATAAA"
     polyA_site      2606
                     /gene="Akt1"
                     /gene_synonym="Akt; LTR-akt; PKB; PKB/Akt; PKBalpha; Rac"
                     /note="major polyA site"
ORIGIN      
        1 ggcggcggca gcaccgagtc ggcgggcggc cggcccagcg cggcagcgca cgcgagtccg
       61 ggaccagcgg agcggaccga gcagcgtcct gtggccggca ccgcggcggc ccagatccgg
      121 ccagcagcgc gcgcccggac gccgctgcct tcagccggcc ccgcccagcg cccgcccgcg
      181 ggatgcggag cggcgggcgc ccgaggccgc ggcccggcta ggcccagtcg cccgcacgcg
      241 gcggcccgac gctgcggcca ggccggctgg gctcagccta ccgagaagag actctgagca
      301 tcatccctgg gttacccctg tctctggggg ccacggatac catgaacgac gtagccattg
      361 tgaaggaggg ctggctgcac aaacgagggg aatatattaa aacctggcgg ccacgctact
      421 tcctcctcaa gaacgatggc acctttattg gctacaagga acggcctcag gatgtggatc
      481 agcgagagtc cccactcaac aacttctcag tggcacaatg ccagctgatg aagacagagc
      541 ggccaaggcc caacaccttt atcatccgct gcctgcagtg gaccacagtc attgagcgca
      601 ccttccatgt ggaaacgcct gaggagcggg aagaatgggc caccgccatt cagactgtgg
      661 cagatggact caagaggcag gaagaagaga cgatggactt ccgatcaggc tcacccagtg
      721 acaactcagg ggctgaagag atggaggtgt ccctggccaa gcccaagcac cgtgtgacca
      781 tgaacgagtt tgagtacctg aagctactgg gcaagggcac ctttgggaag gtgattctgg
      841 tgaaagagaa ggccacaggc cgctactatg ccatgaagat cctcaagaag gaggtcatcg
      901 tcgccaagga tgaggttgcc cacacgctta ctgagaaccg tgtcctgcag aactctaggc
      961 atcccttcct tacggccctc aagtactcat tccagaccca cgaccgcctc tgctttgtca
     1021 tggagtatgc caacgggggc gagctcttct tccacctgtc tcgagagcgt gtgttctccg
     1081 aggaccgggc ccgcttctat ggtgcggaga ttgtgtctgc cctggactac ttgcactccg
     1141 agaagaacgt ggtgtaccgg gacctgaagc tggagaacct catgctggac aaggacgggc
     1201 acatcaagat aacggacttc gggctgtgca aggaggggat caaggacggt gccactatga
     1261 agacattctg cggaacgccg gagtacctgg cccctgaggt gctggaggac aacgactacg
     1321 gccgtgcagt ggactggtgg gggctgggcg tggtcatgta cgagatgatg tgtggccgcc
     1381 tgcccttcta caaccaggac cacgagaagc tgttcgagct gatcctcatg gaggagatcc
     1441 gcttcccgcg cacactcggc cctgaggcca agtccctgct ctccgggctg ctcaagaagg
     1501 accctacaca gaggctcggt gggggctccg aggatgccaa ggagatcatg cagcaccggt
     1561 tctttgccaa catcgtgtgg caggatgtgt atgagaagaa gctgagccca cctttcaagc
     1621 cccaggtcac ctctgagact gacaccaggt atttcgatga ggagttcaca gctcagatga
     1681 tcaccatcac gccgcctgat caagttctcc tactcagcca gtggcacagc ctgaggcctg
     1741 gggcagcggc tggcagctcc acgctcctct gcattgccga gtccagaagc cccgcatgga
     1801 tcatctgaac ctgatgtttt gtttctcgga tgcgctgggg aggaaccttg ccagcctcca
     1861 ggaccagggg aggatgtttc tactgtgggc agcagcctac ctcccagcca ggtcaggagg
     1921 aaaactatcc tggggttttt cttaatttat ttcatccagt ttgagaccac acatgtggcc
     1981 tcagtgccca gaacaattag attcatgtag aaaactatta aggactgacg cgaccatgtg
     2041 caatgtgggc tcatgggtct gggtgggtcc cgtcactgcc cccattggcc tgtccaccct
     2101 ggccgccacc tgtctctagg gtccagggcc aaagtccagc aagaaggcac cagaagcacc
     2161 cccctgtggt atgctaactg gccctctccc tctgggcggg gagaggtcac agctgcttca
     2221 gccctagggc tggatgggat ggccagggct caagtgaggt tgacagagga acaagaatcc
     2281 agtttgttgc tgtgtcccat gctgttcaga gacatttagg ggattttaat cttggtgaca
     2341 ggagagcccc tgccctcccg cacccgctcc cgcgtggtgg ctcttagcgg gtaccctggg
     2401 agcgcctgcc tcacgtgagc ccttctccta gcacttgtcc ttttagatgc tttccctctc
     2461 ccgctgtccg tcaccctggc ctgtcccctc ccggccagac gctggccatt gctgcaccat
     2521 gtcgtttttt acaacattca gcttcagcat ttttactatt ataataagaa actgtccctc
     2581 caaattcaat aaaaattgct tttcaa
//
