LOCUS       NM_025337               1648 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus aldo-keto reductase family 7, member A5 (Akr7a5),
            mRNA.
ACCESSION   NM_025337
VERSION     NM_025337.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1648)
  AUTHORS   Shi,H., Xu,W., Liu,Q., Li,Y., Dong,S. and Zhao,Z.
  TITLE     AKR7A5 knockout promote acute liver injury by inducing inflammatory
            response, oxidative stress and apoptosis in mice
  JOURNAL   J Cell Mol Med 28 (19), e70129 (2024)
   PUBMED   39365156
  REMARK    GeneRIF: AKR7A5 knockout promote acute liver injury by inducing
            inflammatory response, oxidative stress and apoptosis in mice.
REFERENCE   2  (bases 1 to 1648)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1648)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1648)
  AUTHORS   Li,D. and Ellis,E.M.
  TITLE     Aldo-keto reductase 7A5 (AKR7A5) attenuates oxidative stress and
            reactive aldehyde toxicity in V79-4 cells
  JOURNAL   Toxicol In Vitro 28 (4), 707-714 (2014)
   PUBMED   24590062
  REMARK    GeneRIF: These findings indicate the importance of AKR7A5 in
            protecting cells from the damaging effects of oxidative stress, and
            that this cytoprotective function is carried out through multiple
            pathways.
REFERENCE   5  (bases 1 to 1648)
  AUTHORS   Li,D., Liu,Y.R., Zhang,Q.S. and Chu,Y.
  TITLE     [Purification of recombinant AKR7A5 protein and measurement of
            substrate specificity of AKR7A5 towards naphthoquinone and its
            derivatives]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 28 (8), 825-827 (2012)
   PUBMED   22863590
  REMARK    GeneRIF: AKR7A5 has selective substrate specificity towards
            naphthoquinone derivatives, suggesting that the aldo-keto reductase
            could play an important role in metabolism of certain
            naphthoquinone derivatives.
REFERENCE   6  (bases 1 to 1648)
  AUTHORS   Kelly,V.P., Sherratt,P.J., Crouch,D.H. and Hayes,J.D.
  TITLE     Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate
            synthases that associate with the Golgi apparatus define a distinct
            subclass of aldo-keto reductase 7 family proteins
  JOURNAL   Biochem J 366 (Pt 3), 847-861 (2002)
   PUBMED   12071861
REFERENCE   7  (bases 1 to 1648)
  AUTHORS   Hinshelwood,A., McGarvie,G. and Ellis,E.
  TITLE     Characterisation of a novel mouse liver aldo-keto reductase AKR7A5
  JOURNAL   FEBS Lett 523 (1-3), 213-218 (2002)
   PUBMED   12123834
REFERENCE   8  (bases 1 to 1648)
  AUTHORS   Liu,Z. and Huang,C.H.
  TITLE     The mouse Rhl1 and Rhag genes: sequence, organization, expression,
            and chromosomal mapping
  JOURNAL   Biochem Genet 37 (3-4), 119-138 (1999)
   PUBMED   10495887
REFERENCE   9  (bases 1 to 1648)
  AUTHORS   Peters,L.L., Weier,H.U., Walensky,L.D., Snyder,S.H., Parra,M.,
            Mohandas,N. and Conboy,J.G.
  TITLE     Four paralogous protein 4.1 genes map to distinct chromosomes in
            mouse and human
  JOURNAL   Genomics 54 (2), 348-350 (1998)
   PUBMED   9828140
REFERENCE   10 (bases 1 to 1648)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BE652423.1 and AK143203.1.
            
            On Jun 18, 2009 this sequence version replaced NM_025337.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143203.1, AK002664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                BE652423.1         1-61
            62-1648             AK143203.1         61-1647
FEATURES             Location/Qualifiers
     source          1..1648
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 70.64 cM"
     gene            1..1648
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /note="aldo-keto reductase family 7, member A5"
                     /db_xref="GeneID:110198"
                     /db_xref="MGI:MGI:107796"
     exon            1..333
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1115
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /EC_number="1.1.1.n11"
                     /note="SSA reductase; succinic semialdehyde reductase;
                     aldo-keto reductase family 7, member A5 (aflatoxin
                     aldehyde reductase)"
                     /codon_start=1
                     /product="aflatoxin B1 aldehyde reductase member 2"
                     /protein_id="NP_079613.3"
                     /db_xref="CCDS:CCDS18844.1"
                     /db_xref="GeneID:110198"
                     /db_xref="MGI:MGI:107796"
                     /translation="MLRAASRAVGRAAVRSAQRSGTSVGRPLAMSRPPPPRAASGAPL
                     RPATVLGTMEMGRRMDASASAASVRAFLERGHSELDTAFMYCDGQSENILGGLGLGLG
                     SGDCTVKIATKANPWEGKSLKPDSIRSQLETSLKRLQCPRVDLFYLHAPDHSTPVEET
                     LRACHQLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVEAE
                     LLPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNNWAETYRNRFWKEH
                     HFEAIALVEKALQTTYGTNAPRMTSAALRWMYHHSQLQGTRGDAVILGMSSLEQLEQN
                     LAATEEGPLEPAVVEAFDQAWNMVAHECPNYFR"
     exon            334..521
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..626
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..723
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..823
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /inference="alignment:Splign:2.1.0"
     exon            824..953
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1648
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1244..1249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /note="hexamer: AATAAA"
     polyA_site      1288
                     /gene="Akr7a5"
                     /gene_synonym="0610025K21Rik; Afar; Afar1; Akr7a2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcagtctc catgctgcgt gcagcgtcca gagccgtggg ccgcgctgct gttcgctccg
       61 cgcagcgctc cgggacttcg gtcgggcgtc ctctcgccat gtcccggcct ccgccacccc
      121 gcgccgcctc tggcgcccct ctccggcccg ctacggtgct gggcaccatg gagatggggc
      181 gtcgcatgga tgcgagtgct agcgccgctt cggtccgcgc cttcctggag cgcggccaca
      241 gcgagctgga cacggccttc atgtactgcg acggccagtc cgagaacatc ctgggcggcc
      301 tggggctcgg gctgggcagc ggcgactgca cagtgaaaat cgccaccaag gccaacccct
      361 gggaagggaa gtcactgaag cctgacagca tccggtccca gttagagacg tctctgaagc
      421 ggctgcagtg tccccgggtg gatctcttct acttacacgc tcccgaccac agcactcctg
      481 tggaggagac acttcgtgcc tgccaccagc tgcatcagga gggcaagttt gtggagcttg
      541 gtctgtctaa ctatgcctcc tgggaagtgg ctgagatctg taccctctgc aagagcaacg
      601 gctggatcct gccaactgtg taccagggca tgtacaacgc caccacccgg caggtggagg
      661 ccgagctcct cccctgcctc agacacttcg gactgaggtt ctacgcctac aaccctttgg
      721 ctgggggcct gctgactggc aagtataaat acgaagacaa ggatgggaaa caacccgtgg
      781 gccgcttctt tgggaataac tgggctgaga cctacaggaa ccgcttctgg aaggaacacc
      841 actttgaggc catcgccctg gtagaaaagg ccctgcagac cacctatggc accaacgccc
      901 cccgcatgac ctcggccgcc ctgcgctgga tgtaccacca ctcgcagctc cagggcaccc
      961 gaggggacgc agtcatcttg ggcatgtcca gtctggagca gctggagcag aacttggccg
     1021 ccactgagga agggcccctg gagccggctg tcgtggaagc ctttgaccaa gcctggaaca
     1081 tggtcgccca cgagtgtccc aactacttca gatagactgt tgtggctcaa gatcccaggg
     1141 gctcttctgc caccccatgg aggaggagtt acgcctggcc actccttgcc cagtgctgac
     1201 ctagtgtgtg cttttcggct ggtctccacc tgtttcctgt ctgaataaag caggtgtctg
     1261 acctggctgc agccagaact gaacctcaga ccgtctcctc tgctgcccaa cacctgctcc
     1321 ctccaccctg cctggggacc atgagaaagg gtgaaaccag gagttaggct tcagagagca
     1381 cagataggga gagtctcacg ctgcctccaa ggtctcctca ctgtcaccct cgcttttcta
     1441 ctcgtgacag aaccaggtgg gtgtgggtac gcacacctgc taattccagc cctcggagga
     1501 ttacaccacg tgcgaggtca acactgatct atgtagtgag tttcaggcca gccagggata
     1561 cgtaatgaga cctctcagaa acaaacgaaa atttaaaagg cacgtgcttt gaagaaacgg
     1621 aacaattaaa gtcaccatga gagttgtc
//
