LOCUS       NM_018859               1729 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member E1 (Akr1e1),
            mRNA.
ACCESSION   NM_018859
VERSION     NM_018859.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Sakuma,M. and Kubota,S.
  TITLE     Mouse AKR1E1 is an ortholog of pig liver NADPH dependent
            1,5-anhydro-D-fructose reductase
  JOURNAL   Biosci Biotechnol Biochem 72 (3), 872-876 (2008)
   PUBMED   18323634
  REMARK    GeneRIF: confirmed that cloned AKR1E1 is mouse ortholog of pig
            liver 1,5-anhydro-D-fructose reductase based on enzymatic
            properties of purified recombinant protein.
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Vergnes,L., Phan,J., Stolz,A. and Reue,K.
  TITLE     A cluster of eight hydroxysteroid dehydrogenase genes belonging to
            the aldo-keto reductase supergene family on mouse chromosome 13
  JOURNAL   J Lipid Res 44 (3), 503-511 (2003)
   PUBMED   12562828
REFERENCE   4  (bases 1 to 1729)
  AUTHORS   Bohren,K.M., Barski,O.A. and Gabbay,K.H.
  TITLE     Characterization of a novel murine aldo-keto reductase
  JOURNAL   Adv Exp Med Biol 414, 455-464 (1997)
   PUBMED   9059651
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI893997.1, AK002507.1 and BQ174229.1.
            
            On Apr 25, 2006 this sequence version replaced NM_018859.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.214976.1, U68535.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-439               AI893997.1         1-439
            440-1160            AK002507.1         415-1135
            1161-1729           BQ174229.1         1-569               c
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.57 cM"
     gene            1..1729
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /note="aldo-keto reductase family 1, member E1"
                     /db_xref="GeneID:56043"
                     /db_xref="MGI:MGI:1914758"
     exon            1..80
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..947
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /EC_number="1.1.1.263"
                     /note="AF reductase; aldo-keto reductase family 1 member
                     E2; aldo-keto reductase family 1 member C-like protein 2"
                     /codon_start=1
                     /product="1,5-anhydro-D-fructose reductase"
                     /protein_id="NP_061347.2"
                     /db_xref="CCDS:CCDS26226.1"
                     /db_xref="GeneID:56043"
                     /db_xref="MGI:MGI:1914758"
                     /translation="MENIPTVGLGTWKASPGEVTDAVKLAINLGYRHFDCAYLYHNES
                     EVGMGISEKIKEGVVKREDLFVVSKLWCTCHKKSLVKTACTNTLEALNLDYLDLYLIH
                     WPMGFKPGEKDIPLDRNGKVIPSHTSFLDTWEAMEDLVFEGLVKNLGVSNFNHEQLER
                     LLDKPGLRVRPITNQIECHPYLNQKKLIDFCHKRNVSVTAYRPLGGSGGGFHLMDDTV
                     IRKIAKKHGKSPAQILIRFQIQRNLIVIPKSVTPSRIRENIQVFDFELTEKDMEELLS
                     LDKNLRLATFPTTENHQDYPFHIEY"
     exon            81..248
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            249..365
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..443
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            444..566
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            567..664
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            665..737
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..821
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            822..904
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1713
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1285..1290
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /note="hexamer: ATTAAA"
     polyA_site      1313
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /note="major polyA site"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /note="hexamer: CATAAA"
     polyA_site      1622
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
     regulatory      1693..1698
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /note="hexamer: AAGAAA"
     polyA_site      1713
                     /gene="Akr1e1"
                     /gene_synonym="1810061I10Rik; Akr1e2"
                     /note="major polyA site"
ORIGIN      
        1 aaagtgcagg aagaggctga gcctttgagc aaaggggaac catggaaaac atccctacag
       61 tgggcttggg cacctggaag gcctccccag gagaagtgac tgatgcagtt aagttggcta
      121 tcaacctggg ctaccggcac ttcgattgtg cttacttata ccacaatgag agcgaggtgg
      181 gaatgggaat cagtgagaag atcaaggagg gcgtggtgaa gagagaggat ctctttgtag
      241 tcagtaagct gtggtgtacc tgccacaaga agtcattggt gaaaacagca tgcaccaata
      301 ccctggaagc cctaaacttg gattacctgg acctctacct catacactgg cccatgggtt
      361 tcaagcctgg ggaaaaagat atccctttgg atcgcaatgg caaggtcata cccagtcaca
      421 ccagctttct tgacacttgg gaggccatgg aggacctggt gtttgagggt ctggtgaaga
      481 accttggggt gtccaacttt aaccatgaac agcttgagag gcttttggat aagcctggtt
      541 tgagggtcag gccgataact aaccagattg aatgtcaccc atatcttaat caaaagaagc
      601 tgattgattt ttgccataaa agaaatgtgt ctgtgactgc ttaccgtccc ctcggtggct
      661 caggaggtgg gtttcacttg atggatgata ctgtcattcg aaagattgca aagaagcatg
      721 ggaagtctcc tgctcagatt ttgatccgat ttcagatcca aaggaactta atagtgatcc
      781 ccaaatctgt caccccaagt cggattagag agaatatcca ggtatttgat tttgaattaa
      841 ctgaaaaaga tatggaggaa ctcctcagcc tagacaagaa cctccgtttg gccacattcc
      901 ccacaactga aaatcaccaa gactatcctt tccacataga gtattgaaaa cagcttcact
      961 cgccatcatc tctgctcagc agaaccagat caccaagctc tgatccaact ctgtaaaggc
     1021 tatgtggtcc ctgtgtgacc acagcaccag acacagacac agccaagaat gacaacagag
     1081 taagaacaag gaaatcctac ctagaacaga accagttcag agaaaaaata aagacctagg
     1141 tatgagacag ggaaagacca tggaggctgt ggctgcttcc aagttgttag gaatagctga
     1201 gtgcaaagaa tattgtaatt gttgtcagtt agtcgtagcc tttctggctt ctattttcag
     1261 aagtgaaatg ctaattgctc acgaattaaa attaccttca cattttaaga aaacctgctt
     1321 gacagaagtg tttgaataat atgtaagatt tgagaaatta gtataattaa tatccatgag
     1381 atggtttcag taaccacgga cctgaggctg attgtgtact ctactctccc ataattttct
     1441 agatgatatt gaagcaaaat tttcctgtat ttaagagaag aaaaggctat ggagctgaga
     1501 ccccagctca gacaaaatgt gtttttaatt tttcttactt aaaaacttct gtgtgactca
     1561 ttcctaccta ccctactgcc atgcgaatga ggatggaatt ccataaaact gatggtccag
     1621 aacttgttcc tgtctgtatt atgagaatat aaagtatcac cattttttcc tagccaactg
     1681 ttagttggaa taaagaaaat gtgggagccc caaaaaaaaa aaaaaaaaa
//
