LOCUS       NM_145364               2713 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member D1 (Akr1d1),
            mRNA.
ACCESSION   NM_145364
VERSION     NM_145364.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2713)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2713)
  AUTHORS   Gathercole,L.L., Nikolaou,N., Harris,S.E., Arvaniti,A.,
            Poolman,T.M., Hazlehurst,J.M., Kratschmar,D.V., Todorcevic,M.,
            Moolla,A., Dempster,N., Pink,R.C., Saikali,M.F., Bentley,L.,
            Penning,T.M., Ohlsson,C., Cummins,C.L., Poutanen,M., Odermatt,A.,
            Cox,R.D. and Tomlinson,J.W.
  TITLE     AKR1D1 knockout mice develop a sex-dependent metabolic phenotype
  JOURNAL   J Endocrinol 253 (3), 97-113 (2022)
   PUBMED   35318963
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2713)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 2713)
  AUTHORS   Vergnes,L., Phan,J., Stolz,A. and Reue,K.
  TITLE     A cluster of eight hydroxysteroid dehydrogenase genes belonging to
            the aldo-keto reductase supergene family on mouse chromosome 13
  JOURNAL   J Lipid Res 44 (3), 503-511 (2003)
   PUBMED   12562828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157101.9 and BF322487.1.
            
            On Apr 1, 2008 this sequence version replaced NM_145364.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments. A downstream translational start
            codon is selected for this RefSeq based on its better conservation
            in mammalian species. An upstream in-frame start codon is also
            present but is only present in mouse; use of the upstream start
            codon would result in a protein that is 18 aa longer. Leaky
            scanning by ribosomes may allow translation initiation at the
            downstream start codon.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018333.1, ERR2680379.97298.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-165               AC157101.9         94413-94577
            166-330             AC157101.9         96722-96886
            331-447             AC157101.9         100269-100385
            448-525             AC157101.9         114446-114523
            526-648             AC157101.9         118722-118844
            649-758             AC157101.9         121729-121838
            759-924             AC157101.9         122609-122774
            925-1007            AC157101.9         128662-128744
            1008-2279           AC157101.9         131364-132635
            2280-2713           BF322487.1         1-434               c
FEATURES             Location/Qualifiers
     source          1..2713
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 16.44 cM"
     gene            1..2713
                     /gene="Akr1d1"
                     /note="aldo-keto reductase family 1, member D1"
                     /db_xref="GeneID:208665"
                     /db_xref="MGI:MGI:2384785"
     exon            1..165
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..1050
                     /gene="Akr1d1"
                     /EC_number="1.3.1.3"
                     /note="3-oxo-5-beta-steroid 4-dehydrogenase;
                     delta(4)-3-oxosteroid 5-beta-reductase;
                     delta(4)-3-ketosteroid 5-beta-reductase"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member D1"
                     /protein_id="NP_663339.1"
                     /db_xref="CCDS:CCDS20007.1"
                     /db_xref="GeneID:208665"
                     /db_xref="MGI:MGI:2384785"
                     /translation="MNLSAAHHQISLSDGNNIPLIGLGTYSDPRPVPGKTYVAVKTAI
                     DEGYRHIDGAYVYHNEHEVGEAIREKIAEGKVKREEIFYCGKLWNTEHVPSMVLPALE
                     RTLKALKLDYIDLYIIELPMAFKPGKEIYPRDENGRIIYDKTNLCATWEALEACKDAG
                     LVKSLGVSNFNRRQLELILNKPGLKYKPVTNQVECHPYFTQTKLLKFCQQHDIVIVAH
                     SPLGTCRNPSWVNVSSPPLLNDELLTSLGKKYNKTQAQIVLRFNIQRGIVVIPKSFTP
                     ERIKENFQIFDFSLTEEEMKDIDALNKNVRYVELLMWSDHPEYPFHDEY"
     exon            166..330
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..447
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            448..525
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..648
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            649..758
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..924
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            925..1007
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..2699
                     /gene="Akr1d1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2673..2678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1d1"
                     /note="hexamer: AATAAA"
     polyA_site      2699
                     /gene="Akr1d1"
                     /note="major polyA site"
ORIGIN      
        1 taggcacctt ttcaaataat gtgcctctgc cctgttcaga atcaccccag aagcttcaga
       61 ttcttctcta cgatgaacct cagcgctgca caccaccaaa tatccctaag tgatgggaac
      121 aacattccac tcattgggct tggaacctac tcagatccta gaccggtccc tgggaagacc
      181 tatgtggcag tgaagacagc tattgatgag gggtaccggc acattgatgg cgcctatgtt
      241 taccacaatg agcatgaagt cggtgaggcc atcagagaaa agatagcaga agggaaggta
      301 aagagggaag agatcttcta ctgtggaaag ttatggaata cagagcatgt cccatcaatg
      361 gtcctcccag ccctggaaag gacgctaaag gccctcaaac tagattacat agacctttat
      421 attatcgaac tgcccatggc ctttaagcct ggaaaggaaa tttaccctag agatgaaaat
      481 ggccgaatta tatatgacaa aacaaatctg tgtgccacgt gggaggcatt ggaagcttgc
      541 aaagatgctg gcttggtgaa atcccttggg gtgtctaatt ttaaccgcag gcagctggag
      601 ctcatcttga acaagccagg actcaagtac aaaccagtca ctaaccaggt ggagtgccac
      661 ccgtatttca cccagacaaa actcttgaaa ttctgccagc agcatgacat cgtcattgtc
      721 gcacatagcc ccttagggac ctgccgcaac ccatcatggg tgaacgtctc ttctccaccc
      781 ttgttaaatg acgaactcct aacctcactg gggaaaaagt acaataagac acaagctcaa
      841 attgtgttgc gtttcaacat ccagcgaggg atagttgtca ttcctaaaag ctttaccccc
      901 gaaaggatca aagaaaactt tcagatcttt gacttttctc tcacggaaga agaaatgaag
      961 gacattgatg ccttgaataa aaatgtccgc tatgtggagt tgctcatgtg gagtgaccat
     1021 cctgaatacc catttcatga cgaatactga acatggaaat ttcttcaaca gagttttttt
     1081 tttttcttca ttcaagatct taagctgatt aatccactcc agatgtagat aaatggggtc
     1141 ttgctctctt cagattaaga tgggcagaac acaccatgct taacttttgt gtagtattaa
     1201 ctcagctagc tctgatgaag agaaaagaag attcatcttt atttaatcta tctggatagt
     1261 tctttgcaaa tgtcttacta atatctttag atcaatgtct tctagactgt tcatggaaat
     1321 cactaaactt tactcaaaag tagcatgtaa aagcaggtcc aagaatctga gactaatata
     1381 gggagtctga tttgtttaac ctttagcagg acaaagaggt ttgcagttgg cacagttcct
     1441 ggtgctgacc atgaccatga cctaccaaat gtttggacca ttagttgcaa gatggtcaca
     1501 gccaaggcag aaatccacat gccattccta atgcaccttg agtagagata gaactggaag
     1561 tcttgaagag tcctaaagaa gaacataccg taggatgttc cagggctaga ggttcctgca
     1621 gtgcttgcct ggcaggctgg aggcccaggg tgagggaggt ggggatgagg gcaatcggca
     1681 aagccatgct gagtctgttt ttatcatttg tttccatcca gtgtgcccat tcagcctttc
     1741 atgtgcgtga aggatggaca acactgattc tttcttaaat tgtttttgtt taggagggtg
     1801 gggagttgag acagggtctt gtgtagtcca gactgctcac aaacctgctg tgcagttgag
     1861 gccagtcttg aattctgaat ccctggtctt tctcccattt ttaatgccct gagctttcat
     1921 gtgactggta agccctactt gtactatgtt ataatcattc ttgcctgcac tcatcaagaa
     1981 aaccaccatg taaagtggca agaaacaaga tatacaaatc aagctttgta ccataaaatc
     2041 gtctgaagat ggtgattttt tttttaaaaa attattttat gtatatgagt gcactgtagc
     2101 tgtcttcaga aacaccagaa gagggcatca gatctcacta cagatggttg tgagctacca
     2161 cgtggttgct gggatttgaa ctcaggaagt ttggaagagc agcctgtgct cttaaccgct
     2221 gagcatcttt ccagccccca aatgattttt ttttcttttt taaagaagga tttgagaaat
     2281 gctagaagaa aaggctttgt aaaagtagtt tttaaagatc ttaagaatat agtggggtag
     2341 ctatctgaat tttgacaaag ctgaaagttc taaaagagca cgagtcattt tactatatat
     2401 ataaaatttt aaaacatgaa ttaaatgatt acaactgtat ctatttttag ttcatctaaa
     2461 atacaataca tttgcttata ttagatcact ttcaaagggt gagaagattc ttcaaaagta
     2521 atatattttt aatatcaata gtcaaaatca aatggcccaa agagaaccat ttttgagaaa
     2581 ttatcactta aaaatgtgat caacacgaat cgtttttgtt tcaatattgt tagcaatgct
     2641 gttctctggg aaatatttta ttcacaagaa ttaataaaat atgatgattt gttccagcaa
     2701 aaaaaaaaaa aaa
//
