LOCUS       NM_027582               1376 bp    mRNA    linear   ROD 08-FEB-2025
DEFINITION  Mus musculus aldo-keto reductase family 1, member C-like (Akr1cl),
            transcript variant 1, mRNA.
ACCESSION   NM_027582 XM_989981
VERSION     NM_027582.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1376)
  AUTHORS   Endo,S., Matsunaga,T. and Hara,A.
  TITLE     Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase
            with strict substrate specificity
  JOURNAL   Arch Biochem Biophys 674, 108096 (2019)
   PUBMED   31479646
  REMARK    GeneRIF: Akr1cl protein is an NADPH-dependent prostaglandin D2
            11-ketoreductase that catalyzes the conversion of prostagland D2 to
            9alpha,11beta-prostaglandin F2.
REFERENCE   2  (bases 1 to 1376)
  AUTHORS   Klattig,J., Sierig,R., Kruspe,D., Makki,M.S. and Englert,C.
  TITLE     WT1-mediated gene regulation in early urogenital ridge development
  JOURNAL   Sex Dev 1 (4), 238-254 (2007)
   PUBMED   18391535
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ052308.1, AK135492.1 and BX634817.1.
            
            On Jul 16, 2015 this sequence version replaced NM_027582.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051128.1, AK135492.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CJ052308.1         2-12
            12-1364             AK135492.1         4-1356
            1365-1376           BX634817.1         1-12                c
FEATURES             Location/Qualifiers
     source          1..1376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 32.8 cM"
     gene            1..1376
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /note="aldo-keto reductase family 1, member C-like"
                     /db_xref="GeneID:70861"
                     /db_xref="MGI:MGI:1918111"
     exon            1..174
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            175..295
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1183
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="aldo-keto reductase family 1, member C-like
                     isoform 1"
                     /protein_id="NP_081858.2"
                     /db_xref="CCDS:CCDS48282.1"
                     /db_xref="GeneID:70861"
                     /db_xref="MGI:MGI:1918111"
                     /translation="MNPKRYMELSDGHHIPVLGFGTFVPGEVSKSMVAKATKIAIDAG
                     FRHIDSAYFYQNEEEVGLAIRSKVADGTVRREDIFYTSKLPCTCHRPELVQPCLEQSL
                     RKLQLDYVDLYLIHCPVSMKPGNDLIPTDENGKLLFDTVDLCDTWEAMEKCKDSGLAK
                     SIGVSNFNRRQLEMILNKPGLRYKPVCNQVECHPYLNQSKLLDYCKSKDIVLVAYGAL
                     GSQRCKNWIEENAPYLLEDPTLCAMAEKHKQTPALISLRYLLQRGIVIVTKSFNEKRI
                     KENLKVFEFHLPAEDMAVIDRLNRNYRYATARIISAHPNYPFLDEY"
     exon            296..463
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            464..580
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            581..658
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            659..781
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..891
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1057
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1140
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1372
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1342..1347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1372
                     /gene="Akr1cl"
                     /gene_synonym="4921521F21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtcccttcag ttcctgactc tgttctgcag ccctgattga ttagtagcag cttggttaca
       61 atacattttt gtcatctgca ttgacctggt ctttaagtta tattggattt atgttggatt
      121 taagtggacc cacaacactt tgaggaagaa gaagacactc ttcttacttt ggagtaccca
      181 gtgatatcag gaaagtcaga ggcagagcct gcagatgaat cccaagcgct acatggaact
      241 aagtgatggc caccacattc ctgtgcttgg ctttggaacc tttgtcccag gagaggtttc
      301 caagagtatg gttgcaaaag ccaccaaaat agctatagat gctggattcc gccatattga
      361 ctcagcttat ttctaccaaa atgaggagga agtagggctg gccatccgaa gcaaggttgc
      421 tgatggcact gtgaggagag aagatatatt ctacacttca aagcttccct gcacatgtca
      481 tagaccagag ctggtccagc cttgcttgga acaatccctg agaaagcttc agctggatta
      541 tgttgatctg taccttattc actgcccagt gtccatgaag ccaggcaatg atcttattcc
      601 aacagatgaa aatgggaaat tattatttga cacagtggat ctctgtgaca catgggaggc
      661 catggagaag tgtaaggatt cagggttagc caagtccatt ggtgtgtcca actttaaccg
      721 gaggcagctg gagatgatcc tgaacaagcc agggctcagg tacaagcctg tgtgcaacca
      781 ggtagagtgt cacccttatc tgaaccagag caagctcctg gactactgca agtcaaaaga
      841 catcgttctg gttgcctatg gtgctcttgg cagccaacgg tgtaagaact ggatagagga
      901 gaatgcccca tatctcttgg aagacccaac tctgtgtgcc atggcggaaa agcacaagca
      961 aactccggcc ctaatttccc tccggtatct gctgcagcgt gggattgtca ttgtcaccaa
     1021 gagtttcaat gagaagcgga tcaaggagaa cctgaaggtc tttgagttcc acttgccagc
     1081 agaggacatg gcagttatag ataggctgaa cagaaactac cgatatgcta ctgctcgtat
     1141 tatttctgct caccccaatt atccattttt ggatgaatat taacgcggaa gcctttgttg
     1201 tgacatcgct cagagggagc aatgtgggag atgctgtgga tgttgatcag catcacctct
     1261 ggtcgacgtc gacatcaccg tcaacccaca ctgaactgga tggagagggg tggccatggt
     1321 gttttgtgat actttgaaga caataaagtt ttggtctatg aggtacatgt aaaaaa
//
