LOCUS       NM_030611               1347 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member C6 (Akr1c6),
            transcript variant 1, mRNA.
ACCESSION   NM_030611
VERSION     NM_030611.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Gannon,A.L., O'Hara,L., Mason,I.J., Jorgensen,A., Frederiksen,H.,
            Curley,M., Milne,L., Smith,S., Mitchell,R.T. and Smith,L.B.
  TITLE     Androgen Receptor Is Dispensable for X-Zone Regression in the
            Female Adrenal but Regulates Post-Partum Corticosterone Levels and
            Protects Cortex Integrity
  JOURNAL   Front Endocrinol (Lausanne) 11, 599869 (2021)
   PUBMED   33584538
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Fan,L., Peng,G., Hussain,A., Fazli,L., Guns,E., Gleave,M. and Qi,J.
  TITLE     The Steroidogenic Enzyme AKR1C3 Regulates Stability of the
            Ubiquitin Ligase Siah2 in Prostate Cancer Cells
  JOURNAL   J Biol Chem 290 (34), 20865-20879 (2015)
   PUBMED   26160177
  REMARK    GeneRIF: A catalysis-independent role for AKR1C3 on AR activity via
            Siah2 has been identified.
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Huang,C.C., Kraft,C., Moy,N., Ng,L. and Forrest,D.
  TITLE     A Novel Population of Inner Cortical Cells in the Adrenal Gland
            That Displays Sexually Dimorphic Expression of Thyroid Hormone
            Receptor-beta1
  JOURNAL   Endocrinology 156 (6), 2338-2348 (2015)
   PUBMED   25774556
REFERENCE   4  (bases 1 to 1347)
  AUTHORS   Inagawa,M., Nakajima,K., Makino,T., Ogawa,S., Kojima,M., Ito,S.,
            Ikenishi,A., Hayashi,T., Schwartz,R.J., Nakamura,K., Obayashi,T.,
            Tachibana,M., Shinkai,Y., Maeda,K., Miyagawa-Tomita,S. and
            Takeuchi,T.
  TITLE     Histone H3 lysine 9 methyltransferases, G9a and GLP are essential
            for cardiac morphogenesis
  JOURNAL   Mech Dev 130 (11-12), 519-531 (2013)
   PUBMED   23892084
REFERENCE   5  (bases 1 to 1347)
  AUTHORS   Zheng,S., Damoiseaux,R., Chen,L. and Black,D.L.
  TITLE     A broadly applicable high-throughput screening strategy identifies
            new regulators of Dlg4 (Psd-95) alternative splicing
  JOURNAL   Genome Res 23 (6), 998-1007 (2013)
   PUBMED   23636947
REFERENCE   6  (bases 1 to 1347)
  AUTHORS   Lammert,F., Carey,M.C. and Paigen,B.
  TITLE     Chromosomal organization of candidate genes involved in cholesterol
            gallstone formation: a murine gallstone map
  JOURNAL   Gastroenterology 120 (1), 221-238 (2001)
   PUBMED   11208732
  REMARK    Review article
REFERENCE   7  (bases 1 to 1347)
  AUTHORS   Rheault,P., Charbonneau,A. and Luu-The,V.
  TITLE     Structure and activity of the murine type 5 17beta-hydroxysteroid
            dehydrogenase gene(1)
  JOURNAL   Biochim Biophys Acta 1447 (1), 17-24 (1999)
   PUBMED   10500239
REFERENCE   8  (bases 1 to 1347)
  AUTHORS   Rheault,P., Dufort,I., Soucy,P. and Luu-The,V.
  TITLE     Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid
            dehydrogenase to human chromosome bands 10p15-->p14 and mouse
            chromosome 13 region A2 by in situ hybridization: identification of
            a new syntenic relationship
  JOURNAL   Cytogenet Cell Genet 84 (3-4), 241-242 (1999)
   PUBMED   10393440
REFERENCE   9  (bases 1 to 1347)
  AUTHORS   Mustonen,M.V., Poutanen,M.H., Isomaa,V.V., Vihko,P.T. and
            Vihko,R.K.
  TITLE     Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and
            analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in
            mouse embryos and adult tissues
  JOURNAL   Biochem J 325 (Pt 1) (Pt 1), 199-205 (1997)
   PUBMED   9224647
REFERENCE   10 (bases 1 to 1347)
  AUTHORS   Deyashiki,Y., Ohshima,K., Nakanishi,M., Sato,K., Matsuura,K. and
            Hara,A.
  TITLE     Molecular cloning and characterization of mouse estradiol 17
            beta-dehydrogenase (A-specific), a member of the aldoketoreductase
            family
  JOURNAL   J Biol Chem 270 (18), 10461-10467 (1995)
   PUBMED   7737980
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166056.2.
            
            On Mar 23, 2023 this sequence version replaced NM_030611.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149458.1, BC056643.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC166056.2         121481-121600       c
            121-288             AC166056.2         119508-119675       c
            289-405             AC166056.2         117349-117465       c
            406-483             AC166056.2         109526-109603       c
            484-606             AC166056.2         108825-108947       c
            607-716             AC166056.2         106861-106970       c
            717-882             AC166056.2         106477-106642       c
            883-965             AC166056.2         101409-101491       c
            966-1347            AC166056.2         98425-98806         c
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.48 cM"
     gene            1..1347
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /note="aldo-keto reductase family 1, member C6"
                     /db_xref="GeneID:83702"
                     /db_xref="MGI:MGI:1933427"
     exon            1..120
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..1008
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     estradiol 17 beta-dehydrogenase 5; 17-beta-HSD 5;
                     hydroxysteroid 17-beta dehydrogenase 5; aldo-keto
                     reductase family 1, member C1 (aldehyde reductase); 17HSD
                     type 5; estradiol 17-beta-dehydrogenase (A-specific)"
                     /codon_start=1
                     /product="estradiol 17 beta-dehydrogenase 5 isoform 1"
                     /protein_id="NP_085114.1"
                     /db_xref="CCDS:CCDS26223.1"
                     /db_xref="GeneID:83702"
                     /db_xref="MGI:MGI:1933427"
                     /translation="MDSKQQTVRLSDGHFIPILGFGTYAPQEVPKSKATEATKIAIDA
                     GFRHIDSASMYQNEKEVGLAIRSKIADGTVKREDIFYTSKVWCTFHRPELVRVCLEQS
                     LKQLQLDYVDLYLIHFPMAMKPGENYLPKDENGKLIYDAVDICDTWEAMEKCKDAGLA
                     KSIGVSNFNRRQLEKILKKPGLKYKPVCNQVECHPYLNQGKLLDFCRSKDIVLVAYSA
                     LGSHREKQWVDQSSPVLLDNPVLGSMAKKYNRTPALIALRYQLQRGVVVLAKSFSEKR
                     IKENMQVFEFQLTSEDMKVLDDLNKNIRYISGSSFKDHPDFPFWDEY"
     exon            121..288
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            289..405
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            406..483
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            484..606
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            607..716
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            717..882
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            883..965
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     exon            966..1347
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1192..1197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /note="hexamer: AATAAA"
     polyA_site      1217
                     /gene="Akr1c6"
                     /gene_synonym="3alpha-HSD; Akr1c1; Hsd17b5"
                     /note="major polyA site"
ORIGIN      
        1 agaatagtat cttctcagtt ggtgggctga gaagccatgg attctaagca gcagacagtg
       61 cgtctaagtg atggtcactt catccctata ctggggtttg gtacctatgc acctcaagag
      121 gtacctaaga gtaaggctac agaagctact aaaatagcca tagatgctgg tttccgccat
      181 attgattctg cttctatgta tcaaaatgaa aaggaagtag gactagccat ccgaagcaag
      241 atagcagatg gcactgtgaa gagggaagat atattttaca catcaaaggt ttggtgtact
      301 tttcatcgtc cagaactcgt acgggtctgc ttggaacagt cattgaagca actccagttg
      361 gactatgtgg acctgtacct cattcatttc ccaatggcca tgaagccggg agaaaattat
      421 ctcccaaaag atgaaaatgg aaaattaata tatgatgctg tggatatctg tgacacctgg
      481 gaagccatgg agaaatgcaa ggatgcagga ttggccaagt ccattggggt gtccaacttt
      541 aaccgcaggc agctggagaa gatcctgaaa aagccggggc tcaagtacaa gcctgtgtgc
      601 aaccaggtag aatgtcatcc ttatctcaat cagggaaaac ttctggattt ctgcaggtca
      661 aaagacattg ttctggttgc ttacagtgct ctgggaagcc atcgtgaaaa acaatgggtt
      721 gatcagagct ctcctgttct tttggataat ccagttcttg gctcaatggc aaaaaagtac
      781 aatcgaactc ctgcgctgat tgcccttcgc taccagctac aacgtggggt tgtggtcctc
      841 gccaagagtt tctctgagaa gaggataaaa gagaatatgc aggtttttga atttcagttg
      901 acttcagagg acatgaaagt cctcgatgac ctgaataaaa atatccgata cataagtggt
      961 tctagcttta aggaccatcc tgattttcca ttttgggatg aatactaact ggaggtccat
     1021 tttgtgcctt gtgccagatg tcactgcatt ggaagagtgt ataggaagag tattctcaaa
     1081 atgtgatgat tacatatcac cctaatccaa gcttctgagc aattctggct ctgctgaatc
     1141 taccatttta accaagaaag ccaaaactat gtatatttct cctttctaag aaataaaaga
     1201 atcgttattc tttagcattt atcttttgcc agtttatata attcacatat tacaacttat
     1261 cctgagccat gtgcatcttg gaaggattta ctttgaaatg tgtgtgtagg gattgaacta
     1321 ataaaagaca ttttactaac gtatctg
//
