LOCUS       NM_001311132            1329 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member C20 (Akr1c20),
            mRNA.
ACCESSION   NM_001311132 XM_006516464
VERSION     NM_001311132.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Matsumoto,K., Endo,S., Ishikura,S., Matsunaga,T., Tajima,K.,
            El-Kabbani,O. and Hara,A.
  TITLE     Enzymatic properties of a member (AKR1C20) of the aldo-keto
            reductase family
  JOURNAL   Biol Pharm Bull 29 (3), 539-542 (2006)
   PUBMED   16508162
  REMARK    GeneRIF: AKR1C20 is a novel 3alpha(17beta-hydroxysteroid
            dehydrogenase, which may also function as a reductase for
            xenobiotic alpha-dicarbonyl compounds
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Vergnes,L., Phan,J., Stolz,A. and Reue,K.
  TITLE     A cluster of eight hydroxysteroid dehydrogenase genes belonging to
            the aldo-keto reductase supergene family on mouse chromosome 13
  JOURNAL   J Lipid Res 44 (3), 503-511 (2003)
   PUBMED   12562828
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166056.2, AK012162.1 and AI661346.1.
            
            On Jul 24, 2015 this sequence version replaced XM_006516464.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021607.1, AB097220.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC166056.2         32611-32621
            12-318              AK012162.1         1-307
            319-399             AC166056.2         43289-43369
            400-876             AK012162.1         308-784
            877-1329            AI661346.1         15-467              c
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.51 cM"
     gene            1..1329
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /note="aldo-keto reductase family 1, member C20"
                     /db_xref="GeneID:116852"
                     /db_xref="MGI:MGI:2151104"
     exon            1..114
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..1002
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /codon_start=1
                     /product="aldo-keto reductase family 1, member C20"
                     /protein_id="NP_001298061.1"
                     /db_xref="CCDS:CCDS79161.1"
                     /db_xref="GeneID:116852"
                     /db_xref="MGI:MGI:2151104"
                     /translation="MNSKQQTVLLNDGHFIPILGFGTSAPQEVPRSKATEATKIAIDA
                     GFRHIDCAAVYQNEKEVGLAIRSKIVDGTVKREDIFCTSKVWQTFHRPELVQVCLEQS
                     LKQLQLDYVDLYLIHFPIAMKPGENYFPKDENGKFIYDAVDICDTWEAMEKCKDAGLA
                     KSIGVCNFNRRQLEKILSKPGLKYKPVCNQVECHPYLNQRKLLDFCRSKDIVLVAHSA
                     LGSNRDKEWVDKSFPVLLDDPVLGSMAKKYNRTPALIALRYQVQRGVVVLAKSFIEKR
                     IKENMQVFEFQLTSVDMKVLDGLNKNIRYIGSSISEDHPDFPFLDEY"
     exon            115..282
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            283..399
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            400..477
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            478..600
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            601..710
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            711..876
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            877..959
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1329
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1188..1193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1213
                     /gene="Akr1c20"
                     /gene_synonym="2610528B18Rik"
                     /note="major polyA site"
ORIGIN      
        1 gtatcttctc agtcagagga ctgagaagcc atgaattcca agcagcagac agttcttcta
       61 aatgatggtc acttcatccc tatactcggg tttggtacct ctgcacctca agaggtacct
      121 aggagtaagg ctacagaagc caccaaaata gctatagatg ctggtttccg ccatattgat
      181 tgtgctgctg tgtatcaaaa tgaaaaggag gtaggattag ccatcagaag caagattgta
      241 gatggcactg tgaagaggga agatatattt tgcacatcaa aggtttggca aacatttcat
      301 cgtccagaac tggtgcaggt atgcttggaa caatcattga agcaactcca gttagattat
      361 gtggacctgt acctcattca tttcccaata gccatgaagc caggagagaa ttatttccca
      421 aaagatgaga atggaaaatt catatatgat gcagtggata tctgtgacac ctgggaagcc
      481 atggagaaat gcaaggatgc aggattggcc aagtccatcg gggtgtgcaa ctttaaccgc
      541 aggcagctgg agaagatcct gagtaagccg gggctcaagt acaagcctgt gtgcaaccag
      601 gtagaatgtc atccttatct caaccagaga aaacttctgg atttctgcag gtcaaaagac
      661 attgttttgg ttgctcatag tgctctggga agtaaccgtg ataaagaatg ggtggacaag
      721 agctttcctg ttcttttgga tgatccagtt cttggctcaa tggcaaaaaa gtacaatcga
      781 acgcctgcgc tgattgccct tcgctaccag gtgcaacgtg gggttgtggt cctagccaag
      841 agtttcattg agaagaggat aaaagagaat atgcaggttt ttgaatttca gttgacttcg
      901 gtggacatga aagttcttga tggcctgaat aaaaatatcc gatacatagg tagttctatt
      961 tctgaggacc atcctgattt tccatttttg gatgaatact aacatggagg tccctgtcat
     1021 gccttgtgcc agaagtcact acatgggaag actgtataga aaggatactc tcaaaatgtg
     1081 atgattgcat atcaccctca tcctaacttc tgagcaattc tggctctgct gagtctataa
     1141 tcttaagcaa gaaagcaaaa actatatata tttccccctt tctaagaaat aaaagaatca
     1201 tttttcttta gcatttatgt ttgccagctt atattattta tgtattttaa tttatcctga
     1261 tccatttgca tcctggaagg atttacctag aaatatgtgt gtagtgattg aactaataaa
     1321 agacatttt
//
