LOCUS       NM_134066               1199 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member C18 (Akr1c18),
            transcript variant 1, mRNA.
ACCESSION   NM_134066
VERSION     NM_134066.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1199)
  AUTHORS   Shi,T., Fan,Q.Y., Liu,S.B. and Zhang,S.Y.
  TITLE     Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis
            via induction of Akr1c18 expression and prostaglandin F2alpha
            (PGF2alpha) levels
  JOURNAL   Biochem Pharmacol 225, 116309 (2024)
   PUBMED   38788959
  REMARK    GeneRIF: Pregnane X receptor (PXR) deficiency promotes
            hepatocarcinogenesis via induction of Akr1c18 expression and
            prostaglandin F2alpha (PGF2alpha) levels.
REFERENCE   2  (bases 1 to 1199)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1199)
  AUTHORS   Rotgers,E., Nicol,B., Rodriguez,K., Rattan,S., Flaws,J.A. and
            Yao,H.H.
  TITLE     Constitutive expression of Steroidogenic factor-1 (NR5A1) disrupts
            ovarian functions, fertility, and metabolic homeostasis in female
            mice
  JOURNAL   FASEB J 35 (8), e21770 (2021)
   PUBMED   34288113
REFERENCE   4  (bases 1 to 1199)
  AUTHORS   Levy,I., Szarek,E., Maria,A.G., Starrost,M., De La Luz Sierra,M.,
            Faucz,F.R. and Stratakis,C.A.
  TITLE     A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional
            but reduced Pde11a: Phenotype and impact on adrenocortical function
  JOURNAL   Mol Cell Endocrinol 520, 111071 (2021)
   PUBMED   33127481
REFERENCE   5  (bases 1 to 1199)
  AUTHORS   Menard,A., Abou Nader,N., Levasseur,A., St-Jean,G., Le Roy,M.L.G.,
            Boerboom,D., Benoit-Biancamano,M.O. and Boyer,A.
  TITLE     Targeted Disruption of Lats1 and Lats2 in Mice Impairs Adrenal
            Cortex Development and Alters Adrenocortical Cell Fate
  JOURNAL   Endocrinology 161 (5) (2020)
   PUBMED   32243503
REFERENCE   6  (bases 1 to 1199)
  AUTHORS   Piekorz,R.P., Gingras,S., Hoffmeyer,A., Ihle,J.N. and Weinstein,Y.
  TITLE     Regulation of progesterone levels during pregnancy and parturition
            by signal transducer and activator of transcription 5 and
            20alpha-hydroxysteroid dehydrogenase
  JOURNAL   Mol Endocrinol 19 (2), 431-440 (2005)
   PUBMED   15471942
  REMARK    GeneRIF: prolactin activation of Stat5b is important in suppressing
            20alpha-HSD gene expression and thereby allowing the maintenance of
            progesterone levels that are required to sustain pregnancy
REFERENCE   7  (bases 1 to 1199)
  AUTHORS   Hirabayashi,K., Ishida,M., Suzuki,M., Yamanouchi,K. and
            Nishihara,M.
  TITLE     Characterization and functional analysis of the 5'-flanking region
            of the mouse 20alpha-hydroxysteroid dehydrogenase gene
  JOURNAL   Biochem J 382 (Pt 3), 975-980 (2004)
   PUBMED   15222881
  REMARK    GeneRIF: involvement of Sp1 and Sp3 in the expression of the
            20alpha-HSD gene
REFERENCE   8  (bases 1 to 1199)
  AUTHORS   Pelletier,G., Luu-The,V., Li,S. and Labrie,F.
  TITLE     Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse
            brain by in situ hybridization
  JOURNAL   Brain Res Mol Brain Res 125 (1-2), 143-146 (2004)
   PUBMED   15193432
  REMARK    GeneRIF: These results suggest that progesterone can be inactivated
            by 20alpha-hydroxysteroid dehydrogenase in some specific brain
            areas.
REFERENCE   9  (bases 1 to 1199)
  AUTHORS   Vergnes,L., Phan,J., Stolz,A. and Reue,K.
  TITLE     A cluster of eight hydroxysteroid dehydrogenase genes belonging to
            the aldo-keto reductase supergene family on mouse chromosome 13
  JOURNAL   J Lipid Res 44 (3), 503-511 (2003)
   PUBMED   12562828
REFERENCE   10 (bases 1 to 1199)
  AUTHORS   Ishida,M., Hirabayashi,K., Suzuki,M., Yamanouchi,K. and
            Nishihara,M.
  TITLE     Cloning and chromosomal localization of mouse
            20alpha-hydroxysteroid dehydrogenase gene
  JOURNAL   J Reprod Dev 49 (1), 79-85 (2003)
   PUBMED   14967952
  REMARK    GeneRIF: cloning and chromosome mapping of mouse
            20alpha-hydroxysteroid dehydrogenase
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122840.3.
            
            On Aug 22, 2018 this sequence version replaced NM_134066.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK153898.1, AB059565.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               AC122840.3         170847-170978       c
            133-300             AC122840.3         165538-165705       c
            301-417             AC122840.3         164622-164738       c
            418-495             AC122840.3         163550-163627       c
            496-618             AC122840.3         162459-162581       c
            619-728             AC122840.3         157466-157575       c
            729-894             AC122840.3         156934-157099       c
            895-977             AC122840.3         155535-155617       c
            978-1199            AC122840.3         152947-153168       c
FEATURES             Location/Qualifiers
     source          1..1199
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.31 cM"
     gene            1..1199
                     /gene="Akr1c18"
                     /note="aldo-keto reductase family 1, member C18"
                     /db_xref="GeneID:105349"
                     /db_xref="MGI:MGI:2145420"
     exon            1..132
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1020
                     /gene="Akr1c18"
                     /EC_number="1.1.1.149"
                     /note="isoform 1 is encoded by transcript variant 1;
                     20-alpha-hydroxysteroid dehydrogenase; 20-alpha-HSD;
                     20alpha-hydroxysteroid dehydrogenase; 20alpha-HSD"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member C18 isoform
                     1"
                     /protein_id="NP_598827.1"
                     /db_xref="CCDS:CCDS26219.1"
                     /db_xref="GeneID:105349"
                     /db_xref="MGI:MGI:2145420"
                     /translation="MNSKIQKIELNDGHSIPVLGFGTYATEEHLKKKSMESTKIAIDV
                     GFCHIDCSHLYQNEEEIGQAILSKIEDGTVKREDIFYTSKLWSTSHRPELVRPSLENS
                     LRKLNLDYVDLYLIHFPVSLKPGNELLPKDEHGNLIFDTVDLCDTWEAMEKCKDAGLA
                     KSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHLYLNQSKLLAYCKMNDIVLVAYGA
                     LGTQRYKYCINEDTPVLLDDPVLCAMAKKYKRTPALIALRYQLDRGIVALAKSFNEER
                     IRENMQVFDFQLASDDMKILDGLDRNLRYFPADMFKAHPNFPFFDEY"
     exon            133..300
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            301..417
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            418..495
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            496..618
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            619..728
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            729..894
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            895..977
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1199
                     /gene="Akr1c18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1170..1175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1c18"
                     /note="hexamer: AATAAA"
     polyA_site      1195
                     /gene="Akr1c18"
                     /note="major polyA site"
ORIGIN      
        1 aaagcagagg aagagagaga atcttctagg tcagagcagt ggctgagaat gaattccaaa
       61 attcagaaga tagaattaaa tgatggtcac tccattcctg tcctgggctt tggcacctat
      121 gcaactgaag agcatctcaa gaaaaagtct atggagtcca ccaaaatagc tatagatgtt
      181 gggttctgcc atattgattg ttctcacttg taccagaatg aagaagagat aggccaggcc
      241 attctaagca agattgaaga tggcactgtg aaaagggaag atatattcta tacttcgaag
      301 ctttggtcaa cttcccatcg tccagagttg gtcagaccca gcttggaaaa ttccctgagg
      361 aaacttaatt tggactatgt agacctctat ctcattcatt tcccagtgtc tctgaagcca
      421 gggaatgagc ttttgcctaa agatgagcat ggaaacttaa tatttgacac agtggatctc
      481 tgtgacacat gggaggccat ggagaagtgt aaggatgcag ggctggccaa gtccatcggg
      541 gtgtctaact ttaaccgtag acaactggag atgatcctga acaagccagg gctcaagtac
      601 aagcctgtgt gcaaccaggt agaatgccat ctttatctca accagagcaa gctgctggcc
      661 tactgcaaga tgaatgacat tgttctggtt gcctatggtg ccctgggaac tcaaagatac
      721 aaatactgta taaatgagga taccccagtt ctcttggatg atccagttct ttgtgccatg
      781 gcaaagaagt acaagcggac tccagccctg attgcccttc gctaccagct ggaccgtggg
      841 attgtggccc tagccaagag tttcaatgag gagagaatca gagagaacat gcaggtcttt
      901 gatttccaat tggcttcaga tgacatgaaa attttagatg gcctggacag aaatcttcgg
      961 tactttcctg ctgatatgtt taaggctcac cctaactttc cattcttcga tgaatattaa
     1021 gatggaggcc cttgccacga gttctattag aagatctttt gtgtgatgct ggactctcag
     1081 atgccaataa ctcgacacac cgcctccaat cactgcttag caactcaccc ccagttaatt
     1141 caataaattt tgcttctttt ctataaataa ataaaaatat tttgcttcaa cctcatcta
//
