LOCUS       NM_013778               1232 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus aldo-keto reductase family 1, member C13 (Akr1c13),
            mRNA.
ACCESSION   NM_013778
VERSION     NM_013778.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1232)
  AUTHORS   Shimizu R, Ishihara K, Kawashita E, Sago H, Yamakawa K, Mizutani KI
            and Akiba S.
  TITLE     Decrease in the T-box1 gene expression in embryonic brain and adult
            hippocampus of down syndrome mouse models
  JOURNAL   Biochem Biophys Res Commun 535, 87-92 (2021)
   PUBMED   33348080
REFERENCE   2  (bases 1 to 1232)
  AUTHORS   McFarland AP, Burke TP, Carletti AA, Glover RC, Tabakh H, Welch MD
            and Woodward JJ.
  TITLE     RECON-Dependent Inflammation in Hepatocytes Enhances Listeria
            monocytogenes Cell-to-Cell Spread
  JOURNAL   mBio 9 (3), e00526-18 (2018)
   PUBMED   29764944
  REMARK    GeneRIF: Listeria monocytogenes secretion of c-di-AMP inhibits
            RECON ( Akr1c13) activity, drives augmented NF-kappaB activation
            and nitric oxide production, and ultimately enhances intercellular
            spread.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1232)
  AUTHORS   McFarland AP, Luo S, Ahmed-Qadri F, Zuck M, Thayer EF, Goo YA,
            Hybiske K, Tong L and Woodward JJ.
  TITLE     Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase
            RECON Promotes NF-kappaB Activation and Shapes a Proinflammatory
            Antibacterial State
  JOURNAL   Immunity 46 (3), 433-445 (2017)
   PUBMED   28329705
  REMARK    GeneRIF: Akr1c13 functions as a cytosolic sensor for bacterial
            cyclic dinucleotides, shaping inflammatory gene activation
REFERENCE   4  (bases 1 to 1232)
  AUTHORS   Hoffman BG, Zavaglia B, Witzsche J, Ruiz de Algara T, Beach M,
            Hoodless PA, Jones SJ, Marra MA and Helgason CD.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 1232)
  AUTHORS   Endo S, Sanai M, Horie K, Matsunaga T, Ishikura S, Tajima K,
            El-Kabbani O and Hara A.
  TITLE     Characterization of rat and mouse NAD+-dependent
            3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and
            identification of substrate specificity determinants by
            site-directed mutagenesis
  JOURNAL   Arch Biochem Biophys 467 (1), 76-86 (2007)
   PUBMED   17888864
  REMARK    GeneRIF: analysis of rat and mouse NAD+-dependent
            3alpha/17beta/20alpha-hydroxysteroid dehydrogenases.
REFERENCE   6  (bases 1 to 1232)
  AUTHORS   Tachibana M, Nozaki M, Takeda N and Shinkai Y.
  TITLE     Functional dynamics of H3K9 methylation during meiotic prophase
            progression
  JOURNAL   EMBO J 26 (14), 3346-3359 (2007)
   PUBMED   17599069
REFERENCE   7  (bases 1 to 1232)
  AUTHORS   Vergnes L, Phan J, Stolz A and Reue K.
  TITLE     A cluster of eight hydroxysteroid dehydrogenase genes belonging to
            the aldo-keto reductase supergene family on mouse chromosome 13
  JOURNAL   J Lipid Res 44 (3), 503-511 (2003)
   PUBMED   12562828
REFERENCE   8  (bases 1 to 1232)
  AUTHORS   Ikeda S, Okuda-Ashitaka E, Masu Y, Suzuki T, Watanabe K, Nakao M,
            Shingu K and Ito S.
  TITLE     Cloning and characterization of two novel aldo-keto reductases
            (AKR1C12 and AKR1C13) from mouse stomach
  JOURNAL   FEBS Lett 459 (3), 433-437 (1999)
   PUBMED   10526179
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008949.1 and AK220165.1.
            
            [WARNING] On Dec 21, 2023 this sequence was replaced by
            NM_013778.3.
            
            On Apr 2, 2008 this sequence version replaced NM_013778.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220165.1, BC021937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-588               AK008949.1         2-589
            589-1232            AK220165.1         582-1225
FEATURES             Location/Qualifiers
     source          1..1232
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.34 cM"
     gene            1..1232
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /note="aldo-keto reductase family 1, member C13"
                     /db_xref="GeneID:27384"
                     /db_xref="MGI:MGI:1351662"
     exon            1..124
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..1012
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /note="aldo-keto reductase AKR1C13"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member C13"
                     /protein_id="NP_038806.2"
                     /db_xref="CCDS:CCDS26220.1"
                     /db_xref="GeneID:27384"
                     /db_xref="MGI:MGI:1351662"
                     /translation="MSSKQHCVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDV
                     GYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKREDLFITTKLWCTCFRPELVKPALEKS
                     LKKLQLDYVDLYIMHYPVPMKSGDNDFPVNEQGKSLLDTVDFCDTWERLEECKDAGLV
                     KSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQRKLLDYCESKDIVLVAYGA
                     LGTQRYKEWVDQNSPVLLNDPVLCDVAKKNKRSPALIALRYLIQRGIVPLAQSFKENE
                     MRENLQVFGFQLSPEDMKTLDGLNKNFRYLPAEFLVDHPEYPFVEEY"
     exon            125..292
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     exon            293..409
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     exon            410..487
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     exon            488..610
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     exon            611..720
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     exon            721..886
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     exon            887..969
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1232
                     /gene="Akr1c13"
                     /gene_synonym="mKIAA4014"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaatactca ggaagtgctt agccagggga gtgagagaca atgagctcca aacagcactg
       61 tgtcaaacta aatgatggcc acttaattcc tgccctgggc tttggcacct ataaacccaa
      121 ggaggttccc aagagtaagt cactggaggc tgcatgccta gctctagatg ttgggtaccg
      181 ccatgttgat actgcttatg cataccaagt agaagaggag ataggacagg ccattcaaag
      241 caagattaaa gctggggttg taaagagaga agacctgttc atcactacaa agctttggtg
      301 cacttgcttt cgaccagagc tggtcaagcc tgccttggaa aagtcactga aaaagcttca
      361 gctggattat gttgatcttt acattatgca ttacccagtg ccaatgaagt caggggataa
      421 tgattttcca gtaaatgagc aagggaaatc tctgttggac actgtggatt tctgtgacac
      481 atgggagagg ttggaggagt gtaaggatgc aggattggtc aagtccattg gggtgtccaa
      541 ctttaaccac aggcagctgg agcgaatcct caataagcca ggactgaagt acaaacctgt
      601 ctgcaaccag gttgaatgtc atctctattt gaaccagcgt aagctactgg attactgcga
      661 atcaaaagac attgttctcg ttgcttacgg tgctctgggg acccagcgat ataaagaatg
      721 ggtggaccag aactccccag ttctcttgaa tgatccagtt ctttgtgatg tggccaaaaa
      781 gaacaagcga agtcctgcct tgattgcact tcgatacctg attcaacgtg ggattgtgcc
      841 cctggcccag agtttcaaag agaatgagat gagagagaat ttgcaggttt ttggatttca
      901 gttgtcccct gaggacatga aaacactaga tggcctgaac aaaaactttc gataccttcc
      961 agcagagttc cttgttgacc acccagagta tccatttgtg gaggaatatt aacatgggga
     1021 cctaatcatg gcttctgcct gatgtccctg tgtgtggaca gtgatgctgg caatatgacc
     1081 aagatggact gttggatgga cttgtcattt ctgatcaatc ttggttgctt agcaactcac
     1141 attcagctga agctttaatt aatgatctca aagaaatgga atataatttt catgatgctt
     1201 tgaaataaat atgaattttt ctcttaaaaa at
//
