LOCUS       NM_013777               1231 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member C12 (Akr1c12),
            mRNA.
ACCESSION   NM_013777 XM_886035 XM_896555 XM_904820 XM_919021 XM_919030
VERSION     NM_013777.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1231)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1231)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   3  (bases 1 to 1231)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1231)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   5  (bases 1 to 1231)
  AUTHORS   Vergnes,L., Phan,J., Stolz,A. and Reue,K.
  TITLE     A cluster of eight hydroxysteroid dehydrogenase genes belonging to
            the aldo-keto reductase supergene family on mouse chromosome 13
  JOURNAL   J Lipid Res 44 (3), 503-511 (2003)
   PUBMED   12562828
REFERENCE   6  (bases 1 to 1231)
  AUTHORS   Du,Y., Tsai,S., Keller,J.R. and Williams,S.C.
  TITLE     Identification of an interleukin-3-regulated aldoketo reductase
            gene in myeloid cells which may function in autocrine regulation of
            myelopoiesis
  JOURNAL   J Biol Chem 275 (10), 6724-6732 (2000)
   PUBMED   10702227
REFERENCE   7  (bases 1 to 1231)
  AUTHORS   Ikeda,S., Okuda-Ashitaka,E., Masu,Y., Suzuki,T., Watanabe,K.,
            Nakao,M., Shingu,K. and Ito,S.
  TITLE     Cloning and characterization of two novel aldo-keto reductases
            (AKR1C12 and AKR1C13) from mouse stomach
  JOURNAL   FEBS Lett 459 (3), 433-437 (1999)
   PUBMED   10526179
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY148924.1, AK007716.1 and BY583815.1.
            
            On Jan 26, 2006 this sequence version replaced NM_013777.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007716.1, BC063780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 BY148924.1         2-4
            4-944               AK007716.1         2-942
            945-1006            BY583815.1         109-170
            1007-1231           AK007716.1         1005-1229
FEATURES             Location/Qualifiers
     source          1..1231
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 2.39 cM"
     gene            1..1231
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /note="aldo-keto reductase family 1, member C12"
                     /db_xref="GeneID:622402"
                     /db_xref="MGI:MGI:1351661"
     exon            1..127
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1015
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /note="aldo-keto reductase a"
                     /codon_start=1
                     /product="aldo-keto reductase family 1, member C12"
                     /protein_id="NP_038805.2"
                     /db_xref="CCDS:CCDS26222.1"
                     /db_xref="GeneID:622402"
                     /db_xref="MGI:MGI:1351661"
                     /translation="MSSKQHYVKLNDGHLIPALGFGTYKPKEVPKSKSLEAACLALDV
                     GYRHVDTAYAYQVEEEIGQAIQSKIKAGVVKREDLFITTKLWCGCFRPELVKPALEKS
                     LKSLQLDYVDLYLIHYPVPMKPGDNESPLDENGKFLLDTVDFCDTWERLEECKDAGLV
                     KSIGVSNFNHRQLERILNKPGLKYKPVCNQVECHLYLNQSKLLDYCKSKDIVLVAYGA
                     LGTQRYKEWVDQNSPVLLNDPVLCDVAKRNKRSPALIALRYLFQRGIVPLAQSFKENE
                     MRENLQVFEFQLSPEDMKTLDGLNKNFRYLPAEFLADHPEYPFSEEY"
     exon            128..295
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     exon            296..412
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     exon            413..490
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     exon            491..613
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     exon            614..723
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     exon            724..889
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     exon            890..972
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1231
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1205..1210
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
                     /note="hexamer: AATAAA"
     polyA_site      1226
                     /gene="Akr1c12"
                     /gene_synonym="Akra"
ORIGIN      
        1 aacagaagac tcaggaagtg cttagccagg ggagtgagag acaatgagct ccaaacagca
       61 ctatgtcaaa ctaaacgatg gccacttaat tcctgccctg ggctttggca cctataaacc
      121 caaggaggtt cccaagagta agtcactgga ggctgcatgc ctagctctag atgttgggta
      181 ccgccatgtt gatactgctt atgcatacca agtagaagag gagataggac aggccattca
      241 aagcaagatt aaagctgggg ttgtaaagag agaagacctg ttcatcacta caaagctttg
      301 gtgcggttgc tttcgaccag agctggtcaa gcctgctttg gaaaaatcac tgaaaagcct
      361 tcagctggat tatgttgatc tttaccttat acattaccca gtgccaatga agccagggga
      421 taatgaatct ccattagatg agaacgggaa atttctattg gacactgtgg atttctgtga
      481 cacatgggag aggttggagg agtgtaagga tgcaggattg gtcaagtcca ttggggtgtc
      541 caactttaac cacaggcagc tagagagaat cctcaacaag ccaggactga agtacaaacc
      601 tgtctgcaac caggttgaat gtcatctcta tttgaaccag agtaagctat tggattactg
      661 caagtcaaaa gacattgttc tcgttgctta cggtgctctg gggacccagc gatataaaga
      721 atgggtggac cagaactccc cagttctctt gaacgatcca gttctttgtg atgtggccaa
      781 aaggaacaag cgaagccctg ccctaattgc acttcgatac ctgtttcaac gtgggattgt
      841 gcccctggcc cagagtttca aagagaatga gatgagagag aatttgcagg tttttgaatt
      901 tcagttgtcc cctgaggaca tgaaaacact agatggcctg aacaaaaact ttcgatacct
      961 tccagcagag ttccttgctg accacccaga gtatccattt tcagaggaat attaacatgg
     1021 ggacctaatc atgacttctg cctgatgtcc ctgtgtgtgg accataatgc tggtgatgtg
     1081 actcagatgc tggtgaatgg aaacatcatt tctgatcagt cttggttgct tagcaactta
     1141 cattcagcgg aagctttagt tcatgatttc aagaaaaagg aatataattt tgatgacgct
     1201 ttgaaataaa tataaaattt tctctttaaa t
//
