LOCUS       NM_008012               1329 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member B8 (Akr1b8),
            mRNA.
ACCESSION   NM_008012
VERSION     NM_008012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1329)
  AUTHORS   Deng,Q., Yao,Y., Yang,J., Khoshaba,R., Shen,Y., Wang,X. and Cao,D.
  TITLE     AKR1B8 deficiency drives severe DSS-induced acute colitis through
            invasion of luminal bacteria and activation of innate immunity
  JOURNAL   Front Immunol 13, 1042549 (2022)
   PUBMED   36518763
  REMARK    GeneRIF: AKR1B8 deficiency drives severe DSS-induced acute colitis
            through invasion of luminal bacteria and activation of innate
            immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1329)
  AUTHORS   Rajak,S., Gupta,P., Anjum,B., Raza,S., Tewari,A., Ghosh,S.,
            Tripathi,M., Singh,B.K. and Sinha,R.A.
  TITLE     Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic
            steatohepatitis (NASH) in mouse
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (4), 166319 (2022)
   PUBMED   34954342
  REMARK    GeneRIF: Role of AKR1B10 and AKR1B8 in the pathogenesis of
            non-alcoholic steatohepatitis (NASH) in mouse.
REFERENCE   4  (bases 1 to 1329)
  AUTHORS   Cajigas,I., Chakraborty,A., Lynam,M., Swyter,K.R., Bastidas,M.,
            Collens,L., Luo,H., Ay,F. and Kohtz,J.D.
  TITLE     Sox2-Evf2 lncRNA-mediated mechanisms of chromosome topological
            control in developing forebrain
  JOURNAL   Development 148 (6) (2021)
   PUBMED   33593819
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1329)
  AUTHORS   Wang,X., Khoshaba,R., Shen,Y., Cao,Y., Lin,M., Zhu,Y., Cao,Z.,
            Liao,D.F. and Cao,D.
  TITLE     Impaired Barrier Function and Immunity in the Colon of Aldo-Keto
            Reductase 1B8 Deficient Mice
  JOURNAL   Front Cell Dev Biol 9, 632805 (2021)
   PUBMED   33644071
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1329)
  AUTHORS   Ho,H.T., Jenkins,N.A., Copeland,N.G., Gilbert,D.J., Winkles,J.A.,
            Louie,H.W., Lee,F.K., Chung,S.S. and Chung,S.K.
  TITLE     Comparisons of genomic structures and chromosomal locations of the
            mouse aldose reductase and aldose reductase-like genes
  JOURNAL   Eur J Biochem 259 (3), 726-730 (1999)
   PUBMED   10092857
REFERENCE   7  (bases 1 to 1329)
  AUTHORS   Lau,E.T., Cao,D., Lin,C., Chung,S.K. and Chung,S.S.
  TITLE     Tissue-specific expression of two aldose reductase-like genes in
            mice: abundant expression of mouse vas deferens protein and
            fibroblast growth factor-regulated protein in the adrenal gland
  JOURNAL   Biochem J 312 (Pt 2) (Pt 2), 609-615 (1995)
   PUBMED   8526877
REFERENCE   8  (bases 1 to 1329)
  AUTHORS   Fabre,S., Darne,C., Veyssiere,G. and Jean,C.
  TITLE     Characterization of the promoter of the gene for a mouse vas
            deferens protein related to the aldo-keto reductase superfamily:
            effect of steroid hormones and phorbol esters
  JOURNAL   J Steroid Biochem Mol Biol 55 (3-4), 315-325 (1995)
   PUBMED   8541228
REFERENCE   9  (bases 1 to 1329)
  AUTHORS   Wilson,D.K., Nakano,T., Petrash,J.M. and Quiocho,F.A.
  TITLE     1.7 A structure of FR-1, a fibroblast growth factor-induced member
            of the aldo-keto reductase family, complexed with coenzyme and
            inhibitor
  JOURNAL   Biochemistry 34 (44), 14323-14330 (1995)
   PUBMED   7578036
REFERENCE   10 (bases 1 to 1329)
  AUTHORS   Donohue,P.J., Alberts,G.F., Hampton,B.S. and Winkles,J.A.
  TITLE     A delayed-early gene activated by fibroblast growth factor-1
            encodes a protein related to aldose reductase
  JOURNAL   J Biol Chem 269 (11), 8604-8609 (1994)
   PUBMED   7510692
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC115767.14.
            
            On Feb 23, 2018 this sequence version replaced NM_008012.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U04204.1, BC005789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AC115767.14        57500-57650
            152-319             AC115767.14        59610-59777
            320-436             AC115767.14        60815-60931
            437-514             AC115767.14        61485-61562
            515-637             AC115767.14        66686-66808
            638-744             AC115767.14        67076-67182
            745-826             AC115767.14        67591-67672
            827-910             AC115767.14        68561-68644
            911-993             AC115767.14        69257-69339
            994-1329            AC115767.14        71480-71815
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 14.91 cM"
     gene            1..1329
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /note="aldo-keto reductase family 1, member B8"
                     /db_xref="GeneID:14187"
                     /db_xref="MGI:MGI:107673"
     exon            1..151
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1036
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /EC_number="1.1.1.21"
                     /note="AR; protein FR-1; aldehyde reductase; fibroblast
                     growth factor-regulated protein"
                     /codon_start=1
                     /product="aldose reductase-related protein 2"
                     /protein_id="NP_032038.1"
                     /db_xref="CCDS:CCDS19991.1"
                     /db_xref="GeneID:14187"
                     /db_xref="MGI:MGI:107673"
                     /translation="MATFVELSTKAKMPIVGLGTWKSPPNQVKEAVKAAIDAGYRHID
                     CAYAYCNENEVGEAIQEKIKEKAVQREDLFIVSKLWPTCFEKKLLKEAFQKTLTDLKL
                     DYLDLYLIHWPQGLQPGKELFPKDDQGRILTSKTTFLEAWEGMEELVDQGLVKALGVS
                     NFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGISVTAYSPLGSPDR
                     PSAKPEDPSLLEDPKIKEIAAKHEKTSAQVLIRFHIQRNVVVIPKSVTPSRIQENIQV
                     FDFQLSDEEMATILSFNRNWRACLLPETVNMEEYPYDAEY"
     exon            152..319
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            320..436
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            437..514
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..637
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            638..744
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            745..826
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            827..910
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..993
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            994..1329
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1295..1300
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /note="hexamer: AATAAA"
     polyA_site      1323
                     /gene="Akr1b8"
                     /gene_synonym="Fgfrp; Fgrp; FR-1"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcatcc aggacgttaa agcctccatc tgtctcatta acaaggacac agacatctgc
       61 tctcagcaag attttggcag caaccatggc cacgttcgtg gaactcagta ccaaagccaa
      121 gatgcccatt gtgggcctgg gcacctggaa gtctccccca aaccaagtca aagaagctgt
      181 gaaggcggcc attgacgctg ggtatcgcca tatcgactgc gcgtatgcct attgcaacga
      241 gaatgaggtg ggagaagcca tccaagagaa gatcaaagag aaggctgtgc agcgggagga
      301 cctcttcatt gtcagcaagc tgtggcccac ctgctttgag aagaaactgc taaaggaagc
      361 ctttcagaag accctcacgg atctgaagct ggactatttg gacctctatc ttattcactg
      421 gccacaggga cttcagccag gaaaggagtt attccccaaa gatgaccaag gcagaatcct
      481 caccagtaag acaacattct tggaagcctg ggagggcatg gaggaactgg tggaccaggg
      541 gctggtgaaa gctctgggcg tctccaactt caaccacttc cagattgaaa ggctcctgaa
      601 caagcctgga ctgaaacata agccagtgac caaccaggtt gagtgtcatc cttacctcac
      661 ccaggaaaaa ctgatccagt actgtcactc gaagggcatc tctgtcactg cctacagtcc
      721 cctgggctcc ccagacaggc ctagcgccaa gccagaggac ccttcactat tagaggaccc
      781 caaaattaaa gagattgccg ccaagcacga gaaaacctca gcccaggttc tgattcggtt
      841 tcacatccag aggaacgtgg tggtgatccc gaagtctgtg acgccatcac gtatacagga
      901 gaacattcag gtctttgatt tccagttgag tgacgaggag atggccacta tccttagctt
      961 caacagaaac tggagggcct gcctgctgcc tgagacagta aacatggaag aatatcccta
     1021 tgatgcagaa tactgaagct gagtcagccc acgaggcttc cttcctcttt gctgatgcac
     1081 acttccctcc tggagtcctg tttaagccca gcctgcctga catcctgcta taggcaaggc
     1141 tgtgtttaaa tccccacgct gaaccaggga cagactgttg cgagcaaatg cgactcggag
     1201 aagcgaacgg acatctcctt cactaatttg acctgaccgg atgtttgtca acaaccagga
     1261 actctggtaa catttgaggg catgcagata aaataataaa gaatgagaac attaacaaat
     1321 gtatccaac
//
