LOCUS       NM_009731               1248 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member B7 (Akr1b7),
            mRNA.
ACCESSION   NM_009731
VERSION     NM_009731.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1248)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   2  (bases 1 to 1248)
  AUTHORS   Xu,Z., Wang,W., Yang,T., Li,L., Ma,X., Chen,J., Wang,J., Huang,Y.,
            Gould,J., Lu,H., Du,W., Sahu,S.K., Yang,F., Li,Z., Hu,Q., Hua,C.,
            Hu,S., Liu,Y., Cai,J., You,L., Zhang,Y., Li,Y., Zeng,W., Chen,A.,
            Wang,B., Liu,L., Chen,F., Ma,K., Xu,X. and Wei,X.
  TITLE     STOmicsDB: a comprehensive database for spatial transcriptomics
            data sharing, analysis and visualization
  JOURNAL   Nucleic Acids Res 52 (D1), D1053-D1061 (2024)
   PUBMED   37953328
REFERENCE   3  (bases 1 to 1248)
  AUTHORS   Gu,H., Yang,K., Shen,Z., Jia,K., Liu,P., Pan,M. and Sun,C.
  TITLE     ER stress-induced adipocytes secrete-aldo-keto reductase
            1B7-containing exosomes that cause nonalcoholic steatohepatitis in
            mice
  JOURNAL   Free Radic Biol Med 163, 220-233 (2021)
   PUBMED   33359683
  REMARK    GeneRIF: ER stress-induced adipocytes secrete-aldo-keto reductase
            1B7-containing exosomes that cause nonalcoholic steatohepatitis in
            mice.
REFERENCE   4  (bases 1 to 1248)
  AUTHORS   Levy,I., Szarek,E., Maria,A.G., Starrost,M., De La Luz Sierra,M.,
            Faucz,F.R. and Stratakis,C.A.
  TITLE     A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional
            but reduced Pde11a: Phenotype and impact on adrenocortical function
  JOURNAL   Mol Cell Endocrinol 520, 111071 (2021)
   PUBMED   33127481
REFERENCE   5  (bases 1 to 1248)
  AUTHORS   England,A.R., Chaney,C.P., Das,A., Patel,M., Malewska,A.,
            Armendariz,D., Hon,G.C., Strand,D.W., Drake,K.A. and Carroll,T.J.
  TITLE     Identification and characterization of cellular heterogeneity
            within the developing renal interstitium
  JOURNAL   Development 147 (15) (2020)
   PUBMED   32586976
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1248)
  AUTHORS   Manin,M., Lecher,P., Martinez,A., Tournadre,S. and Jean,C.
  TITLE     Exportation of mouse vas deferens protein, a protein without a
            signal peptide, from mouse vas deferens epithelium: a model of
            apocrine secretion
  JOURNAL   Biol Reprod 52 (1), 50-62 (1995)
   PUBMED   7711183
REFERENCE   7  (bases 1 to 1248)
  AUTHORS   Fabre,S., Manin,M., Pailhoux,E., Veyssiere,G. and Jean,C.
  TITLE     Identification of a functional androgen response element in the
            promoter of the gene for the androgen-regulated aldose
            reductase-like protein specific to the mouse vas deferens
  JOURNAL   J Biol Chem 269 (8), 5857-5864 (1994)
   PUBMED   8119928
REFERENCE   8  (bases 1 to 1248)
  AUTHORS   Pailhoux,E., Veyssiere,G., Fabre,S., Tournaire,C. and Jean,C.
  TITLE     The genomic organization and DNA sequence of the mouse vas deferens
            androgen-regulated protein gene
  JOURNAL   J Steroid Biochem Mol Biol 42 (6), 561-568 (1992)
   PUBMED   1637719
REFERENCE   9  (bases 1 to 1248)
  AUTHORS   Pailhoux,E.A., Martinez,A., Veyssiere,G.M. and Jean,C.G.
  TITLE     Androgen-dependent protein from mouse vas deferens. cDNA cloning
            and protein homology with the aldo-keto reductase superfamily
  JOURNAL   J Biol Chem 265 (32), 19932-19936 (1990)
   PUBMED   2123194
REFERENCE   10 (bases 1 to 1248)
  AUTHORS   Martinez,A., Pailhoux,E., Berger,M. and Jean,C.
  TITLE     Androgen regulation of the mRNA encoding a major protein of the
            mouse vas deferens
  JOURNAL   Mol Cell Endocrinol 72 (3), 201-211 (1990)
   PUBMED   1981196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN833345.1 and BC086929.1.
            
            On Nov 16, 2007 this sequence version replaced NM_009731.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147775.1, AK002705.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                CN833345.1         3-29
            28-1248             BC086929.1         1-1221
FEATURES             Location/Qualifiers
     source          1..1248
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 14.95 cM"
     gene            1..1248
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /note="aldo-keto reductase family 1, member B7"
                     /db_xref="GeneID:11997"
                     /db_xref="MGI:MGI:101918"
     exon            1..114
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..999
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /EC_number="1.1.1.21"
                     /note="androgen regulated vas deferens protein; aldose
                     reductase-related protein 1; aldehyde reductase; vas
                     deferens androgen-dependent protein"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member B7"
                     /protein_id="NP_033861.2"
                     /db_xref="CCDS:CCDS19993.1"
                     /db_xref="GeneID:11997"
                     /db_xref="MGI:MGI:101918"
                     /translation="MATFVELSTKAKMPLVGLGTWKSSPGQVKEAVKAAIDAGYRHID
                     CAYVYHNENEVGEAIQEKIKENAVKREDLFIVSKLWATFFEKSLVKKAFQNTLSDLKL
                     DYLDLYLVHWPQGFQAGNALLPKDNKGKVLLSKSTFLDAWEAMEELVDQGLVKALGIS
                     NFNHFQIERLLNKPGLKHKPVTNQIESHPYLTQEKLIQYCQSKGIAVTAYSPLGSPDR
                     PYAKPEDPVVMEIPKIKEIAAKHKKTVAQVLIRFHVQRNVVVIPKSVTPSRIQENLQV
                     FDFQLSEEDMAAILSFNRNWRACDLLDARTEEDYPFHEEY"
     exon            115..282
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            283..399
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            400..477
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            478..600
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            601..707
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            708..789
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            790..873
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            874..956
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     exon            957..1248
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1242
                     /gene="Akr1b7"
                     /gene_synonym="AR; Avdp; MVDP"
ORIGIN      
        1 gaaagcaggc atttcatctg ctcactcaga gaactctctg cagcaaccat ggccaccttc
       61 gtggaactca gtaccaaagc caagatgccc cttgtgggcc tgggcacctg gaagtcttcc
      121 ccaggccaag tcaaggaagc cgtgaaggcg gccattgatg ctgggtatcg ccacattgac
      181 tgtgcctatg tgtatcacaa tgagaatgag gtgggagaag ctatccaaga gaagatcaaa
      241 gagaatgctg tgaagcggga ggatctcttc atcgtcagca agctgtgggc cacattcttt
      301 gagaaaagcc tggtgaagaa agccttccag aacaccctct cggatctgaa gctggactat
      361 ctggacctgt atctggtcca ctggccacag ggatttcagg ctgggaatgc gttattaccc
      421 aaagacaata aaggcaaagt tctcctgagt aaatccacat tcttggatgc ctgggaggcc
      481 atggaggaac tggtggacca ggggctggtg aaagctctgg gcatctccaa cttcaaccac
      541 ttccagattg aaaggctcct gaacaagcct ggactaaaac ataagccagt gaccaaccag
      601 attgagagcc acccttatct cacccaggaa aaactgatcc aatactgtca atccaagggc
      661 atcgctgtta cagcctacag tcccctgggc tccccagaca ggccttatgc caagccagaa
      721 gaccccgtag taatggagat tcccaagatc aaagagattg ctgcaaaaca caagaaaaca
      781 gtagctcagg ttctgattcg gttccatgtc caaaggaatg tggtggtgat ccccaagtct
      841 gtgacaccct cacgcataca ggagaacctg caggtcttcg acttccagtt gagtgaggag
      901 gacatggctg ccattctcag cttcaacagg aactggaggg cctgtgacct gttggatgca
      961 aggactgaag aggactatcc tttccacgag gaatactgag gtccacttgc ttgatgagat
     1021 ccgtgcatga tagattcctt cgtctctcta aaatcaacct ggatgtaggc taccatctgg
     1081 caatgcagga tttaaatttt tgtgttcatc aaggagcaag aaaatgttcc agagaaacga
     1141 agggcaacgg ttctcactag cgagggctga gcacatgttt gtcatcagga gcatgtagta
     1201 tggtaacact gaagatacaa tgatagaaca ataaaaaagc aataatag
//
