LOCUS       NM_172398               1341 bp    mRNA    linear   ROD 04-AUG-2023
DEFINITION  Mus musculus aldo-keto reductase family 1, member B10 (Akr1b10),
            transcript variant 1, mRNA.
ACCESSION   NM_172398 XM_973812
VERSION     NM_172398.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1341)
  AUTHORS   Rajak S, Gupta P, Anjum B, Raza S, Tewari A, Ghosh S, Tripathi M,
            Singh BK and Sinha RA.
  TITLE     Role of AKR1B10 and AKR1B8 in the pathogenesis of non-alcoholic
            steatohepatitis (NASH) in mouse
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1868 (4), 166319 (2022)
   PUBMED   34954342
  REMARK    GeneRIF: Role of AKR1B10 and AKR1B8 in the pathogenesis of
            non-alcoholic steatohepatitis (NASH) in mouse.
REFERENCE   2  (bases 1 to 1341)
  AUTHORS   Gimenez-Dejoz J, Weber S, Barski OA, Moller G, Adamski J, Pares X,
            Porte S and Farres J.
  TITLE     Characterization of AKR1B16, a novel mouse aldo-keto reductase
  JOURNAL   Chem Biol Interact 276, 182-193 (2017)
   PUBMED   28322781
  REMARK    GeneRIF: AKR1B16 reduced aliphatic and aromatic carbonyl compounds,
            using NADPH as a cofactor, with moderate or low activity (highest
            kcat values around 5 min(-1)). AKR1B16 showed poor inhibition with
            classical AKR inhibitors, tolrestat being the most potent.
REFERENCE   3  (bases 1 to 1341)
  AUTHORS   Li H, Yang AL, Chung YT, Zhang W, Liao J and Yang GY.
  TITLE     Sulindac inhibits pancreatic carcinogenesis in
            LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing
            aldo-keto reductase family 1B10 (AKR1B10)
  JOURNAL   Carcinogenesis 34 (9), 2090-2098 (2013)
   PUBMED   23689354
  REMARK    GeneRIF: Our results demonstrate that sulindac inhibits pancreatic
            carcinogenesis by the inhibition of Kras protein prenylation by
            targeting AKR1B10.
REFERENCE   4  (bases 1 to 1341)
  AUTHORS   Salabei JK, Li XP, Petrash JM, Bhatnagar A and Barski OA.
  TITLE     Functional expression of novel human and murine AKR1B genes
  JOURNAL   Chem Biol Interact 191 (1-3), 177-184 (2011)
   PUBMED   21276782
  REMARK    GeneRIF: AKR1B15 and Akr1b16 genes are expressed as functional
            proteins in human and murine tissues [Akr1b16]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK075865.1, AK082777.1 and BY430637.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_973812.1, NM_172398.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK075865.1, AK087002.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AK075865.1         3-45
            44-434              AK082777.1         2-392
            435-446             AK075865.1         437-448
            447-1312            AK082777.1         405-1270
            1313-1341           BY430637.1         360-388
FEATURES             Location/Qualifiers
     source          1..1341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 14.93 cM"
     gene            1..1341
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /note="aldo-keto reductase family 1, member B10"
                     /db_xref="GeneID:67861"
                     /db_xref="MGI:MGI:1915111"
     exon            1..161
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1046
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /EC_number="1.1.1.2"
                     /note="aldo-keto reductase family 1, member B10 (aldose
                     reductase)"
                     /codon_start=1
                     /product="aldo-keto reductase family 1, member B10"
                     /protein_id="NP_765986.3"
                     /db_xref="CCDS:CCDS19992.1"
                     /db_xref="GeneID:67861"
                     /db_xref="MGI:MGI:1915111"
                     /translation="MAAFVTLLTGAKMPIVGLGTWKSPPAKVREAVKVAIDAGYRHID
                     CAYVYQNESEVGEAIQEKIQEKAVKREDLFIVSKLWSTFFEKSLVKKAFQNTLSDLKL
                     DYLDLYLIHWPQGFQSGNVFLPTDDKGSILSSKYTFLDAWEAMEELVDQGLVKALGVS
                     NFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGITITAYSPLGSPDR
                     PSAKPEDPLLLEIPKIKEIAAKHKRTAAQVLIRFHIERNVVVIPKSVTPSRIQENIQV
                     FDFQLSEEDMAAILSFNRNWRACGLFAASHNEDFPFHAEY"
     exon            162..329
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            330..446
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            447..524
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            525..647
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            648..754
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            755..836
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            837..920
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1003
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1341
                     /gene="Akr1b10"
                     /gene_synonym="2310005E10Rik; Akr1b16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcctgtct cctcaaggac acggaaccag ttgccagact cctaatttag gcaaaggctc
       61 ccgtctgttc cctttgaacc gtttctgcag caaccatggc cgccttcgtg acgctcctta
      121 ccggagccaa gatgcccatt gtgggcctgg gcacctggaa gtctccccca gctaaagtca
      181 gggaagctgt gaaggtggcc attgatgctg ggtatcgcca cattgattgt gcctatgtct
      241 atcagaatga gagcgaggtg ggagaagcca tccaagagaa gatccaggag aaggctgtga
      301 agcgggagga cctcttcatc gtcagcaagc tgtggtccac cttctttgag aaaagcctgg
      361 tgaagaaagc cttccagaac accctctcgg atctgaagct tgactacctg gacctgtatc
      421 taatccactg gccacaggga tttcagtctg gaaatgtctt tttacccaca gatgataaag
      481 gcagtattct cagcagtaaa tatacgttct tggatgcttg ggaggccatg gaggaactgg
      541 tggaccaggg gctggtgaaa gctctgggtg tctccaactt caaccacttc cagattgaaa
      601 ggctcctgaa caagcctgga ctgaaacata agccagtgac caaccaggtc gagtgtcacc
      661 cttacctcac ccaggaaaaa ctgatccagt actgtcactc caagggcatc accatcacag
      721 cctacagtcc cctgggctcc ccagacaggc ctagtgccaa accagaggac cccctattac
      781 tggagattcc caagatcaaa gagattgctg caaagcacaa gaggactgca gcacaggttc
      841 tgattcggtt ccatatagag aggaacgtgg tggtgatccc caagtctgtg acaccttctc
      901 gaatacagga gaacattcag gtcttcgact tccagttaag tgaggaggac atggccgcca
      961 ttctcagctt caacaggaac tggagggcct gtggcctgtt tgcagcaagt cataacgagg
     1021 acttcccttt ccatgcggaa tactgaagcc aagtaccaga tgcgcttgcc tggaggacac
     1081 tcttcactga tatgcaaccc gctcctactg actcctattt ttgccaagcc tattggatat
     1141 cataccaaac cagcctcaac agtgcaattc tgcatttaaa ttctcatgtt caactagaag
     1201 cagactgtca caggaagatg catctcagca aagggcaatg tttgtcacta atttgacctg
     1261 gccggatgtt tgtcagaaac caggaacact aataacactg aagattaaaa agataaaata
     1321 ataaaaatag caataatcgt a
//
