LOCUS       NM_009658               1402 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus aldo-keto reductase family 1 member B (Akr1b1), mRNA.
ACCESSION   NM_009658
VERSION     NM_009658.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1402)
  AUTHORS   Yu,P.C., Hou,D., Chang,B., Liu,N., Xu,C.H., Chen,X., Hu,C.L.,
            Liu,T., Wang,X., Zhang,Q., Liu,P., Jiang,Y., Fei,M.Y., Zong,L.J.,
            Zhang,J.Y., Liu,H., Chen,B.Y., Chen,S.B., Wang,Y., Li,Z.J., Li,X.,
            Deng,C.H., Ren,Y.Y., Zhao,M., Jiang,S., Wang,R., Jin,J., Yang,S.,
            Xue,K., Shi,J., Chang,C.K., Shen,S., Wang,Z., He,P.C., Chen,Z.,
            Chen,S.J., Sun,X.J. and Wang,L.
  TITLE     SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control
            leukemogenesis
  JOURNAL   Dev Cell 59 (15), 1954-1971 (2024)
   PUBMED   38776924
  REMARK    GeneRIF: SMARCA5 reprograms AKR1B1-mediated fructose metabolism to
            control leukemogenesis.
REFERENCE   2  (bases 1 to 1402)
  AUTHORS   Mandava,A., Pham,B., Pedler,M., Shieh,B., Gopalakrishnan,H. and
            Petrash,J.M.
  TITLE     High incidence of sebaceous gland inflammation in aldose
            reductase-deficient mice
  JOURNAL   Chem Biol Interact 392, 110905 (2024)
   PUBMED   38373627
  REMARK    GeneRIF: High incidence of sebaceous gland inflammation in aldose
            reductase-deficient mice.
REFERENCE   3  (bases 1 to 1402)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 1402)
  AUTHORS   Syamprasad,N.P., Rajdev,B., Jain,S., Panda,S.R., Puppala,E.R.,
            Chaudhari,P., Vaidya,J.R., Kumar,G.J. and Naidu,V.G.M.
  TITLE     Pivotal role of AKR1B1 in pathogenesis of colitis associated
            colorectal carcinogenesis
  JOURNAL   Int Immunopharmacol 119, 110145 (2023)
   PUBMED   37044030
  REMARK    GeneRIF: Pivotal role of AKR1B1 in pathogenesis of colitis
            associated colorectal carcinogenesis.
REFERENCE   5  (bases 1 to 1402)
  AUTHORS   Beyoglu,D., Huang,P., Skelton-Badlani,D., Zong,C., Popov,Y.V. and
            Idle,J.R.
  TITLE     Metabolic Hijacking of Hexose Metabolism to Ascorbate Synthesis Is
            the Unifying Biochemical Basis of Murine Liver Fibrosis
  JOURNAL   Cells 12 (3), 485 (2023)
   PUBMED   36766828
  REMARK    GeneRIF: Metabolic Hijacking of Hexose Metabolism to Ascorbate
            Synthesis Is the Unifying Biochemical Basis of Murine Liver
            Fibrosis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1402)
  AUTHORS   Daoudal,S., Tournaire,C., Halere,A., Veyssiere,G. and Jean,C.
  TITLE     Isolation of the mouse aldose reductase promoter and identification
            of a tonicity-responsive element
  JOURNAL   J Biol Chem 272 (5), 2615-2619 (1997)
   PUBMED   9006894
REFERENCE   7  (bases 1 to 1402)
  AUTHORS   Gui,T., Tanimoto,T., Kokai,Y. and Nishimura,C.
  TITLE     Presence of a closely related subgroup in the aldo-ketoreductase
            family of the mouse
  JOURNAL   Eur J Biochem 227 (1-2), 448-453 (1995)
   PUBMED   7851421
REFERENCE   8  (bases 1 to 1402)
  AUTHORS   Prochazka,M., Staeheli,P., Holmes,R.S. and Haller,O.
  TITLE     Interferon-induced guanylate-binding proteins: mapping of the
            murine Gbp-1 locus to chromosome 3
  JOURNAL   Virology 145 (2), 273-279 (1985)
   PUBMED   3927587
REFERENCE   9  (bases 1 to 1402)
  AUTHORS   Mather,P.B. and Holmes,R.S.
  TITLE     Aldehyde reductase isozymes in the mouse: evidence for two new loci
            and localization of Ahr-3 on chromosome 7
  JOURNAL   Biochem Genet 23 (5-6), 483-496 (1985)
   PUBMED   3899099
REFERENCE   10 (bases 1 to 1402)
  AUTHORS   Duley,J.A. and Holmes,R.S.
  TITLE     Biochemical genetics of aldehyde reductase in the mouse: Ahr-1--a
            new locus linked to the alcohol dehydrogenase gene complex on
            chromosome 3
  JOURNAL   Biochem Genet 20 (11-12), 1067-1083 (1982)
   PUBMED   6762206
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY749711.1, AK164682.1 and AV301527.1.
            
            On Nov 20, 2007 this sequence version replaced NM_009658.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021655.1, AK153949.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BY749711.1         1-46
            47-1396             AK164682.1         2-1351
            1397-1402           AV301527.1         282-287
FEATURES             Location/Qualifiers
     source          1..1402
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 14.87 cM"
     gene            1..1402
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /note="aldo-keto reductase family 1 member B"
                     /db_xref="GeneID:11677"
                     /db_xref="MGI:MGI:1353494"
     exon            1..150
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            151..318
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            319..435
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            436..513
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            514..636
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            637..743
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            744..825
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            826..909
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            910..992
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1402
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1378..1383
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /note="hexamer: AATAAA"
     polyA_site      1402
                     /gene="Akr1b1"
                     /gene_synonym="Ahr-1; Ahr1; Akr1b3; Aldor1; Aldr1; ALR2;
                     AR"
                     /note="major polyA site"
ORIGIN      
        1 tacaggccgt tggggctatt taaaggtgcg cgcccgagcc agcgctgcac atttgccggt
       61 ccgggtttgt aacgtgcagc gatcatggcc agccatctgg aactcaacaa cggcaccaag
      121 atgcccaccc tgggcctggg cacctggaag tcccctcctg gccaggtgac tgaggccgtg
      181 aaagttgcta ttgacttggg gtaccgccac attgactgcg cccaggtgta ccagaatgag
      241 aaggaggtgg gagtggccct ccaggagaag ctcaaggagc aggtggtgaa gcggcaggat
      301 ctcttcattg tcagcaagct gtggtgcacg ttccatgaca agagcatggt gaaaggagcc
      361 ttccagaaga cactgagcga cctgcagctg gactacctgg atctctacct tattcactgg
      421 ccaacggggt tcaagcctgg gcccgactat ttcccactgg atgcctcagg gaacgtgata
      481 cctagtgaca ccgattttgt ggacacttgg acggctatgg aacaactagt ggatgaaggt
      541 ttggtgaaaa caatcggtgt ctccaacttc aaccctcttc agattgagag gatcttgaac
      601 aaacctggct taaaatataa gcctgcggtg aaccagatcg agtgccaccc gtacctaact
      661 caggagaagc tgattgaata ctgccacagc aaaggcatcg tggtgacagc atatagtccc
      721 cttggttctc ctgacaggcc ctgggccaag cctgaagatc cgtctctcct ggaggatccc
      781 aggatcaaag caattgcagc caagtacaat aaaactacag cccaggtgct gatccggttc
      841 cccattcaga ggaacttggt agtgatcccc aagtctgtga caccagtgcg cattgctgag
      901 aacttgaagg tctttgactt tgaggtgagc agcgaggaca tggccactct actcagctac
      961 aacaggaact ggagggtgtg cgccttgatg agctgtgcca aacacaagga ttaccccttc
     1021 cacgccgaag tctgaagctg tggcgagcag atccctgctc ctcctcaagt ggcttgcacc
     1081 tgttctttct gcctcatctg cccttgcaag tgtcctgtgt ctctgcacta ggtggcacct
     1141 tgcaaaccag atggtgagag ttagttagtt tgacatagag tctggagggc agtaccagta
     1201 gccaaggtgt ttcttccagc cttccttggt ctttcttctt acccacctgg aggactttaa
     1261 cacaagtacc ctttccaacc aaagagaagc aagctttaga gtccaagccg tgccactaac
     1321 acttaaatgt gagtgcttag aactgtaatc ctttgggtca gacttctcct tgcctcaaat
     1381 aaaaactgct tttgtgaatt tg
//
