LOCUS       NM_021473               1435 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus aldo-keto reductase family 1, member A1 (Akr1a1),
            mRNA.
ACCESSION   NM_021473 XM_905275
VERSION     NM_021473.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1435)
  AUTHORS   Stomberski,C.T., Venetos,N.M., Zhou,H.L., Qian,Z., Collison,B.R.,
            Field,S.J., Premont,R.T. and Stamler,J.S.
  TITLE     A multienzyme S-nitrosylation cascade regulates cholesterol
            homeostasis
  JOURNAL   Cell Rep 41 (4), 111538 (2022)
   PUBMED   36288700
REFERENCE   2  (bases 1 to 1435)
  AUTHORS   Kimura,S., Osaki,T., Homma,T., Kimura,S., Kobayashi,S., Nakane,M.,
            Miyata,S., Itoh,H., Kawamae,K. and Fujii,J.
  TITLE     The concerted elevation of conjugation reactions is associated with
            the aggravation of acetaminophen toxicity in Akr1a-knockout mice
            with an ascorbate insufficiency
  JOURNAL   Life Sci 304, 120694 (2022)
   PUBMED   35679914
  REMARK    GeneRIF: The concerted elevation of conjugation reactions is
            associated with the aggravation of acetaminophen toxicity in
            Akr1a-knockout mice with an ascorbate insufficiency.
REFERENCE   3  (bases 1 to 1435)
  AUTHORS   Ishii,N., Homma,T., Takeda,Y., Aung,N.Y., Yamada,K.I., Miyata,S.,
            Asao,H., Yamakawa,M. and Fujii,J.
  TITLE     Developmental retardation in neonates of aldehyde reductase
            (AKR1A)-deficient mice is associated with low ascorbic acid and
            high corticosterone levels
  JOURNAL   J Nutr Biochem 91, 108604 (2021)
   PUBMED   33549889
  REMARK    GeneRIF: Developmental retardation in neonates of aldehyde
            reductase (AKR1A)-deficient mice is associated with low ascorbic
            acid and high corticosterone levels.
REFERENCE   4  (bases 1 to 1435)
  AUTHORS   Takahashi,M., Homma,T., Yamada,K.I., Miyata,S., Nakajima,O. and
            Fujii,J.
  TITLE     Genetic ablation of aldehyde reductase (Akr1a) augments exercise
            endurance in mice via activation of the PGC-1alpha-involved pathway
  JOURNAL   Life Sci 249, 117501 (2020)
   PUBMED   32142766
  REMARK    GeneRIF: genetic ablation of AKR1A activates the PGC-1alpha pathway
            and spare glucose, which would consequently confer exercise
            endurance
REFERENCE   5  (bases 1 to 1435)
  AUTHORS   Stomberski,C.T., Anand,P., Venetos,N.M., Hausladen,A., Zhou,H.L.,
            Premont,R.T. and Stamler,J.S.
  TITLE     AKR1A1 is a novel mammalian S-nitroso-glutathione reductase
  JOURNAL   J Biol Chem 294 (48), 18285-18293 (2019)
   PUBMED   31649033
REFERENCE   6  (bases 1 to 1435)
  AUTHORS   Barski,O.A., Papusha,V.Z., Ivanova,M.M., Rudman,D.M. and
            Finegold,M.J.
  TITLE     Developmental expression and function of aldehyde reductase in
            proximal tubules of the kidney
  JOURNAL   Am J Physiol Renal Physiol 289 (1), F200-F207 (2005)
   PUBMED   15769935
REFERENCE   7  (bases 1 to 1435)
  AUTHORS   Barski,O.A., Papusha,V.Z., Kunkel,G.R. and Gabbay,K.H.
  TITLE     Regulation of aldehyde reductase expression by STAF and CHOP
  JOURNAL   Genomics 83 (1), 119-129 (2004)
   PUBMED   14667815
REFERENCE   8  (bases 1 to 1435)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 1435)
  AUTHORS   Allan,D. and Lohnes,D.
  TITLE     Cloning and developmental expression of mouse aldehyde reductase
            (AKR1A4)
  JOURNAL   Mech Dev 94 (1-2), 271-275 (2000)
   PUBMED   10842086
REFERENCE   10 (bases 1 to 1435)
  AUTHORS   Tulsiani,D.R. and Touster,O.
  TITLE     Studies on dehydrogenases of the glucuronate-xylulose cycle in the
            livers of diabetic mice and rats
  JOURNAL   Diabetes 28 (9), 793-798 (1979)
   PUBMED   38160
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL831786.7, BY329410.1, AK164461.1 and BC046762.1.
            
            On Dec 16, 2011 this sequence version replaced NM_021473.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY207463.1, BC046762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AL831786.7         25643-25656         c
            15-46               BY329410.1         2-33
            47-1413             AK164461.1         2-1368
            1414-1435           BC046762.1         1320-1341
FEATURES             Location/Qualifiers
     source          1..1435
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 53.26 cM"
     gene            1..1435
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /note="aldo-keto reductase family 1, member A1"
                     /db_xref="GeneID:58810"
                     /db_xref="MGI:MGI:1929955"
     exon            1..336
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            337..426
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1320
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /EC_number="1.1.1.2"
                     /EC_number="1.1.1.54"
                     /EC_number="1.1.1.19"
                     /EC_number="1.1.1.20"
                     /EC_number="1.1.1.372"
                     /note="aldehyde reductase; alcohol dehydrogenase;
                     aldo-keto reductase family 1, member A4 (aldehyde
                     reductase); glucuronate reductase; glucuronolactone
                     reductase; scorR; S-nitroso-CoA reductase"
                     /codon_start=1
                     /product="aldo-keto reductase family 1 member A1"
                     /protein_id="NP_067448.1"
                     /db_xref="CCDS:CCDS18514.1"
                     /db_xref="GeneID:58810"
                     /db_xref="MGI:MGI:1929955"
                     /translation="MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHI
                     DCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADL
                     QLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALG
                     LSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDR
                     AWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQV
                     FDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY"
     exon            427..546
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            547..698
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            699..894
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1094
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1167
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1254
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1414
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1395..1400
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /note="hexamer: AATAAA"
     polyA_site      1414
                     /gene="Akr1a1"
                     /gene_synonym="2610201A18Rik; Akr1a4"
                     /note="major polyA site"
ORIGIN      
        1 gggcgcggcc agccacccaa gactgtccac gtagcttgtg cgcatgcaca gtttcgggac
       61 cccggccctt ccagacgttc gtggtggagt gagaggttcc caggggagga atgtgcaaag
      121 tcccagcttt ggcttctact ccctcttcta cttcgcagga cagtgggggt ctcctccgtc
      181 ctgcgcgtag ttctgggagc cgggccctcg ctcctccctg gggtggggct gccgcttctc
      241 cgccggactt aagtcgggcc ctgttgcctc agtactggag tgcagagctg aattcgggcc
      301 actttgtctt ttccacagcc tgtgctcact gccaagggga caatgacggc ctccagtgtc
      361 ctcctgcaca ctggacagaa gatgcctctg attggtctgg ggacatggaa gagtgagcct
      421 ggtcaggtga aagcagccat taaacatgcc cttagcgcag gctaccgcca cattgattgt
      481 gcttctgtat atggcaatga aactgagatt ggggaggccc tgaaggagag tgtggggtca
      541 ggcaaggcag tccctcgaga ggagctgttt gtgacatcca agctgtggaa tactaagcac
      601 caccctgagg atgtagaacc tgccctccgg aagacactgg ctgatctgca actggagtat
      661 ttggacctct atttgatgca ctggccttat gcctttgagc ggggagacaa tccctttccc
      721 aagaatgccg atggaactgt cagatatgac tcaactcact ataaagagac ctggaaggct
      781 ctggaggtac tggtggcaaa ggggctggtg aaagccctgg gcttgtccaa cttcaacagt
      841 cggcagattg atgatgtcct cagtgtggcc tctgtgcgcc cagctgtctt gcaggtggaa
      901 tgccatccat acctggctca gaatgagctc attgcccact gtcacgcacg gggcttggag
      961 gtgactgctt atagcccctt gggttcctct gaccgtgctt ggcgccatcc tgatgagcca
     1021 gtcctgcttg aagaaccagt agtcttggca ctagctgaaa aacatggccg atctccagct
     1081 cagatcttgc ttagatggca ggttcagcgg aaagtgatct gcatccccaa aagcatcaat
     1141 ccttcccgca tccttcagaa cattcaggta tttgatttca cctttagccc agaggagatg
     1201 aaacaattag atgctctgaa caaaaattgg cggtatattg tgcccatgat tacggtggat
     1261 gggaagaggg ttcccagaga tgctggacac cctctgtatc cctttaatga cccatactga
     1321 gacctatagt ttctcagctt ccctttcagt tctcctgcta agcattgcct gctactcccc
     1381 agaaagaagg aatcaataaa gccattgaag tgtaaaaaaa aaaaaaaaaa aaaaa
//
