LOCUS       NM_007432               2550 bp    mRNA    linear   ROD 09-JUN-2024
DEFINITION  Mus musculus alkaline phosphatase 3, intestine, not Mn requiring
            (Akp3), mRNA.
ACCESSION   NM_007432 XM_978105
VERSION     NM_007432.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2550)
  AUTHORS   Liu,Y., Cavallaro,P.M., Kim,B.M., Liu,T., Wang,H., Kuhn,F.,
            Adiliaghdam,F., Liu,E., Vasan,R., Samarbafzadeh,E., Farber,M.Z.,
            Li,J., Xu,M., Mohad,V., Choi,M. and Hodin,R.A.
  TITLE     A role for intestinal alkaline phosphatase in preventing liver
            fibrosis
  JOURNAL   Theranostics 11 (1), 14-26 (2021)
   PUBMED   33391458
  REMARK    GeneRIF: A role for intestinal alkaline phosphatase in preventing
            liver fibrosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2550)
  AUTHORS   Kuhn,F., Adiliaghdam,F., Cavallaro,P.M., Hamarneh,S.R., Tsurumi,A.,
            Hoda,R.S., Munoz,A.R., Dhole,Y., Ramirez,J.M., Liu,E., Vasan,R.,
            Liu,Y., Samarbafzadeh,E., Nunez,R.A., Farber,M.Z., Chopra,V.,
            Malo,M.S., Rahme,L.G. and Hodin,R.A.
  TITLE     Intestinal alkaline phosphatase targets the gut barrier to prevent
            aging
  JOURNAL   JCI Insight 5 (6), 134049 (2020)
   PUBMED   32213701
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2550)
  AUTHORS   Yang,W.H., Heithoff,D.M., Aziz,P.V., Haslund-Gourley,B.,
            Westman,J.S., Narisawa,S., Pinkerton,A.B., Millan,J.L., Nizet,V.,
            Mahan,M.J. and Marth,J.D.
  TITLE     Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes
            by Discrete Pathogens Fuels Sepsis
  JOURNAL   Cell Host Microbe 24 (4), 500-513 (2018)
   PUBMED   30308156
REFERENCE   4  (bases 1 to 2550)
  AUTHORS   Sasaki,S., Segawa,H., Hanazaki,A., Kirino,R., Fujii,T., Ikuta,K.,
            Noguchi,M., Sasaki,S., Koike,M., Tanifuji,K., Shiozaki,Y.,
            Kaneko,I., Tatsumi,S., Shimohata,T., Kawai,Y., Narisawa,S.,
            Millan,J.L. and Miyamoto,K.I.
  TITLE     A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic
            Phosphate Homeostasis
  JOURNAL   Kidney Blood Press Res 43 (5), 1409-1424 (2018)
   PUBMED   30212831
  REMARK    GeneRIF: intestinal Akp3 deletion affects Na+-dependent Pi
            transport in the small intestine. In the adenine-induced renal
            failure model, Akp3 is predicted to be a factor contributing to
            suppression of the plasma Pi concentration.
REFERENCE   5  (bases 1 to 2550)
  AUTHORS   Vercalsteren,E., Vranckx,C., Lijnen,H.R., Hemmeryckx,B. and
            Scroyen,I.
  TITLE     Adiposity and metabolic health in mice deficient in intestinal
            alkaline phosphatase
  JOURNAL   Adipocyte 7 (3), 149-155 (2018)
   PUBMED   30064292
  REMARK    GeneRIF: data do not support a functional role of AKP3 in adipose
            tissue development, or insulin sensitivity
REFERENCE   6  (bases 1 to 2550)
  AUTHORS   Vidal,S.M., Epstein,D.J., Malo,D., Weith,A., Vekemans,M. and
            Gros,P.
  TITLE     Identification and mapping of six microdissected genomic DNA probes
            to the proximal region of mouse chromosome 1
  JOURNAL   Genomics 14 (1), 32-37 (1992)
   PUBMED   1358796
REFERENCE   7  (bases 1 to 2550)
  AUTHORS   Traut,W., Seldin,M.F. and Winking,H.
  TITLE     Genetic mapping and assignment of a long-range repeat cluster to
            band D of chromosome 1 in Mus musculus and M. spretus
  JOURNAL   Cytogenet Cell Genet 60 (2), 128-130 (1992)
   PUBMED   1611911
REFERENCE   8  (bases 1 to 2550)
  AUTHORS   Epstein,D.J., Vekemans,M. and Gros,P.
  TITLE     Splotch (Sp2H), a mutation affecting development of the mouse
            neural tube, shows a deletion within the paired homeodomain of
            Pax-3
  JOURNAL   Cell 67 (4), 767-774 (1991)
   PUBMED   1682057
REFERENCE   9  (bases 1 to 2550)
  AUTHORS   Malo,D., Schurr,E., Epstein,D.J., Vekemans,M., Skamene,E. and
            Gros,P.
  TITLE     The host resistance locus Bcg is tightly linked to a group of
            cytoskeleton-associated protein genes that include villin and
            desmin
  JOURNAL   Genomics 10 (2), 356-364 (1991)
   PUBMED   1676979
REFERENCE   10 (bases 1 to 2550)
  AUTHORS   Epstein,D.J., Malo,D., Vekemans,M. and Gros,P.
  TITLE     Molecular characterization of a deletion encompassing the splotch
            mutation on mouse chromosome 1
  JOURNAL   Genomics 10 (1), 89-93 (1991)
   PUBMED   2045114
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102611.10.
            
            On Jun 17, 2019 this sequence version replaced NM_007432.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC115745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               AC102611.10        83221-83341
            122-238             AC102611.10        83425-83541
            239-354             AC102611.10        83659-83774
            355-529             AC102611.10        83894-84068
            530-702             AC102611.10        84147-84319
            703-837             AC102611.10        84577-84711
            838-910             AC102611.10        84793-84865
            911-1045            AC102611.10        84995-85129
            1046-1237           AC102611.10        85203-85394
            1238-1351           AC102611.10        85597-85710
            1352-2550           AC102611.10        85797-86995
FEATURES             Location/Qualifiers
     source          1..2550
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.06 cM"
     gene            1..2550
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /note="alkaline phosphatase 3, intestine, not Mn
                     requiring"
                     /db_xref="GeneID:11648"
                     /db_xref="MGI:MGI:87984"
     exon            1..121
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            122..238
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            239..354
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            355..529
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            530..702
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            703..837
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            838..910
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1045
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1237
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1351
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..2550
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2528..2533
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /note="hexamer: AATAAA"
     polyA_site      2550
                     /gene="Akp3"
                     /gene_synonym="Akp-3; dIAP; IAP"
                     /note="major polyA site"
ORIGIN      
        1 gatccctggt gtctcgtgtc tttgtctgct gctgtcccgc caccagcccc agccatgcag
       61 ggcacctggg tgctgctgct gctgggcctc aggctacagc tgtcccttag tgtcattcca
      121 gtggaggagg agaacccggc cttctggaac aagaaggcag ccgaggccct ggatgctgcc
      181 aagaagctgc agcccattca gacatcagct aagaacctca tcatcttcct gggtgacggg
      241 atgggggtac caacagtgac agccaccagg atcctaaagg gacagttgga aggtcatcta
      301 ggacctgaga cacccctagc catggaccgc ttcccatata tggctctgtc caagacatac
      361 agtgtggaca gacaggttcc agacagtgca agcacggcca ccgcctacct gtgtggggtc
      421 aagaccaact acaagaccat cggcgtgagc gcagccgcga gattcgacca gtgcaacacc
      481 acatttggca atgaggtctt ctcagtgatg taccgtgcca agaaagcagg aaaatccgta
      541 ggtgtggtga ccaccaccag agtgcagcac gcctctccct cgggcacata tgttcacaca
      601 gtgaaccgca attggtatgg ggatgctgac atgcctgcct ctgcgctgcg ggaaggttgc
      661 aaggacattg ctacacaact catctccaac atggacatta atgtgatcct tggtgggggc
      721 cgaaaataca tgtttcctgc tggaacccca gaccccgagt atccaaatga tgctaatgag
      781 actggaacca gattggatgg caggaatctg gtgcaggaat ggctgtcaaa gcaccaggga
      841 tcccagtatg tttggaatcg tgaacaactc attcagaagg cccaggatcc gtcagtgaca
      901 tacctcatgg gcctctttga gcctgtagac acaaaatttg atattcaacg agatcccctg
      961 atggacccat ctctgaagga tatgacagag gcggccgtga aagtgctaag caggaacccc
     1021 aaaggctttt atctctttgt ggaggggggc cgaatcgacc gtggtcacca tctgggcaca
     1081 gcttatctgg cgctgactga ggctgtgatg ttcgacttag ccatcgagag ggccagccag
     1141 ctcactagtg aacgcgacac tctgaccata gtcactgctg accactccca tgtcttctcc
     1201 tttggtggct acacacttcg agggacctcc atcttcgggc tggctcccct caatgctctg
     1261 gacggcaagc cctacacctc catcctgtat ggcaacggcc caggctatgt cggtacaggg
     1321 gaaagaccca acgtcaccgc cgctgaaagc agtggctcat cgtaccggca gcaggctgct
     1381 gtgccggtga agtcggagac ccacggcggg gaggacgtgg cgatattcgc gcgtggcccg
     1441 caggcgcact tgctgcacgg ggtgcaggag cagaactaca tcgcgcacgt catggccttc
     1501 gcaggctgcc tggagcccta caccgactgc ggcttggcac cccctgcaga tgaaagccag
     1561 accaccacga caacccgcca gaccaccatc accaccacca ccaccaccac caccaccaca
     1621 accaccccgg tccataacag cgccagaagc ctgggcccag ccaccgcccc gctggctctg
     1681 gcgctgctgg ccggaatgct gatgctacta ctaggggctc ctgcggagtc ctaaactcca
     1741 gcacatctag gctccaccca ctaggtccca cgccctcacc tggtccttcc cttccctgac
     1801 ctcagtgctc cctgcattct gggtgcgggc tctaccccag gatcctctct ctgtctttct
     1861 gctactggcc tcatgtctag ccctaccttg cattgcagct tccaggttcc tcctacccag
     1921 gcactcacaa agggcaatca cctctgagct agcagccagc ctcagacccc acagagttac
     1981 ttctccccag gcagcatgac caccaaggcc ttgaccctcc cggggcaatc cggactctcc
     2041 ttttgccctc atccatcagc ccctagcaaa agataggatc ccagcaataa tttgtggagg
     2101 accaaacatg cacctgccca ttggcactct ctccgagctt gaatccatcc ttacaggctc
     2161 tgtacccagg actaaggcac aagagaacac agagagaggc tgtcttccca ctactcctcg
     2221 gtctaatctg ctggcaggtg gcaaggctac ggtgctgggt acccctagcc agcctttgac
     2281 atagttcttc ctcgatgtct ctggaccagc tccacattca aaacccatca tgggctcagc
     2341 cataccaacc cacagagcga agattctgaa atcgttcagc cctttcatgt ctattgccca
     2401 gctaggagat tcaaagagct gtaccccacc ccactctcag gtcatctcag gttgcaccta
     2461 aatttctgaa ctgagaaaag tccctaactt cccaggtctg cattcccctg gggagagtca
     2521 agtcaataat aaagaatgta ttcaatacaa
//
