LOCUS       NM_001045514            5480 bp    mRNA    linear   ROD 31-OCT-2023
DEFINITION  Mus musculus AT-hook transcription factor (Akna), transcript
            variant 1, mRNA.
ACCESSION   NM_001045514
VERSION     NM_001045514.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5480)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5480)
  AUTHORS   Camargo Ortega G, Falk S, Johansson PA, Peyre E, Broix L, Sahu SK,
            Hirst W, Schlichthaerle T, De Juan Romero C, Draganova K, Vinopal
            S, Chinnappa K, Gavranovic A, Karakaya T, Steininger T, Merl-Pham
            J, Feederle R, Shao W, Shi SH, Hauck SM, Jungmann R, Bradke F,
            Borrell V, Geerlof A, Reber S, Tiwari VK, Huttner WB,
            Wilsch-Brauninger M, Nguyen L and Gotz M.
  TITLE     The centrosome protein AKNA regulates neurogenesis via microtubule
            organization
  JOURNAL   Nature 567 (7746), 113-117 (2019)
   PUBMED   30787442
REFERENCE   3  (bases 1 to 5480)
  AUTHORS   Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K,
            Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre
            A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt
            AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,
            Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S,
            Wohnoutka P, Hawrylycz MJ, Puelles L and Jones AR.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 5480)
  AUTHORS   Ma W, Ortiz-Quintero B, Rangel R, McKeller MR, Herrera-Rodriguez S,
            Castillo EF, Schluns KS, Hall M, Zhang H, Suh WK, Okada H, Mak TW,
            Zhou Y, Blackburn MR and Martinez-Valdez H.
  TITLE     Coordinate activation of inflammatory gene networks, alveolar
            destruction and neonatal death in AKNA deficient mice
  JOURNAL   Cell Res 21 (11), 1564-1577 (2011)
   PUBMED   21606955
  REMARK    GeneRIF: targeted deletions of mouse AKNA, a hypothetical
            AT-hook-like transcription factor, sensitize mice to
            pathogen-induced inflammation and cause sudden neonatal death
REFERENCE   5  (bases 1 to 5480)
  AUTHORS   Machold R, Klein C and Fishell G.
  TITLE     Genes expressed in Atoh1 neuronal lineages arising from the
            r1/isthmus rhombic lip
  JOURNAL   Gene Expr Patterns 11 (5-6), 349-359 (2011)
   PUBMED   21440680
REFERENCE   6  (bases 1 to 5480)
  AUTHORS   Okazaki N, Kikuno R, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga
            Y, Nagase T, Ohara O and Koga H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683828.8, BY206723.1, BC092227.1 and BC036324.1.
            
            [WARNING] On Dec 6, 2023 this sequence was replaced by
            NM_001045514.4.
            
            On Mar 12, 2015 this sequence version replaced NM_001045514.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219382.62153.1,
                                           SRR9219381.193136.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL683828.8         116996-117063       c
            69-330              BY206723.1         1-262
            331-5464            BC092227.1         112-5245
            5465-5476           BC036324.1         3645-3656
            5477-5480           AL683828.8         80741-80744         c
FEATURES             Location/Qualifiers
     source          1..5480
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 33.96 cM"
     gene            1..5480
                     /gene="Akna"
                     /note="AT-hook transcription factor"
                     /db_xref="GeneID:100182"
                     /db_xref="MGI:MGI:2140340"
     exon            1..227
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            228..592
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..4557
                     /gene="Akna"
                     /note="AT-hook-containing transcription factor"
                     /codon_start=1
                     /product="microtubule organization protein AKNA"
                     /protein_id="NP_001038979.1"
                     /db_xref="CCDS:CCDS38777.1"
                     /db_xref="GeneID:100182"
                     /db_xref="MGI:MGI:2140340"
                     /translation="MASSGAKAQWVGPSLGQGPRRRRWAWAEEQDTDGRRDQGWGNSQ
                     SLPEAPSPELLEDFRRAQEHLPPLEWDPDMQDSEESSGEETEADDASSPEGSTVPLPW
                     LSRSNQQLDMSEEELDEASGRPEVDLAGESCTELECEDQGDSSPPPPGQGPAKGWVTF
                     IKQGSNYRPSEHLEAQPSVEHSRTKSWSSGTVSLRQPSDSLGSTWEGDTEVPQPSILP
                     KALPQSPCHNFPHPGDRNGGDVAPATPTEFRDSLAAPAQNAECSAGTWGEETTSLPSS
                     RPEDQTWKRTKTSPKPLPSRFTGSVSPLSTRLGAIKKVVPQHKQGATLAGHSSSQAPK
                     YGRGRRLNYPLPDFSKVGPRVRFPKDENYRPPKSRGHNRQQGSTRPLIFKSPAEIVRD
                     VLLSSGEASLAKESSLAHTITRVPQEFQTPEQATELVHQLQEDYHKLLTKYAEAENTI
                     DQLRLGAKVHLYSDPPQPSQSFCSGSMPQGSKVLSFSIPQPRVAEWWPDPAQDPQASE
                     ATGWPFPRTDLSPSSSPGVATPGRLPQSQGIATDQPSTGQTQALTSQASRLLAKVQSF
                     EELVLAGHLPPQDQIKSLEQLRAAHMALEAEYLQACREELLDPQLDASQGSPRTLNLC
                     RELEAEIYHLGQRLEELQDHMDQTQRETEPCRPDLQDSTPTMSFLPQSAHLSMPSGPV
                     SLPDGQTYQEPATTTTTSPGSSCTLPINKKLSLSIKTEESPRGLPVPLRDRTLQVEQD
                     FHGLLERYLSVKSLPEALRDEDEDDLEEEEEEQDHQGPLEVDSPATAPGKTEAVRVPP
                     GERPTQAEESHRDATQEDEEQMGPMKSPDFRPSMARDTYTPVLDTAEVAQRGTKAMVS
                     HQSSLTSLEESRPSELLPRKALLRAGGPHTEEPWMVSPETDSGFVGSETSIVSPFTQT
                     PEHRLSHVSTSGPSAQHLTASVPGDRTSHPKARGLMVPRRATETGIPRSRTQQHFSSL
                     SSPGRGAQSCHLEETSVAKIAVPRSEFKRQKQISKQLLPSGRTSPDSAPAPTAASTPH
                     GSAESTANLLLNRTERDQAIKDLQAEVSRLRLQLEDSLHRPHPDGPACVASAFNHSTQ
                     TQEKLGSSPSWGPHYGSKSTERLSREPNGVEPAEPMGRRRARSSSVPRDVPRLYLSSE
                     SESPAPRLSSEKSRTFEEHPEAAQWGTRPQSSSKRRERVSFRGQYTGQEYHILSPKAI
                     LKDSGTPSCPHCHPIRTQDTGSAVSRDTTRGSSAADTLRCALCGEVKSSAEADGSSSG
                     PSEKNTPKKPSTPILKRKNRQTGSPVRMAPGLWYLAAAPPAPAPPALAYISSAPIMPY
                     LPPTVYYAAPAPTSAQTASPQPARGPRRTRHSVQLGLNDLEELQAALREAAQAAENVR
                     STTRQLSRSLSADLRHARSLRGSCLF"
     exon            593..1641
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1642..1716
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1717..1873
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            1874..2028
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2088
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2089..2216
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2418
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2419..2582
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..2783
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3003
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3110
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3319
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3482
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3483..3656
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3657..3772
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3773..3919
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4015
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4135
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            4136..4316
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
     exon            4317..5480
                     /gene="Akna"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcgcttcct gcaaggagga ggaggcaagg caaggcctca gctgcagggg cggggagaag
       61 tggggaggga tgcttgtctg tgagctgagg ccgttctggc tggcagagca gtctggaggc
      121 gttccaggct gctgtggagg cagggggctc cccaggtttg aaacaaagac cttgtgggca
      181 gctcccctga gcccaggccg gcaggatggt ggtgtagtac tagtgaggcc acaggcagga
      241 tggctggtgc tgagaggaac cacttgtgat ttggaccccc agctgcagct cagtctcttg
      301 aagatgaagt ggcccaggtg aagccaggcc aggccaagtc ccatggccag ctcaggggca
      361 aaggcacaat gggttgggcc aagcctgggg caagggcccc gaaggcggcg ctgggcttgg
      421 gctgaggaac aagatacaga tggaagaaga gaccagggct ggggaaacag ccagtctctt
      481 cccgaagccc ccagtcctga gctcctagag gacttccgtc gggcacagga gcacctgcca
      541 cccctggagt gggacccaga catgcaggac tccgaagagt cttctggaga agagaccgaa
      601 gctgacgatg caagcagccc agagggttcc accgtgcctc tgccctggct ctccaggagc
      661 aaccaacagc tggacatgtc tgaagaggag ctggatgagg cctctgggag gcctgaggta
      721 gacttagctg gagagagttg tacggagctt gagtgtgaag accagggaga ttccagccct
      781 ccacctccag gacaggggcc agccaaaggc tgggtcacct ttatcaaaca aggcagtaac
      841 tacagacctt cagagcatct cgaggcccag ccatctgttg aacatagccg cacaaagtct
      901 tggagcagtg gaactgtgag cctccgtcaa cctagtgaca gccttggttc tacctgggaa
      961 ggagataccg aagtccctca gccttccatc ttgcccaaag ccctgccaca gagtccgtgc
     1021 cacaactttc cacacccagg tgacagaaat ggaggtgacg ttgctccggc aacacccaca
     1081 gaattccggg actccttagc agcgccagcc cagaatgccg agtgctctgc aggcacgtgg
     1141 ggggaagaaa ccaccagcct acccagctct cggcctgagg accaaacctg gaagaggact
     1201 aagacatcac ctaagccact gccctcccgg tttactggtt ctgtcagccc cctgagtact
     1261 cggcttgggg caataaagaa agttgtgccc cagcacaagc agggagccac tctggctggt
     1321 cactcttctt cacaagctcc caagtatggc agggggcgcc gcctgaacta cccactcccc
     1381 gacttctcca aggtggggcc ccgggtgagg tttcccaaag atgagaacta ccgacccccg
     1441 aagtccagag gccacaacag gcaacaaggc tctaccagac ccctcatctt caagtcgcca
     1501 gctgagattg ttcgggatgt actgttgagt agtggagagg cgtccctggc caaggaatct
     1561 tctcttgctc acaccatcac cagggtgccc caggagttcc agacacccga acaagccact
     1621 gagctagttc atcagctcca ggaggactat cacaagctcc tcaccaagta tgcggaggct
     1681 gagaacacta tcgaccaact tcgccttggg gccaaggtgc acctgtattc agacccacca
     1741 cagcccagtc agagcttctg ctcggggtca atgccacaag gaagcaaggt cttatccttc
     1801 tctatcccgc aacccagagt agcagagtgg tggcctgacc ctgcccagga tccacaggcc
     1861 tctgaggcca cagggtggcc gttcccacga acagacctga gtccctcctc gtcccccggc
     1921 gtggccactc cagggcggct tcctcagagc cagggcattg ccacagacca gccctccaca
     1981 ggacagaccc aggcactgac ctctcaggcc agccggctcc tggccaaggt gcagtccttc
     2041 gaggaactgg tactggctgg acacctccca cctcaggacc aaatcaagag cttggagcaa
     2101 ctgagggcag cccacatggc cctagaggca gagtacctgc aggcctgcag agaagagctc
     2161 ctggaccctc agcttgatgc ctctcagggg agtcccagga ccctcaacct ctgcagggag
     2221 ctagaagcag agatatacca cctgggacag cgcctggaag agctacagga ccatatggac
     2281 cagacccaaa gagagacaga gccatgtagg ccagacctgc aagacagcac cccaaccatg
     2341 tcctttctgc cccagtcagc tcatctgtcc atgccttcag gacctgtctc cttgccagat
     2401 ggccaaacct accaggagcc tgccaccacc accaccacct cccctggaag ctcttgcacg
     2461 ctccccatca acaagaagtt aagcctgagc atcaaaactg aggaaagccc aagaggtctc
     2521 ccggtcccac tcagggacag gacgcttcag gtggagcagg acttccatgg ccttctggag
     2581 agatacctca gcgttaaatc cctccctgaa gccttgaggg atgaagatga ggatgacctg
     2641 gaggaggagg aagaggagca ggaccatcaa ggccccttgg aagttgatag tccagccaca
     2701 gctccaggga aaacagaagc cgtgagggta ccaccaggag agcgcccaac acaggctgag
     2761 gaaagccata gggatgctac ccaggaggat gaggaacaga tgggacctat gaagtcacca
     2821 gacttccggc catccatggc cagagatacg tacacaccag tcctggatac agctgaagtg
     2881 gctcaacggg gcaccaaagc catggtgtca catcagagca gtctgaccag cctggaagag
     2941 agcaggccct cagagctcct tcctcgaaaa gccctgcttc gggctggtgg gccccacact
     3001 gaggagccct ggatggtgtc accagagaca gacagtggct tcgtgggctc agaaaccagt
     3061 atagtgtcac ccttcaccca gaccccagag caccggctct cccatgtcag cacttcagga
     3121 ccatcagctc aacacctcac tgcctctgtg cctggtgata gaacctccca tcccaaggcc
     3181 aggggtctca tggttcccag aagagccact gagactggca tacccagaag ccgaacccag
     3241 cagcatttct ccagcctgag ctctcccggg agaggggcac agagctgcca cctagaggag
     3301 acatcagtgg ctaaaatagc ggttcccagg tctgagttca agagacagaa gcagatttcc
     3361 aaacagctcc ttcccagtgg aagaaccagc cccgactctg ccccagctcc cacagctgcc
     3421 tccacgcccc atggatcagc agagagcact gccaacctcc tcctcaacag gacagagcgc
     3481 gaccaggcca tcaaggatct gcaggcggag gtgtcacggc tccgccttca actggaggac
     3541 agcctgcacc ggccacaccc agacggccca gcctgtgtag cttctgcttt caaccactcc
     3601 acccagaccc aggaaaagct gggttcctca ccctcctggg gcccccacta tggcagtaaa
     3661 tccacagaga ggctgtctag ggagcctaat ggtgtagagc cagctgagcc aatgggaaga
     3721 cgtcgagcca ggtcctcttc ggtgcctcgg gatgtaccca gactgtacct aagttctgaa
     3781 tcggagtcgc ctgcccctcg gctctcatct gagaagagca ggacctttga ggagcacccc
     3841 gaggctgcac agtgggggac aagaccacag agcagctcga agcggaggga aagagtttcc
     3901 ttccggggtc aatacacagg ccaggagtac cacattctat ccccaaaggc catcctgaag
     3961 gacagtggca caccgtcctg tccccactgc catcccatta ggacccagga cacaggcagt
     4021 gctgtctcta gagacaccac acggggctca tctgccgctg acaccctccg ctgtgccctg
     4081 tgtggtgaag tcaagtcctc tgcagaagca gatggctcca gctcaggtcc ctctgagaag
     4141 aacaccccca aaaagccttc cacccccatc ctcaaacgga agaacaggca gacgggctcg
     4201 ccagtacgaa tggcccctgg actctggtac ctggctgctg cgcccccagc cccagcccca
     4261 ccggctttgg cctacatctc ctcagctccc attatgcctt atctaccacc cactgtgtac
     4321 tatgcagccc cagcacctac ctcagcccag acagcttccc cgcagcctgc tcggggacct
     4381 cggagaaccc ggcactcagt ccaactgggt ctgaatgacc tggaggagct gcaggccgca
     4441 ctcagagagg ctgcacaggc cgccgagaac gttcgctcca ccacccgcca gctgagccgc
     4501 tccctgtctg cggacctgcg ccatgcccgt agcctgcgag gctcctgcct tttctgactc
     4561 cctggagact ctgagactaa gtaggcaggc agccgctgtt gtttcccagt caacagtctc
     4621 ctggtaccac tgatggctgg aagatgtcac gttcccctcc ccaggagtgc cacctgattc
     4681 atgtggcgta tttaaaatgg agagacattg gcctagtcag gagtggatga atgtctgggg
     4741 gccaactctg tctaacaggt gtagtgatca tggctccctc tgtcgagtca gagtcgctga
     4801 gactcctcct cgtccccctc ctgcccatgt gcttctgcag ctaataatgt ggctcttact
     4861 ggacagaatg tctttacact ggggagctaa cttgggcttg gacctgtctc agaaggccag
     4921 agaggaaaag aaaagtctag ggtctctgaa gcattttgga cactgcctgt gatagctact
     4981 ctgaggcagg cgttgtcagg gagaagaact agttagggat tttgttccta gtaactagtg
     5041 ggcaggggta gtacttgggg acccattaat gtcttggggc tgaggcctca gctgacgcac
     5101 gcccagctct tctgtggtta cagaagtttt tcccatgagc tcatggagta gaagctgctc
     5161 atgtaggcca ggaagcaccc agcagcctca gacataccca ctatgtcttt ggcatccact
     5221 taggaccaag ctaccttgcc aggccctggc ctgaggctga tagaccaggc cggtacccgt
     5281 ttccctgtcc catagcagag tgacctcaac atttctggga tgtgtgtgtg tgtgtgtgtg
     5341 tgtgtgtgtg tgtgtgtgtg tgtgttatca cagattgttt atatatttga ggcatttttt
     5401 aaaaatctat ttttgttata aaacaaatga aggaaaataa ataatgaact taagaacggg
     5461 caaagaaatc cccaaagcta
//
