LOCUS       NM_001007589            1729 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus akirin 2 (Akirin2), mRNA.
ACCESSION   NM_001007589 XM_485367
VERSION     NM_001007589.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Peek,S.L., Bosch,P.J., Bahl,E., Iverson,B.J., Parida,M., Bais,P.,
            Manak,J.R., Michaelson,J.J., Burgess,R.W. and Weiner,J.A.
  TITLE     p53-mediated neurodegeneration in the absence of the nuclear
            protein Akirin2
  JOURNAL   iScience 25 (2), 103814 (2022)
   PUBMED   35198879
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Bosch,P.J., Fuller,L.C. and Weiner,J.A.
  TITLE     A critical role for the nuclear protein Akirin2 in the formation of
            mammalian muscle in vivo
  JOURNAL   Genesis 57 (5), e23286 (2019)
   PUBMED   30801883
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Bosch,P.J., Fuller,L.C. and Weiner,J.A.
  TITLE     An essential role for the nuclear protein Akirin2 in mouse limb
            interdigital tissue regression
  JOURNAL   Sci Rep 8 (1), 12240 (2018)
   PUBMED   30116001
  REMARK    GeneRIF: essential role for the nuclear protein Akirin2 in mouse
            limb interdigital tissue regression
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1729)
  AUTHORS   Bosch,P.J., Fuller,L.C., Sleeth,C.M. and Weiner,J.A.
  TITLE     Akirin2 is essential for the formation of the cerebral cortex
  JOURNAL   Neural Dev 11 (1), 21 (2016)
   PUBMED   27871306
  REMARK    GeneRIF: Data demonstrate a previously-unsuspected role for Akirin2
            in early cortical development and, given its known nuclear roles,
            suggest that it may act to regulate gene expression patterns
            critical for early progenitor cell behavior and cortical neuron
            production.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1729)
  AUTHORS   Tartey,S. and Takeuchi,O.
  TITLE     Akirin2-Mediated Transcriptional Control by Recruiting SWI/SNF
            Complex in B Cells
  JOURNAL   Crit Rev Immunol 36 (5), 395-406 (2016)
   PUBMED   28605346
  REMARK    GeneRIF: this review discusses current understanding of the
            molecular mechanisms that have instrumental roles in governing the
            inflammatory response with special emphasis on Akirin2 in B cells
            Review article
REFERENCE   6  (bases 1 to 1729)
  AUTHORS   Tartey,S., Matsushita,K., Imamura,T., Wakabayashi,A., Ori,D.,
            Mino,T. and Takeuchi,O.
  TITLE     Essential Function for the Nuclear Protein Akirin2 in B Cell
            Activation and Humoral Immune Responses
  JOURNAL   J Immunol 195 (2), 519-527 (2015)
   PUBMED   26041538
  REMARK    GeneRIF: The nuclear protein akirin2 has an essential function in B
            cell activation and humoral immune responses.
REFERENCE   7  (bases 1 to 1729)
  AUTHORS   Tartey,S., Matsushita,K., Vandenbon,A., Ori,D., Imamura,T.,
            Mino,T., Standley,D.M., Hoffmann,J.A., Reichhart,J.M., Akira,S. and
            Takeuchi,O.
  TITLE     Akirin2 is critical for inducing inflammatory genes by bridging
            IkappaB-zeta and the SWI/SNF complex
  JOURNAL   EMBO J 33 (20), 2332-2348 (2014)
   PUBMED   25107474
  REMARK    GeneRIF: The IkappaB-zeta-Akirin2-BAF60 complex physically links
            the NF-kappaB and SWI/SNF complexes in innate immune cell
            activation.
REFERENCE   8  (bases 1 to 1729)
  AUTHORS   Goto,A., Matsushita,K., Gesellchen,V., El Chamy,L.,
            Kuttenkeuler,D., Takeuchi,O., Hoffmann,J.A., Akira,S., Boutros,M.
            and Reichhart,J.M.
  TITLE     Akirins are highly conserved nuclear proteins required for
            NF-kappaB-dependent gene expression in drosophila and mice
  JOURNAL   Nat Immunol 9 (1), 97-104 (2008)
   PUBMED   18066067
  REMARK    Erratum:[Nat Immunol. 2008 Feb;9(2):216]
REFERENCE   9  (bases 1 to 1729)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL807397.6, BE336109.1, BC082305.1 and AK005836.1.
            
            On Feb 9, 2006 this sequence version replaced NM_001007589.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005836.1, CB573520.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                AL807397.6         138056-138094
            40-503              BE336109.1         1-464
            504-711             BC082305.1         192-399
            712-816             AK005836.1         391-495
            817-1729            BC082305.1         3177-4089
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 16.8 cM"
     gene            1..1729
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /note="akirin 2"
                     /db_xref="GeneID:433693"
                     /db_xref="MGI:MGI:1889364"
     exon            1..659
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..1036
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /codon_start=1
                     /product="akirin-2"
                     /protein_id="NP_001007590.2"
                     /db_xref="CCDS:CCDS18027.1"
                     /db_xref="GeneID:433693"
                     /db_xref="MGI:MGI:1889364"
                     /translation="MACGATLKRTLDFDPLLSPASPKRRRCAPLSAPASAAASPAAAT
                     AAAAASAAAASPQKYLRMEPSPFGDVSSRLTTEQILYNIKQEYKRMQKRRHLEASFQQ
                     ADPGCTSDSQPHAFLISGPASPGTSSATSSPLKKEQPLFTLRQVGMICERLLKEREEK
                     VREEYEEILNTKLAEQYDAFVKFTHDQIMRRYGEQPASYVS"
     exon            660..803
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            804..953
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1025
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1026..1719
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1701..1706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /note="hexamer: AATAAA"
     polyA_site      1719
                     /gene="Akirin2"
                     /gene_synonym="2700059D21Rik; Akirin-2"
                     /note="major polyA site"
ORIGIN      
        1 gttattgacg ccatattggg gccggcggcg ggtggcagag ttgttccgtg gagaagagag
       61 ggtcgagtgc attgcttagc tctgtacggc cgggctacct cgcagctccc gcgcgtggcc
      121 gccactcacg agcttccgtc tgcaccggcg tgtcggagat cgcgtctggg tcgcgccact
      181 ggccgggtcc acttccgaag ggagcgggtc tccgcgcagg agccccggcg cgctcagccc
      241 gagcgcacgg cgggggcggc ccggcctctc gggagcggcc ccgagccggc ggcgcgaccc
      301 tcgcgcctcg cccgcctgcc ctgtcgcggc tccgccgtcc cgggccccac acccaccggg
      361 cacctcggag ggcccgtttg cccccgtcct tcccggcccc gcccgagccg agcctcggcc
      421 gcccgccacc atggcgtgcg gagccactct gaaaaggact ctggatttcg acccgctgct
      481 gagccccgca tctccgaagc ggaggcggtg cgcgcctttg tcggcgccgg cttcggctgc
      541 cgcctcccct gccgccgcca ccgccgccgc cgccgcctcg gccgcggccg cctcgccgca
      601 gaagtatctc cggatggagc cttccccctt cggcgacgtc tcttcccggc tcaccacaga
      661 acaaattctg tacaacataa aacaggaata taaacgcatg cagaagagaa gacatttaga
      721 agctagtttt cagcaggcag atccaggttg tacttccgat tcacagccac atgcatttct
      781 catcagtgga ccagcatcac cagggacttc atctgcaaca tcctcaccat taaaaaaaga
      841 acagccctta tttactctaa ggcaggttgg aatgatctgt gaacgtttgt tgaaagaacg
      901 ggaagagaaa gttcgagaag aatatgaaga aatactgaat acaaaacttg cagaacaata
      961 tgatgctttt gtgaagttta cgcatgatca gataatgcgg cgatatggag aacagcctgc
     1021 tagttatgtt tcatgaatcg cgctttttgc atttgtgggc tgccttgttc tttgttgagt
     1081 tgttgcagga ggtcccaact atgacatgca gcaatgccag tacccatctg tgaatacagg
     1141 ttatttcaag ctttcgtcag tggcaaccac tcttaggcag cagcaattgg ttttggaaat
     1201 ttccgtgatg tcattaccac ctgaatgtgg acctttgcta cttgtattaa gaccagtggc
     1261 ctcgttttgc tgtatcatta caatttggct tctttatatt aatgtttgaa agggattaaa
     1321 cctggcattc tagaacatgc ccttcactgg ttatgtaaat aaaactgtag aatgacacgt
     1381 cagatgaagt tagtgtgatt ttaattgtgc actacaacca agctgtaacc agttattaat
     1441 aacttagaat gtaatcccag gacatttaag cagttagtct acagtacttc tgtgagatag
     1501 tggaagagga ggaagaggag ggcatttctg tatttcagga cttttcttgg ggtttcagaa
     1561 tgggtttata tgattttctt tattattttt tggtagtttt atttattcta tcagtctttt
     1621 taacaaatgt ttattgctgc acctcctccc cagtgtatta ttgttttact acccttgtag
     1681 cactggagtt tagttggaaa aataaaacat ttacttctaa aaaaaaaaa
//
