LOCUS       NM_023423               2383 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus akirin 1 (Akirin1), mRNA.
ACCESSION   NM_023423
VERSION     NM_023423.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2383)
  AUTHORS   Rao,V.V., Sangiah,U., Mary,K.A., Akira,S. and Mohanty,A.
  TITLE     Role of Akirin1 in the regulation of skeletal muscle fiber-type
            switch
  JOURNAL   J Cell Biochem 120 (7), 11284-11304 (2019)
   PUBMED   30746755
REFERENCE   2  (bases 1 to 2383)
  AUTHORS   Nunes,A.M., Wuebbles,R.D., Sarathy,A., Fontelonga,T.M., Deries,M.,
            Burkin,D.J. and Thorsteinsdottir,S.
  TITLE     Impaired fetal muscle development and JAK-STAT activation mark
            disease onset and progression in a mouse model for
            merosin-deficient congenital muscular dystrophy
  JOURNAL   Hum Mol Genet 26 (11), 2018-2033 (2017)
   PUBMED   28334989
REFERENCE   3  (bases 1 to 2383)
  AUTHORS   Abdulhaleem,F.A., Song,X., Kawano,R., Uezono,N., Ito,A., Ahmed,G.,
            Hossain,M., Nakashima,K., Tanaka,H. and Ohta,K.
  TITLE     Akhirin regulates the proliferation and differentiation of neural
            stem cells in intact and injured mouse spinal cord
  JOURNAL   Dev Neurobiol 75 (5), 494-504 (2015)
   PUBMED   25331329
  REMARK    GeneRIF: that mouse Akhirin plays a crucial role in mouse spinal
            cord formation by regulating the ependymal niche in the central
            canal
REFERENCE   4  (bases 1 to 2383)
  AUTHORS   Molyneaux,B.J., Goff,L.A., Brettler,A.C., Chen,H.H., Hrvatin,S.,
            Rinn,J.L. and Arlotta,P.
  TITLE     DeCoN: genome-wide analysis of in vivo transcriptional dynamics
            during pyramidal neuron fate selection in neocortex
  JOURNAL   Neuron 85 (2), 275-288 (2015)
   PUBMED   25556833
  REMARK    Erratum:[Neuron. 2016 Jan 6;89(1):235]
REFERENCE   5  (bases 1 to 2383)
  AUTHORS   Dong,Y., Pan,J.S. and Zhang,L.
  TITLE     Myostatin suppression of Akirin1 mediates glucocorticoid-induced
            satellite cell dysfunction
  JOURNAL   PLoS One 8 (3), e58554 (2013)
   PUBMED   23516508
  REMARK    GeneRIF: glucocorticoids stimulate myostatin which inhibits Akirin1
            expression and the reparative functions of satellite cells
REFERENCE   6  (bases 1 to 2383)
  AUTHORS   Salerno,M.S., Dyer,K., Bracegirdle,J., Platt,L., Thomas,M.,
            Siriett,V., Kambadur,R. and Sharma,M.
  TITLE     Akirin1 (Mighty), a novel promyogenic factor regulates muscle
            regeneration and cell chemotaxis
  JOURNAL   Exp Cell Res 315 (12), 2012-2021 (2009)
   PUBMED   19406121
  REMARK    GeneRIF: myostatin regulates key steps of muscle regeneration
            including chemotaxis of inflammatory cells, SC activation and
            migration through akirin1.
REFERENCE   7  (bases 1 to 2383)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2383)
  AUTHORS   Marshall,A., Salerno,M.S., Thomas,M., Davies,T., Berry,C., Dyer,K.,
            Bracegirdle,J., Watson,T., Dziadek,M., Kambadur,R., Bower,R. and
            Sharma,M.
  TITLE     Mighty is a novel promyogenic factor in skeletal myogenesis
  JOURNAL   Exp Cell Res 314 (5), 1013-1029 (2008)
   PUBMED   18255059
  REMARK    GeneRIF: Mighty is a critical promyogenic factor which plays a key
            role in the signalling pathway downstream of Myostatin.
REFERENCE   9  (bases 1 to 2383)
  AUTHORS   Goto,A., Matsushita,K., Gesellchen,V., El Chamy,L.,
            Kuttenkeuler,D., Takeuchi,O., Hoffmann,J.A., Akira,S., Boutros,M.
            and Reichhart,J.M.
  TITLE     Akirins are highly conserved nuclear proteins required for
            NF-kappaB-dependent gene expression in drosophila and mice
  JOURNAL   Nat Immunol 9 (1), 97-104 (2008)
   PUBMED   18066067
  REMARK    Erratum:[Nat Immunol. 2008 Feb;9(2):216]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY315833.1, AK078055.1 and AI451245.1.
            
            On Aug 6, 2005 this sequence version replaced NM_023423.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146017.1, AK159632.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               BY315833.1         4-218
            216-2199            AK078055.1         172-2155
            2200-2383           AI451245.1         1-184               c
FEATURES             Location/Qualifiers
     source          1..2383
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 57.42 cM"
     gene            1..2383
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /note="akirin 1"
                     /db_xref="GeneID:68050"
                     /db_xref="MGI:MGI:1915300"
     exon            1..352
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..711
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /note="mighty protein; protein mighty"
                     /codon_start=1
                     /product="akirin-1"
                     /protein_id="NP_075912.2"
                     /db_xref="CCDS:CCDS18619.1"
                     /db_xref="GeneID:68050"
                     /db_xref="MGI:MGI:1915300"
                     /translation="MACGATLKRPMEFEAALLSPGSPKRRRCAPLPGPTPGLRPPDAE
                     PPPLQMQTPPASLQQPAPPGSERRLPTPEQIFQNIKQEYNRYQRWRHLEVVLSQSEAC
                     TSETQPSSSALTAPGSPGAFWMKKDQPTFTLRQVGIICERLLKDYEDKVREEYEQILS
                     TKLAEQYESFVKFTHDQIMRRYGTRPTSYVS"
     exon            353..493
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..628
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            629..700
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            701..2370
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      888
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /note="major polyA site"
     regulatory      2183..2188
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2213
                     /gene="Akirin1"
                     /gene_synonym="6330407G11Rik"
ORIGIN      
        1 aggcggggcc agcgcggctg ccgggtgccg gaggcgccat tggagccggc ttggcttggg
       61 agccgtagct gaagagttgg atccagggca gtccttgctg ccgcgtctgc gtctggtctc
      121 tggcccttcc gcgggatggc gtgcggggcg acactgaagc ggcccatgga gttcgaggcg
      181 gcgctgctga gccccggttc cccgaagcgg cgacgctgcg cccctctgcc cggccccact
      241 ccgggcctca ggcccccgga cgccgagccg ccgccgcttc agatgcagac gccgccggcg
      301 agcctccagc agcctgcccc acccggcagc gagcgtcgtc ttccaactcc cgagcaaatt
      361 tttcagaaca taaaacaaga atataatcgt taccagagat ggagacattt agaagttgtt
      421 ctcagtcaaa gcgaagcctg tacttcagaa actcagcctt cctcctcggc acttactgca
      481 ccaggttctc caggtgcttt ctggatgaag aaggaccagc ccacctttac ccttcgacaa
      541 gtggggataa tatgtgagcg tctcttaaaa gactatgaag ataaagtccg agaggagtat
      601 gagcaaatcc tcagtaccaa actcgcagaa cagtatgaat cgtttgtgaa attcacgcat
      661 gatcagatca tgcggcgata cgggacaagg ccaacaagct atgtatcctg aagccttctt
      721 gcctatctgg gtaccaggtg tgacctcaag agatggctgc tgtacacttt ttgcaactgg
      781 tttgatatca catttcagct ccaactttgc atcctgagaa cacttaaatg tttctgcagg
      841 tccattttat acaacttgaa agaccttaaa actttctggt tgccacaagc atatctttct
      901 tttctgctca tccactaaac agctgtgccc tactgtgata ggttttccag acaaagtacc
      961 tggaacagca gtctagcaaa gaatgccttc agtggcactc aacacgtgga gtctccccaa
     1021 gcacagctct gtgagaagtg tgagtgtgtg cgtgtgtgtg tctgtgtttt aagttattat
     1081 ttgtattgtg caaaaaaaaa ttttgatctt ggggattctg gctgtgaatt tgatgcacga
     1141 caattatggt taaaaacatt ttcttggtct acagaagatc attaatgttt ggtgaccata
     1201 taggttgtaa cagtgggttg tttatttgta ggtattatcg ttaaatacag ggactgtttc
     1261 caggcacaga atttgaaatg taagttagga tggacattag atgtgattat gatgatctag
     1321 ggaaggtctg cagtcctgaa tctgcaaata cgtggtgaga aattagaaca aactggagac
     1381 aggctatcag tacatggact ctgcctagct gtgctggaaa aatactttga ctccaagcct
     1441 taaaatatcc tgtggagtct gagctcacct cattcataca gtcacggagc tccctgaacg
     1501 ctgaacttct acagggaaaa gatctcccct ggagcggaag atcagggtgt cctcggagcg
     1561 tgtaacaagt gcggggctgg gccaggctca cagcactgct acctgggagg agccgctcac
     1621 cttcgcatca gttccaacat agaatctgga ccctttgtcc aggttacccc aaactctcct
     1681 gaggtgtccg tgttcaaccc ttagagcttg gttttggcaa taccctgcct gaagttgctt
     1741 attggctgtt ctctgccttg gtcccaaggc tgtgagcaga aagcagcctc tgttttgagg
     1801 aggtgggatt taagtataca tttattttta ctgtgacttg ttcaggacca cattttacaa
     1861 aatgccttgt ttcctttact gttgttttgg aaaggaaagt tttatgaaaa ctgttttagt
     1921 ttgaatatag aatagttata ttaattacgg ctttattttg gaaaaatctt gagttttaat
     1981 tcaaatgttt gctaatacct tccaaagtaa ggtgatattc agagacagtt gttgtgatca
     2041 gctggcttgc ggacatttct ggggtattca catttgaaga ttccttatta atgaatgtct
     2101 ttgacttaaa tctaaccaaa aactgcaaca ttattctttg tacattttca ttatatagtg
     2161 ttaacaagct tagttgcaaa cgaataaaat acttaagcta tttgtttacc ttgccttctt
     2221 gatgctgtga tgatgtgtat tagttcagat aactctcata aggctgctat aaccattccc
     2281 acagttccac agcctgttgg agatttacag actctgagag cccaccagtg ctcttttaat
     2341 aattaaagaa tgactgactt gcttaaagga aaaaaaaaaa aaa
//
