LOCUS       NM_020616               1037 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus A kinase interacting protein 1 (Akip1), mRNA.
ACCESSION   NM_020616
VERSION     NM_020616.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1037)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1037)
  AUTHORS   Nijholt,K.T., Sanchez-Aguilera,P.I., Mahmoud,B., Gerding,A.,
            Wolters,J.C., Wolters,A.H.G., Giepmans,B.N.G., Sillje,H.H.W., de
            Boer,R.A., Bakker,B.M. and Westenbrink,B.D.
  TITLE     A Kinase Interacting Protein 1 regulates mitochondrial protein
            levels in energy metabolism and promotes mitochondrial turnover
            after exercise
  JOURNAL   Sci Rep 13 (1), 18822 (2023)
   PUBMED   37914850
  REMARK    GeneRIF: A Kinase Interacting Protein 1 regulates mitochondrial
            protein levels in energy metabolism and promotes mitochondrial
            turnover after exercise.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1037)
  AUTHORS   Nijholt,K.T., Sanchez-Aguilera,P.I., Booij,H.G.,
            Oberdorf-Maass,S.U., Dokter,M.M., Wolters,A.H.G., Giepmans,B.N.G.,
            van Gilst,W.H., Brown,J.H., de Boer,R.A., Sillje,H.H.W. and
            Westenbrink,B.D.
  TITLE     A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte
            elongation and physiological cardiac remodelling
  JOURNAL   Sci Rep 13 (1), 4046 (2023)
   PUBMED   36899057
  REMARK    GeneRIF: A Kinase Interacting Protein 1 (AKIP1) promotes
            cardiomyocyte elongation and physiological cardiac remodelling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1037)
  AUTHORS   Zhu,L., Gao,T., Huang,Y., Jin,J., Wang,D., Zhang,L., Jin,Y., Li,P.,
            Hu,Y., Wu,Y., Liu,H., Dong,Q., Wang,G., Zheng,T., Song,C., Bai,Y.,
            Zhang,X., Liu,Y., Yang,W., Xu,K., Zou,G., Zhao,L., Cao,R.,
            Zhong,W., Xia,X., Xiao,G., Liu,X. and Cao,C.
  TITLE     Ebola virus VP35 hijacks the PKA-CREB1 pathway for replication and
            pathogenesis by AKIP1 association
  JOURNAL   Nat Commun 13 (1), 2256 (2022)
   PUBMED   35474062
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1037)
  AUTHORS   Tian,Z.Q., Jiang,H. and Lu,Z.B.
  TITLE     MiR-320 regulates cardiomyocyte apoptosis induced by
            ischemia-reperfusion injury by targeting AKIP1
  JOURNAL   Cell Mol Biol Lett 23, 41 (2018)
   PUBMED   30181740
  REMARK    GeneRIF: miR-320 plays an important role in regulating
            cardiomyocyte apoptosis induced by ischemia-reperfusion injury by
            targeting AKIP1 and inducing the mitochondrial apoptotic pathway.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1037)
  AUTHORS   Sastri,M., Haushalter,K.J., Panneerselvam,M., Chang,P.,
            Fridolfsson,H., Finley,J.C., Ng,D., Schilling,J.M., Miyanohara,A.,
            Day,M.E., Hakozaki,H., Petrosyan,S., Koller,A., King,C.C.,
            Darshi,M., Blumenthal,D.K., Ali,S.S., Roth,D.M., Patel,H.H. and
            Taylor,S.S.
  TITLE     A kinase interacting protein (AKIP1) is a key regulator of cardiac
            stress
  JOURNAL   Proc Natl Acad Sci U S A 110 (5), E387-E396 (2013)
   PUBMED   23319652
  REMARK    GeneRIF: Data indicate A-kinase interacting protein 1 (AKIP1) as a
            critical molecular regulator and a therapeutic control point for
            stress adaptation in the heart.
REFERENCE   7  (bases 1 to 1037)
  AUTHORS   Yu,K.P., Itokawa,T., Zhu,M.L., Syam,S., Seth,A. and Insogna,K.
  TITLE     Breast cancer-associated gene 3 (BCA3) is a novel Rac1-interacting
            protein
  JOURNAL   J Bone Miner Res 22 (4), 628-637 (2007)
   PUBMED   17227220
REFERENCE   8  (bases 1 to 1037)
  AUTHORS   Sastri,M., Barraclough,D.M., Carmichael,P.T. and Taylor,S.S.
  TITLE     A-kinase-interacting protein localizes protein kinase A in the
            nucleus
  JOURNAL   Proc Natl Acad Sci U S A 102 (2), 349-354 (2005)
   PUBMED   15630084
REFERENCE   9  (bases 1 to 1037)
  AUTHORS   Kitching,R., Li,H., Wong,M.J., Kanaganayakam,S., Kahn,H. and
            Seth,A.
  TITLE     Characterization of a novel human breast cancer associated gene
            (BCA3) encoding an alternatively spliced proline-rich protein
  JOURNAL   Biochim Biophys Acta 1625 (1), 116-121 (2003)
   PUBMED   12527432
REFERENCE   10 (bases 1 to 1037)
  AUTHORS   Amid,C., Bahr,A., Mujica,A., Sampson,N., Bikar,S.E.,
            Winterpacht,A., Zabel,B., Hankeln,T. and Schmidt,E.R.
  TITLE     Comparative genomic sequencing reveals a strikingly similar
            architecture of a conserved syntenic region on human chromosome
            11p15.3 (including gene ST5) and mouse chromosome 7
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 284-290 (2001)
   PUBMED   11528127
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132584.5 and AK163012.1.
            
            On Jun 5, 2018 this sequence version replaced NM_020616.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK163012.1, SRR7345562.4945475.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC132584.5         78497-78508
            13-1028             AK163012.1         1-1016
            1029-1037           AC132584.5         86997-87005
FEATURES             Location/Qualifiers
     source          1..1037
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.44 cM"
     gene            1..1037
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /note="A kinase interacting protein 1"
                     /db_xref="GeneID:57373"
                     /db_xref="MGI:MGI:3041226"
     exon            1..99
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /inference="alignment:Splign:2.1.0"
     exon            100..324
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..744
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /note="proline-rich protein BCA3; PKA-interacting protein;
                     breast cancer-associated gene 3 protein; A kinase (PRKA)
                     interacting protein 1"
                     /codon_start=1
                     /product="A-kinase-interacting protein 1"
                     /protein_id="NP_065641.1"
                     /db_xref="CCDS:CCDS21736.1"
                     /db_xref="GeneID:57373"
                     /db_xref="MGI:MGI:3041226"
                     /translation="MEYCLAAAALNGVDRRSLQRSARLGREVLERAKRRAVDWHSPER
                     SRGNVGVLYRQGPYQERWSVPGSQRLLGEREERCPTLSSSFGAMAEFMDYTSSQCGKY
                     YLSMPEEGGATHVYRYHRRKPPEMHMYSDTGHSQEQRNCRGETSVGQESIYQTSEHSQ
                     ESSWPTENISKDLYIEVYPGTYSVTVGSSALSKKTHVVAVDPGQSVDLVFPV"
     exon            325..405
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /inference="alignment:Splign:2.1.0"
     exon            406..519
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /inference="alignment:Splign:2.1.0"
     exon            520..600
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /inference="alignment:Splign:2.1.0"
     exon            601..1037
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /inference="alignment:Splign:2.1.0"
     regulatory      790..795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /note="hexamer: AATAAA"
     polyA_site      816
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /note="major polyA site"
     regulatory      1011..1016
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /note="hexamer: AATAAA"
     polyA_site      1037
                     /gene="Akip1"
                     /gene_synonym="BCA3; C11orf17; D7H11orf17; D930014E17Rik;
                     ICRFP703B1614Q5.6; ORF27"
                     /note="major polyA site"
ORIGIN      
        1 agcagttagc ttggcaactg gcgcgaaaga agggccgcgg gaacacggaa ggcgtgtccg
       61 tgtgagcgct atgcgcgtgc gcccggagaa gcaggccggg gagacatgga atactgtctg
      121 gcggccgcgg cgctgaacgg agtggaccgg cgctcgctcc agcgctctgc tcggctgggg
      181 agggaagtat tggagcgcgc caagaggagg gcagtggact ggcattctcc agagcgatcc
      241 agaggcaacg tgggggtcct ttaccgccag ggcccctacc aggaaagatg gtcggtccct
      301 ggttcccagc gcctcctagg agagagagaa gaaaggtgcc caacccttag ctcttccttc
      361 ggagcaatgg ctgaattcat ggactatact tcaagtcagt gtgggaaata ctacttgtct
      421 atgccagagg aaggaggagc aacccatgtc taccgttatc acagaaggaa acctccagag
      481 atgcacatgt actcagatac tgggcacagt caggaacaaa gaaactgcag aggcgagaca
      541 tctgttggac aagaaagcat ctaccaaaca tcagagcatt ctcaagagtc ctcttggcct
      601 actgagaaca tctctaagga cctctacatc gaagtctacc cagggaccta ttctgtcact
      661 gtgggctcca gtgccttatc caagaagacg cacgtggttg cagttgaccc cgggcaaagt
      721 gtggacttgg tcttccccgt gtgatgttga ccgtcactac caacatttca ctctcaaagt
      781 agcaagaaga ataaaaccac cctataattg ccttaataat gatgcatcaa tcttgatttt
      841 aatgctggct gtagtggggc agcctttctg aactggagtc gatctctttc aagctcattt
      901 taacctgaaa ttatagaagc cccctatcct gtgtgcctga aaacagtaat gtaatggtgc
      961 tgtctgagca gcttttactg ctggcttccc aagtaagtgt taattatcgt aataaaggga
     1021 gagactggaa gtaaaaa
//
