LOCUS       NM_017476               2045 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus A kinase anchor protein 8-like (Akap8l), transcript
            variant 1, mRNA.
ACCESSION   NM_017476
VERSION     NM_017476.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2045)
  AUTHORS   Zhang,W.Y., Wei,Q.Q., Zhang,T., Wang,C.S., Chen,J., Wang,J.H.,
            Xie,X. and Jiang,P.
  TITLE     Microglial AKAP8L: a key mediator in diabetes-associated cognitive
            impairment via autophagy inhibition and neuroinflammation
            triggering
  JOURNAL   J Neuroinflammation 21 (1), 177 (2024)
   PUBMED   39033121
  REMARK    GeneRIF: Microglial AKAP8L: a key mediator in diabetes-associated
            cognitive impairment via autophagy inhibition and neuroinflammation
            triggering.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2045)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2045)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   4  (bases 1 to 2045)
  AUTHORS   Yang,Y., Mahaffey,C.L., Berube,N. and Frankel,W.N.
  TITLE     Interaction between fidgetin and protein kinase A-anchoring protein
            AKAP95 is critical for palatogenesis in the mouse
  JOURNAL   J Biol Chem 281 (31), 22352-22359 (2006)
   PUBMED   16751186
REFERENCE   5  (bases 1 to 2045)
  AUTHORS   Sayer,J.A., Manczak,M., Akileswaran,L., Reddy,P.H. and Coghlan,V.M.
  TITLE     Interaction of the nuclear matrix protein NAKAP with HypA and
            huntingtin: implications for nuclear toxicity in Huntington's
            disease pathogenesis
  JOURNAL   Neuromolecular Med 7 (4), 297-310 (2005)
   PUBMED   16391387
REFERENCE   6  (bases 1 to 2045)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT033751.4.
            
            On Mar 31, 2022 this sequence version replaced NM_017476.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046801.1, AB028921.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                CT033751.4         142150-142213       c
            65-139              CT033751.4         136987-137061       c
            140-172             CT033751.4         130454-130486       c
            173-416             CT033751.4         129934-130177       c
            417-870             CT033751.4         127948-128401       c
            871-967             CT033751.4         127770-127866       c
            968-1038            CT033751.4         127621-127691       c
            1039-1099           CT033751.4         127226-127286       c
            1100-1208           CT033751.4         126251-126359       c
            1209-1350           CT033751.4         124666-124807       c
            1351-1456           CT033751.4         124474-124579       c
            1457-1587           CT033751.4         124142-124272       c
            1588-1683           CT033751.4         113559-113654       c
            1684-2045           CT033751.4         113087-113448       c
FEATURES             Location/Qualifiers
     source          1..2045
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.5 cM"
     gene            1..2045
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /note="A kinase anchor protein 8-like"
                     /db_xref="GeneID:54194"
                     /db_xref="MGI:MGI:1860606"
     exon            1..64
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..1977
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     neighbor of A-kinase anchoring protein 95; AKAP8-like
                     protein; neighbor of AKAP95; A kinase (PRKA) anchor
                     protein 8-like"
                     /codon_start=1
                     /product="A-kinase anchor protein 8-like isoform 1"
                     /protein_id="NP_059504.2"
                     /db_xref="CCDS:CCDS50058.1"
                     /db_xref="GeneID:54194"
                     /db_xref="MGI:MGI:1860606"
                     /translation="MSYTGFVQGSETTLQSTYCDTSAQPTCDYGYGTWNSGTNRGYEN
                     YGYGYGYGQDNTTNYGYGMATSHSWEMASSDTNANPSASGSASADSVLSRINQRLDMM
                     PHLETDMIQGGVYGSGGGERYDSYEACDSRAILSERDLYRSSYDYGELDPEMEMAYEG
                     QYDAYRDQFRMRGGDTFGPRAQGWARDARSGRPMASGYGRMWEDPMGARGQCMPGASR
                     LPSLFSQNIIPEYGMFQGMRGGGAFSGGSRFGFGFGNGMKQMRRTWKTWTTADFRTKK
                     KKRKQGGSPDEPDSKATRTDCSDNSDSDNDEGTEGEAAEGTESAEAMEKGSRAEGEDE
                     EGKEDGREGKEDSEKGALTAQDESSQAKRKLQASKKSQDKQKKRQRDRMVERIQFVCS
                     LCKYRTFYEDEMGSHLDSKFHKEHFKYVGTKLPKQTADFLQEYVTNKTKKTEELRKTV
                     EDLDGLIQQIYRDQDLTQEIAMEHFVKKVEAAHCAACDLFIPMQFGIIQKHLKTMDHN
                     RNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPFTDNPEEEKEQDEVEAGA
                     LDEGAPSEATELTEGVPAQPPVPLEPAPGTTTPPPPPPPEEEESPVPLLGGALQCQIR
                     GIPGLDMEDDEEGGGGP"
     exon            65..139
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            140..172
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            173..416
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            417..870
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            871..967
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1038
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1099
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1208
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1350
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1456
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1587
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1588..1683
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..2045
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2024..2029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /note="hexamer: AATAAA"
     polyA_site      2045
                     /gene="Akap8l"
                     /gene_synonym="HAP95; Nakap95"
                     /note="major polyA site"
ORIGIN      
        1 agacgcgcag agtagcggtc tgtgtccacg gctcgggtgt tctctgcggc catgagctac
       61 acaggttttg tccaaggatc cgaaaccact ttgcagtcta cgtactgtga caccagtgcc
      121 cagcccacct gtgattatgg atatggaact tggaactctg ggacaaatag aggctacgag
      181 aactatggtt atggctatgg ctatggccag gataacacca ccaactatgg gtatggtatg
      241 gccacttcac actcttggga aatggctagc tctgacacaa atgcaaaccc tagtgcctcg
      301 ggtagcgcca gtgccgattc cgttttatcc agaattaacc agcgcttaga tatgatgccg
      361 cacttggaga cagacatgat acaaggaggt gtgtacggct caggtggtgg agagagatat
      421 gactcctatg aggcctgtga ctcaagggcc atcctgagtg aacgagacct ctaccggtca
      481 agctatgact atggcgagct tgaccctgag atggaaatgg cctatgaggg ccaatatgat
      541 gcctaccgtg accagtttcg aatgcgtgga ggagatacat ttggtccaag ggctcagggc
      601 tgggcccggg atgcccggag tggacggcca atggcctcgg gctatgggcg catgtgggaa
      661 gatcccatgg gggcccgggg ccagtgcatg cctggtgcct cccggctgcc ctccctcttc
      721 tcccagaaca tcatacccga gtatggcatg ttccagggca tgcgtggtgg gggtgccttc
      781 tctggtggct cccgatttgg ctttggattt ggcaatggca tgaagcagat gaggcgtacc
      841 tggaagacct ggaccacagc cgacttccgg accaaaaaga agaagagaaa gcagggtggc
      901 agtcctgatg agccagacag caaagctacc agaacagact gctcagacaa cagtgactca
      961 gacaatgatg aaggcactga gggggaagct gcagagggta ctgaaagtgc tgaggctatg
     1021 gagaaaggct cccgagcaga aggagaagac gaggagggaa aagaggatgg gagagaaggc
     1081 aaagaagatt cggagaaagg ggccctgacc gcccaggatg agagcagcca ggccaagcgc
     1141 aagttgcagg caagcaagaa gagccaagac aaacagaaaa agcggcagcg agaccgtatg
     1201 gtggaaagga tccagtttgt gtgttctctc tgcaaatacc ggaccttcta tgaggatgag
     1261 atgggtagcc accttgacag caagttccac aaggaacact tcaaatatgt aggcaccaag
     1321 cttccaaagc aaactgctga cttcctgcag gaatatgtca ccaacaagac caagaagacg
     1381 gaggagctcc gaaaaactgt ggaggacctt gatggtctga tccaacaaat ctacagagac
     1441 caagatctga cccaagagat tgctatggag cattttgtga agaaggtaga ggcggcccac
     1501 tgtgcagcct gtgacctttt catccccatg cagtttggaa tcatccaaaa gcatctcaag
     1561 acgatggatc acaaccgaaa ccgcaggctt atgatggagc agtccaagaa gtcctcgctt
     1621 atggtggccc gcagtattct caacaacaag ctcattagca agaagctgga gcgatatctg
     1681 aagggcgaga atcctttcac tgacaaccca gaggaggaaa aggaacaaga cgaggtggag
     1741 gctggcgctc tggatgaagg ggcaccaagc gaagcgacag agctcacaga gggcgtgccg
     1801 gcacagcccc ccgtgcccct ggagcccgcc ccagggacta caacaccgcc acctccgcca
     1861 ccaccagaag aggaggagag ccctgtaccc ttgctgggcg gagcgctgca gtgtcagatc
     1921 cgcgggatcc cgggcctcga catggaagac gacgaggagg gcggtggggg tccataaccc
     1981 ttacccggca gggctcccgt ggccgaggct ggaagtccag cctaataaag tgctttccca
     2041 tctga
//
