LOCUS       NM_019774               3801 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus A kinase anchor protein 8 (Akap8), transcript variant
            1, mRNA.
ACCESSION   NM_019774
VERSION     NM_019774.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3801)
  AUTHORS   Li,W., Hu,J., Shi,B., Palomba,F., Digman,M.A., Gratton,E. and
            Jiang,H.
  TITLE     Biophysical properties of AKAP95 protein condensates regulate
            splicing and tumorigenesis
  JOURNAL   Nat Cell Biol 22 (8), 960-972 (2020)
   PUBMED   32719551
  REMARK    GeneRIF: Biophysical properties of AKAP95 protein condensates
            regulate splicing and tumorigenesis.
REFERENCE   2  (bases 1 to 3801)
  AUTHORS   Suzuki,A., Abdallah,N., Gajera,M., Jun,G., Jia,P., Zhao,Z. and
            Iwata,J.
  TITLE     Genes and microRNAs associated with mouse cleft palate: A
            systematic review and bioinformatics analysis
  JOURNAL   Mech Dev 150, 21-27 (2018)
   PUBMED   29475039
REFERENCE   3  (bases 1 to 3801)
  AUTHORS   Schilders,K., Eenjes,E., Edel,G., de Munck,A.B., van Kempen,M.B.,
            Demmers,J., Wijnen,R., Tibboel,D. and Rottier,R.J.
  TITLE     Generation of a biotinylatable Sox2 mouse model to identify Sox2
            complexes in vivo
  JOURNAL   Transgenic Res 27 (1), 75-85 (2018)
   PUBMED   29383478
REFERENCE   4  (bases 1 to 3801)
  AUTHORS   Jiang,H., Lu,X., Shimada,M., Dou,Y., Tang,Z. and Roeder,R.G.
  TITLE     Regulation of transcription by the MLL2 complex and MLL
            complex-associated AKAP95
  JOURNAL   Nat Struct Mol Biol 20 (10), 1156-1163 (2013)
   PUBMED   23995757
REFERENCE   5  (bases 1 to 3801)
  AUTHORS   Hoffmann,S., Tomasik,G. and Polanski,Z.
  TITLE     DNA methylation, histone modifications and behaviour of AKAP95
            during mouse oocyte growth and upon nuclear transfer of foreign
            chromatin into fully grown prophase oocytes
  JOURNAL   Folia Biol (Krakow) 60 (3-4), 163-170 (2012)
   PUBMED   23342911
  REMARK    GeneRIF: This study showed an increase in the level of global DNA
            methylation starting in oocytes with diameters around 60 microm,
            increases in histone h4, and decreases in AKAP95.
REFERENCE   6  (bases 1 to 3801)
  AUTHORS   Kamada,S., Kikkawa,U., Tsujimoto,Y. and Hunter,T.
  TITLE     A-kinase-anchoring protein 95 functions as a potential carrier for
            the nuclear translocation of active caspase 3 through an
            enzyme-substrate-like association
  JOURNAL   Mol Cell Biol 25 (21), 9469-9477 (2005)
   PUBMED   16227597
REFERENCE   7  (bases 1 to 3801)
  AUTHORS   Arsenijevic,T., Degraef,C., Dumont,J.E., Roger,P.P. and Pirson,I.
  TITLE     A novel partner for D-type cyclins: protein kinase A-anchoring
            protein AKAP95
  JOURNAL   Biochem J 378 (Pt 2), 673-679 (2004)
   PUBMED   14641107
REFERENCE   8  (bases 1 to 3801)
  AUTHORS   Bomar,J., Moreira,P., Balise,J.J. and Collas,P.
  TITLE     Differential regulation of maternal and paternal chromosome
            condensation in mitotic zygotes
  JOURNAL   J Cell Sci 115 (Pt 14), 2931-2940 (2002)
   PUBMED   12082153
REFERENCE   9  (bases 1 to 3801)
  AUTHORS   Akileswaran,L., Taraska,J.W., Sayer,J.A., Gettemy,J.M. and
            Coghlan,V.M.
  TITLE     A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix
            and associates with p68 RNA helicase
  JOURNAL   J Biol Chem 276 (20), 17448-17454 (2001)
   PUBMED   11279182
REFERENCE   10 (bases 1 to 3801)
  AUTHORS   Coghlan,V.M., Langeberg,L.K., Fernandez,A., Lamb,N.J. and
            Scott,J.D.
  TITLE     Cloning and characterization of AKAP 95, a nuclear protein that
            associates with the regulatory subunit of type II cAMP-dependent
            protein kinase
  JOURNAL   J Biol Chem 269 (10), 7658-7665 (1994)
   PUBMED   8125992
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC060209.1, AK004801.1 and
            BC060170.1.
            
            On Mar 31, 2015 this sequence version replaced NM_019774.4.
            
            Summary: This gene encodes a member of the A-kinase anchoring
            protein (AKAP) family. These proteins are characterized by their
            ability to bind to the R subunit of protein kinase A (PKA) and
            anchor the protein at different subcellular locations. This protein
            has been shown to regulate apoptosis and to be involved in
            palatogenesis. Knockdown of this gene has been associated with
            altered histone modifications and reduced expression of
            developmental genes in mouse embryonic stem cells. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Mar 2015].
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164138,
                              SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-94                BC060209.1         1-94
            95-2760             AK004801.1         4-2669
            2761-3801           BC060170.1         3544-4584
FEATURES             Location/Qualifiers
     source          1..3801
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.48 cM"
     gene            1..3801
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /note="A kinase anchor protein 8"
                     /db_xref="GeneID:56399"
                     /db_xref="MGI:MGI:1928488"
     exon            1..154
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..2199
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /note="isoform 1 is encoded by transcript variant 1;
                     A-kinase anchor protein 95 kDa; A kinase (PRKA) anchor
                     protein 8"
                     /codon_start=1
                     /product="A-kinase anchor protein 8 isoform 1"
                     /protein_id="NP_062748.2"
                     /db_xref="CCDS:CCDS37555.1"
                     /db_xref="GeneID:56399"
                     /db_xref="MGI:MGI:1928488"
                     /translation="MEQGYGGYGAWSAGPANTQGTYGSGMTSWQGYENYNYYNAQNTS
                     VPAGTPYSYGPASWEATKTNDGGLAAGSPAMHVASFAPEPCTDNSDSLIAKINQRLDM
                     LSKEGGRGGISSGGEGVQDRDSSFRFQPYESYDARPCIPEHNPYRPGYGYDYDFDLGT
                     DRNGSFGGTFNDCRDPAPERGSLDGFLRGRGQGRFQDRSNSSTFIRSDPFMPPSASEP
                     LSTTWNELNYMGGRGLGGPSTSRPPPSLFSQSMAPDYSMMGMQGVGGFGGTMPYGCGR
                     SQTRIRDWPRRRGFERFGPDNMGRKRKQFPLYEEPDAKLARADSDGDLSENDDGAGDL
                     RSGDEEFRGEDDLCDSRKQRGEKEDEDEDVKKRREKQRRRDRMRDRAADRIQFACSVC
                     KFRSFEDEEIQKHLQSKFHKETLRFISTKLPDKTVEFLQEYIINRNKKIEKRRQELLE
                     KESPKPKPDPFKGIGQEHFFKKIEAAHCLACDMLIPAQHQLLQRHLHSVDHNHNRRLA
                     AEQFKKTSLHVAKSVLNNKHIVKMLEKYLKGEDPFVNETADLETEGDENVGEEKEETP
                     EEVAAEVLAEVITAAVKAVEGEGEPAAAHSDVLTEVEGPVDTAEASSDPHTEKLLEEQ
                     TCEAASETRSIEDKTRGEAAEARNEAAMPTADAGSTLPVIAIPGIMEDELEQTGAEAK
                     DIPTE"
     exon            155..193
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            194..226
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            227..506
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            507..987
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1117
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1164
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1198
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1286
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1287..1428
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1522
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1653
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1749
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..3784
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2746..2751
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /note="hexamer: AATAAA"
     polyA_site      2763
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
     regulatory      3764..3769
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /note="hexamer: AATAAA"
     polyA_site      3782
                     /gene="Akap8"
                     /gene_synonym="1200016A02Rik; AKAP-8; AKAP95"
                     /note="major polyA site"
ORIGIN      
        1 gcccatttga gcaaccaatg gtagcgccca gaaagagacg tacgctcttc gtcttccagt
       61 agcagacagc acgttgaacg catgcgttct gagcgaatct aagacaagga tctgctggcg
      121 ggtcgcgtcg cagacatgga gcaaggctac ggaggctatg gggcatggag tgctggacct
      181 gccaacaccc agggtacata tggaagtggt atgaccagct ggcaaggtta tgaaaactac
      241 aactactaca atgcccagaa caccagtgtc cctgcaggaa caccctatag ttacggccca
      301 gcctcatggg aggccaccaa gaccaatgat ggtggcctgg cagctgggag ccctgccatg
      361 catgtggcgt cttttgcccc agagccatgt accgacaact cagactcgct cattgccaag
      421 atcaatcaac gtttggacat gttgtctaag gaaggaggca ggggtgggat cagcagcggt
      481 ggggagggcg tgcaggaccg agacagctcc ttccgcttcc agccatacga gtcctacgac
      541 gccaggccct gtatacctga gcataatccc taccgccccg gctacggtta tgattatgac
      601 tttgacttgg gaactgaccg caatggtagc tttggtggga cattcaacga ctgtcgggac
      661 ccagccccag agcggggctc ccttgatggt ttcttgaggg gccggggcca gggccgcttc
      721 caagaccgga gcaactccag caccttcata cgtagtgacc ctttcatgcc accctcagcc
      781 tcggagccct tatccactac gtggaatgag ctgaactaca tgggtggccg tggtctcggt
      841 gggccctcca ccagcaggcc acctccttcc ctcttctccc agtccatggc ccctgactac
      901 agcatgatgg gcatgcaggg ggtgggcggt tttggtggta ccatgcctta cggatgtggc
      961 cggtcccaga cgcggatacg ggattggcct agaaggaggg ggtttgaacg ctttggacca
     1021 gacaacatgg gcaggaagcg gaagcagttt ccattgtatg aagaacctga tgccaaactg
     1081 gcccgtgctg acagtgacgg agatctgtct gaaaacgatg atggagctgg tgacttaaga
     1141 tcaggagatg aagaattcag gggggaggat gacttgtgtg actccaggaa gcagagagga
     1201 gaaaaggagg acgaggatga ggatgtgaag aagagacggg agaaacaaag gaggagagac
     1261 aggatgcggg accgagcagc tgacaggatt cagtttgcct gttctgtatg caagtttcgt
     1321 agctttgaag atgaagaaat tcaaaagcat ctgcaaagta aatttcacaa agagactttg
     1381 cgatttataa gtaccaaact gcccgacaag acagtagaat tcctccagga gtacatcata
     1441 aacaggaata agaaaattga gaaacggcgt caggagttgt tggagaagga gagccctaaa
     1501 cccaaaccag atccattcaa aggcattggc caggagcatt tcttcaaaaa gattgaagcc
     1561 gcacattgcc tagcctgtga catgctgatt cctgcgcagc atcagcttct ccagcggcat
     1621 ctgcattccg tggaccataa ccataatcga aggttggctg ctgagcagtt caagaaaaca
     1681 agtctccatg tggctaagag tgttttgaac aacaaacata tagtgaagat gctggaaaaa
     1741 tacctcaagg gtgaggatcc ttttgtcaat gaaactgctg accttgagac agaaggagat
     1801 gaaaatgtag gagaggagaa ggaggagaca ccagaggagg tagctgccga agtcttagca
     1861 gaggtgatca cagcagcagt gaaggctgta gagggggaag gagaacctgc tgcagcgcat
     1921 agtgacgtcc taactgaagt ggaagggcct gtggacacag cagaggccag cagtgacccc
     1981 cacactgaaa agctactaga agagcagacc tgtgaagcag catctgaaac caggagcatc
     2041 gaagacaaga ccagaggtga ggctgctgag gccagaaacg aagcagctat gccaacagca
     2101 gacgcaggaa gcacgttacc tgtcatagca atcccgggaa tcatggaaga tgagctggaa
     2161 caaactggtg cagaggccaa agatattccc accgaatgat ttttttcttc cctgtttcaa
     2221 gggatatgtt atatatcatg tgttcttttt attttataag atgtactagg gtgtgtatta
     2281 tttggtggaa agattgggcc atttccttcc caatgtacct caaggattga tgctatacag
     2341 tagatggctt cctacctctg ttagaataca aaaagaggta aaccattttc ccaagtggcc
     2401 tttgatggct atctgtgcac tgcagttaga ataataaaag tagatcttcc tggtaattgt
     2461 taagtcctaa aacggacaga atgtgaggat ttttttgtgt gtgtgttatg tttttgtttg
     2521 gttggtcttt gtttcgtttt atttgctttt tctcctggaa agcaatttgt tacaaatata
     2581 acttgtttga gggggaaaaa attaattatt taggggaatt cccttattca catatgaatt
     2641 tattcataaa ttatgcatgg ttgatgtggg acacacacga ttcaaccatc catgtgtgcg
     2701 agagctcaga ttgtgccccc taccaataac agtcctgcct gtttcaataa acatcagacc
     2761 aattttttgt ttgttttgtt tttggttggt tggtttttcg agacagggtt tctctctgta
     2821 gccctgactg tcctggaact cactctgtag accaggcagg cctcaaactc agaaatctac
     2881 ctgcctctgc ctcccaagtg ctgggattaa aggcatgcgc caccatgccc ggctcatcag
     2941 accttttttt aaggccttta ttttagcttt ggcattgaga tagcatcttg cttggaccaa
     3001 gcttgccttt gaattcaatc ctcctatctc agtctctgga gtactaggac catgtgtgta
     3061 cagccaagct cagctgggct ttggttttat aatacactgt attctatgtt cctcacctga
     3121 tgtggcagca tcctgttaac taaaggcata acaagatggt gaccttggcc tgtgtataag
     3181 attgtcagag ctgttccata ggaagcatgc ctacctgggc ctctagagtg aagacactgc
     3241 cgaaggcatt cgttctctct gttcagtgct tgctaatcag tttgatgttt gtgttccacc
     3301 tctatttgtg caggattatg ggtttttgtt ttgttttctc ttaattttgt tatttccacc
     3361 taaaagtact taggaaaaaa acctgaaatt actcattgat gaaaaacaaa tgtaaacttc
     3421 cgtagatggg atctatctgt aaaaagctca cacagttacg taaagatgtt tcattttaag
     3481 caaatagtat tcctttggca gttctgagtc tgagaaaggg aggctcagca tgtctgtaaa
     3541 gtagcatgta ctaggtttta tagggtcagt atgatgggtt ttcctccctt ttgaagttac
     3601 aatactgtgt ccattaactg tacacagatc acatcttgga aatatcaacc agtgaagaat
     3661 tataaaagag gcaataaaat attgcaggga ttaaatcagc actctgtgaa ggagcattac
     3721 tagggggtag gagatgcact ttgggaatat cctcgaaaca agcaataaac tgatgccacg
     3781 aagaaaaaaa aaaaaaaaaa a
//
