LOCUS       NM_001379238            3151 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus A kinase anchor protein 7 (Akap7), transcript variant
            3, mRNA.
ACCESSION   NM_001379238
VERSION     NM_001379238.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3151)
  AUTHORS   Murakami,M., Xu,F., Ohba,T., Kobayashi,T., Inoue,Y., Murakami,A.M.,
            Miyoshi,I., Ono,K. and Tohse,N.
  TITLE     Requirement of the Ca2+ channel beta2 subunit for sympathetic PKA
            phosphorylation
  JOURNAL   J Pharmacol Sci 145 (3), 253-261 (2021)
   PUBMED   33602505
  REMARK    GeneRIF: Requirement of the Ca(2+) channel beta2 subunit for
            sympathetic PKA phosphorylation.
REFERENCE   3  (bases 1 to 3151)
  AUTHORS   Jones,B.W., Deem,J., Younts,T.J., Weisenhaus,M., Sanford,C.A.,
            Slack,M.C., Chin,J., Nachmanson,D., McKennon,A., Castillo,P.E. and
            McKnight,G.S.
  TITLE     Targeted deletion of AKAP7 in dentate granule cells impairs spatial
            discrimination
  JOURNAL   Elife 5, e20695 (2016)
   PUBMED   27911261
  REMARK    GeneRIF: Genetic ablation of AKAP7 specifically from dentate
            granule cells results in disruption of mossy fiber-CA3 pyramidal
            neuron long-term potentiation directly initiated by cAMP, and the
            AKAP7 mutant mice are selectively deficient in pattern separation
            behaviors. The results suggest that the AKAP7/PKA complex in the
            mossy fiber projections plays an essential role in synaptic
            plasticity and contextual memory formation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3151)
  AUTHORS   Chen,S., Osaki,N. and Shimotoyodome,A.
  TITLE     Green tea catechins enhance norepinephrine-induced lipolysis via a
            protein kinase A-dependent pathway in adipocytes
  JOURNAL   Biochem Biophys Res Commun 461 (1), 1-7 (2015)
   PUBMED   25849890
  REMARK    GeneRIF: The results demonstrate that green tea catechins enhance
            lipolysis in the presence of norepinephrine via a PKA-dependent
            pathway in 3T3-L1 adipocytes, providing a potential mechanism by
            which green tea catechins could reduce body fat.
REFERENCE   5  (bases 1 to 3151)
  AUTHORS   Cheng,Q. and Yakel,J.L.
  TITLE     Presynaptic alpha7 nicotinic acetylcholine receptors enhance
            hippocampal mossy fiber glutamatergic transmission via PKA
            activation
  JOURNAL   J Neurosci 34 (1), 124-133 (2014)
   PUBMED   24381273
  REMARK    GeneRIF: Protein kinase A activation enhances hippocampal mossy
            fiber glutamatergic transmission.
REFERENCE   6  (bases 1 to 3151)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 3151)
  AUTHORS   Brown,R.L., August,S.L., Williams,C.J. and Moss,S.B.
  TITLE     AKAP7gamma is a nuclear RI-binding AKAP
  JOURNAL   Biochem Biophys Res Commun 306 (2), 394-401 (2003)
   PUBMED   12804576
  REMARK    GeneRIF: AKAP7gamma is the first nuclear AKAP to bind RI and may be
            responsible for positioning PKA via RI and/or RII to regulate
            PKA-mediated gene transcription in both somatic cells and oocytes
REFERENCE   8  (bases 1 to 3151)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3151)
  AUTHORS   Hulme,J.T., Ahn,M., Hauschka,S.D., Scheuer,T. and Catterall,W.A.
  TITLE     A novel leucine zipper targets AKAP15 and cyclic AMP-dependent
            protein kinase to the C terminus of the skeletal muscle Ca2+
            channel and modulates its function
  JOURNAL   J Biol Chem 277 (6), 4079-4087 (2002)
   PUBMED   11733497
REFERENCE   10 (bases 1 to 3151)
  AUTHORS   Fraser,I.D., Tavalin,S.J., Lester,L.B., Langeberg,L.K.,
            Westphal,A.M., Dean,R.A., Marrion,N.V. and Scott,J.D.
  TITLE     A novel lipid-anchored A-kinase Anchoring Protein facilitates
            cAMP-responsive membrane events
  JOURNAL   EMBO J 17 (8), 2261-2272 (1998)
   PUBMED   9545239
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153550.10 and AC153549.5.
            
            Transcript Variant: This variant (3), as well as variant 1, encodes
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3353756.1,
                                           SRR7652917.488850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AC153550.10        93416-93567
            153-284             AC153550.10        100765-100896
            285-433             AC153550.10        106454-106602
            434-570             AC153550.10        118854-118990
            571-731             AC153550.10        123027-123187
            732-844             AC153549.5         20948-21060
            845-992             AC153549.5         39928-40075
            993-3151            AC153549.5         89438-91596
FEATURES             Location/Qualifiers
     source          1..3151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 12.26 cM"
     gene            1..3151
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /note="A kinase anchor protein 7"
                     /db_xref="GeneID:432442"
                     /db_xref="MGI:MGI:1859150"
     exon            1..152
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     exon            153..284
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     exon            285..433
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     exon            434..570
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     exon            571..731
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     exon            732..844
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     exon            845..992
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     exon            993..3151
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2093..2098
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /note="hexamer: ATTAAA"
     polyA_site      2117
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /note="major polyA site"
     regulatory      3128..3133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /note="hexamer: AATAAA"
     polyA_site      3151
                     /gene="Akap7"
                     /gene_synonym="6430401D08; AKAP15; Akap18"
                     /note="major polyA site"
ORIGIN      
        1 cctcctgaag cggcgggtgc cggggatgct gcgactcgcg gggcgttgcg cctccgcagg
       61 cctggccgcc gcggcccgcg cccccgccgt cccgcgcgcc ccgggcccgc gcctccgtct
      121 ctgcgccgcg accatggagc gccccgccgt gggaaaacta gattccggta cgtgtgaaca
      181 tatatcagga gaagaggaag tggcacgaga actggaaccc agccctgtag gttccctgac
      241 agacatgccg tttgctgctg tagatattca agatgactgt ggaagccctg atgtacctca
      301 agcaaaccca aagagaagca aagaagaaga agaagataga ggcgacaaga atgatcatgt
      361 gaagaagagg aaaaaagcca aaaaagatta tcagcccaac tatttcctgt ccattccgat
      421 caccaacaaa aagattacaa ccggaattaa agtcttgcaa aattcgatac tacagcagga
      481 taagcgactg accaaagcca tggtgggcga cggctccttt catattacct tgctagtgat
      541 gcagttatta aacgaagatg aagtaaatat cggtaccgat gcacttttgg aattgaagcc
      601 attcgttgag gagatccttg aagggaaaca cttggctttg cccttccaag ggattggcac
      661 tttccaaggt caggttggct ttgtgaagct ggcagatgga gaccatgtta gcgcactcct
      721 ggagatagca gagactgcga aaagaacatt tcgggaaaaa ggcatcctag ctggagaaag
      781 cagaactttt aagccccacc tgacctttat gaagctgtcc aaagcaccga tgctcaggaa
      841 gaagggagtg agaaaaatcg agcctggatt gtatgaacaa tttatcgacc acagatttgg
      901 agaagaacta ttgtaccaga tagatctctg ctccatgctg aagaaaaaac agagcaatgg
      961 ttattaccac tgtgagtctt ccatcgtgat cggtgagaag gaccgaaggg agcctgagga
     1021 tgctgaactg gtcaggctca gtaagaggct ggtggagaac gccgtgctca aggctgtcca
     1081 gcagtaccta gaagagacgc agaacaaaaa gcagccaggg gaggggaact ccaccaaagc
     1141 tgaggaggga gatcggaatg gtgatggcag tgataacaac cggaagtgag agctgaatcc
     1201 agtccggtcc gatgcccctc tgctaagtcg tagactaact cgcaatgtgt cttgttcaag
     1261 ccctggagat cacctaatac ttctctgatt gatgtgattg atgcgttcgg tgttgctgcg
     1321 acacaacaga aaagaatggg gtgctgggac cagcagaaga aattaattta cagaagaaca
     1381 acactaagtc ggtgtgccat cgaccatgca caagggagag cgggcttttc ggaccgcctg
     1441 cctgactcac aaggcggagg gagggagagg acttgccaca gacagaatac tgccgtttac
     1501 attgcttcga tcctttgact actttatcgg aggccaaaac ttgcacacag ctatcaagtg
     1561 ctaagttcag tttgtcattg ttgaaatgac cattagtata gtgagtccac aatgtttcct
     1621 gtttgtcctc tatgtgttgt taccacacgg tgatctttat ttacagtaaa ttaagtttcg
     1681 tgtaaagtat atatttttgg taaaatgcaa tcttttctat gaaatgtggg tgatgtttta
     1741 aaggttttta agccttattt tgataagtca atgtgccata tttaatgtac ttcattgata
     1801 tttgtacttt aaatgtatta tataattttt ccccttaggc aagaagccag ttggaaccca
     1861 agacttaatt aatgaagctt tgcaccgaga aaggatggag ctgaaatcca aagtgaaaca
     1921 gataaaagaa cttttgttaa agcctgagac tcaggccaag attagaaagg agctttttga
     1981 aggaagagtt tttaataatg gtagtccaac aagcaatgct gatttcaacc tgattttgcc
     2041 atagctctcc actgttgtta tgcctggtaa agtgtttatg aactctcagc ccattaaata
     2101 gctctttggt gagtaaacag agtgttctta cagtttctac aaagcccaca aaccaacact
     2161 tggtaaggaa ttaacaactt cttgccaaag aaaacatatt tttgccttat catggtcatc
     2221 atcaccatta tcaccatcat caccatcgtc accatcatcg tcatcaccat aaagttgagt
     2281 tttagaatgt tcgttttggt atctttgact cattttatag aaataacttc ttaattagct
     2341 gttgtaagat gttccatggg gtccttgcag ataatattgc gcatacatat atatatacat
     2401 gtatgtatgt atgtatgtat gtatgtatgt atatatatat gcacacacac tatgaaaaac
     2461 actatgaaaa atcctttaca gacaaaaaac aacaagaaaa caaaaataaa ccatcaacag
     2521 tattctaagg gtcacctgcc tcctgttgat gtaagggtca cctgcctcct gttgatgtgg
     2581 cccttgtcac ttcagaggaa gcattgtccg ggcttgtcca gtgtcacagt ccttttgctg
     2641 agcgtttgaa tgcttattgc tatcagtact tgaatgaaca tcagtaagtg taatcattgt
     2701 agtcatgggt taagaatgtt ttataatatc tatattatta tttttcactg ataaaagtac
     2761 agttgcattt ttttttttaa tttcttagtg aagaatgttc agggctctta tttcctactc
     2821 tatgaagata agcccaaggc tgtgttcttt acgatttgag tagtttgcac tggttcattt
     2881 ataaacgagc attcttgagg tgtttccccc catgtgatgt ttctttgtaa cagctctttg
     2941 ggtagttact ttaaaattgc tgctactggt agatgatggg gaaggaagta gttagagatg
     3001 aaatatgtaa tcctcccaca cacagtccag tttgctcgtg tattctggtt attttttcac
     3061 tgggtagctg atactacatg aattcatgat gtattccttt atacggccct acgttttcat
     3121 gccctgtaat aaaagtactc tttcccctgt t
//
