LOCUS       NM_001101471            6685 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus A kinase anchor protein 5 (Akap5), mRNA.
ACCESSION   NM_001101471 XM_138063 XM_915706
VERSION     NM_001101471.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6685)
  AUTHORS   Wang,S.Y., Xia,Z.X., Yang,S.W., Chen,W.K., Zhao,Y.L., Li,M.D.,
            Tian,D., Pan,Y., Lin,X.S., Zhu,X.Q., Huang,Z., Liu,J.M., Lai,Z.M.,
            Tao,W.C. and Shen,Z.C.
  TITLE     Regulation of depressive-like behaviours by palmitoylation: Role of
            AKAP150 in the basolateral amygdala
  JOURNAL   Br J Pharmacol 181 (13), 1897-1915 (2024)
   PUBMED   38413375
  REMARK    GeneRIF: Regulation of depressive-like behaviours by
            palmitoylation: Role of AKAP150 in the basolateral amygdala.
REFERENCE   2  (bases 1 to 6685)
  AUTHORS   Simmons,S.C., Flerlage,W.J., Langlois,L.D., Shepard,R.D.,
            Bouslog,C., Thomas,E.H., Gouty,K.M., Sanderson,J.L., Gouty,S.,
            Cox,B.M., Dell'Acqua,M.L. and Nugent,F.S.
  TITLE     AKAP150-anchored PKA regulates synaptic transmission and
            plasticity, neuronal excitability and CRF neuromodulation in the
            mouse lateral habenula
  JOURNAL   Commun Biol 7 (1), 345 (2024)
   PUBMED   38509283
  REMARK    GeneRIF: AKAP150-anchored PKA regulates synaptic transmission and
            plasticity, neuronal excitability and CRF neuromodulation in the
            mouse lateral habenula.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6685)
  AUTHORS   Martinez,T.P., Larsen,M.E., Sullivan,E., Woolfrey,K.M. and
            Dell'Acqua,M.L.
  TITLE     Amyloid-beta-induced dendritic spine elimination requires
            Ca2+-permeable AMPA receptors, AKAP-Calcineurin-NFAT signaling, and
            the NFAT target gene Mdm2
  JOURNAL   eNeuro 11 (3) (2024) In press
   PUBMED   38331575
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 6685)
  AUTHORS   Bai,X., Zhang,K., Ou,C., Mu,Y., Chi,D., Zhang,J., Huang,J., Li,X.,
            Zhang,Y., Huang,W. and Ouyang,H.
  TITLE     AKAP150 from nucleus accumbens dopamine D1 and D2
            receptor-expressing medium spiny neurons regulates morphine
            withdrawal
  JOURNAL   iScience 26 (11), 108227 (2023)
   PUBMED   37953959
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6685)
  AUTHORS   Bai,X., Zhang,K., Ou,C., Nie,B., Zhang,J., Huang,Y., Zhang,Y.,
            Huang,J., Ouyang,H., Cao,M. and Huang,W.
  TITLE     Selective activation of AKAP150/TRPV1 in ventrolateral
            periaqueductal gray GABAergic neurons facilitates conditioned place
            aversion in male mice
  JOURNAL   Commun Biol 6 (1), 742 (2023)
   PUBMED   37460788
  REMARK    GeneRIF: Selective activation of AKAP150/TRPV1 in ventrolateral
            periaqueductal gray GABAergic neurons facilitates conditioned place
            aversion in male mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6685)
  AUTHORS   Nijholt,I.M., Ostroveanu,A., de Bruyn,M., Luiten,P.G., Eisel,U.L.
            and Van der Zee,E.A.
  TITLE     Both exposure to a novel context and associative learning induce an
            upregulation of AKAP150 protein in mouse hippocampus
  JOURNAL   Neurobiol Learn Mem 87 (4), 693-696 (2007)
   PUBMED   17270471
  REMARK    GeneRIF: AKAP150 protein levels were increased upon exposing mice
            to the novel context independent of the training protocol. After
            habituation, only mice that learned to associate the context with
            the footshock showed an upregulation of AKAP150.
REFERENCE   7  (bases 1 to 6685)
  AUTHORS   Hall,D.D., Davare,M.A., Shi,M., Allen,M.L., Weisenhaus,M.,
            McKnight,G.S. and Hell,J.W.
  TITLE     Critical role of cAMP-dependent protein kinase anchoring to the
            L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in
            neurons
  JOURNAL   Biochemistry 46 (6), 1635-1646 (2007)
   PUBMED   17279627
REFERENCE   8  (bases 1 to 6685)
  AUTHORS   Sandoz,G., Thummler,S., Duprat,F., Feliciangeli,S., Vinh,J.,
            Escoubas,P., Guy,N., Lazdunski,M. and Lesage,F.
  TITLE     AKAP150, a switch to convert mechano-, pH- and arachidonic
            acid-sensitive TREK K(+) channels into open leak channels
  JOURNAL   EMBO J 25 (24), 5864-5872 (2006)
   PUBMED   17110924
  REMARK    GeneRIF: The association of AKAP150 with TREK channels integrates
            them into a postsynaptic scaffold where both G-protein-coupled
            membrane receptors and TREK-1 dock simultaneously.
REFERENCE   9  (bases 1 to 6685)
  AUTHORS   Weiwad,M., Edlich,F., Erdmann,F., Jarczowski,F., Kilka,S., Dorn,M.,
            Pechstein,A. and Fischer,G.
  TITLE     A reassessment of the inhibitory capacity of human FKBP38 on
            calcineurin
  JOURNAL   FEBS Lett 579 (7), 1591-1596 (2005)
   PUBMED   15757646
REFERENCE   10 (bases 1 to 6685)
  AUTHORS   Tavalin,S.J., Colledge,M., Hell,J.W., Langeberg,L.K., Huganir,R.L.
            and Scott,J.D.
  TITLE     Regulation of GluR1 by the A-kinase anchoring protein 79 (AKAP79)
            signaling complex shares properties with long-term depression
  JOURNAL   J Neurosci 22 (8), 3044-3051 (2002)
   PUBMED   11943807
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC120002.24.
            
            On or before Oct 13, 2007 this sequence version replaced
            XM_915706.3, XM_138063.7.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219381.144830.1,
                                           SRR9219380.82722.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-99                AC120002.24        162053-162151
            100-6685            AC120002.24        164728-171313
FEATURES             Location/Qualifiers
     source          1..6685
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 33.73 cM"
     gene            1..6685
                     /gene="Akap5"
                     /gene_synonym="3526401B18Rik; AKAP 150; AKAP-5; AKAP150;
                     Gm258; P150"
                     /note="A kinase anchor protein 5"
                     /db_xref="GeneID:238276"
                     /db_xref="MGI:MGI:2685104"
     exon            1..99
                     /gene="Akap5"
                     /gene_synonym="3526401B18Rik; AKAP 150; AKAP-5; AKAP150;
                     Gm258; P150"
                     /inference="alignment:Splign:2.1.0"
     exon            100..6685
                     /gene="Akap5"
                     /gene_synonym="3526401B18Rik; AKAP 150; AKAP-5; AKAP150;
                     Gm258; P150"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6658..6663
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap5"
                     /gene_synonym="3526401B18Rik; AKAP 150; AKAP-5; AKAP150;
                     Gm258; P150"
                     /note="hexamer: AATAAA"
     polyA_site      6682
                     /gene="Akap5"
                     /gene_synonym="3526401B18Rik; AKAP 150; AKAP-5; AKAP150;
                     Gm258; P150"
                     /note="major polyA site"
ORIGIN      
        1 agagggctgc gcgctccgcg gtctccgggg ctctccgttg tttgggcccg tgctcctcga
       61 cctcgggagc agagctggcc agagaccgcg acgatctggg ttgggcttca aataaagaag
      121 aagttgagcc aggaaagtgc tttcattcaa agagtaaatt aaaagaagac accgtgaggc
      181 tcagataaac aaggcgttcg tgtcctgaag aagtcacaga aacagctgtg gtgtgagggg
      241 agagtggaca cgtaggagaa atcggagctg gtgtgatatt tctgtcacaa aagactttcg
      301 gaggaaggga aaagacacgt ttctagagaa tgaaagagtg cagcgtcaaa atggagacca
      361 gcgtttctga gattcaggta gagacgaagg acgagaaggg accagtagca gccagtcctc
      421 agaaagagag gcaggagaga aaaacagcca cactctgctt caagagaagg aagaaagcga
      481 acaagacaaa acccaaagcc ggttccagga ctgctgagga gacaaagaaa catacccccg
      541 aagctggggg ctctggtcaa cggcaaccag cgggtgcctg ggcctccatc aaaggccttg
      601 tgacacacag gaaaaggtcc gagcctgcaa agaagcagaa gccgcctgag gcagaggtgc
      661 agcccgagga tggggctctt cctaagaaaa aggcaaaatc cagacttaag tttccttgcc
      721 taagattctc aagaggggca aagagaagtc gtcattccaa actcacagaa gattcaggct
      781 acgtcagagt ccagggagag gcagacgatt tggagataaa agcccagacc cagccagatg
      841 accaggcaat ccaggctggg tctacccagg gcctacagga aggtgtgttg gtgagagatg
      901 gtaagaagag ccaagaatca cacataagca acagcgtcac ctcgggagag aatgtgatcg
      961 ccatagaact ggaattagaa aacaaatctt ctgctatcca gatgggaact cctgagctgg
     1021 aaaaggagac taaggtgatc acggaaaagc caagtgtgca gacgcagcga gcaagtctac
     1081 ttgagagttc agcagcaggc agccctcggt cagtgacttc tgctgctcct ccatcaccag
     1141 caaccacaca tcaacatagt ctggaagaac ccagtaatgg catccgggaa agtgccccaa
     1201 gtgggaaaga tgacaggaga aagactgctg ctgaagaaaa gaaatcagga gagactgcac
     1261 tgggccaggc agaggaagct gcagttggcc aggcagacaa aagggcacta agccaggccg
     1321 gagaagctac agcgggccac ccagaggaag ctactgtgat ccaggcagag agtcaggcaa
     1381 aggaagggaa actgagccag gcagaggaaa ctacagtggc ccaggcaaag gaaactgtat
     1441 tgagtcaggc aaaggaaggt gaactgagcc aggcaaagaa agctacagtt ggccaggcag
     1501 aggaagctac aattgaccac acagagaaag tcacagtgga tcaggcagag gaaaccacag
     1561 tgggtcaggc agaagaagct acagttggtc aggcagggga agctatattg agccaagcaa
     1621 aggaagctac agttgttggt caggcagagg aagctacagt tgatcgggca gaggaagcta
     1681 ctgttggtca ggcagaggaa gctacagttg gccacacaga gaaagtcaca gtggatcagg
     1741 cagaggaagc cacggtgggt caggcagagg aagctactgt tggtcaggca gaggaagcta
     1801 cagttgattg ggcagaaaaa cccacagttg gtcaggcaga ggaagccaca gtgggtcagg
     1861 cagaggaagc tacagttggc cacacagaga aagtcacagt ggatcaggca gaggaagcaa
     1921 cagtgggtca ggcagaggaa gctacagttg gccacacaga gaaagtcaca gtggatcatg
     1981 cagaggaagc cacagtgggt caggcagagg aagctacagt tggacaggca gagaaagtca
     2041 cagtggatca tgcagaggaa gccacagtgg gtcaggcaga ggaagctaca gttggacagg
     2101 cagagaaagt cacagtggat catgcagagg aagccacagt gggtcaggca gaggaagcta
     2161 cagttggaca ggcagagaaa gtcacagtgg atcaggcaga ggaacccaca gtggatcagg
     2221 ctgaggaagc tatatcgagc catgcaccag atctgaaaga aaatggaatt gatacagaga
     2281 aaccgagatc agaagaaagc aaacgaatgg agccaattgc tattatcatt actgacactg
     2341 aaatcagtga atttgatgtt aagaagtcta aaaatgttcc taagcaattc ctaatttcaa
     2401 tggaaaacga gcaagtgggg gtttttgcta atgatagtga tttcgagggg agaacttcag
     2461 aacagtatga aacactctta atagaaacag catcttctct cgtcaagaat gctatcgagt
     2521 tgtctgtaga acagctggtt aatgaaatgg tttccgagga taatcaaata aatacgctgt
     2581 tccagtgact tcgtttccag gtcacgaaaa gaaagggggg aaaaaaaccc ttgaaagatg
     2641 aattctttta tccctttgtg gcacttcttt ctcagtaata aattagaggc ttatcatctg
     2701 tggaatctaa gggtacagtt ccagcccaga agtgctaaag gatcaatgaa ggttgtaaaa
     2761 ctctgtcatt gaaacacagt tctggactgg agggagtcag cacagatcac agtgcgaagt
     2821 gacttatggg gaggtgtgga agtggcaggc aatagcccag tgctttgagg agggaagact
     2881 actgagcact gggtatgcta tatggttctt taatgtcact aagtctgggt ttctttctga
     2941 tggttcgacc ctgggttata ggtgaacgct ccattcgctt tccttttaca gggtcttcct
     3001 gctgtctcta gtggtgaatc aggtgagtgg gcttttctag tcttgagcaa gttctgtact
     3061 aaaggtgttc atgggttcct tcggtcaggc caatagttaa cacatgtgta ggcatggaca
     3121 caggaagtgt gttctctccc caacatccct ctgcccagaa gacctgtata tacccatctg
     3181 tgagtgaacc tttctcctga gaaatcaaat ggggaagagt atatttttta tccaggaggc
     3241 aaacttccca ggtagcaaag gattctaata gcagagctac ttctttgggt tgtttttttg
     3301 tttgtttgtt ttttccagat agtatttctc tgtgtaaccc tggctgtcct ggaactcgct
     3361 ctatagacca ggctggcctc gaactcacag aattccgact gcctctgctt cccaagtgct
     3421 ggtcgagatt aaaggtatgg gtcatcatcg cctggctaaa gggccaggaa accgtaatat
     3481 tcttgtgaaa atagttcttg gccaaacata aactatgtaa tgaactgaat aaaaggtcaa
     3541 aattcacact aaagcctaga ttttcaacac cagtattttt cattttgtct agccataaca
     3601 ctgtaacata ctacccaacc ccacacgtta gggtccatat tgtacagcac ccccatccca
     3661 ctatctaaac taagtgatac tgtttctact tgttacaaaa gatgtggtac acatggtaca
     3721 atgtctgttg agcatcttct tgaggcatga gcaccactag ttggtttggt tgttattttt
     3781 gttttttgtg ttgttgttgt tttcaagaca aggtttctct gtgtaacctt ggctgtcctg
     3841 aaactcactc tgtagaccag gctggcctcc aacttagaga tccgcctgcc tctgcttcct
     3901 gagtgctggg actaaagtcg tgcgccacca ctgtccagcg agcactgctt attttcatcc
     3961 actttgcact tacactgtgt ttatgggctg catatgtata cactgctttt tcctatcttt
     4021 tattttgtaa atacatattg tgatcttgtg caaaagtaac taatgtggct ttgaaaatta
     4081 accaaatggt ggatgtttag caagattctt ggctggaatg tgaaaatatt ttcttcaggc
     4141 ttgcctatct tcatgtttgt aatgggtgat ggggtatcat tcaatttaga taaaaacaca
     4201 acaccccttc aataaattta ttttaatggt tttcctctta gacataaaac taaaaatcac
     4261 tcctaaatca tctttgaaag aatattttaa cccactgtat atggtgctaa tagacttgta
     4321 tagatagcta ccagcaaata tgtttaaaat gaacttttaa aagcctggtt aaagttggta
     4381 cactttgcag tactttaaac aattctgtat ctatttacta taagaatggc tccaaggaga
     4441 gccacattac actcacatta aggtttctaa tctcttatga atgagtaaaa tctataagat
     4501 acaagctctt agttattgaa gatattctgg gtttggagat tttgaaaagc aggcacaaag
     4561 taaatttgta attttggggg taagatagta gccctgggtt tcagggtgtg tgtgtgtgtg
     4621 tgtgtgtgtg tgtgtgtgtg tgtgtgtatg ttccctacac tactatttga taattatacc
     4681 tttggttaga aggtattgtt ataattgatt gtttttataa gaaaatatat tctccttcat
     4741 tcttaagtat tttctctggc tttttaaagc ataattccaa cctgtaagca gaatgcagaa
     4801 attcattagt gggtcacaac cctaagtatc tgctatgtgg ccaaatgata gtgaatctta
     4861 gggtggtcca aactattctg ttgttataaa aataagagat ggcttggaag tctgccatca
     4921 tttttttttt tttttttttt ggtaatggga tgtatttcaa gcagtttgac tttctatgca
     4981 aactatatag aaagattctg actcaattta cacccttgtg gccttaaacg gacccattta
     5041 gatgcatcaa cttagggtag tcacattaat tttcattgaa atttgccttt aatgaacatt
     5101 agctaagatc aaatttcttc ttgaagtcgg aaatttctaa ggctgggggc gtctatcaga
     5161 tccttgataa tttttcagtg tcttctcttc accccctgaa gtcaagcgtt attcacacag
     5221 cacagaggat acaagcactt gcctcgatct ttttgtgtgt gactattcac ttaacatttg
     5281 ttcagcgtac ttttttaaga tattaaaaat agtccccagt aacatctaag taaaggcagc
     5341 agaaaacaaa agacctttcc aacagaaatc atgttccctg ccaccccctc cacctccaag
     5401 aataataagc atgtggcaca aatggatctc ttcagaaaag ctgtctgcat aattttcctc
     5461 caggtaacgg gcttgacagc atgaagatgg ggatgatctt aattggtcta ctacttagtg
     5521 gagtcttaga cacggcttta cttctgagag acaatgcggt ctcgacagtg tatcgagaga
     5581 ggcttcgtgc ttgagactca ttagctctgt ggcctatgag aaggccctgg ggcagccttg
     5641 cacatgcatc cagcccagag ttcatttcat ctgcaaatgt ctgatttcca gttgccttat
     5701 tatttttttt ttatatagct gagaattgtt tttagggggt tgtggcagaa tttttaaaat
     5761 aattgttaga ctttcaaacc ctgttttttg aaaagttcct ttagtcagct tcaccgaata
     5821 agtagtctac ttcctggtta aatgctaaat gcaccaggat ttgactttta tacctgccag
     5881 ttttgcactt ttagaatacc tttgtttaag ttgtagagtt ttttttgttt gtttgttttt
     5941 ttgtctttgt ccagagctga ggaccgaacc cagggccttg cgcttgctag gcaagcgctc
     6001 taccactgag ctaaatcccc aaccccagtt gtagagttct tgaggttcaa gttcctgttt
     6061 tacagcgcaa ctaagtttct tacatgaaat tgaaaatttc aatccatttt gcattttatc
     6121 acacattttt ggaaagaatt tttgtaatga tccttgatga ccaaaattta ttagaatgac
     6181 tttacataaa gtatgggtgc cccaataaag ttggattcaa cacgttaaca cctgtcaaag
     6241 actatgataa taggcctcct acagctcatc ctgggtaggg tgtgtgtgtg tgtgtgtgtg
     6301 tgtgtgtgtg tgtgtgtgtg taaaggaggt ggcaacagaa gccaggacag gggtgaggca
     6361 gagccaccga caatgcaaaa ggggaagtag aaaggatgga gaagttgggg tctgaacata
     6421 aaccgtatat ctcctctgat ttgtgaccag gtgcaggaga aggcctgata atgtcacata
     6481 tgtcggttct ttgcctgtag aaatgttaag tggacgagcc atcagaacca taagagtacc
     6541 actttgtatc ctcattgaaa ttagtactac tgtgactcaa aagctgatag taaagaaata
     6601 atactctgta gagaaaaagg tttcaagctg aattgattca tgtactgact aatacagaat
     6661 aaatgttata ttagctcatt tagtt
//
