LOCUS       NM_009650               3173 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus A kinase anchor protein 3 (Akap3), mRNA.
ACCESSION   NM_009650
VERSION     NM_009650.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3173)
  AUTHORS   Liang,Z., Dai,C., He,F., Wang,Y., Huang,Y., Li,H., Wu,Y., Hu,Y. and
            Xu,K.
  TITLE     AKAP3-mediated type I PKA signaling is required for mouse sperm
            hyperactivation and fertilitydagger
  JOURNAL   Biol Reprod 110 (4), 684-697 (2024)
   PUBMED   38145487
  REMARK    GeneRIF: AKAP3-mediated type I PKA signaling is required for mouse
            sperm hyperactivation and fertilitydagger.
REFERENCE   2  (bases 1 to 3173)
  AUTHORS   Wang,Y., Huang,X., Sun,G., Chen,J., Wu,B., Luo,J., Tang,S., Dai,P.,
            Zhang,F., Li,J. and Wang,L.
  TITLE     Coiled-coil domain-containing 38 is required for acrosome
            biogenesis and fibrous sheath assembly in mice
  JOURNAL   J Genet Genomics 51 (4), 407-418 (2024)
   PUBMED   37709195
REFERENCE   3  (bases 1 to 3173)
  AUTHORS   Tripathi,A., John,A.A., Kumar,D., Kaushal,S.K., Singh,D.P.,
            Husain,N., Sarkar,J. and Singh,D.
  TITLE     MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with
            LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling
            pathway
  JOURNAL   Front Endocrinol (Lausanne) 13, 977347 (2022)
   PUBMED   36267566
  REMARK    GeneRIF: MiR-539-3p impairs osteogenesis by suppressing Wnt
            interaction with LRP-6 co-receptor and subsequent inhibition of
            Akap-3 signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3173)
  AUTHORS   Xia,Q., Cui,G., Fan,Y., Wang,X., Hu,G., Wang,L., Luo,X., Yang,L.,
            Cai,Q., Xu,K., Guo,W., Gao,M., Li,Y., Wu,J., Li,W., Chen,J., Qi,H.,
            Peng,G. and Yao,H.
  TITLE     RNA helicase DDX5 acts as a critical regulator for survival of
            neonatal mouse gonocytes
  JOURNAL   Cell Prolif 54 (5), e13000 (2021)
   PUBMED   33666296
REFERENCE   5  (bases 1 to 3173)
  AUTHORS   Xu,K., Yang,L., Zhang,L. and Qi,H.
  TITLE     Lack of AKAP3 disrupts integrity of the subcellular structure and
            proteome of mouse sperm and causes male sterility
  JOURNAL   Development 147 (2) (2020)
   PUBMED   31969357
  REMARK    GeneRIF: AKAP3 is essential for the formation of the specific
            subcellular structure of the sperm flagellum, motility of sperm and
            male fertility.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3173)
  AUTHORS   Krisfalusi,M., Miki,K., Magyar,P.L. and O'Brien,D.A.
  TITLE     Multiple glycolytic enzymes are tightly bound to the fibrous sheath
            of mouse spermatozoa
  JOURNAL   Biol Reprod 75 (2), 270-278 (2006)
   PUBMED   16687649
REFERENCE   7  (bases 1 to 3173)
  AUTHORS   Lea,I.A., Widgren,E.E. and O'Rand,M.G.
  TITLE     Association of sperm protein 17 with A-kinase anchoring protein 3
            in flagella
  JOURNAL   Reprod Biol Endocrinol 2, 57 (2004)
   PUBMED   15257753
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3173)
  AUTHORS   Brown,P.R., Miki,K., Harper,D.B. and Eddy,E.M.
  TITLE     A-kinase anchoring protein 4 binding proteins in the fibrous sheath
            of the sperm flagellum
  JOURNAL   Biol Reprod 68 (6), 2241-2248 (2003)
   PUBMED   12606363
REFERENCE   9  (bases 1 to 3173)
  AUTHORS   Carr,D.W., Fujita,A., Stentz,C.L., Liberty,G.A., Olson,G.E. and
            Narumiya,S.
  TITLE     Identification of sperm-specific proteins that interact with
            A-kinase anchoring proteins in a manner similar to the type II
            regulatory subunit of PKA
  JOURNAL   J Biol Chem 276 (20), 17332-17338 (2001)
   PUBMED   11278869
REFERENCE   10 (bases 1 to 3173)
  AUTHORS   Vijayaraghavan,S., Liberty,G.A., Mohan,J., Winfrey,V.P., Olson,G.E.
            and Carr,D.W.
  TITLE     Isolation and molecular characterization of AKAP110, a novel,
            sperm-specific protein kinase A-anchoring protein
  JOURNAL   Mol Endocrinol 13 (5), 705-717 (1999)
   PUBMED   10319321
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN837067.1, AF093406.1 and BC100458.1.
            
            On Nov 16, 2007 this sequence version replaced NM_009650.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF093406.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-75                CN837067.1         4-78
            76-228              AF093406.1         1-153
            229-3150            BC100458.1         102-3023
            3151-3173           AF093406.1         3077-3099
FEATURES             Location/Qualifiers
     source          1..3173
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 61.92 cM"
     gene            1..3173
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /note="A kinase anchor protein 3"
                     /db_xref="GeneID:11642"
                     /db_xref="MGI:MGI:1341149"
     exon            1..153
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /inference="alignment:Splign:2.1.0"
     exon            154..254
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /inference="alignment:Splign:2.1.0"
     exon            255..365
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /inference="alignment:Splign:2.1.0"
     CDS             366..2960
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /note="Protein kinase A-anchoring protein 3; A-kinase
                     anchor protein 110 kDa; AKAP-3; AKAP 110; A kinase (PRKA)
                     anchor protein 3"
                     /codon_start=1
                     /product="A-kinase anchor protein 3"
                     /protein_id="NP_033780.2"
                     /db_xref="CCDS:CCDS20558.1"
                     /db_xref="GeneID:11642"
                     /db_xref="MGI:MGI:1341149"
                     /translation="MADRVDWLQSQSGVCKVGVYSPGDNQHQDWKMDTSTDPVRVLSW
                     LRKDLEKSTAGFQDSRFKPGESSFVEEVAYPVDQRKGFCVDYYNTTNKGSPGRLHFEM
                     SHKENPSQGLISHVGNGGSIDEVSFYANRLTNLVIAMARKEINEKIHGAENKCVHQSL
                     YMGDEPTPHKSLSTVASELVNETVTACSKNISSDKAPGSGDRASGSSQAPGLRYTSTL
                     KIKESTKEGKCPDDKPGTKKSFFYKEVFESRNAGDAKEGGRSLPGDQKLFRTSPDNRP
                     DDFSNSISQGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLMKHAKEVVSD
                     LIDSFMKNLHGVTGSLMTDTDFVSAVKRSFFSHGSQKATDIMDAMLGKLYNVMFAKKF
                     PENIRRARDKSESYSLISTKSRAGDPKLSNLNFAMKSESKLKENLFSTCKLEKEKTCA
                     ETLGEHIIKEGLHMWHKSQQKSPGLERAAKLGNAPQEVSFECPDPCEANPPHQPQPPE
                     NFANFMCDSDSWAKDLIVSALLLIQYHLAQGGKMDAQSFLEAAASTNFPTNKPPPPSP
                     VVQDECKLKSPPHKICDQEQTEKKDLMSVIFNFIRNLLSETIFKSSRNCESNVHEQNT
                     QEEEIHPCERPKTPCERPITPPAPKFCEDEEATGGALSGLTKMVANQLDNCMNGQMVE
                     HLMDSVMKLCLIIAKSCDSPLSELGEEKCGDASRPNSAFPDNLYECLPVKGTGTAEAL
                     LQNAYLTIHNELRGLSGQPPEGCEIPKVIVSNHNLADTVQNKQLQAVLQWVAASELNV
                     PILYFAGDDEGIQEKLLQLSATAVEKGRSVGEVLQSVLRYEKERQLDEAVGNVTRLQL
                     LDWLMANL"
     exon            366..461
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /inference="alignment:Splign:2.1.0"
     exon            462..2804
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /inference="alignment:Splign:2.1.0"
     exon            2805..3153
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3129..3134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /note="hexamer: ATTAAA"
     polyA_site      3153
                     /gene="Akap3"
                     /gene_synonym="Prka3"
                     /note="major polyA site"
ORIGIN      
        1 gatgtcactc cctagtgcca acaaggagga ggtgcatgga aggctgggga gggaaacaag
       61 atcttcagct gagtaagaac atcccagcat cttcattgac tttaaaagta tattctggag
      121 tcttctgtgg ttccctataa cagagcttca gaggttctcc gattttaaga aagatgagct
      181 gcctggaatt acaaatgggc aggacttttc tattcactct ttcaacagaa aattactaag
      241 caccaacgtt aaagagtcct tatatattac atggcaggag gggtgggtag acttagggat
      301 agtgaagaca ccaataaggc tcattcggag tcttccttgt atctcaaaac ccatcctcaa
      361 taaggatggc ggatagggtt gactggttac aaagtcaaag tggcgtttgc aaagttggtg
      421 tctattcacc tggagacaac caacaccaag actggaaaat ggacacatca acagatcctg
      481 tccgagtgct cagctggctc cgcaaagacc tggagaaaag tacagcgggc ttccaggact
      541 cgaggttcaa gcctggagag tcatcgtttg tggaggaagt ggcttaccca gtggaccaac
      601 gaaaaggttt ctgtgttgat tattacaata ccaccaacaa gggcagtcca ggaagattgc
      661 attttgagat gtctcacaag gagaaccctt cccagggcct catttcccat gttggtaatg
      721 ggggttccat agacgaagtt tccttctatg ccaaccgcct cacaaaccta gtgatcgcca
      781 tggcccgaaa ggagatcaat gagaagatcc acggcgctga aaacaaatgt gtccatcagt
      841 cattgtatat gggggatgag cccacacccc acaaaagctt gagtacagtg gcctctgagc
      901 tcgtgaacga gacagtcacc gcatgttcca agaacatttc cagtgacaaa gctcccggct
      961 ctggagacag ggcctcgggg tcgtcacagg cccctggtct aagatacacg agcactctga
     1021 agatcaagga gagtacaaag gaaggcaagt gtccagacga caagcccggc actaagaagt
     1081 ctttcttcta taaggaagtg tttgagtccc ggaatgcagg agatgccaag gagggcggga
     1141 ggtccttacc aggagatcaa aaactgttca ggaccagccc cgacaacagg cctgatgact
     1201 tttcaaactc tatcagtcaa gggatcatga cctacgccaa cagcgtggtg tctgacatga
     1261 tggtctccat catgaagacg ctgaagatcc aggtgaagga cacaaccatc gccacgattc
     1321 tgctgaagaa ggtgctgatg aagcacgcaa aggaggttgt ctccgacctc atcgactcct
     1381 tcatgaagaa cctccacggc gtcacgggaa gcctcatgac tgacacagac tttgtctcgg
     1441 ccgtgaaacg aagttttttt tctcatggaa gccaaaaggc cacagatatc atggatgcca
     1501 tgctgggcaa gctatacaat gtgatgtttg ccaagaaatt ccctgagaac atccggagag
     1561 ccagggacaa gtcggagagt tactccctta tctccacgaa atcacgggct ggtgacccaa
     1621 agctctcaaa tttgaacttt gcgatgaagt cagaatcaaa gctgaaagaa aatttgtttt
     1681 ctacatgcaa actagagaaa gagaagacgt gtgccgaaac tctgggtgag catattatta
     1741 aggagggact gcacatgtgg cacaagagtc agcaaaaatc tcctggcttg gagcgtgccg
     1801 caaaactggg taacgctcca caggaggtct cctttgagtg cccagatcct tgtgaggcaa
     1861 accctcctca ccaacctcag ccaccagaga attttgcaaa ttttatgtgt gactcagact
     1921 cctgggccaa ggacctgatt gtatccgccc tgcttctgat tcagtatcac ctggcacagg
     1981 gaggaaagat ggatgctcag agcttcctgg aagctgctgc cagcaccaat tttcccacca
     2041 acaagccacc tcctccttct cctgtagttc aggatgagtg caaacttaag tctcctcccc
     2101 acaagatatg tgaccaagaa caaacagaaa agaaagatct gatgagtgtc atcttcaatt
     2161 ttatccggaa cttactcagc gagaccatat tcaagagtag ccgtaactgt gaatccaatg
     2221 tgcatgagca gaacactcag gaagaagaga tacacccgtg tgaaaggcct aagactccat
     2281 gtgaaaggcc tattaccccg cctgccccga aattctgtga ggatgaggag gccactggtg
     2341 gtgccttatc tgggctaacc aagatggttg ccaaccagct agacaactgt atgaatgggc
     2401 agatggtgga gcacctgatg gactcggtga tgaagttatg cctcattatt gccaagtcct
     2461 gtgactctcc cctgtcggag ctgggagagg aaaagtgtgg ggatgccagc cggccaaatt
     2521 ctgccttccc agataactta tatgagtgcc taccagtcaa gggcacaggg acagctgaag
     2581 ccctcctgca gaacgcctac ctcaccatcc ataatgaact gagaggtttg tcaggacagc
     2641 cccccgaggg ctgtgaaatc cccaaggtga tcgtcagcaa ccacaatctg gctgacaccg
     2701 ttcagaacaa gcaactgcaa gctgtccttc agtgggtggc tgcctcagag ctcaatgtcc
     2761 ctattttgta ctttgctggt gacgatgaag gaatccagga gaagctgctt cagctctcag
     2821 ccactgccgt ggagaaaggc cgcagcgtcg gggaggttct gcagtcggtg ctgaggtacg
     2881 agaaggagcg acagctggat gaagcagtgg gaaatgtcac gcggctgcag ctgctggact
     2941 ggctgatggc aaacctgtga ttggggccta ccctgagttc cctcagcggg ccgagtcccc
     3001 gccccctcag ccccctccat gccccacaga gccctaaagt cccctccatg ccacgcacac
     3061 tagacatgcc atctaacgct actcactgga ttttgcagat tttcttgtcc atgcgagcaa
     3121 ggacataaat taaaagatta cagttaaagg gcaaaaaaaa aaaaaaaaaa aaa
//
